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13 similar compounds to monomer 50003519

Compile data set for download or QSAR
Wt: 483.4
BDBM50003524
Wt: 424.5
BDBM50003512
Wt: 370.4
BDBM50003513
Wt: 410.5
BDBM50003516
Wt: 396.4
BDBM50003522
Wt: 414.4
BDBM50003539
Wt: 410.5
BDBM50003551
Wt: 439.5
BDBM50003475
Wt: 385.5
BDBM50003480
Wt: 439.5
BDBM50003484
Wt: 320.3
BDBM50003495
Wt: 286.3
BDBM50003500
Wt: 370.4
BDBM50003505

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50003524,50003512,50003513,50003516,50003522,50003539,50003551,50003475,50003480,50003484,50003495,50003500,50003505   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003513
PNG
(CHEMBL423524 | [4-(2-Naphthalen-1-yl-acetyl)-piper...)
Show SMILES O=C(Cc1cccc2ccccc12)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C23H22N4O/c24-16-22(20-8-4-10-25-17-20)26-11-13-27(14-12-26)23(28)15-19-7-3-6-18-5-1-2-9-21(18)19/h1-10,17,22H,11-15H2
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n/an/a 76n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003475
PNG
(CHEMBL543420 | {4-[2-(2,2-Diphenyl-ethylamino)-ace...)
Show SMILES O=C(CNCC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H29N5O/c28-18-26(24-12-7-13-29-19-24)31-14-16-32(17-15-31)27(33)21-30-20-25(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,19,25-26,30H,14-17,20-21H2
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n/an/a 220n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003495
PNG
((4-Phenylacetyl-piperazin-1-yl)-pyridin-3-yl-aceto...)
Show SMILES O=C(Cc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C19H20N4O/c20-14-18(17-7-4-8-21-15-17)22-9-11-23(12-10-22)19(24)13-16-5-2-1-3-6-16/h1-8,15,18H,9-13H2
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n/an/a 2.70E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003516
PNG
(CHEMBL335044 | [4-(2,3-Diphenyl-propionyl)-piperaz...)
Show SMILES O=C(C(Cc1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H26N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)24(22-10-5-2-6-11-22)18-21-8-3-1-4-9-21/h1-13,20,24-25H,14-18H2
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n/an/a 230n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003524
PNG
(CHEMBL3216197 | CHEMBL544141 | [4-(2,2-Diphenyl-pr...)
Show SMILES Cl.Cl.CC(C(=O)N1CCN(CC1)C(C#N)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O/c1-26(22-10-4-2-5-11-22,23-12-6-3-7-13-23)25(31)30-17-15-29(16-18-30)24(19-27)21-9-8-14-28-20-21/h2-14,20,24H,15-18H2,1H3
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n/an/a 1.90n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003539
PNG
(2-(4-Diphenylacetyl-piperazin-1-yl)-2-pyridin-3-yl...)
Show SMILES NC(=O)C(N1CCN(CC1)C(=O)C(c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C25H26N4O2/c26-24(30)23(21-12-7-13-27-18-21)28-14-16-29(17-15-28)25(31)22(19-8-3-1-4-9-19)20-10-5-2-6-11-20/h1-13,18,22-23H,14-17H2,(H2,26,30)
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n/an/a 2.00E+5n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003500
PNG
(CHEMBL134025 | [4-(2,2-Dimethyl-propionyl)-piperaz...)
Show SMILES CC(C)(C)C(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C16H22N4O/c1-16(2,3)15(21)20-9-7-19(8-10-20)14(11-17)13-5-4-6-18-12-13/h4-6,12,14H,7-10H2,1-3H3
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n/an/a 5.20E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003480
PNG
(2,2-Diphenyl-1-[4-(1-pyridin-3-yl-ethyl)-piperazin...)
Show SMILES CC(N1CCN(CC1)C(=O)C(c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C25H27N3O/c1-20(23-13-8-14-26-19-23)27-15-17-28(18-16-27)25(29)24(21-9-4-2-5-10-21)22-11-6-3-7-12-22/h2-14,19-20,24H,15-18H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003512
PNG
(CHEMBL133964 | [4-(2,4-Diphenyl-butyryl)-piperazin...)
Show SMILES O=C(C(CCc1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H28N4O/c28-20-26(24-12-7-15-29-21-24)30-16-18-31(19-17-30)27(32)25(23-10-5-2-6-11-23)14-13-22-8-3-1-4-9-22/h1-12,15,21,25-26H,13-14,16-19H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003505
PNG
(CHEMBL132636 | [4-(2-Naphthalen-2-yl-acetyl)-piper...)
Show SMILES O=C(Cc1ccc2ccccc2c1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C23H22N4O/c24-16-22(21-6-3-9-25-17-21)26-10-12-27(13-11-26)23(28)15-18-7-8-19-4-1-2-5-20(19)14-18/h1-9,14,17,22H,10-13,15H2
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n/an/a 720n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003484
PNG
(CHEMBL336816 | N-{2-[4-(Cyano-pyridin-3-yl-methyl)...)
Show SMILES O=C(NCCN1CCN(CC1)C(C#N)c1cccnc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29N5O/c28-20-25(24-12-7-13-29-21-24)32-18-16-31(17-19-32)15-14-30-27(33)26(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,21,25-26H,14-19H2,(H,30,33)
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n/an/a 36n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003551
PNG
(2-(4-Diphenylacetyl-piperazin-1-yl)-2-pyridin-3-yl...)
Show SMILES CC(C#N)(N1CCN(CC1)C(=O)C(c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C26H26N4O/c1-26(20-27,23-13-8-14-28-19-23)30-17-15-29(16-18-30)25(31)24(21-9-4-2-5-10-21)22-11-6-3-7-12-22/h2-14,19,24H,15-18H2,1H3
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n/an/a 240n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003522
PNG
((4-Diphenylacetyl-piperazin-1-yl)-pyridin-3-yl-ace...)
Show SMILES O=C(C(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C25H24N4O/c26-18-23(22-12-7-13-27-19-22)28-14-16-29(17-15-28)25(30)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,19,23-24H,14-17H2
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n/an/a 10n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair