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2 similar compounds to monomer 50036189

Compile data set for download or QSAR
Wt: 181.2
BDBM50005844
Wt: 181.2
BDBM50005845

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50005844,50005845   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50005844
PNG
((2S,5'R)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@@H]1CC2(CO1)CN1CCC2CC1
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.30E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...


J Med Chem 35: 1541-50 (1992)


Article DOI: 10.1021/jm00087a007
BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50005845
PNG
((2S,5'S)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@H]1CC2(CO1)CN1CCC2CC1
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.50E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against Muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...


J Med Chem 35: 1541-50 (1992)


Article DOI: 10.1021/jm00087a007
BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50005844
PNG
((2S,5'R)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@@H]1CC2(CO1)CN1CCC2CC1
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>2.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand


J Med Chem 35: 1541-50 (1992)


Article DOI: 10.1021/jm00087a007
BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50005845
PNG
((2S,5'S)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@H]1CC2(CO1)CN1CCC2CC1
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>2.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against Muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand


J Med Chem 35: 1541-50 (1992)


Article DOI: 10.1021/jm00087a007
BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50005845
PNG
((2S,5'S)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@H]1CC2(CO1)CN1CCC2CC1
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m0/s1
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against Muscarinic acetylcholine receptor M3 in guinea pig parotid gland using (-)-[3H]-QNB as radiol...


J Med Chem 35: 1541-50 (1992)


Article DOI: 10.1021/jm00087a007
BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50005844
PNG
((2S,5'R)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@@H]1CC2(CO1)CN1CCC2CC1
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m1/s1
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.30E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M3 in guinea pig parotid gland using (-)-[3H]-QNB as radio...


J Med Chem 35: 1541-50 (1992)


Article DOI: 10.1021/jm00087a007
BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair