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8 similar compounds to monomer 50044969

Compile data set for download or QSAR
Wt: 221.2
BDBM48563
Purchase
Wt: 240.2
BDBM50041111
Wt: 269.2
BDBM50041140
Wt: 237.2
BDBM50044960
Wt: 239.2
BDBM50044963
Purchase
Wt: 239.2
BDBM50044968
Wt: 239.2
BDBM50385979
Wt: 235.2
BDBM50385980

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 48563,50041111,50041140,50044960,50044963,50044968,50385979,50385980   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
eukaryotic translation initiation factor 4 gamma, 1 isoform 4


(Homo sapiens (Human))
BDBM48563
PNG
(2-phenyl-1H-quinolin-4-one | 2-phenyl-4-quinolone ...)
Show SMILES Oc1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C15H11NO/c17-15-10-14(11-6-2-1-3-7-11)16-13-9-5-4-8-12(13)15/h1-10H,(H,16,17)
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n/an/a 6.40E+4n/an/an/an/an/an/a



Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay


Assay Description
Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2RN3686
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50041111
PNG
(7-Fluoro-2-pyridin-2-yl-1H-quinolin-4-one | CHEMBL...)
Show SMILES Oc1cc(nc2cc(F)ccc12)-c1ccccn1
Show InChI InChI=1S/C14H9FN2O/c15-9-4-5-10-12(7-9)17-13(8-14(10)18)11-3-1-2-6-16-11/h1-8H,(H,17,18)
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n/an/a>4.00E+4n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)


Article DOI: 10.1021/jm00034a010
BindingDB Entry DOI: 10.7270/Q2ZC81XN
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50041140
PNG
(7-Fluoro-2-(4-methoxy-phenyl)-1H-quinolin-4-one | ...)
Show SMILES COc1ccc(cc1)-c1cc(O)c2ccc(F)cc2n1
Show InChI InChI=1S/C16H12FNO2/c1-20-12-5-2-10(3-6-12)14-9-16(19)13-7-4-11(17)8-15(13)18-14/h2-9H,1H3,(H,18,19)
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n/an/a>4.00E+4n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)


Article DOI: 10.1021/jm00034a010
BindingDB Entry DOI: 10.7270/Q2ZC81XN
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM48563
PNG
(2-phenyl-1H-quinolin-4-one | 2-phenyl-4-quinolone ...)
Show SMILES Oc1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C15H11NO/c17-15-10-14(11-6-2-1-3-7-11)16-13-9-5-4-8-12(13)15/h1-10H,(H,16,17)
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n/an/a 7.30E+3n/an/an/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization(ITP)


J Med Chem 44: 3932-6 (2001)


Article DOI: 10.1021/jm0101085
BindingDB Entry DOI: 10.7270/Q2PK0FFW
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50044960
PNG
(7-Hydroxy-2-phenyl-1H-quinolin-4-one | CHEMBL15634)
Show SMILES Oc1ccc2c(O)cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C15H11NO2/c17-11-6-7-12-14(8-11)16-13(9-15(12)18)10-4-2-1-3-5-10/h1-9,17H,(H,16,18)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Institute of Pharmaceutical Chemistry

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 36: 1146-56 (1993)


Article DOI: 10.1021/jm00061a005
BindingDB Entry DOI: 10.7270/Q2BV7H8S
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50044963
PNG
(6-Fluoro-2-phenyl-1H-quinolin-4-one | CHEMBL16098)
Show SMILES Oc1cc(nc2ccc(F)cc12)-c1ccccc1
Show InChI InChI=1S/C15H10FNO/c16-11-6-7-13-12(8-11)15(18)9-14(17-13)10-4-2-1-3-5-10/h1-9H,(H,17,18)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Institute of Pharmaceutical Chemistry

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 36: 1146-56 (1993)


Article DOI: 10.1021/jm00061a005
BindingDB Entry DOI: 10.7270/Q2BV7H8S
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50385980
PNG
(CHEMBL1353974)
Show SMILES Cc1ccc(cc1)-c1cc(O)c2ccccc2n1
Show InChI InChI=1S/C16H13NO/c1-11-6-8-12(9-7-11)15-10-16(18)13-4-2-3-5-14(13)17-15/h2-10H,1H3,(H,17,18)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by fluorometric analysis


Eur J Med Chem 54: 10-21 (2012)


Article DOI: 10.1016/j.ejmech.2012.04.002
BindingDB Entry DOI: 10.7270/Q22J6CW7
More data for this
Ligand-Target Pair
Cathepsin V


(Homo sapiens (Human))
BDBM48563
PNG
(2-phenyl-1H-quinolin-4-one | 2-phenyl-4-quinolone ...)
Show SMILES Oc1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C15H11NO/c17-15-10-14(11-6-2-1-3-7-11)16-13-9-5-4-8-12(13)15/h1-10H,(H,16,17)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by fluorometric analysis


Eur J Med Chem 54: 10-21 (2012)


Article DOI: 10.1016/j.ejmech.2012.04.002
BindingDB Entry DOI: 10.7270/Q22J6CW7
More data for this
Ligand-Target Pair
Cathepsin V


(Homo sapiens (Human))
BDBM50385979
PNG
(CHEMBL2042448)
Show SMILES Oc1cc(nc2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C15H10FNO/c16-11-7-5-10(6-8-11)14-9-15(18)12-3-1-2-4-13(12)17-14/h1-9H,(H,17,18)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by fluorometric analysis


Eur J Med Chem 54: 10-21 (2012)


Article DOI: 10.1016/j.ejmech.2012.04.002
BindingDB Entry DOI: 10.7270/Q22J6CW7
More data for this
Ligand-Target Pair
Cathepsin V


(Homo sapiens (Human))
BDBM50385980
PNG
(CHEMBL1353974)
Show SMILES Cc1ccc(cc1)-c1cc(O)c2ccccc2n1
Show InChI InChI=1S/C16H13NO/c1-11-6-8-12(9-7-11)15-10-16(18)13-4-2-3-5-14(13)17-15/h2-10H,1H3,(H,17,18)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by fluorometric analysis


Eur J Med Chem 54: 10-21 (2012)


Article DOI: 10.1016/j.ejmech.2012.04.002
BindingDB Entry DOI: 10.7270/Q22J6CW7
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM48563
PNG
(2-phenyl-1H-quinolin-4-one | 2-phenyl-4-quinolone ...)
Show SMILES Oc1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C15H11NO/c17-15-10-14(11-6-2-1-3-7-11)16-13-9-5-4-8-12(13)15/h1-10H,(H,16,17)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by fluorometric analysis


Eur J Med Chem 54: 10-21 (2012)


Article DOI: 10.1016/j.ejmech.2012.04.002
BindingDB Entry DOI: 10.7270/Q22J6CW7
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50385979
PNG
(CHEMBL2042448)
Show SMILES Oc1cc(nc2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C15H10FNO/c16-11-7-5-10(6-8-11)14-9-15(18)12-3-1-2-4-13(12)17-14/h1-9H,(H,17,18)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by fluorometric analysis


Eur J Med Chem 54: 10-21 (2012)


Article DOI: 10.1016/j.ejmech.2012.04.002
BindingDB Entry DOI: 10.7270/Q22J6CW7
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50044968
PNG
(8-Fluoro-2-phenyl-1H-quinolin-4-one | CHEMBL15450)
Show SMILES Oc1cc(nc2c(F)cccc12)-c1ccccc1
Show InChI InChI=1S/C15H10FNO/c16-12-8-4-7-11-14(18)9-13(17-15(11)12)10-5-2-1-3-6-10/h1-9H,(H,17,18)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Institute of Pharmaceutical Chemistry

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 36: 1146-56 (1993)


Article DOI: 10.1021/jm00061a005
BindingDB Entry DOI: 10.7270/Q2BV7H8S
More data for this
Ligand-Target Pair