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25 similar compounds to monomer 50040985

Wt: 345.3
BDBM50005917
Wt: 345.3
BDBM50040991
Wt: 347.3
BDBM50040974
Wt: 329.3
BDBM50040975
Wt: 373.3
BDBM50040979
Wt: 345.3
BDBM50040981
Wt: 395.4
BDBM50040988
Wt: 359.3
BDBM50040990
Wt: 393.4
BDBM50041001
Wt: 347.3
BDBM50040961
Wt: 347.3
BDBM50040973
Wt: 359.3
BDBM50040980
Wt: 347.3
BDBM50040982
Wt: 331.3
BDBM50040983
Wt: 411.4
BDBM50040984
Displayed 1 to 15 (of 25 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 63 hits for monomerid = 50005917,50040991,50040974,50040975,50040979,50040981,50040988,50040990,50041001,50040961,50040973,50040980,50040982,50040983,50040984   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50005917
PNG
(CHEMBL3234681)
Show SMILES CC(C)(C)NC(=O)c1nn(c2[C@@H]3CC[C@@H](C3)c12)-c1ccc(F)cc1F
Show InChI InChI=1S/C19H21F2N3O/c1-19(2,3)22-18(25)16-15-10-4-5-11(8-10)17(15)24(23-16)14-7-6-12(20)9-13(14)21/h6-7,9-11H,4-5,8H2,1-3H3,(H,22,25)/t10-,11+/m0/s1
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12n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to rat CB2 receptor


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50005917
PNG
(CHEMBL3234681)
Show SMILES CC(C)(C)NC(=O)c1nn(c2[C@@H]3CC[C@@H](C3)c12)-c1ccc(F)cc1F
Show InChI InChI=1S/C19H21F2N3O/c1-19(2,3)22-18(25)16-15-10-4-5-11(8-10)17(15)24(23-16)14-7-6-12(20)9-13(14)21/h6-7,9-11H,4-5,8H2,1-3H3,(H,22,25)/t10-,11+/m0/s1
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n/an/an/an/a 854n/an/an/an/a


TBA

Assay Description
Agonist activity at human CB1 receptor assessed as inhibition of forskolin-induced cAMP production preincubated for 15 mins followed by forskolin cha...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]Astemizole from human ERG channel


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ERG channel by patch clamp technique


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040973
PNG
(CHEMBL3354972)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1c(F)cccc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)14-11-7-9-6-10(9)15(11)23(22-14)16-12(19)4-3-5-13(16)20/h3-5,9-10,24H,6-8H2,1-2H3,(H,21,25)/t9-,10-/s2
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n/an/an/an/a 2.30E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040974
PNG
(CHEMBL3354971)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1cc(F)ccc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-7-10(19)3-4-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 0.900n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040975
PNG
(CHEMBL3354970)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-8-10-7-13(10)16(14)22(21-15)12-5-3-11(19)4-6-12/h3-6,10,13,23H,7-9H2,1-2H3,(H,20,24)/t10-,13-/s2
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n/an/an/an/a 25n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040979
PNG
(CHEMBL3354966)
Show SMILES Fc1ccc(c(F)c1)-n1nc(C(=O)NCC2CCOCC2)c2C[C@@H]3C[C@@H]3c12
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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n/an/an/an/a 76n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040980
PNG
(CHEMBL3354965)
Show SMILES Fc1ccc(c(F)c1)-n1nc(C(=O)NC2CCOCC2)c2C[C@@H]3C[C@@H]3c12
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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n/an/an/an/a 39n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040981
PNG
(CHEMBL3354964)
Show SMILES OCC1(CC1)NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 25n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040982
PNG
(CHEMBL3354963)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040983
PNG
(CHEMBL3354962)
Show SMILES CC(C)(C)NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a 7.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040984
PNG
(CHEMBL3354961)
Show SMILES C[C@@]12CC[C@@H](C1)C(C)(C)[C@@H]2NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C24H27F2N3O/c1-23(2)13-6-7-24(3,11-13)22(23)27-21(30)19-16-9-12-8-15(12)20(16)29(28-19)18-5-4-14(25)10-17(18)26/h4-5,10,12-13,15,22H,6-9,11H2,1-3H3,(H,27,30)/t12-,13+,15-,22+,24-/s2
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n/an/an/an/a 1.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040988
PNG
(CHEMBL3354957)
Show SMILES OC[C@H](NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18+/s2
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n/an/an/an/a 5.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040990
PNG
(CHEMBL3354954)
Show SMILES OCC1(CCC1)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C19H19F2N3O2/c20-11-2-3-15(14(21)8-11)24-17-12-6-10(12)7-13(17)16(23-24)18(26)22-19(9-25)4-1-5-19/h2-3,8,10,12,25H,1,4-7,9H2,(H,22,26)/t10-,12-/s2
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n/an/an/an/a 1.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040991
PNG
(CHEMBL3354953)
Show SMILES OCC1(CC1)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 3.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor


(MOUSE)
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 2.87E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at mouse recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1 (CB1R)


(Mus musculus (Mouse))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at mouse recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040984
PNG
(CHEMBL3354961)
Show SMILES C[C@@]12CC[C@@H](C1)C(C)(C)[C@@H]2NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C24H27F2N3O/c1-23(2)13-6-7-24(3,11-13)22(23)27-21(30)19-16-9-12-8-15(12)20(16)29(28-19)18-5-4-14(25)10-17(18)26/h4-5,10,12-13,15,22H,6-9,11H2,1-3H3,(H,27,30)/t12-,13+,15-,22+,24-/s2
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n/an/an/an/a 217n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040983
PNG
(CHEMBL3354962)
Show SMILES CC(C)(C)NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040982
PNG
(CHEMBL3354963)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040981
PNG
(CHEMBL3354964)
Show SMILES OCC1(CC1)NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040980
PNG
(CHEMBL3354965)
Show SMILES Fc1ccc(c(F)c1)-n1nc(C(=O)NC2CCOCC2)c2C[C@@H]3C[C@@H]3c12
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040979
PNG
(CHEMBL3354966)
Show SMILES Fc1ccc(c(F)c1)-n1nc(C(=O)NCC2CCOCC2)c2C[C@@H]3C[C@@H]3c12
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040975
PNG
(CHEMBL3354970)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-8-10-7-13(10)16(14)22(21-15)12-5-3-11(19)4-6-12/h3-6,10,13,23H,7-9H2,1-2H3,(H,20,24)/t10-,13-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040974
PNG
(CHEMBL3354971)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1cc(F)ccc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-7-10(19)3-4-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040973
PNG
(CHEMBL3354972)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1c(F)cccc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)14-11-7-9-6-10(9)15(11)23(22-14)16-12(19)4-3-5-13(16)20/h3-5,9-10,24H,6-8H2,1-2H3,(H,21,25)/t9-,10-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM50041001
PNG
(CHEMBL3354942)
Show SMILES CC(C)(NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1/C23H21F2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 0.900n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50041001
PNG
(CHEMBL3354942)
Show SMILES CC(C)(NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1/C23H21F2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 16n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor


(Rattus norvegicus (rat))
BDBM50040973
PNG
(CHEMBL3354972)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1c(F)cccc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)14-11-7-9-6-10(9)15(11)23(22-14)16-12(19)4-3-5-13(16)20/h3-5,9-10,24H,6-8H2,1-2H3,(H,21,25)/t9-,10-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040991
PNG
(CHEMBL3354953)
Show SMILES OCC1(CC1)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040990
PNG
(CHEMBL3354954)
Show SMILES OCC1(CCC1)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C19H19F2N3O2/c20-11-2-3-15(14(21)8-11)24-17-12-6-10(12)7-13(17)16(23-24)18(26)22-19(9-25)4-1-5-19/h2-3,8,10,12,25H,1,4-7,9H2,(H,22,26)/t10-,12-/s2
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n/an/an/an/a 105n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM50040988
PNG
(CHEMBL3354957)
Show SMILES OC[C@H](NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18+/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50041001
PNG
(CHEMBL3354942)
Show SMILES CC(C)(NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1/C23H21F2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 52n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 13n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040991
PNG
(CHEMBL3354953)
Show SMILES OCC1(CC1)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 47n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040990
PNG
(CHEMBL3354954)
Show SMILES OCC1(CCC1)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C19H19F2N3O2/c20-11-2-3-15(14(21)8-11)24-17-12-6-10(12)7-13(17)16(23-24)18(26)22-19(9-25)4-1-5-19/h2-3,8,10,12,25H,1,4-7,9H2,(H,22,26)/t10-,12-/s2
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n/an/an/an/a 6.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040988
PNG
(CHEMBL3354957)
Show SMILES OC[C@H](NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18+/s2
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n/an/an/an/a 4.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040984
PNG
(CHEMBL3354961)
Show SMILES C[C@@]12CC[C@@H](C1)C(C)(C)[C@@H]2NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C24H27F2N3O/c1-23(2)13-6-7-24(3,11-13)22(23)27-21(30)19-16-9-12-8-15(12)20(16)29(28-19)18-5-4-14(25)10-17(18)26/h4-5,10,12-13,15,22H,6-9,11H2,1-3H3,(H,27,30)/t12-,13+,15-,22+,24-/s2
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n/an/an/an/a 591n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040983
PNG
(CHEMBL3354962)
Show SMILES CC(C)(C)NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a 12n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040982
PNG
(CHEMBL3354963)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 39n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040981
PNG
(CHEMBL3354964)
Show SMILES OCC1(CC1)NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 88n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040980
PNG
(CHEMBL3354965)
Show SMILES Fc1ccc(c(F)c1)-n1nc(C(=O)NC2CCOCC2)c2C[C@@H]3C[C@@H]3c12
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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n/an/an/an/a 183n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040979
PNG
(CHEMBL3354966)
Show SMILES Fc1ccc(c(F)c1)-n1nc(C(=O)NCC2CCOCC2)c2C[C@@H]3C[C@@H]3c12
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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n/an/an/an/a 67n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040975
PNG
(CHEMBL3354970)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-8-10-7-13(10)16(14)22(21-15)12-5-3-11(19)4-6-12/h3-6,10,13,23H,7-9H2,1-2H3,(H,20,24)/t10-,13-/s2
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n/an/an/an/a 35n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040974
PNG
(CHEMBL3354971)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1cc(F)ccc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-7-10(19)3-4-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 7.90n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor 2 (CB2)


(Rattus norvegicus (Rat))
BDBM50040973
PNG
(CHEMBL3354972)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1c(F)cccc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)14-11-7-9-6-10(9)15(11)23(22-14)16-12(19)4-3-5-13(16)20/h3-5,9-10,24H,6-8H2,1-2H3,(H,21,25)/t9-,10-/s2
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n/an/an/an/a 2.80E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor


(Rattus norvegicus (rat))
BDBM50041001
PNG
(CHEMBL3354942)
Show SMILES CC(C)(NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1/C23H21F2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 59n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
Cannabinoid receptor


(Rattus norvegicus (rat))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES CC(C)(CO)NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1ccc(F)cc1F
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)

More data for this
Ligand-Target Pair
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