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4 similar compounds to monomer 50001944

Compile data set for download or QSAR
Wt: 529.6
BDBM50001947
Wt: 499.5
BDBM50001949
Wt: 529.6
BDBM50001950
Wt: 529.6
BDBM50001951

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50001947,50001949,50001950,50001951   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50001950
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@@H](O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19+,22+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain aminopeptidase


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50001951
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@H](O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19+,22+/m0/s1
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n/an/a 1.09E+4n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain aminopeptidase


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50001947
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)C(O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19-,22?/m1/s1
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n/an/a 330n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain aminopeptidase


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001947
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)C(O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19-,22?/m1/s1
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n/an/a 9.12E+4n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as subst...


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50001949
PNG
(2-(2,6-Diamino-hexanoylamino)-3-[2-(2-nitro-phenyl...)
Show SMILES COC(=O)[C@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN
Show InChI InChI=1S/C24H29N5O5S/c1-34-24(31)19(27-22(30)17(26)9-6-7-13-25)14-16-15-8-2-3-10-18(15)28-23(16)35-21-12-5-4-11-20(21)29(32)33/h2-5,8,10-12,17,19,28H,6-7,9,13-14,25-26H2,1H3,(H,27,30)/t17-,19-/m0/s1
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n/an/a 4.00E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase B using L-lysine-beta napthylamide as subs...


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001949
PNG
(2-(2,6-Diamino-hexanoylamino)-3-[2-(2-nitro-phenyl...)
Show SMILES COC(=O)[C@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN
Show InChI InChI=1S/C24H29N5O5S/c1-34-24(31)19(27-22(30)17(26)9-6-7-13-25)14-16-15-8-2-3-10-18(15)28-23(16)35-21-12-5-4-11-20(21)29(32)33/h2-5,8,10-12,17,19,28H,6-7,9,13-14,25-26H2,1H3,(H,27,30)/t17-,19-/m0/s1
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n/an/a 2.61E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50001951
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@H](O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19+,22+/m0/s1
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n/an/a 9.82E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase B (AP-B) using L-lysine-beta napthylamide ...


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001951
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@H](O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19+,22+/m0/s1
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n/an/a 2.25E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as subst...


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001950
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@@H](O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19+,22+/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as subst...


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50001947
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)C(O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19-,22?/m1/s1
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n/an/a 4.86E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase B (AP-B) using L-lysine-beta napthylamide ...


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50001950
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@@H](O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19+,22+/m1/s1
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n/an/a 1.01E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase B (AP-B) using L-lysine-beta napthylamide ...


J Med Chem 35: 889-95 (1992)


Article DOI: 10.1021/jm00083a013
BindingDB Entry DOI: 10.7270/Q2X92BWN
More data for this
Ligand-Target Pair