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11 similar compounds to monomer 50003490

Compile data set for download or QSAR
Wt: 497.4
BDBM50003514
Wt: 407.3
BDBM50003517
Wt: 464.4
BDBM50003529
Wt: 453.5
BDBM50003520
Wt: 453.5
BDBM50003526
Wt: 453.5
BDBM50003541
Wt: 396.5
BDBM50003542
Wt: 385.5
BDBM50003488
Wt: 426.5
BDBM50003510
Wt: 424.5
BDBM50045991
Wt: 362.4
BDBM50046006

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50003514,50003517,50003529,50003520,50003526,50003541,50003542,50003488,50003510,50045991,50046006   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003510
PNG
(CHEMBL103753 | [4-(3-Hydroxy-3,3-diphenyl-propiony...)
Show SMILES OC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O2/c27-19-24(21-8-7-13-28-20-21)29-14-16-30(17-15-29)25(31)18-26(32,22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-13,20,24,32H,14-18H2
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n/an/a 21n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003541
PNG
(CHEMBL553093 | N-{2-[4-(Cyano-pyridin-3-yl-methyl)...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)NCCN1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C28H31N5O/c29-21-27(25-12-7-13-30-22-25)33-18-16-32(17-19-33)15-14-31-28(34)20-26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-13,22,26-27H,14-20H2,(H,31,34)
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n/an/a 5.50E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003526
PNG
(2-[4-(Cyano-pyridin-3-yl-methyl)-piperazin-1-yl]-N...)
Show SMILES O=C(CN1CCN(CC1)C(C#N)c1cccnc1)NCCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31N5O/c29-20-27(25-12-7-14-30-21-25)33-18-16-32(17-19-33)22-28(34)31-15-13-26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-12,14,21,26-27H,13,15-19,22H2,(H,31,34)
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n/an/a 240n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003529
PNG
((4-{2-[Methyl-(3-phenyl-propyl)-amino]-acetyl}-pip...)
Show SMILES Cl.Cl.CN(CCCc1ccccc1)CC(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C23H29N5O/c1-26(12-6-9-20-7-3-2-4-8-20)19-23(29)28-15-13-27(14-16-28)22(17-24)21-10-5-11-25-18-21/h2-5,7-8,10-11,18,22H,6,9,12-16,19H2,1H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003520
PNG
(CHEMBL552805 | {4-[2-(3,3-Diphenyl-propylamino)-ac...)
Show SMILES O=C(CNCCC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C28H31N5O/c29-20-27(25-12-7-14-30-21-25)32-16-18-33(19-17-32)28(34)22-31-15-13-26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-12,14,21,26-27,31H,13,15-19,22H2
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n/an/a 86n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046006
PNG
((2-Methyl-pyridin-3-yl)-[4-(3-phenyl-butyryl)-pipe...)
Show SMILES CC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C22H26N4O/c1-17(19-7-4-3-5-8-19)15-22(27)26-13-11-25(12-14-26)21(16-23)20-9-6-10-24-18(20)2/h3-10,17,21H,11-15H2,1-2H3
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n/an/a 32n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003514
PNG
(CHEMBL3216401 | CHEMBL545075 | [4-(2-Benzyl-3-phen...)
Show SMILES Cl.Cl.O=C(C(Cc1ccccc1)Cc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H28N4O/c28-20-26(24-12-7-13-29-21-24)30-14-16-31(17-15-30)27(32)25(18-22-8-3-1-4-9-22)19-23-10-5-2-6-11-23/h1-13,21,25-26H,14-19H2
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n/an/a 11n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003488
PNG
(3,3-Diphenyl-1-(4-pyridin-3-ylmethyl-piperazin-1-y...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C25H27N3O/c29-25(28-16-14-27(15-17-28)20-21-8-7-13-26-19-21)18-24(22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-13,19,24H,14-18,20H2
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n/an/a 520n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003542
PNG
(CHEMBL542731 | [4-(3,3-Diphenyl-propyl)-piperazin-...)
Show SMILES N#CC(N1CCN(CCC(c2ccccc2)c2ccccc2)CC1)c1cccnc1
Show InChI InChI=1S/C26H28N4/c27-20-26(24-12-7-14-28-21-24)30-18-16-29(17-19-30)15-13-25(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-12,14,21,25-26H,13,15-19H2
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n/an/a 630n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003510
PNG
(CHEMBL103753 | [4-(3-Hydroxy-3,3-diphenyl-propiony...)
Show SMILES OC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O2/c27-19-24(21-8-7-13-28-20-21)29-14-16-30(17-15-29)25(31)18-26(32,22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-13,20,24,32H,14-18H2
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n/an/a 21n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045991
PNG
(CHEMBL100642 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H28N4O/c1-21-24(13-8-14-29-21)26(20-28)30-15-17-31(18-16-30)27(32)19-25(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,25-26H,15-19H2,1H3
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n/an/a 18n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003517
PNG
(CHEMBL3215980 | CHEMBL543663 | [4-(3-Phenyl-propio...)
Show SMILES Cl.Cl.O=C(CCc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C20H22N4O/c21-15-19(18-7-4-10-22-16-18)23-11-13-24(14-12-23)20(25)9-8-17-5-2-1-3-6-17/h1-7,10,16,19H,8-9,11-14H2
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n/an/a 520n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair