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6 similar compounds to monomer 50003510

Compile data set for download or QSAR
Wt: 453.5
BDBM50003541
Wt: 410.5
BDBM50003490
Wt: 378.4
BDBM50045958
Wt: 441.5
BDBM50045963
Wt: 476.5
BDBM50045971
Wt: 440.5
BDBM50045995

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50003541,50003490,50045958,50045963,50045971,50045995   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003541
PNG
(CHEMBL553093 | N-{2-[4-(Cyano-pyridin-3-yl-methyl)...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)NCCN1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C28H31N5O/c29-21-27(25-12-7-13-30-22-25)33-18-16-32(17-19-33)15-14-31-28(34)20-26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-13,22,26-27H,14-20H2,(H,31,34)
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n/an/a 5.50E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003490
PNG
(CHEMBL101245 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H26N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,20,24-25H,14-18H2
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n/an/a 20n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003490
PNG
(CHEMBL101245 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H26N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,20,24-25H,14-18H2
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n/an/a 20n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045963
PNG
(CHEMBL100522 | [4-(3-Hydroxy-3-phenyl-3-pyridin-3-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(O)(c1ccccc1)c1cccnc1
Show InChI InChI=1S/C26H27N5O2/c1-20-23(10-6-12-29-20)24(18-27)30-13-15-31(16-14-30)25(32)17-26(33,21-7-3-2-4-8-21)22-9-5-11-28-19-22/h2-12,19,24,33H,13-17H2,1H3
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n/an/a 32n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045958
PNG
(CHEMBL99833 | [4-(3-Hydroxy-3-phenyl-butyryl)-pipe...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(C)(O)c1ccccc1
Show InChI InChI=1S/C22H26N4O2/c1-17-19(9-6-10-24-17)20(16-23)25-11-13-26(14-12-25)21(27)15-22(2,28)18-7-4-3-5-8-18/h3-10,20,28H,11-15H2,1-2H3
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n/an/a 36n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045971
PNG
(CHEMBL99794 | {4-[3,3-Bis-(4-fluoro-phenyl)-3-hydr...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(O)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H26F2N4O2/c1-19-24(3-2-12-31-19)25(18-30)32-13-15-33(16-14-32)26(34)17-27(35,20-4-8-22(28)9-5-20)21-6-10-23(29)11-7-21/h2-12,25,35H,13-17H2,1H3
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n/an/a 75n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045995
PNG
(CHEMBL100641 | [4-(3-Hydroxy-3,3-diphenyl-propiony...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H28N4O2/c1-21-24(13-8-14-29-21)25(20-28)30-15-17-31(18-16-30)26(32)19-27(33,22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,25,33H,15-19H2,1H3
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n/an/a 17n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair