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19 similar compounds to monomer 50000890

Compile data set for download or QSAR
Wt: 273.2
BDBM50000918
Wt: 286.2
BDBM50000919
Wt: 315.3
BDBM50000923
Wt: 315.3
BDBM50000904
Wt: 315.3
BDBM50000932
Wt: 287.3
BDBM50000867
Wt: 301.2
BDBM50000941
Wt: 301.2
BDBM50000869
Wt: 315.3
BDBM50000873
Wt: 282.2
BDBM50000874
Wt: 329.3
BDBM50000942
Wt: 268.2
BDBM50000907
Wt: 329.3
BDBM50000881
Wt: 275.2
BDBM50000913
Wt: 259.2
BDBM50000882
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 50000918,50000919,50000923,50000904,50000932,50000867,50000941,50000869,50000873,50000874,50000942,50000907,50000881,50000913,50000882   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000932
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-2-22-14(20)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
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n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 66n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000919
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES NC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H14N4O3/c15-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(16-10)18-14(20)17-11/h3-4,6-7H,1-2,5H2,(H2,15,19)(H2,16,17,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000918
PNG
(7-(4-Hydroxy-butoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c18-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h3-4,7-8,18H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000913
PNG
(7-(2,3-Dihydroxy-propoxy)-1,3-dihydro-imidazo[4,5-...)
Show SMILES OCC(O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1/C13H13N3O4/c17-5-8(18)6-20-9-1-2-10-7(3-9)4-11-12(14-10)16-13(19)15-11/h1-4,8,17-18H,5-6H2,(H2,14,15,16,19)
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n/an/an/an/a 1.19E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000874
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCC#N)ccc3nc2[nH]1
Show InChI InChI=1S/C15H14N4O2/c16-6-2-1-3-7-21-11-4-5-12-10(8-11)9-13-14(17-12)19-15(20)18-13/h4-5,8-9H,1-3,7H2,(H2,17,18,19,20)
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000881
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CC(C)OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-10(2)24-15(21)4-3-7-23-12-5-6-13-11(8-12)9-14-16(18-13)20-17(22)19-14/h5-6,8-10H,3-4,7H2,1-2H3,(H2,18,19,20,22)
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n/an/an/an/a 12n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000874
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCC#N)ccc3nc2[nH]1
Show InChI InChI=1S/C15H14N4O2/c16-6-2-1-3-7-21-11-4-5-12-10(8-11)9-13-14(17-12)19-15(20)18-13/h4-5,8-9H,1-3,7H2,(H2,17,18,19,20)
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n/an/an/an/a 1.32E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000923
PNG
(Acetic acid 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]...)
Show SMILES CC(=O)OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-10(20)22-6-2-3-7-23-12-4-5-13-11(8-12)9-14-15(17-13)19-16(21)18-14/h4-5,8-9H,2-3,6-7H2,1H3,(H2,17,18,19,21)
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n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/a 400n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000919
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES NC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H14N4O3/c15-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(16-10)18-14(20)17-11/h3-4,6-7H,1-2,5H2,(H2,15,19)(H2,16,17,18,20)
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n/an/an/an/a 6.04E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000941
PNG
(Acetic acid 3-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]...)
Show SMILES CC(=O)OCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-9(19)21-5-2-6-22-11-3-4-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h3-4,7-8H,2,5-6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 330n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000932
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-2-22-14(20)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 38n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000918
PNG
(7-(4-Hydroxy-butoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c18-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h3-4,7-8,18H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000913
PNG
(7-(2,3-Dihydroxy-propoxy)-1,3-dihydro-imidazo[4,5-...)
Show SMILES OCC(O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1/C13H13N3O4/c17-5-8(18)6-20-9-1-2-10-7(3-9)4-11-12(14-10)16-13(19)15-11/h1-4,8,17-18H,5-6H2,(H2,14,15,16,19)
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n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000873
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c20-14(21)4-2-1-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(22)18-13/h5-6,8-9H,1-4,7H2,(H,20,21)(H2,17,18,19,22)
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n/an/an/an/a 3.17E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000942
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-20-14-10-11-9-12(24-8-4-3-5-15(21)23-2)6-7-13(11)18-16(14)19-17(20)22/h6-7,9-10H,3-5,8H2,1-2H3,(H,18,19,22)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000904
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-2-4-14(20)21)5-6-12(10)17-15(13)18-16(19)22/h5-6,8-9H,2-4,7H2,1H3,(H,20,21)(H,17,18,22)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000882
PNG
(7-(3-Hydroxy-propoxy)-1,3-dihydro-imidazo[4,5-b]qu...)
Show SMILES OCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O3/c17-4-1-5-19-9-2-3-10-8(6-9)7-11-12(14-10)16-13(18)15-11/h2-3,6-7,17H,1,4-5H2,(H2,14,15,16,18)
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n/an/a 9n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000882
PNG
(7-(3-Hydroxy-propoxy)-1,3-dihydro-imidazo[4,5-b]qu...)
Show SMILES OCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O3/c17-4-1-5-19-9-2-3-10-8(6-9)7-11-12(14-10)16-13(18)15-11/h2-3,6-7,17H,1,4-5H2,(H2,14,15,16,18)
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n/an/an/an/a 770n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 83n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma PRP


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000867
PNG
(7-(4-Hydroxy-pentyloxy)-1,3-dihydro-imidazo[4,5-b]...)
Show SMILES CC(O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1/C15H17N3O3/c1-9(19)3-2-6-21-11-4-5-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h4-5,7-9,19H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000881
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CC(C)OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-10(2)24-15(21)4-3-7-23-12-5-6-13-11(8-12)9-14-16(18-13)20-17(22)19-14/h5-6,8-10H,3-4,7H2,1-2H3,(H2,18,19,20,22)
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n/an/an/an/a 590n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000918
PNG
(7-(4-Hydroxy-butoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c18-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h3-4,7-8,18H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/an/an/a 90n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000904
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-2-4-14(20)21)5-6-12(10)17-15(13)18-16(19)22/h5-6,8-9H,2-4,7H2,1H3,(H,20,21)(H,17,18,22)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000942
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-20-14-10-11-9-12(24-8-4-3-5-15(21)23-2)6-7-13(11)18-16(14)19-17(20)22/h6-7,9-10H,3-5,8H2,1-2H3,(H,18,19,22)
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n/an/an/an/a 9.11E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000867
PNG
(7-(4-Hydroxy-pentyloxy)-1,3-dihydro-imidazo[4,5-b]...)
Show SMILES CC(O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1/C15H17N3O3/c1-9(19)3-2-6-21-11-4-5-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h4-5,7-9,19H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 100n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000873
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c20-14(21)4-2-1-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(22)18-13/h5-6,8-9H,1-4,7H2,(H,20,21)(H2,17,18,19,22)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000882
PNG
(7-(3-Hydroxy-propoxy)-1,3-dihydro-imidazo[4,5-b]qu...)
Show SMILES OCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O3/c17-4-1-5-19-9-2-3-10-8(6-9)7-11-12(14-10)16-13(18)15-11/h2-3,6-7,17H,1,4-5H2,(H2,14,15,16,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000907
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=c1[nH]c2cc3cc(OCCCC#N)ccc3nc2[nH]1
Show InChI InChI=1S/C14H12N4O2/c15-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(16-11)18-14(19)17-12/h3-4,7-8H,1-2,6H2,(H2,16,17,18,19)
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n/an/an/an/a 600n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50000867
PNG
(7-(4-Hydroxy-pentyloxy)-1,3-dihydro-imidazo[4,5-b]...)
Show SMILES CC(O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1/C15H17N3O3/c1-9(19)3-2-6-21-11-4-5-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h4-5,7-9,19H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 520n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ADP-induced platelet aggregation in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000941
PNG
(Acetic acid 3-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]...)
Show SMILES CC(=O)OCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-9(19)21-5-2-6-22-11-3-4-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h3-4,7-8H,2,5-6H2,1H3,(H2,16,17,18,20)
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000907
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=c1[nH]c2cc3cc(OCCCC#N)ccc3nc2[nH]1
Show InChI InChI=1S/C14H12N4O2/c15-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(16-11)18-14(19)17-12/h3-4,7-8H,1-2,6H2,(H2,16,17,18,19)
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n/an/an/an/a 180n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000873
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c20-14(21)4-2-1-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(22)18-13/h5-6,8-9H,1-4,7H2,(H,20,21)(H2,17,18,19,22)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000881
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CC(C)OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-10(2)24-15(21)4-3-7-23-12-5-6-13-11(8-12)9-14-16(18-13)20-17(22)19-14/h5-6,8-10H,3-4,7H2,1-2H3,(H2,18,19,20,22)
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n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000907
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=c1[nH]c2cc3cc(OCCCC#N)ccc3nc2[nH]1
Show InChI InChI=1S/C14H12N4O2/c15-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(16-11)18-14(19)17-12/h3-4,7-8H,1-2,6H2,(H2,16,17,18,19)
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000942
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-20-14-10-11-9-12(24-8-4-3-5-15(21)23-2)6-7-13(11)18-16(14)19-17(20)22/h6-7,9-10H,3-5,8H2,1-2H3,(H,18,19,22)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000904
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-2-4-14(20)21)5-6-12(10)17-15(13)18-16(19)22/h5-6,8-9H,2-4,7H2,1H3,(H,20,21)(H,17,18,22)
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n/an/a 80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000919
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES NC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H14N4O3/c15-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(16-10)18-14(20)17-11/h3-4,6-7H,1-2,5H2,(H2,15,19)(H2,16,17,18,20)
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n/an/an/an/a 3.02E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000932
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-2-22-14(20)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 630n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000918
PNG
(7-(4-Hydroxy-butoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c18-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h3-4,7-8,18H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000913
PNG
(7-(2,3-Dihydroxy-propoxy)-1,3-dihydro-imidazo[4,5-...)
Show SMILES OCC(O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1/C13H13N3O4/c17-5-8(18)6-20-9-1-2-10-7(3-9)4-11-12(14-10)16-13(19)15-11/h1-4,8,17-18H,5-6H2,(H2,14,15,16,19)
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n/an/an/an/a 260n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000919
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES NC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H14N4O3/c15-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(16-10)18-14(20)17-11/h3-4,6-7H,1-2,5H2,(H2,15,19)(H2,16,17,18,20)
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000923
PNG
(Acetic acid 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]...)
Show SMILES CC(=O)OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-10(20)22-6-2-3-7-23-12-4-5-13-11(8-12)9-14-15(17-13)19-16(21)18-14/h4-5,8-9H,2-3,6-7H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 950n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair