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2 similar compounds to monomer 50003488

Compile data set for download or QSAR
Wt: 453.5
BDBM50003541
Wt: 410.5
BDBM50003490

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50003541,50003490   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003541
PNG
(CHEMBL553093 | N-{2-[4-(Cyano-pyridin-3-yl-methyl)...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)NCCN1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C28H31N5O/c29-21-27(25-12-7-13-30-22-25)33-18-16-32(17-19-33)15-14-31-28(34)20-26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-13,22,26-27H,14-20H2,(H,31,34)
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PC sid
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Similars

Article
PubMed
n/an/a 5.50E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003490
PNG
(CHEMBL101245 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H26N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,20,24-25H,14-18H2
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Article
PubMed
n/an/a 20n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003490
PNG
(CHEMBL101245 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H26N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,20,24-25H,14-18H2
MMDB

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 20n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair