BindingDB logo
myBDB logout

142 similar compounds to monomer 50002184

Compile data set for download or QSAR
Wt: 1362.6
BDBM50019482
Wt: 1362.6
BDBM50002346
Wt: 1416.7
BDBM50002347
Wt: 1645.0
BDBM50002178
Wt: 1645.0
BDBM50002179
Wt: 1616.9
BDBM50002180
Wt: 1574.9
BDBM50002181
Wt: 1574.9
BDBM50002182
Wt: 1574.9
BDBM50002183
Wt: 1616.9
BDBM50002185
Wt: 1616.9
BDBM50002186
Wt: 1417.7
BDBM50454202
Wt: 1467.7
BDBM50454203
Wt: 994.1
BDBM50010529
Wt: 952.1
BDBM50010530
Displayed 1 to 15 (of 142 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 57 hits for monomerid = 50019482,50002346,50002347,50002178,50002179,50002180,50002181,50002182,50002183,50002185,50002186,50454202,50454203,50010529,50010530   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002186
PNG
(CHEMBL440987 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Lys...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N23O15/c1-8-47(6)64(74(114)96-57(25-14-17-35-86-48(7)101)75(115)100-38-20-28-61(100)73(113)95-54(24-13-16-34-79)68(108)97-58(39-45(2)3)70(110)92-53(65(81)105)23-12-15-33-78)99-69(109)56(27-19-37-88-77(84)85)93-67(107)55(26-18-36-87-76(82)83)94-71(111)59(40-46(4)5)98-72(112)60(42-49-21-10-9-11-22-49)91-63(104)44-89-62(103)43-90-66(106)52(80)41-50-29-31-51(102)32-30-50/h9-11,21-22,29-32,45-47,52-61,64,102H,8,12-20,23-28,33-44,78-80H2,1-7H3,(H2,81,105)(H,86,101)(H,89,103)(H,90,106)(H,91,104)(H,92,110)(H,93,107)(H,94,111)(H,95,113)(H,96,114)(H,97,108)(H,98,112)(H,99,109)(H4,82,83,87)(H4,84,85,88)/t47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.00420n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002182
PNG
(CHEMBL415617 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Lys...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N23O14/c1-7-46(6)62(72(111)94-55(24-13-16-34-78)73(112)98-37-19-27-59(98)71(110)93-52(23-12-15-33-77)66(105)95-56(38-44(2)3)68(107)90-51(63(80)102)22-11-14-32-76)97-67(106)54(26-18-36-86-75(83)84)91-65(104)53(25-17-35-85-74(81)82)92-69(108)57(39-45(4)5)96-70(109)58(41-47-20-9-8-10-21-47)89-61(101)43-87-60(100)42-88-64(103)50(79)40-48-28-30-49(99)31-29-48/h8-10,20-21,28-31,44-46,50-59,62,99H,7,11-19,22-27,32-43,76-79H2,1-6H3,(H2,80,102)(H,87,100)(H,88,103)(H,89,101)(H,90,107)(H,91,104)(H,92,108)(H,93,110)(H,94,111)(H,95,105)(H,96,109)(H,97,106)(H4,81,82,85)(H4,83,84,86)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.00670n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50002185
PNG
(CHEMBL438741 | Tyr-Gly-Gly-Phe-Leu-Lys(Ac)-Arg-Ile...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N23O15/c1-8-47(6)64(74(114)96-57(27-19-37-88-77(84)85)75(115)100-38-20-28-61(100)73(113)95-55(24-13-16-34-79)68(108)97-58(39-45(2)3)70(110)92-53(65(81)105)23-12-15-33-78)99-69(109)56(26-18-36-87-76(82)83)93-67(107)54(25-14-17-35-86-48(7)101)94-71(111)59(40-46(4)5)98-72(112)60(42-49-21-10-9-11-22-49)91-63(104)44-89-62(103)43-90-66(106)52(80)41-50-29-31-51(102)32-30-50/h9-11,21-22,29-32,45-47,52-61,64,102H,8,12-20,23-28,33-44,78-80H2,1-7H3,(H2,81,105)(H,86,101)(H,89,103)(H,90,106)(H,91,104)(H,92,110)(H,93,107)(H,94,111)(H,95,113)(H,96,114)(H,97,108)(H,98,112)(H,99,109)(H4,82,83,87)(H4,84,85,88)/t47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0180n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO to opioid receptor mu of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002347
PNG
(CHEMBL425806 | [N-cyclopropyl methylTyr1, D-pro10]...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NCC1CC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C67H109N21O13/c1-5-40(4)55(62(98)84-47(20-13-31-77-67(73)74)63(99)88-32-14-21-52(88)61(97)85-48(64(100)101)17-9-10-28-68)87-58(94)46(19-12-30-76-66(71)72)82-57(93)45(18-11-29-75-65(69)70)83-59(95)50(33-39(2)3)86-60(96)51(35-41-15-7-6-8-16-41)81-54(91)38-79-53(90)37-80-56(92)49(78-36-43-22-23-43)34-42-24-26-44(89)27-25-42/h6-8,15-16,24-27,39-40,43,45-52,55,78,89H,5,9-14,17-23,28-38,68H2,1-4H3,(H,79,90)(H,80,92)(H,81,91)(H,82,93)(H,83,95)(H,84,98)(H,85,97)(H,86,96)(H,87,94)(H,100,101)(H4,69,70,75)(H4,71,72,76)(H4,73,74,77)/t40-,45-,46-,47-,48-,49-,50-,51-,52+,55-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0200n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Tested for inhibitory effect on binding of [3H]bremazocine to opioid receptor kappa in guinea pig cerebellum membranes


J Med Chem 35: 4638-9 (1993)


Article DOI: 10.1021/jm00102a019
BindingDB Entry DOI: 10.7270/Q2416XPM
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002181
PNG
(CHEMBL266717 | Tyr-Gly-Gly-Phe-Leu-Lys-Arg-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N23O14/c1-7-46(6)62(72(111)94-55(26-18-36-86-75(83)84)73(112)98-37-19-27-59(98)71(110)93-53(24-13-16-34-78)66(105)95-56(38-44(2)3)68(107)90-51(63(80)102)22-11-14-32-76)97-67(106)54(25-17-35-85-74(81)82)91-65(104)52(23-12-15-33-77)92-69(108)57(39-45(4)5)96-70(109)58(41-47-20-9-8-10-21-47)89-61(101)43-87-60(100)42-88-64(103)50(79)40-48-28-30-49(99)31-29-48/h8-10,20-21,28-31,44-46,50-59,62,99H,7,11-19,22-27,32-43,76-79H2,1-6H3,(H2,80,102)(H,87,100)(H,88,103)(H,89,101)(H,90,107)(H,91,104)(H,92,108)(H,93,110)(H,94,111)(H,95,105)(H,96,109)(H,97,106)(H4,81,82,85)(H4,83,84,86)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0200n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002183
PNG
(CHEMBL266515 | Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N23O14/c1-7-46(6)62(72(111)94-55(26-18-36-86-75(83)84)73(112)98-37-19-27-59(98)71(110)93-52(23-12-15-33-77)66(105)95-56(38-44(2)3)68(107)90-51(63(80)102)22-11-14-32-76)97-67(106)53(24-13-16-34-78)91-65(104)54(25-17-35-85-74(81)82)92-69(108)57(39-45(4)5)96-70(109)58(41-47-20-9-8-10-21-47)89-61(101)43-87-60(100)42-88-64(103)50(79)40-48-28-30-49(99)31-29-48/h8-10,20-21,28-31,44-46,50-59,62,99H,7,11-19,22-27,32-43,76-79H2,1-6H3,(H2,80,102)(H,87,100)(H,88,103)(H,89,101)(H,90,107)(H,91,104)(H,92,108)(H,93,110)(H,94,111)(H,95,105)(H,96,109)(H,97,106)(H4,81,82,85)(H4,83,84,86)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0210n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002185
PNG
(CHEMBL438741 | Tyr-Gly-Gly-Phe-Leu-Lys(Ac)-Arg-Ile...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N23O15/c1-8-47(6)64(74(114)96-57(27-19-37-88-77(84)85)75(115)100-38-20-28-61(100)73(113)95-55(24-13-16-34-79)68(108)97-58(39-45(2)3)70(110)92-53(65(81)105)23-12-15-33-78)99-69(109)56(26-18-36-87-76(82)83)93-67(107)54(25-14-17-35-86-48(7)101)94-71(111)59(40-46(4)5)98-72(112)60(42-49-21-10-9-11-22-49)91-63(104)44-89-62(103)43-90-66(106)52(80)41-50-29-31-51(102)32-30-50/h9-11,21-22,29-32,45-47,52-61,64,102H,8,12-20,23-28,33-44,78-80H2,1-7H3,(H2,81,105)(H,86,101)(H,89,103)(H,90,106)(H,91,104)(H,92,110)(H,93,107)(H,94,111)(H,95,113)(H,96,114)(H,97,108)(H,98,112)(H,99,109)(H4,82,83,87)(H4,84,85,88)/t47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0240n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0300n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Affinity against Opioid receptor kappa 1 was determined by measuring the inhibition of [3H]-bremazocine binding to guinea pig cerebellar membranes


J Med Chem 40: 2733-9 (1997)


Article DOI: 10.1021/jm960747t
BindingDB Entry DOI: 10.7270/Q2D50M2D
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0300n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Tested for inhibitory effect on binding of [3H]bremazocine to opioid receptor kappa in guinea pig cerebellum membranes


J Med Chem 35: 4638-9 (1993)


Article DOI: 10.1021/jm00102a019
BindingDB Entry DOI: 10.7270/Q2416XPM
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50002178
PNG
(CHEMBL440446 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N25O15/c1-8-46(6)63(73(116)98-56(26-18-36-90-77(85)86)74(117)102-37-19-27-60(102)72(115)97-53(23-13-15-33-87-47(7)103)67(110)99-57(38-44(2)3)69(112)94-52(64(80)107)22-12-14-32-78)101-68(111)55(25-17-35-89-76(83)84)95-66(109)54(24-16-34-88-75(81)82)96-70(113)58(39-45(4)5)100-71(114)59(41-48-20-10-9-11-21-48)93-62(106)43-91-61(105)42-92-65(108)51(79)40-49-28-30-50(104)31-29-49/h9-11,20-21,28-31,44-46,51-60,63,104H,8,12-19,22-27,32-43,78-79H2,1-7H3,(H2,80,107)(H,87,103)(H,91,105)(H,92,108)(H,93,106)(H,94,112)(H,95,109)(H,96,113)(H,97,115)(H,98,116)(H,99,110)(H,100,114)(H,101,111)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t46-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,63-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0300n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO to opioid receptor mu of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50002186
PNG
(CHEMBL440987 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Lys...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N23O15/c1-8-47(6)64(74(114)96-57(25-14-17-35-86-48(7)101)75(115)100-38-20-28-61(100)73(113)95-54(24-13-16-34-79)68(108)97-58(39-45(2)3)70(110)92-53(65(81)105)23-12-15-33-78)99-69(109)56(27-19-37-88-77(84)85)93-67(107)55(26-18-36-87-76(82)83)94-71(111)59(40-46(4)5)98-72(112)60(42-49-21-10-9-11-22-49)91-63(104)44-89-62(103)43-90-66(106)52(80)41-50-29-31-51(102)32-30-50/h9-11,21-22,29-32,45-47,52-61,64,102H,8,12-20,23-28,33-44,78-80H2,1-7H3,(H2,81,105)(H,86,101)(H,89,103)(H,90,106)(H,91,104)(H,92,110)(H,93,107)(H,94,111)(H,95,113)(H,96,114)(H,97,108)(H,98,112)(H,99,109)(H4,82,83,87)(H4,84,85,88)/t47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0430n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO to opioid receptor mu of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50002182
PNG
(CHEMBL415617 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Lys...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N23O14/c1-7-46(6)62(72(111)94-55(24-13-16-34-78)73(112)98-37-19-27-59(98)71(110)93-52(23-12-15-33-77)66(105)95-56(38-44(2)3)68(107)90-51(63(80)102)22-11-14-32-76)97-67(106)54(26-18-36-86-75(83)84)91-65(104)53(25-17-35-85-74(81)82)92-69(108)57(39-45(4)5)96-70(109)58(41-47-20-9-8-10-21-47)89-61(101)43-87-60(100)42-88-64(103)50(79)40-48-28-30-49(99)31-29-48/h8-10,20-21,28-31,44-46,50-59,62,99H,7,11-19,22-27,32-43,76-79H2,1-6H3,(H2,80,102)(H,87,100)(H,88,103)(H,89,101)(H,90,107)(H,91,104)(H,92,108)(H,93,110)(H,94,111)(H,95,105)(H,96,109)(H,97,106)(H4,81,82,85)(H4,83,84,86)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0460n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO to opioid receptor mu of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002178
PNG
(CHEMBL440446 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N25O15/c1-8-46(6)63(73(116)98-56(26-18-36-90-77(85)86)74(117)102-37-19-27-60(102)72(115)97-53(23-13-15-33-87-47(7)103)67(110)99-57(38-44(2)3)69(112)94-52(64(80)107)22-12-14-32-78)101-68(111)55(25-17-35-89-76(83)84)95-66(109)54(24-16-34-88-75(81)82)96-70(113)58(39-45(4)5)100-71(114)59(41-48-20-10-9-11-21-48)93-62(106)43-91-61(105)42-92-65(108)51(79)40-49-28-30-50(104)31-29-49/h9-11,20-21,28-31,44-46,51-60,63,104H,8,12-19,22-27,32-43,78-79H2,1-7H3,(H2,80,107)(H,87,103)(H,91,105)(H,92,108)(H,93,106)(H,94,112)(H,95,109)(H,96,113)(H,97,115)(H,98,116)(H,99,110)(H,100,114)(H,101,111)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t46-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,63-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0530n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50002183
PNG
(CHEMBL266515 | Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N23O14/c1-7-46(6)62(72(111)94-55(26-18-36-86-75(83)84)73(112)98-37-19-27-59(98)71(110)93-52(23-12-15-33-77)66(105)95-56(38-44(2)3)68(107)90-51(63(80)102)22-11-14-32-76)97-67(106)53(24-13-16-34-78)91-65(104)54(25-17-35-85-74(81)82)92-69(108)57(39-45(4)5)96-70(109)58(41-47-20-9-8-10-21-47)89-61(101)43-87-60(100)42-88-64(103)50(79)40-48-28-30-49(99)31-29-48/h8-10,20-21,28-31,44-46,50-59,62,99H,7,11-19,22-27,32-43,76-79H2,1-6H3,(H2,80,102)(H,87,100)(H,88,103)(H,89,101)(H,90,107)(H,91,104)(H,92,108)(H,93,110)(H,94,111)(H,95,105)(H,96,109)(H,97,106)(H4,81,82,85)(H4,83,84,86)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0550n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO to opioid receptor mu of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50002179
PNG
(CHEMBL263597 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)=O)C(N)=O
Show InChI InChI=1S/C77H129N25O15/c1-8-46(6)63(73(116)98-56(26-18-36-90-77(85)86)74(117)102-37-19-27-60(102)72(115)97-53(23-12-14-32-78)67(110)99-57(38-44(2)3)69(112)94-52(64(80)107)22-13-15-33-87-47(7)103)101-68(111)55(25-17-35-89-76(83)84)95-66(109)54(24-16-34-88-75(81)82)96-70(113)58(39-45(4)5)100-71(114)59(41-48-20-10-9-11-21-48)93-62(106)43-91-61(105)42-92-65(108)51(79)40-49-28-30-50(104)31-29-49/h9-11,20-21,28-31,44-46,51-60,63,104H,8,12-19,22-27,32-43,78-79H2,1-7H3,(H2,80,107)(H,87,103)(H,91,105)(H,92,108)(H,93,106)(H,94,112)(H,95,109)(H,96,113)(H,97,115)(H,98,116)(H,99,110)(H,100,114)(H,101,111)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t46-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,63-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0610n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO to opioid receptor mu of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50002181
PNG
(CHEMBL266717 | Tyr-Gly-Gly-Phe-Leu-Lys-Arg-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N23O14/c1-7-46(6)62(72(111)94-55(26-18-36-86-75(83)84)73(112)98-37-19-27-59(98)71(110)93-53(24-13-16-34-78)66(105)95-56(38-44(2)3)68(107)90-51(63(80)102)22-11-14-32-76)97-67(106)54(25-17-35-85-74(81)82)91-65(104)52(23-12-15-33-77)92-69(108)57(39-45(4)5)96-70(109)58(41-47-20-9-8-10-21-47)89-61(101)43-87-60(100)42-88-64(103)50(79)40-48-28-30-49(99)31-29-48/h8-10,20-21,28-31,44-46,50-59,62,99H,7,11-19,22-27,32-43,76-79H2,1-6H3,(H2,80,102)(H,87,100)(H,88,103)(H,89,101)(H,90,107)(H,91,104)(H,92,108)(H,93,110)(H,94,111)(H,95,105)(H,96,109)(H,97,106)(H4,81,82,85)(H4,83,84,86)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0750n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO to opioid receptor mu of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019482
PNG
(DYNORPHIN A (1-11) | NH2-Tyr-Gly-Gly-D-Trp-Leu-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48-,51-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.128n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]-bremazocine binding to Opioid receptor kappa 1 in guinea pig cerebellum membrane homogenates.


J Med Chem 29: 1913-7 (1986)


Article DOI: 10.1021/jm00160a019
BindingDB Entry DOI: 10.7270/Q2Z89BCJ
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002180
PNG
(CHEMBL263583 | Tyr-Gly-Gly-Phe-Leu-Arg-Lys(Ac)-Ile...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N23O15/c1-8-47(6)64(74(114)96-57(27-19-37-88-77(84)85)75(115)100-38-20-28-61(100)73(113)95-54(24-13-16-34-79)68(108)97-58(39-45(2)3)70(110)92-53(65(81)105)23-12-15-33-78)99-69(109)55(25-14-17-35-86-48(7)101)93-67(107)56(26-18-36-87-76(82)83)94-71(111)59(40-46(4)5)98-72(112)60(42-49-21-10-9-11-22-49)91-63(104)44-89-62(103)43-90-66(106)52(80)41-50-29-31-51(102)32-30-50/h9-11,21-22,29-32,45-47,52-61,64,102H,8,12-20,23-28,33-44,78-80H2,1-7H3,(H2,81,105)(H,86,101)(H,89,103)(H,90,106)(H,91,104)(H,92,110)(H,93,107)(H,94,111)(H,95,113)(H,96,114)(H,97,108)(H,98,112)(H,99,109)(H4,82,83,87)(H4,84,85,88)/t47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.140n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002179
PNG
(CHEMBL263597 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)=O)C(N)=O
Show InChI InChI=1S/C77H129N25O15/c1-8-46(6)63(73(116)98-56(26-18-36-90-77(85)86)74(117)102-37-19-27-60(102)72(115)97-53(23-12-14-32-78)67(110)99-57(38-44(2)3)69(112)94-52(64(80)107)22-13-15-33-87-47(7)103)101-68(111)55(25-17-35-89-76(83)84)95-66(109)54(24-16-34-88-75(81)82)96-70(113)58(39-45(4)5)100-71(114)59(41-48-20-10-9-11-21-48)93-62(106)43-91-61(105)42-92-65(108)51(79)40-49-28-30-50(104)31-29-49/h9-11,20-21,28-31,44-46,51-60,63,104H,8,12-19,22-27,32-43,78-79H2,1-7H3,(H2,80,107)(H,87,103)(H,91,105)(H,92,108)(H,93,106)(H,94,112)(H,95,109)(H,96,113)(H,97,115)(H,98,116)(H,99,110)(H,100,114)(H,101,111)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t46-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,63-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.150n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50002180
PNG
(CHEMBL263583 | Tyr-Gly-Gly-Phe-Leu-Arg-Lys(Ac)-Ile...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N23O15/c1-8-47(6)64(74(114)96-57(27-19-37-88-77(84)85)75(115)100-38-20-28-61(100)73(113)95-54(24-13-16-34-79)68(108)97-58(39-45(2)3)70(110)92-53(65(81)105)23-12-15-33-78)99-69(109)55(25-14-17-35-86-48(7)101)93-67(107)56(26-18-36-87-76(82)83)94-71(111)59(40-46(4)5)98-72(112)60(42-49-21-10-9-11-22-49)91-63(104)44-89-62(103)43-90-66(106)52(80)41-50-29-31-51(102)32-30-50/h9-11,21-22,29-32,45-47,52-61,64,102H,8,12-20,23-28,33-44,78-80H2,1-7H3,(H2,81,105)(H,86,101)(H,89,103)(H,90,106)(H,91,104)(H,92,110)(H,93,107)(H,94,111)(H,95,113)(H,96,114)(H,97,108)(H,98,112)(H,99,109)(H4,82,83,87)(H4,84,85,88)/t47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.180n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO to opioid receptor mu of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.240n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Affinity against Opioid receptor mu 1 was determined by measuring the inhibition of [3H]-DAMGO binding to rat forebrain membranes


J Med Chem 40: 2733-9 (1997)


Article DOI: 10.1021/jm960747t
BindingDB Entry DOI: 10.7270/Q2D50M2D
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.240n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Tested for inhibitory effect on binding of [3H]DAMGO to opioid receptor mu in guinea pig cerebellum membranes


J Med Chem 35: 4638-9 (1993)


Article DOI: 10.1021/jm00102a019
BindingDB Entry DOI: 10.7270/Q2416XPM
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50002185
PNG
(CHEMBL438741 | Tyr-Gly-Gly-Phe-Leu-Lys(Ac)-Arg-Ile...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N23O15/c1-8-47(6)64(74(114)96-57(27-19-37-88-77(84)85)75(115)100-38-20-28-61(100)73(113)95-55(24-13-16-34-79)68(108)97-58(39-45(2)3)70(110)92-53(65(81)105)23-12-15-33-78)99-69(109)56(26-18-36-87-76(82)83)93-67(107)54(25-14-17-35-86-48(7)101)94-71(111)59(40-46(4)5)98-72(112)60(42-49-21-10-9-11-22-49)91-63(104)44-89-62(103)43-90-66(106)52(80)41-50-29-31-51(102)32-30-50/h9-11,21-22,29-32,45-47,52-61,64,102H,8,12-20,23-28,33-44,78-80H2,1-7H3,(H2,81,105)(H,86,101)(H,89,103)(H,90,106)(H,91,104)(H,92,110)(H,93,107)(H,94,111)(H,95,113)(H,96,114)(H,97,108)(H,98,112)(H,99,109)(H4,82,83,87)(H4,84,85,88)/t47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.420n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE to opioid receptor delta of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50002178
PNG
(CHEMBL440446 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N25O15/c1-8-46(6)63(73(116)98-56(26-18-36-90-77(85)86)74(117)102-37-19-27-60(102)72(115)97-53(23-13-15-33-87-47(7)103)67(110)99-57(38-44(2)3)69(112)94-52(64(80)107)22-12-14-32-78)101-68(111)55(25-17-35-89-76(83)84)95-66(109)54(24-16-34-88-75(81)82)96-70(113)58(39-45(4)5)100-71(114)59(41-48-20-10-9-11-21-48)93-62(106)43-91-61(105)42-92-65(108)51(79)40-49-28-30-50(104)31-29-49/h9-11,20-21,28-31,44-46,51-60,63,104H,8,12-19,22-27,32-43,78-79H2,1-7H3,(H2,80,107)(H,87,103)(H,91,105)(H,92,108)(H,93,106)(H,94,112)(H,95,109)(H,96,113)(H,97,115)(H,98,116)(H,99,110)(H,100,114)(H,101,111)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t46-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,63-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.450n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE to opioid receptor delta of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50002180
PNG
(CHEMBL263583 | Tyr-Gly-Gly-Phe-Leu-Arg-Lys(Ac)-Ile...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N23O15/c1-8-47(6)64(74(114)96-57(27-19-37-88-77(84)85)75(115)100-38-20-28-61(100)73(113)95-54(24-13-16-34-79)68(108)97-58(39-45(2)3)70(110)92-53(65(81)105)23-12-15-33-78)99-69(109)55(25-14-17-35-86-48(7)101)93-67(107)56(26-18-36-87-76(82)83)94-71(111)59(40-46(4)5)98-72(112)60(42-49-21-10-9-11-22-49)91-63(104)44-89-62(103)43-90-66(106)52(80)41-50-29-31-51(102)32-30-50/h9-11,21-22,29-32,45-47,52-61,64,102H,8,12-20,23-28,33-44,78-80H2,1-7H3,(H2,81,105)(H,86,101)(H,89,103)(H,90,106)(H,91,104)(H,92,110)(H,93,107)(H,94,111)(H,95,113)(H,96,114)(H,97,108)(H,98,112)(H,99,109)(H4,82,83,87)(H4,84,85,88)/t47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.10n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE to opioid receptor delta of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50002186
PNG
(CHEMBL440987 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Lys...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C77H129N23O15/c1-8-47(6)64(74(114)96-57(25-14-17-35-86-48(7)101)75(115)100-38-20-28-61(100)73(113)95-54(24-13-16-34-79)68(108)97-58(39-45(2)3)70(110)92-53(65(81)105)23-12-15-33-78)99-69(109)56(27-19-37-88-77(84)85)93-67(107)55(26-18-36-87-76(82)83)94-71(111)59(40-46(4)5)98-72(112)60(42-49-21-10-9-11-22-49)91-63(104)44-89-62(103)43-90-66(106)52(80)41-50-29-31-51(102)32-30-50/h9-11,21-22,29-32,45-47,52-61,64,102H,8,12-20,23-28,33-44,78-80H2,1-7H3,(H2,81,105)(H,86,101)(H,89,103)(H,90,106)(H,91,104)(H,92,110)(H,93,107)(H,94,111)(H,95,113)(H,96,114)(H,97,108)(H,98,112)(H,99,109)(H4,82,83,87)(H4,84,85,88)/t47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE to opioid receptor delta of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50002183
PNG
(CHEMBL266515 | Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N23O14/c1-7-46(6)62(72(111)94-55(26-18-36-86-75(83)84)73(112)98-37-19-27-59(98)71(110)93-52(23-12-15-33-77)66(105)95-56(38-44(2)3)68(107)90-51(63(80)102)22-11-14-32-76)97-67(106)53(24-13-16-34-78)91-65(104)54(25-17-35-85-74(81)82)92-69(108)57(39-45(4)5)96-70(109)58(41-47-20-9-8-10-21-47)89-61(101)43-87-60(100)42-88-64(103)50(79)40-48-28-30-49(99)31-29-48/h8-10,20-21,28-31,44-46,50-59,62,99H,7,11-19,22-27,32-43,76-79H2,1-6H3,(H2,80,102)(H,87,100)(H,88,103)(H,89,101)(H,90,107)(H,91,104)(H,92,108)(H,93,110)(H,94,111)(H,95,105)(H,96,109)(H,97,106)(H4,81,82,85)(H4,83,84,86)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.60n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE to opioid receptor delta of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.70n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Affinity against Opioid receptor kappa 1 was determined by measuring the inhibition of [3H]U69,593 binding to guinea pig cerebellar membranes


J Med Chem 40: 2733-9 (1997)


Article DOI: 10.1021/jm960747t
BindingDB Entry DOI: 10.7270/Q2D50M2D
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50002182
PNG
(CHEMBL415617 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Lys...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N23O14/c1-7-46(6)62(72(111)94-55(24-13-16-34-78)73(112)98-37-19-27-59(98)71(110)93-52(23-12-15-33-77)66(105)95-56(38-44(2)3)68(107)90-51(63(80)102)22-11-14-32-76)97-67(106)54(26-18-36-86-75(83)84)91-65(104)53(25-17-35-85-74(81)82)92-69(108)57(39-45(4)5)96-70(109)58(41-47-20-9-8-10-21-47)89-61(101)43-87-60(100)42-88-64(103)50(79)40-48-28-30-49(99)31-29-48/h8-10,20-21,28-31,44-46,50-59,62,99H,7,11-19,22-27,32-43,76-79H2,1-6H3,(H2,80,102)(H,87,100)(H,88,103)(H,89,101)(H,90,107)(H,91,104)(H,92,108)(H,93,110)(H,94,111)(H,95,105)(H,96,109)(H,97,106)(H4,81,82,85)(H4,83,84,86)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.90n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE to opioid receptor delta of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.10n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Tested for inhibitory effect on binding of [3H]DPDPE to opioid receptor delta in guinea pig cerebellum membranes


J Med Chem 35: 4638-9 (1993)


Article DOI: 10.1021/jm00102a019
BindingDB Entry DOI: 10.7270/Q2416XPM
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.10n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Affinity against Opioid receptor delta 1 was determined by measuring the inhibition of [3H]-DPDPE binding to rat forebrain membranes


J Med Chem 40: 2733-9 (1997)


Article DOI: 10.1021/jm960747t
BindingDB Entry DOI: 10.7270/Q2D50M2D
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50019482
PNG
(DYNORPHIN A (1-11) | NH2-Tyr-Gly-Gly-D-Trp-Leu-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48-,51-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]DAGO([[3H]-D-Ala,MePhe4,Glyol5]enkephalin) binding to mu sites in rat brain homogenates.


J Med Chem 29: 1913-7 (1986)


Article DOI: 10.1021/jm00160a019
BindingDB Entry DOI: 10.7270/Q2Z89BCJ
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50002179
PNG
(CHEMBL263597 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)=O)C(N)=O
Show InChI InChI=1S/C77H129N25O15/c1-8-46(6)63(73(116)98-56(26-18-36-90-77(85)86)74(117)102-37-19-27-60(102)72(115)97-53(23-12-14-32-78)67(110)99-57(38-44(2)3)69(112)94-52(64(80)107)22-13-15-33-87-47(7)103)101-68(111)55(25-17-35-89-76(83)84)95-66(109)54(24-16-34-88-75(81)82)96-70(113)58(39-45(4)5)100-71(114)59(41-48-20-10-9-11-21-48)93-62(106)43-91-61(105)42-92-65(108)51(79)40-49-28-30-50(104)31-29-49/h9-11,20-21,28-31,44-46,51-60,63,104H,8,12-19,22-27,32-43,78-79H2,1-7H3,(H2,80,107)(H,87,103)(H,91,105)(H,92,108)(H,93,106)(H,94,112)(H,95,109)(H,96,113)(H,97,115)(H,98,116)(H,99,110)(H,100,114)(H,101,111)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t46-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,63-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.60n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE to opioid receptor delta of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50002181
PNG
(CHEMBL266717 | Tyr-Gly-Gly-Phe-Leu-Lys-Arg-Ile-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N23O14/c1-7-46(6)62(72(111)94-55(26-18-36-86-75(83)84)73(112)98-37-19-27-59(98)71(110)93-53(24-13-16-34-78)66(105)95-56(38-44(2)3)68(107)90-51(63(80)102)22-11-14-32-76)97-67(106)54(25-17-35-85-74(81)82)91-65(104)52(23-12-15-33-77)92-69(108)57(39-45(4)5)96-70(109)58(41-47-20-9-8-10-21-47)89-61(101)43-87-60(100)42-88-64(103)50(79)40-48-28-30-49(99)31-29-48/h8-10,20-21,28-31,44-46,50-59,62,99H,7,11-19,22-27,32-43,76-79H2,1-6H3,(H2,80,102)(H,87,100)(H,88,103)(H,89,101)(H,90,107)(H,91,104)(H,92,108)(H,93,110)(H,94,111)(H,95,105)(H,96,109)(H,97,106)(H4,81,82,85)(H4,83,84,86)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.90n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE to opioid receptor delta of rat fore brain membranes was determined


J Med Chem 35: 4330-3 (1992)


Article DOI: 10.1021/jm00101a010
BindingDB Entry DOI: 10.7270/Q2FB51W2
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50002347
PNG
(CHEMBL425806 | [N-cyclopropyl methylTyr1, D-pro10]...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NCC1CC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C67H109N21O13/c1-5-40(4)55(62(98)84-47(20-13-31-77-67(73)74)63(99)88-32-14-21-52(88)61(97)85-48(64(100)101)17-9-10-28-68)87-58(94)46(19-12-30-76-66(71)72)82-57(93)45(18-11-29-75-65(69)70)83-59(95)50(33-39(2)3)86-60(96)51(35-41-15-7-6-8-16-41)81-54(91)38-79-53(90)37-80-56(92)49(78-36-43-22-23-43)34-42-24-26-44(89)27-25-42/h6-8,15-16,24-27,39-40,43,45-52,55,78,89H,5,9-14,17-23,28-38,68H2,1-4H3,(H,79,90)(H,80,92)(H,81,91)(H,82,93)(H,83,95)(H,84,98)(H,85,97)(H,86,96)(H,87,94)(H,100,101)(H4,69,70,75)(H4,71,72,76)(H4,73,74,77)/t40-,45-,46-,47-,48-,49-,50-,51-,52+,55-/m0/s1
UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9.60n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Tested for inhibitory effect on binding of [3H]DAMGO to opioid receptor mu in guinea pig cerebellum membranes


J Med Chem 35: 4638-9 (1993)


Article DOI: 10.1021/jm00102a019
BindingDB Entry DOI: 10.7270/Q2416XPM
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50019482
PNG
(DYNORPHIN A (1-11) | NH2-Tyr-Gly-Gly-D-Trp-Leu-Arg...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48-,51-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]DSLET([[3H]-D-Ser2,Leu5,Thr6]enkephalin binding to Opioid receptor delta 1 in rat brain homogenates.


J Med Chem 29: 1913-7 (1986)


Article DOI: 10.1021/jm00160a019
BindingDB Entry DOI: 10.7270/Q2Z89BCJ
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Affinity against Opioid receptor kappa 3 was determined by measuring the inhibition of [3H]-NalBzoH binding to guinea pig cerebellar membranes


J Med Chem 40: 2733-9 (1997)


Article DOI: 10.1021/jm960747t
BindingDB Entry DOI: 10.7270/Q2D50M2D
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50002347
PNG
(CHEMBL425806 | [N-cyclopropyl methylTyr1, D-pro10]...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NCC1CC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C67H109N21O13/c1-5-40(4)55(62(98)84-47(20-13-31-77-67(73)74)63(99)88-32-14-21-52(88)61(97)85-48(64(100)101)17-9-10-28-68)87-58(94)46(19-12-30-76-66(71)72)82-57(93)45(18-11-29-75-65(69)70)83-59(95)50(33-39(2)3)86-60(96)51(35-41-15-7-6-8-16-41)81-54(91)38-79-53(90)37-80-56(92)49(78-36-43-22-23-43)34-42-24-26-44(89)27-25-42/h6-8,15-16,24-27,39-40,43,45-52,55,78,89H,5,9-14,17-23,28-38,68H2,1-4H3,(H,79,90)(H,80,92)(H,81,91)(H,82,93)(H,83,95)(H,84,98)(H,85,97)(H,86,96)(H,87,94)(H,100,101)(H4,69,70,75)(H4,71,72,76)(H4,73,74,77)/t40-,45-,46-,47-,48-,49-,50-,51-,52+,55-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
558n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Tested for inhibitory effect on binding of [3H]DPDPE to opioid receptor delta in guinea pig cerebellum membranes


J Med Chem 35: 4638-9 (1993)


Article DOI: 10.1021/jm00102a019
BindingDB Entry DOI: 10.7270/Q2416XPM
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50454202
PNG
(CHEMBL2369126)
Show SMILES CC[C@@H](C)[C@@H](NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C67H112N22O12/c1-7-39(5)53(87-52(91)37-80-56(93)44(69)35-42-25-27-43(90)28-26-42)62(99)86-50(36-41-18-10-9-11-19-41)60(97)85-49(34-38(3)4)59(96)83-46(21-14-30-77-65(71)72)57(94)82-47(22-15-31-78-66(73)74)58(95)88-54(40(6)8-2)63(100)84-48(23-16-32-79-67(75)76)64(101)89-33-17-24-51(89)61(98)81-45(55(70)92)20-12-13-29-68/h9-11,18-19,25-28,38-40,44-51,53-54,90H,7-8,12-17,20-24,29-37,68-69H2,1-6H3,(H2,70,92)(H,80,93)(H,81,98)(H,82,94)(H,83,96)(H,84,100)(H,85,97)(H,86,99)(H,87,91)(H,88,95)(H4,71,72,77)(H4,73,74,78)(H4,75,76,79)/t39-,40+,44+,45+,46+,47+,48+,49+,50+,51+,53-,54+/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 55n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of binding [3H]U-69,539 at Opioid receptor kappa 1 of guinea pig brain membrane (GPB) homogenates.


J Med Chem 39: 2456-60 (1996)


Article DOI: 10.1021/jm950655o
BindingDB Entry DOI: 10.7270/Q2C828D7
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)
BDBM50454202
PNG
(CHEMBL2369126)
Show SMILES CC[C@@H](C)[C@@H](NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C67H112N22O12/c1-7-39(5)53(87-52(91)37-80-56(93)44(69)35-42-25-27-43(90)28-26-42)62(99)86-50(36-41-18-10-9-11-19-41)60(97)85-49(34-38(3)4)59(96)83-46(21-14-30-77-65(71)72)57(94)82-47(22-15-31-78-66(73)74)58(95)88-54(40(6)8-2)63(100)84-48(23-16-32-79-67(75)76)64(101)89-33-17-24-51(89)61(98)81-45(55(70)92)20-12-13-29-68/h9-11,18-19,25-28,38-40,44-51,53-54,90H,7-8,12-17,20-24,29-37,68-69H2,1-6H3,(H2,70,92)(H,80,93)(H,81,98)(H,82,94)(H,83,96)(H,84,100)(H,85,97)(H,86,99)(H,87,91)(H,88,95)(H4,71,72,77)(H4,73,74,78)(H4,75,76,79)/t39-,40+,44+,45+,46+,47+,48+,49+,50+,51+,53-,54+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Agonistic activity towards Opioid receptor delta 1 was determined by evaluating the inhibitory activity towards electrically stimulated mouse vas def...


J Med Chem 39: 2456-60 (1996)


Article DOI: 10.1021/jm950655o
BindingDB Entry DOI: 10.7270/Q2C828D7
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Affinity against Opioid receptor kappa 2 was determined by measuring the inhibition of [3H]-bremazocine binding to guinea pig cerebellar membranes


J Med Chem 40: 2733-9 (1997)


Article DOI: 10.1021/jm960747t
BindingDB Entry DOI: 10.7270/Q2D50M2D
More data for this
Ligand-Target Pair
Opioid receptors; mu/kappa/delta


(Homo sapiens (Human))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.220n/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Tested for opioid receptor agonistic activity in guinea pig ileum


J Med Chem 35: 4638-9 (1993)


Article DOI: 10.1021/jm00102a019
BindingDB Entry DOI: 10.7270/Q2416XPM
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50010529
PNG
(2-[5-Guanidino-2-(5-guanidino-2-{2-[2-(2-{2-[3-(4-...)
Show SMILES CN[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O
Show InChI InChI=1S/C47H75N15O9/c1-27(2)21-34(40(48)66)61-43(69)33(14-10-20-55-47(51)52)59-42(68)32(13-9-19-54-46(49)50)60-44(70)36(22-28(3)4)62-45(71)37(24-29-11-7-6-8-12-29)58-39(65)26-56-38(64)25-57-41(67)35(53-5)23-30-15-17-31(63)18-16-30/h6-8,11-12,15-18,27-28,32-37,53,63H,9-10,13-14,19-26H2,1-5H3,(H2,48,66)(H,56,64)(H,57,67)(H,58,65)(H,59,68)(H,60,70)(H,61,69)(H,62,71)(H4,49,50,54)(H4,51,52,55)/t32-,33-,34-,35-,36-,37-/m0/s1
UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+3n/an/an/an/an/an/a



Eisai Co., Ltd.

Curated by ChEMBL


Assay Description
Evaluated for inhibitory activity against Opioid receptor mu 1 of guinea pig ileum (GPI)


J Med Chem 33: 206-12 (1990)


Article DOI: 10.1021/jm00163a034
BindingDB Entry DOI: 10.7270/Q2QV3KG6
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.260n/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Opioid receptor kappa 1 using [3H]-diprenorphine as radioligand in guinea pig cerebellar membrane in absence...


J Med Chem 40: 2733-9 (1997)


Article DOI: 10.1021/jm960747t
BindingDB Entry DOI: 10.7270/Q2D50M2D
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50010530
PNG
(2-[5-Guanidino-2-(5-guanidino-2-{2-[2-(2-{2-[3-(4-...)
Show SMILES CN[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O
Show InChI InChI=1S/C44H69N15O9/c1-25(2)20-32(37(45)63)59-41(67)31(13-9-19-52-44(48)49)58-40(66)30(12-8-18-51-43(46)47)57-38(64)26(3)55-42(68)34(22-27-10-6-5-7-11-27)56-36(62)24-53-35(61)23-54-39(65)33(50-4)21-28-14-16-29(60)17-15-28/h5-7,10-11,14-17,25-26,30-34,50,60H,8-9,12-13,18-24H2,1-4H3,(H2,45,63)(H,53,61)(H,54,65)(H,55,68)(H,56,62)(H,57,64)(H,58,66)(H,59,67)(H4,46,47,51)(H4,48,49,52)/t26-,30+,31+,32+,33+,34-/m1/s1
UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



Eisai Co., Ltd.

Curated by ChEMBL


Assay Description
Evaluated for inhibitory activity against Opioid receptor mu 1 of guinea pig ileum (GPI)


J Med Chem 33: 206-12 (1990)


Article DOI: 10.1021/jm00163a034
BindingDB Entry DOI: 10.7270/Q2QV3KG6
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50002346
PNG
(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C63H103N21O13/c1-5-37(4)51(58(94)80-44(20-13-29-74-63(70)71)59(95)84-30-14-21-48(84)57(93)81-45(60(96)97)17-9-10-26-64)83-54(90)43(19-12-28-73-62(68)69)78-53(89)42(18-11-27-72-61(66)67)79-55(91)46(31-36(2)3)82-56(92)47(33-38-15-7-6-8-16-38)77-50(87)35-75-49(86)34-76-52(88)41(65)32-39-22-24-40(85)25-23-39/h6-8,15-16,22-25,36-37,41-48,51,85H,5,9-14,17-21,26-35,64-65H2,1-4H3,(H,75,86)(H,76,88)(H,77,87)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,92)(H,83,90)(H,96,97)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74)/t37-,41-,42-,43-,44-,45-,46-,47-,48+,51-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Opioid receptor kappa 1 using [3H]-diprenorphine as radioligand in guinea pig cerebellar membrane in presenc...


J Med Chem 40: 2733-9 (1997)


Article DOI: 10.1021/jm960747t
BindingDB Entry DOI: 10.7270/Q2D50M2D
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)
BDBM50010530
PNG
(2-[5-Guanidino-2-(5-guanidino-2-{2-[2-(2-{2-[3-(4-...)
Show SMILES CN[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O
Show InChI InChI=1S/C44H69N15O9/c1-25(2)20-32(37(45)63)59-41(67)31(13-9-19-52-44(48)49)58-40(66)30(12-8-18-51-43(46)47)57-38(64)26(3)55-42(68)34(22-27-10-6-5-7-11-27)56-36(62)24-53-35(61)23-54-39(65)33(50-4)21-28-14-16-29(60)17-15-28/h5-7,10-11,14-17,25-26,30-34,50,60H,8-9,12-13,18-24H2,1-4H3,(H2,45,63)(H,53,61)(H,54,65)(H,55,68)(H,56,62)(H,57,64)(H,58,66)(H,59,67)(H4,46,47,51)(H4,48,49,52)/t26-,30+,31+,32+,33+,34-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.80E+3n/an/an/an/an/an/a



Eisai Co., Ltd.

Curated by ChEMBL


Assay Description
Evaluated for inhibitory activity against Opioid receptor delta 1 of mouse vas deferens (MVD).


J Med Chem 33: 206-12 (1990)


Article DOI: 10.1021/jm00163a034
BindingDB Entry DOI: 10.7270/Q2QV3KG6
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50010530
PNG
(2-[5-Guanidino-2-(5-guanidino-2-{2-[2-(2-{2-[3-(4-...)
Show SMILES CN[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O
Show InChI InChI=1S/C44H69N15O9/c1-25(2)20-32(37(45)63)59-41(67)31(13-9-19-52-44(48)49)58-40(66)30(12-8-18-51-43(46)47)57-38(64)26(3)55-42(68)34(22-27-10-6-5-7-11-27)56-36(62)24-53-35(61)23-54-39(65)33(50-4)21-28-14-16-29(60)17-15-28/h5-7,10-11,14-17,25-26,30-34,50,60H,8-9,12-13,18-24H2,1-4H3,(H2,45,63)(H,53,61)(H,54,65)(H,55,68)(H,56,62)(H,57,64)(H,58,66)(H,59,67)(H4,46,47,51)(H4,48,49,52)/t26-,30+,31+,32+,33+,34-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



Eisai Co., Ltd.

Curated by ChEMBL


Assay Description
Evaluated for inhibitory activity against Opioid receptor kappa 1 of rabbit vas deferens (RVD)


J Med Chem 33: 206-12 (1990)


Article DOI: 10.1021/jm00163a034
BindingDB Entry DOI: 10.7270/Q2QV3KG6
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50010529
PNG
(2-[5-Guanidino-2-(5-guanidino-2-{2-[2-(2-{2-[3-(4-...)
Show SMILES CN[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O
Show InChI InChI=1S/C47H75N15O9/c1-27(2)21-34(40(48)66)61-43(69)33(14-10-20-55-47(51)52)59-42(68)32(13-9-19-54-46(49)50)60-44(70)36(22-28(3)4)62-45(71)37(24-29-11-7-6-8-12-29)58-39(65)26-56-38(64)25-57-41(67)35(53-5)23-30-15-17-31(63)18-16-30/h6-8,11-12,15-18,27-28,32-37,53,63H,9-10,13-14,19-26H2,1-5H3,(H2,48,66)(H,56,64)(H,57,67)(H,58,65)(H,59,68)(H,60,70)(H,61,69)(H,62,71)(H4,49,50,54)(H4,51,52,55)/t32-,33-,34-,35-,36-,37-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Eisai Co., Ltd.

Curated by ChEMBL


Assay Description
Evaluated for inhibitory activity against Opioid receptor kappa 1 of rabbit vas deferens (RVD)


J Med Chem 33: 206-12 (1990)


Article DOI: 10.1021/jm00163a034
BindingDB Entry DOI: 10.7270/Q2QV3KG6
More data for this
Ligand-Target Pair
Opioid receptors; mu/kappa/delta


(Homo sapiens (Human))
BDBM50002347
PNG
(CHEMBL425806 | [N-cyclopropyl methylTyr1, D-pro10]...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NCC1CC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C67H109N21O13/c1-5-40(4)55(62(98)84-47(20-13-31-77-67(73)74)63(99)88-32-14-21-52(88)61(97)85-48(64(100)101)17-9-10-28-68)87-58(94)46(19-12-30-76-66(71)72)82-57(93)45(18-11-29-75-65(69)70)83-59(95)50(33-39(2)3)86-60(96)51(35-41-15-7-6-8-16-41)81-54(91)38-79-53(90)37-80-56(92)49(78-36-43-22-23-43)34-42-24-26-44(89)27-25-42/h6-8,15-16,24-27,39-40,43,45-52,55,78,89H,5,9-14,17-23,28-38,68H2,1-4H3,(H,79,90)(H,80,92)(H,81,91)(H,82,93)(H,83,95)(H,84,98)(H,85,97)(H,86,96)(H,87,94)(H,100,101)(H4,69,70,75)(H4,71,72,76)(H4,73,74,77)/t40-,45-,46-,47-,48-,49-,50-,51-,52+,55-/m0/s1
PDB

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20n/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Tested for opioid receptor agonistic activity in guinea pig ileum


J Med Chem 35: 4638-9 (1993)


Article DOI: 10.1021/jm00102a019
BindingDB Entry DOI: 10.7270/Q2416XPM
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 57 total )  |  Next  |  Last  >>