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35 similar compounds to monomer 50003570

Wt: 636.6
BDBM50003567
Wt: 608.6
BDBM50003568
Wt: 334.4
BDBM50032407
Wt: 298.4
BDBM50085028
Wt: 284.4
BDBM50085029
Wt: 374.5
BDBM50085030
Wt: 312.4
BDBM50085031
Wt: 338.5
BDBM50085032
Wt: 346.5
BDBM50085020
Wt: 298.4
BDBM50085022
Wt: 374.5
BDBM50085023
Wt: 270.4
BDBM50085024
Wt: 324.5
BDBM50085025
Wt: 353.5
BDBM50085026
Wt: 270.4
BDBM50124000
Displayed 1 to 15 (of 34 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 77 hits for monomerid = 50003567,50003568,50032407,50085028,50085029,50085030,50085031,50085032,50085020,50085022,50085023,50085024,50085025,50085026,50124000   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085020
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(Nc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C24H30N2/c1-17-23-14-19-10-11-21(25-20-6-4-3-5-7-20)15-22(19)24(17,2)12-13-26(23)16-18-8-9-18/h3-7,10-11,15,17-18,23,25H,8-9,12-14,16H2,1-2H3/t17-,23?,24-/m0/s1
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0.540n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085020
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(Nc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C24H30N2/c1-17-23-14-19-10-11-21(25-20-6-4-3-5-7-20)15-22(19)24(17,2)12-13-26(23)16-18-8-9-18/h3-7,10-11,15,17-18,23,25H,8-9,12-14,16H2,1-2H3/t17-,23?,24-/m0/s1
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0.540n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.


J Med Chem 43: 3558-65 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085020
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(Nc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C24H30N2/c1-17-23-14-19-10-11-21(25-20-6-4-3-5-7-20)15-22(19)24(17,2)12-13-26(23)16-18-8-9-18/h3-7,10-11,15,17-18,23,25H,8-9,12-14,16H2,1-2H3/t17-,23?,24-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.


J Med Chem 43: 3558-65 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085020
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(Nc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C24H30N2/c1-17-23-14-19-10-11-21(25-20-6-4-3-5-7-20)15-22(19)24(17,2)12-13-26(23)16-18-8-9-18/h3-7,10-11,15,17-18,23,25H,8-9,12-14,16H2,1-2H3/t17-,23?,24-/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Sigma opioid receptor


(Homo sapiens)
BDBM50032407
PNG
((3-Benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-...)
Show SMILES CC1C2Cc3ccc(cc3C1(C)CCN2Cc1ccccc1)N(C)C
Show InChI InChI=1S/C23H30N2/c1-17-22-14-19-10-11-20(24(3)4)15-21(19)23(17,2)12-13-25(22)16-18-8-6-5-7-9-18/h5-11,15,17,22H,12-14,16H2,1-4H3
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1.80n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity measured on Sigma receptor type 1 from guinea pig brain membranes using [3H]pentazocine as radioligand.


J Med Chem 38: 2978-85 (1995)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085028
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CCNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H30N2/c1-4-21-17-8-7-16-11-19-14(2)20(3,18(16)12-17)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19,21H,4-6,9-11,13H2,1-3H3/t14-,19?,20-/m0/s1
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3.30n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085028
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CCNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H30N2/c1-4-21-17-8-7-16-11-19-14(2)20(3,18(16)12-17)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19,21H,4-6,9-11,13H2,1-3H3/t14-,19?,20-/m0/s1
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3.30n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085024
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Show SMILES C[C@H]1C2Cc3ccc(N)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C18H26N2/c1-12-17-9-14-5-6-15(19)10-16(14)18(12,2)7-8-20(17)11-13-3-4-13/h5-6,10,12-13,17H,3-4,7-9,11,19H2,1-2H3/t12-,17?,18-/m0/s1
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4.10n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085028
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CCNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H30N2/c1-4-21-17-8-7-16-11-19-14(2)20(3,18(16)12-17)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19,21H,4-6,9-11,13H2,1-3H3/t14-,19?,20-/m0/s1
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5.10n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor mu 1 obtained from guinea pig brain membranes using [3H]DAMGO as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085028
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CCNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H30N2/c1-4-21-17-8-7-16-11-19-14(2)20(3,18(16)12-17)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19,21H,4-6,9-11,13H2,1-3H3/t14-,19?,20-/m0/s1
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5.10n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085020
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(Nc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C24H30N2/c1-17-23-14-19-10-11-21(25-20-6-4-3-5-7-20)15-22(19)24(17,2)12-13-26(23)16-18-8-9-18/h3-7,10-11,15,17-18,23,25H,8-9,12-14,16H2,1-2H3/t17-,23?,24-/m0/s1
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5.20n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.


J Med Chem 43: 3558-65 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085029
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C19H28N2/c1-13-18-10-15-6-7-16(20-3)11-17(15)19(13,2)8-9-21(18)12-14-4-5-14/h6-7,11,13-14,18,20H,4-5,8-10,12H2,1-3H3/t13-,18?,19-/m0/s1
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8.5n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085029
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C19H28N2/c1-13-18-10-15-6-7-16(20-3)11-17(15)19(13,2)8-9-21(18)12-14-4-5-14/h6-7,11,13-14,18,20H,4-5,8-10,12H2,1-3H3/t13-,18?,19-/m0/s1
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8.5n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085026
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-(4-me...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCN(C)CC1
Show InChI InChI=1S/C23H35N3/c1-17-22-14-19-6-7-20(25-12-10-24(3)11-13-25)15-21(19)23(17,2)8-9-26(22)16-18-4-5-18/h6-7,15,17-18,22H,4-5,8-14,16H2,1-3H3/t17-,22?,23-/m0/s1
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8.80n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085026
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-(4-me...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCN(C)CC1
Show InChI InChI=1S/C23H35N3/c1-17-22-14-19-6-7-20(25-12-10-24(3)11-13-25)15-21(19)23(17,2)8-9-26(22)16-18-4-5-18/h6-7,15,17-18,22H,4-5,8-14,16H2,1-3H3/t17-,22?,23-/m0/s1
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8.80n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085023
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(NCCc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C26H34N2/c1-19-25-16-22-10-11-23(27-14-12-20-6-4-3-5-7-20)17-24(22)26(19,2)13-15-28(25)18-21-8-9-21/h3-7,10-11,17,19,21,25,27H,8-9,12-16,18H2,1-2H3/t19-,25?,26-/m0/s1
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9n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085023
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(NCCc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C26H34N2/c1-19-25-16-22-10-11-23(27-14-12-20-6-4-3-5-7-20)17-24(22)26(19,2)13-15-28(25)18-21-8-9-21/h3-7,10-11,17,19,21,25,27H,8-9,12-16,18H2,1-2H3/t19-,25?,26-/m0/s1
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9n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor mu 1 obtained from guinea pig brain membranes using [3H]DAMGO as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085020
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(Nc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C24H30N2/c1-17-23-14-19-10-11-21(25-20-6-4-3-5-7-20)15-22(19)24(17,2)12-13-26(23)16-18-8-9-18/h3-7,10-11,15,17-18,23,25H,8-9,12-14,16H2,1-2H3/t17-,23?,24-/m0/s1
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9.40n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085024
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Show SMILES C[C@H]1C2Cc3ccc(N)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C18H26N2/c1-12-17-9-14-5-6-15(19)10-16(14)18(12,2)7-8-20(17)11-13-3-4-13/h5-6,10,12-13,17H,3-4,7-9,11,19H2,1-2H3/t12-,17?,18-/m0/s1
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9.5n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085023
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(NCCc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C26H34N2/c1-19-25-16-22-10-11-23(27-14-12-20-6-4-3-5-7-20)17-24(22)26(19,2)13-15-28(25)18-21-8-9-21/h3-7,10-11,17,19,21,25,27H,8-9,12-16,18H2,1-2H3/t19-,25?,26-/m0/s1
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11n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085023
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(NCCc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C26H34N2/c1-19-25-16-22-10-11-23(27-14-12-20-6-4-3-5-7-20)17-24(22)26(19,2)13-15-28(25)18-21-8-9-21/h3-7,10-11,17,19,21,25,27H,8-9,12-16,18H2,1-2H3/t19-,25?,26-/m0/s1
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11n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085029
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C19H28N2/c1-13-18-10-15-6-7-16(20-3)11-17(15)19(13,2)8-9-21(18)12-14-4-5-14/h6-7,11,13-14,18,20H,4-5,8-10,12H2,1-3H3/t13-,18?,19-/m0/s1
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13n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor mu 1 obtained from guinea pig brain membranes using [3H]DAMGO as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085029
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C19H28N2/c1-13-18-10-15-6-7-16(20-3)11-17(15)19(13,2)8-9-21(18)12-14-4-5-14/h6-7,11,13-14,18,20H,4-5,8-10,12H2,1-3H3/t13-,18?,19-/m0/s1
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13n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085022
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N(C)C
Show InChI InChI=1S/C20H30N2/c1-14-19-11-16-7-8-17(21(3)4)12-18(16)20(14,2)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19H,5-6,9-11,13H2,1-4H3/t14-,19?,20-/m0/s1
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18n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085028
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CCNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H30N2/c1-4-21-17-8-7-16-11-19-14(2)20(3,18(16)12-17)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19,21H,4-6,9-11,13H2,1-3H3/t14-,19?,20-/m0/s1
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19n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085028
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CCNc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C20H30N2/c1-4-21-17-8-7-16-11-19-14(2)20(3,18(16)12-17)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19,21H,4-6,9-11,13H2,1-3H3/t14-,19?,20-/m0/s1
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19n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor delta 1 obtained from guinea pig brain membranes using [3H]naltrindole as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085026
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-(4-me...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCN(C)CC1
Show InChI InChI=1S/C23H35N3/c1-17-22-14-19-6-7-20(25-12-10-24(3)11-13-25)15-21(19)23(17,2)8-9-26(22)16-18-4-5-18/h6-7,15,17-18,22H,4-5,8-14,16H2,1-3H3/t17-,22?,23-/m0/s1
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21n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085026
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-(4-me...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCN(C)CC1
Show InChI InChI=1S/C23H35N3/c1-17-22-14-19-6-7-20(25-12-10-24(3)11-13-25)15-21(19)23(17,2)8-9-26(22)16-18-4-5-18/h6-7,15,17-18,22H,4-5,8-14,16H2,1-3H3/t17-,22?,23-/m0/s1
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21n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor mu 1 obtained from guinea pig brain membranes using [3H]DAMGO as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085022
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N(C)C
Show InChI InChI=1S/C20H30N2/c1-14-19-11-16-7-8-17(21(3)4)12-18(16)20(14,2)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19H,5-6,9-11,13H2,1-4H3/t14-,19?,20-/m0/s1
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33n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085030
PNG
(Benzyl-((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N(C)Cc1ccccc1
Show InChI InChI=1S/C26H34N2/c1-19-25-15-22-11-12-23(27(3)17-20-7-5-4-6-8-20)16-24(22)26(19,2)13-14-28(25)18-21-9-10-21/h4-8,11-12,16,19,21,25H,9-10,13-15,17-18H2,1-3H3/t19-,25?,26-/m0/s1
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44n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085030
PNG
(Benzyl-((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N(C)Cc1ccccc1
Show InChI InChI=1S/C26H34N2/c1-19-25-15-22-11-12-23(27(3)17-20-7-5-4-6-8-20)16-24(22)26(19,2)13-14-28(25)18-21-9-10-21/h4-8,11-12,16,19,21,25H,9-10,13-15,17-18H2,1-3H3/t19-,25?,26-/m0/s1
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44n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085022
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N(C)C
Show InChI InChI=1S/C20H30N2/c1-14-19-11-16-7-8-17(21(3)4)12-18(16)20(14,2)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19H,5-6,9-11,13H2,1-4H3/t14-,19?,20-/m0/s1
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46n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085030
PNG
(Benzyl-((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N(C)Cc1ccccc1
Show InChI InChI=1S/C26H34N2/c1-19-25-15-22-11-12-23(27(3)17-20-7-5-4-6-8-20)16-24(22)26(19,2)13-14-28(25)18-21-9-10-21/h4-8,11-12,16,19,21,25H,9-10,13-15,17-18H2,1-3H3/t19-,25?,26-/m0/s1
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56n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor mu 1 obtained from guinea pig brain membranes using [3H]DAMGO as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085030
PNG
(Benzyl-((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N(C)Cc1ccccc1
Show InChI InChI=1S/C26H34N2/c1-19-25-15-22-11-12-23(27(3)17-20-7-5-4-6-8-20)16-24(22)26(19,2)13-14-28(25)18-21-9-10-21/h4-8,11-12,16,19,21,25H,9-10,13-15,17-18H2,1-3H3/t19-,25?,26-/m0/s1
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56n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085031
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CC(C)Nc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C21H32N2/c1-14(2)22-18-8-7-17-11-20-15(3)21(4,19(17)12-18)9-10-23(20)13-16-5-6-16/h7-8,12,14-16,20,22H,5-6,9-11,13H2,1-4H3/t15-,20?,21-/m0/s1
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78n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085031
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CC(C)Nc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C21H32N2/c1-14(2)22-18-8-7-17-11-20-15(3)21(4,19(17)12-18)9-10-23(20)13-16-5-6-16/h7-8,12,14-16,20,22H,5-6,9-11,13H2,1-4H3/t15-,20?,21-/m0/s1
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78n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085022
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N(C)C
Show InChI InChI=1S/C20H30N2/c1-14-19-11-16-7-8-17(21(3)4)12-18(16)20(14,2)9-10-22(19)13-15-5-6-15/h7-8,12,14-15,19H,5-6,9-11,13H2,1-4H3/t14-,19?,20-/m0/s1
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82n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor mu 1 obtained from guinea pig brain membranes using [3H]DAMGO as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085032
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-piper...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCCCC1
Show InChI InChI=1S/C23H34N2/c1-17-22-14-19-8-9-20(24-11-4-3-5-12-24)15-21(19)23(17,2)10-13-25(22)16-18-6-7-18/h8-9,15,17-18,22H,3-7,10-14,16H2,1-2H3/t17-,22?,23-/m0/s1
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95n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085024
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Show SMILES C[C@H]1C2Cc3ccc(N)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C18H26N2/c1-12-17-9-14-5-6-15(19)10-16(14)18(12,2)7-8-20(17)11-13-3-4-13/h5-6,10,12-13,17H,3-4,7-9,11,19H2,1-2H3/t12-,17?,18-/m0/s1
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110n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor delta 1 obtained from guinea pig brain membranes using [3H]naltrindole as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085024
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Show SMILES C[C@H]1C2Cc3ccc(N)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C18H26N2/c1-12-17-9-14-5-6-15(19)10-16(14)18(12,2)7-8-20(17)11-13-3-4-13/h5-6,10,12-13,17H,3-4,7-9,11,19H2,1-2H3/t12-,17?,18-/m0/s1
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110n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085023
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(NCCc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C26H34N2/c1-19-25-16-22-10-11-23(27-14-12-20-6-4-3-5-7-20)17-24(22)26(19,2)13-15-28(25)18-21-8-9-21/h3-7,10-11,17,19,21,25,27H,8-9,12-16,18H2,1-2H3/t19-,25?,26-/m0/s1
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160n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085023
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES C[C@H]1C2Cc3ccc(NCCc4ccccc4)cc3[C@@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C26H34N2/c1-19-25-16-22-10-11-23(27-14-12-20-6-4-3-5-7-20)17-24(22)26(19,2)13-15-28(25)18-21-8-9-21/h3-7,10-11,17,19,21,25,27H,8-9,12-16,18H2,1-2H3/t19-,25?,26-/m0/s1
PDB

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160n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor delta 1 obtained from guinea pig brain membranes using [3H]naltrindole as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085031
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CC(C)Nc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C21H32N2/c1-14(2)22-18-8-7-17-11-20-15(3)21(4,19(17)12-18)9-10-23(20)13-16-5-6-16/h7-8,12,14-16,20,22H,5-6,9-11,13H2,1-4H3/t15-,20?,21-/m0/s1
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240n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50085031
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES CC(C)Nc1ccc2CC3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C21H32N2/c1-14(2)22-18-8-7-17-11-20-15(3)21(4,19(17)12-18)9-10-23(20)13-16-5-6-16/h7-8,12,14-16,20,22H,5-6,9-11,13H2,1-4H3/t15-,20?,21-/m0/s1
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240n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor mu 1 obtained from guinea pig brain membranes using [3H]DAMGO as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085026
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-(4-me...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCN(C)CC1
Show InChI InChI=1S/C23H35N3/c1-17-22-14-19-6-7-20(25-12-10-24(3)11-13-25)15-21(19)23(17,2)8-9-26(22)16-18-4-5-18/h6-7,15,17-18,22H,4-5,8-14,16H2,1-3H3/t17-,22?,23-/m0/s1
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250n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor delta 1 obtained from guinea pig brain membranes using [3H]naltrindole as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50085026
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-(4-me...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCN(C)CC1
Show InChI InChI=1S/C23H35N3/c1-17-22-14-19-6-7-20(25-12-10-24(3)11-13-25)15-21(19)23(17,2)8-9-26(22)16-18-4-5-18/h6-7,15,17-18,22H,4-5,8-14,16H2,1-3H3/t17-,22?,23-/m0/s1
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250n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus)
BDBM50032407
PNG
((3-Benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-...)
Show SMILES CC1C2Cc3ccc(cc3C1(C)CCN2Cc1ccccc1)N(C)C
Show InChI InChI=1S/C23H30N2/c1-17-22-14-19-10-11-20(24(3)4)15-21(19)23(17,2)12-13-25(22)16-18-8-6-5-7-9-18/h5-11,15,17,22H,12-14,16H2,1-4H3
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258n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity at Sigma receptor type 2 on rat liver membranes receptor by [3H]DTG displacement.


J Med Chem 38: 2978-85 (1995)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085032
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-piper...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCCCC1
Show InChI InChI=1S/C23H34N2/c1-17-22-14-19-8-9-20(24-11-4-3-5-12-24)15-21(19)23(17,2)10-13-25(22)16-18-6-7-18/h8-9,15,17-18,22H,3-7,10-14,16H2,1-2H3/t17-,22?,23-/m0/s1
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300n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligand


Bioorg Med Chem Lett 10: 183-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085032
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-piper...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCCCC1
Show InChI InChI=1S/C23H34N2/c1-17-22-14-19-8-9-20(24-11-4-3-5-12-24)15-21(19)23(17,2)10-13-25(22)16-18-6-7-18/h8-9,15,17-18,22H,3-7,10-14,16H2,1-2H3/t17-,22?,23-/m0/s1
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300n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50085025
PNG
((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-pyrro...)
Show SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCCC1
Show InChI InChI=1S/C22H32N2/c1-16-21-13-18-7-8-19(23-10-3-4-11-23)14-20(18)22(16,2)9-12-24(21)15-17-5-6-17/h7-8,14,16-17,21H,3-6,9-13,15H2,1-2H3/t16-,21?,22-/m0/s1
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410n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
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