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3 similar compounds to monomer 50003350

Compile data set for download or QSAR
Wt: 251.3
BDBM50006583
Wt: 293.4
BDBM50006590
Wt: 223.3
BDBM50006597

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50006583,50006590,50006597   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50006583
PNG
(1-Methyl-5-(4-pentyl-[1,2,5]thiadiazol-3-yl)-1,2,3...)
Show SMILES CCCCCc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C13H21N3S/c1-3-4-5-8-12-13(15-17-14-12)11-7-6-9-16(2)10-11/h7H,3-6,8-10H2,1-2H3
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n/an/a 170n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand.


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50006583
PNG
(1-Methyl-5-(4-pentyl-[1,2,5]thiadiazol-3-yl)-1,2,3...)
Show SMILES CCCCCc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C13H21N3S/c1-3-4-5-8-12-13(15-17-14-12)11-7-6-9-16(2)10-11/h7H,3-6,8-10H2,1-2H3
Reactome pathway
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 146n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50006597
PNG
(1-Methyl-5-(4-propyl-[1,2,5]thiadiazol-3-yl)-1,2,3...)
Show SMILES CCCc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3S/c1-3-5-10-11(13-15-12-10)9-6-4-7-14(2)8-9/h6H,3-5,7-8H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50006590
PNG
(1-Methyl-5-(4-octyl-[1,2,5]thiadiazol-3-yl)-1,2,3,...)
Show SMILES CCCCCCCCc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C16H27N3S/c1-3-4-5-6-7-8-11-15-16(18-20-17-15)14-10-9-12-19(2)13-14/h10H,3-9,11-13H2,1-2H3
Reactome pathway
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 428n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand.


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50006590
PNG
(1-Methyl-5-(4-octyl-[1,2,5]thiadiazol-3-yl)-1,2,3,...)
Show SMILES CCCCCCCCc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C16H27N3S/c1-3-4-5-6-7-8-11-15-16(18-20-17-15)14-10-9-12-19(2)13-14/h10H,3-9,11-13H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand.


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50006597
PNG
(1-Methyl-5-(4-propyl-[1,2,5]thiadiazol-3-yl)-1,2,3...)
Show SMILES CCCc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3S/c1-3-5-10-11(13-15-12-10)9-6-4-7-14(2)8-9/h6H,3-5,7-8H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 84n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand.


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair