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3 similar compounds to monomer 50003532

Compile data set for download or QSAR
Wt: 335.4
BDBM50003537
Wt: 425.5
BDBM50003544
Wt: 385.4
BDBM50003554

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50003537,50003544,50003554   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003544
PNG
(CHEMBL132852 | {4-[2-(Benzyl-phenyl-amino)-acetyl]...)
Show SMILES O=C(CN(Cc1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H27N5O/c27-18-25(23-10-7-13-28-19-23)29-14-16-30(17-15-29)26(32)21-31(24-11-5-2-6-12-24)20-22-8-3-1-4-9-22/h1-13,19,25H,14-17,20-21H2
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Article
PubMed
n/an/a 24n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003554
PNG
(CHEMBL540829 | {4-[2-(Naphthalen-1-ylamino)-acetyl...)
Show SMILES O=C(CNc1cccc2ccccc12)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C23H23N5O/c24-15-22(19-7-4-10-25-16-19)27-11-13-28(14-12-27)23(29)17-26-21-9-3-6-18-5-1-2-8-20(18)21/h1-10,16,22,26H,11-14,17H2
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Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003537
PNG
(CHEMBL134094 | [4-(2-Phenylamino-acetyl)-piperazin...)
Show SMILES O=C(CNc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C19H21N5O/c20-13-18(16-5-4-8-21-14-16)23-9-11-24(12-10-23)19(25)15-22-17-6-2-1-3-7-17/h1-8,14,18,22H,9-12,15H2
MMDB

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Article
PubMed
n/an/a 130n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair