BindingDB logo
myBDB logout

10 similar compounds to monomer 50000901

Compile data set for download or QSAR
Wt: 329.3
BDBM50000924
Wt: 315.3
BDBM50000895
Wt: 301.2
BDBM50000929
Wt: 315.3
BDBM50000904
Wt: 301.2
BDBM50000930
Wt: 315.3
BDBM50000932
Wt: 301.2
BDBM50000869
Wt: 329.3
BDBM50000942
Wt: 315.3
BDBM50000916
Wt: 287.2
BDBM50000886

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50000924,50000895,50000929,50000904,50000930,50000932,50000869,50000942,50000916,50000886   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000924
PNG
(4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b...)
Show SMILES COC(=O)CCCOc1ccc2nc3n(C)c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-19-14-10-11-9-12(24-8-4-5-15(21)23-3)6-7-13(11)18-16(14)20(2)17(19)22/h6-7,9-10H,4-5,8H2,1-3H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 66n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000886
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H13N3O4/c18-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(15-10)17-14(20)16-11/h3-4,6-7H,1-2,5H2,(H,18,19)(H2,15,16,17,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000924
PNG
(4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b...)
Show SMILES COC(=O)CCCOc1ccc2nc3n(C)c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-19-14-10-11-9-12(24-8-4-5-15(21)23-3)6-7-13(11)18-16(14)20(2)17(19)22/h6-7,9-10H,4-5,8H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>8.75E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000895
PNG
(4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2n(C)c1=O
Show InChI InChI=1S/C16H17N3O4/c1-18-13-9-10-8-11(23-7-3-4-14(20)21)5-6-12(10)17-15(13)19(2)16(18)22/h5-6,8-9H,3-4,7H2,1-2H3,(H,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9.41E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000930
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-12-8-9-7-10(22-6-2-3-13(19)20)4-5-11(9)16-14(12)17-15(18)21/h4-5,7-8H,2-3,6H2,1H3,(H,19,20)(H,16,17,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.06E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000929
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2nc3ccc(OCCCC(O)=O)cc3cc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-14-12(17-15(18)21)8-9-7-10(4-5-11(9)16-14)22-6-2-3-13(19)20/h4-5,7-8H,2-3,6H2,1H3,(H,17,21)(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000895
PNG
(4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2n(C)c1=O
Show InChI InChI=1S/C16H17N3O4/c1-18-13-9-10-8-11(23-7-3-4-14(20)21)5-6-12(10)17-15(13)19(2)16(18)22/h5-6,8-9H,3-4,7H2,1-2H3,(H,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000932
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-2-22-14(20)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 38n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000886
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H13N3O4/c18-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(15-10)17-14(20)16-11/h3-4,6-7H,1-2,5H2,(H,18,19)(H2,15,16,17,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.50E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000916
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3n(C)c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-15-13(18-16(19)21)9-10-8-11(5-6-12(10)17-15)23-7-3-4-14(20)22-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 360n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000942
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-20-14-10-11-9-12(24-8-4-3-5-15(21)23-2)6-7-13(11)18-16(14)19-17(20)22/h6-7,9-10H,3-5,8H2,1-2H3,(H,18,19,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000904
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-2-4-14(20)21)5-6-12(10)17-15(13)18-16(19)22/h5-6,8-9H,2-4,7H2,1H3,(H,20,21)(H,17,18,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 83n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma PRP


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000886
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H13N3O4/c18-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(15-10)17-14(20)16-11/h3-4,6-7H,1-2,5H2,(H,18,19)(H2,15,16,17,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.04E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000895
PNG
(4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2n(C)c1=O
Show InChI InChI=1S/C16H17N3O4/c1-18-13-9-10-8-11(23-7-3-4-14(20)21)5-6-12(10)17-15(13)19(2)16(18)22/h5-6,8-9H,3-4,7H2,1-2H3,(H,20,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000904
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-2-4-14(20)21)5-6-12(10)17-15(13)18-16(19)22/h5-6,8-9H,2-4,7H2,1H3,(H,20,21)(H,17,18,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000930
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-12-8-9-7-10(22-6-2-3-13(19)20)4-5-11(9)16-14(12)17-15(18)21/h4-5,7-8H,2-3,6H2,1H3,(H,19,20)(H,16,17,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000942
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-20-14-10-11-9-12(24-8-4-3-5-15(21)23-2)6-7-13(11)18-16(14)19-17(20)22/h6-7,9-10H,3-5,8H2,1-2H3,(H,18,19,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9.11E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000929
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2nc3ccc(OCCCC(O)=O)cc3cc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-14-12(17-15(18)21)8-9-7-10(4-5-11(9)16-14)22-6-2-3-13(19)20/h4-5,7-8H,2-3,6H2,1H3,(H,17,21)(H,19,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>2.65E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000930
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-12-8-9-7-10(22-6-2-3-13(19)20)4-5-11(9)16-14(12)17-15(18)21/h4-5,7-8H,2-3,6H2,1H3,(H,19,20)(H,16,17,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000916
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3n(C)c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-15-13(18-16(19)21)9-10-8-11(5-6-12(10)17-15)23-7-3-4-14(20)22-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000886
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H13N3O4/c18-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(15-10)17-14(20)16-11/h3-4,6-7H,1-2,5H2,(H,18,19)(H2,15,16,17,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000942
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-20-14-10-11-9-12(24-8-4-3-5-15(21)23-2)6-7-13(11)18-16(14)19-17(20)22/h6-7,9-10H,3-5,8H2,1-2H3,(H,18,19,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000904
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-2-4-14(20)21)5-6-12(10)17-15(13)18-16(19)22/h5-6,8-9H,2-4,7H2,1H3,(H,20,21)(H,17,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000932
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-2-22-14(20)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 630n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000929
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2nc3ccc(OCCCC(O)=O)cc3cc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-14-12(17-15(18)21)8-9-7-10(4-5-11(9)16-14)22-6-2-3-13(19)20/h4-5,7-8H,2-3,6H2,1H3,(H,17,21)(H,19,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.66E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000916
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3n(C)c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-15-13(18-16(19)21)9-10-8-11(5-6-12(10)17-15)23-7-3-4-14(20)22-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.99E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000932
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-2-22-14(20)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair