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2 similar compounds to monomer 50003473

Compile data set for download or QSAR
Wt: 332.3
BDBM50003549
Wt: 422.5
BDBM50045998

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50003549,50045998   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045998
PNG
(CHEMBL103903 | [4-(3,3-Diphenyl-acryloyl)-piperazi...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)C=C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H26N4O/c1-21-24(13-8-14-29-21)26(20-28)30-15-17-31(18-16-30)27(32)19-25(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,19,26H,15-18H2,1H3
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 26n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003549
PNG
(CHEMBL423891 | [4-(3-Phenyl-acryloyl)-piperazin-1-...)
Show SMILES O=C(\C=C\c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C20H20N4O/c21-15-19(18-7-4-10-22-16-18)23-11-13-24(14-12-23)20(25)9-8-17-5-2-1-3-6-17/h1-10,16,19H,11-14H2/b9-8+
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair