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10 similar compounds to monomer 50003504

Compile data set for download or QSAR
Wt: 429.3
BDBM50003502
Wt: 379.2
BDBM50003478
Wt: 464.4
BDBM50003529
Wt: 439.5
BDBM50003523
Wt: 439.5
BDBM50003528
Wt: 363.4
BDBM50003543
Wt: 286.3
BDBM50003500
Wt: 425.5
BDBM50003506
Wt: 377.4
BDBM50003511
Wt: 377.4
BDBM50368448

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50003502,50003478,50003529,50003523,50003528,50003543,50003500,50003506,50003511,50368448   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50368448
PNG
(CHEMBL1203313)
Show SMILES O=C(CNCCCc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C22H27N5O/c23-16-21(20-9-5-11-24-17-20)26-12-14-27(15-13-26)22(28)18-25-10-4-8-19-6-2-1-3-7-19/h1-3,5-7,9,11,17,21,25H,4,8,10,12-15,18H2
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n/an/a 530n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003478
PNG
((4-Benzoyl-piperazin-1-yl)-pyridin-3-yl-acetonitri...)
Show SMILES Cl.Cl.O=C(N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C18H18N4O/c19-13-17(16-7-4-8-20-14-16)21-9-11-22(12-10-21)18(23)15-5-2-1-3-6-15/h1-8,14,17H,9-12H2
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n/an/a 4.80E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003502
PNG
(CHEMBL3215754 | CHEMBL545304 | [4-(Naphthalene-2-c...)
Show SMILES Cl.Cl.O=C(N1CCN(CC1)C(C#N)c1cccnc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H20N4O/c23-15-21(20-6-3-9-24-16-20)25-10-12-26(13-11-25)22(27)19-8-7-17-4-1-2-5-18(17)14-19/h1-9,14,16,21H,10-13H2
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n/an/a 2.50E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003529
PNG
((4-{2-[Methyl-(3-phenyl-propyl)-amino]-acetyl}-pip...)
Show SMILES Cl.Cl.CN(CCCc1ccccc1)CC(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C23H29N5O/c1-26(12-6-9-20-7-3-2-4-8-20)19-23(29)28-15-13-27(14-16-28)22(17-24)21-10-5-11-25-18-21/h2-5,7-8,10-11,18,22H,6,9,12-16,19H2,1H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003506
PNG
(CHEMBL322184 | CHEMBL545771 | {4-[2-(Benzhydryl-am...)
Show SMILES O=C(CNC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H27N5O/c27-18-24(23-12-7-13-28-19-23)30-14-16-31(17-15-30)25(32)20-29-26(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,19,24,26,29H,14-17,20H2
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n/an/a 9.10n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003506
PNG
(CHEMBL322184 | CHEMBL545771 | {4-[2-(Benzhydryl-am...)
Show SMILES O=C(CNC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H27N5O/c27-18-24(23-12-7-13-28-19-23)30-14-16-31(17-15-30)25(32)20-29-26(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,19,24,26,29H,14-17,20H2
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n/an/a 9.10n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003543
PNG
(CHEMBL554463 | {4-[2-(1-Phenyl-ethylamino)-acetyl]...)
Show SMILES CC(NCC(=O)N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C21H25N5O/c1-17(18-6-3-2-4-7-18)24-16-21(27)26-12-10-25(11-13-26)20(14-22)19-8-5-9-23-15-19/h2-9,15,17,20,24H,10-13,16H2,1H3
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n/an/a 36n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003528
PNG
(CHEMBL545072 | {4-[2-(Benzhydryl-methyl-amino)-ace...)
Show SMILES CN(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29N5O/c1-30(27(22-9-4-2-5-10-22)23-11-6-3-7-12-23)21-26(33)32-17-15-31(16-18-32)25(19-28)24-13-8-14-29-20-24/h2-14,20,25,27H,15-18,21H2,1H3
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n/an/a 60n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003500
PNG
(CHEMBL134025 | [4-(2,2-Dimethyl-propionyl)-piperaz...)
Show SMILES CC(C)(C)C(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C16H22N4O/c1-16(2,3)15(21)20-9-7-19(8-10-20)14(11-17)13-5-4-6-18-12-13/h4-6,12,14H,7-10H2,1-3H3
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n/an/a 5.20E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003523
PNG
(CHEMBL544607 | [4-(2-Dibenzylamino-acetyl)-piperaz...)
Show SMILES O=C(CN(Cc1ccccc1)Cc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H29N5O/c28-18-26(25-12-7-13-29-19-25)31-14-16-32(17-15-31)27(33)22-30(20-23-8-3-1-4-9-23)21-24-10-5-2-6-11-24/h1-13,19,26H,14-17,20-22H2
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n/an/a 32n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003511
PNG
((4-{2-[Methyl-(1-phenyl-ethyl)-amino]-acetyl}-pipe...)
Show SMILES CC(N(C)CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C22H27N5O/c1-18(19-7-4-3-5-8-19)25(2)17-22(28)27-13-11-26(12-14-27)21(15-23)20-9-6-10-24-16-20/h3-10,16,18,21H,11-14,17H2,1-2H3
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n/an/a 240n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair