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21 similar compounds to monomer 50007393

Compile data set for download or QSAR
Wt: 161.2
BDBM50007408
Purchase
Wt: 307.4
BDBM50007396
Wt: 293.4
BDBM50007400
Purchase
Wt: 205.2
BDBM50018143
Purchase
Wt: 243.3
BDBM50018145
Wt: 233.3
BDBM50018106
Wt: 248.3
BDBM50018074
Wt: 279.4
BDBM50047020
Wt: 293.4
BDBM50062600
Purchase
Wt: 217.3
BDBM50109385
Wt: 217.3
BDBM50109387
Wt: 203.3
BDBM50109391
Wt: 293.4
BDBM50159011
Wt: 228.3
BDBM50265407
Wt: 304.4
BDBM50265436
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50007408,50007396,50007400,50018143,50018145,50018106,50018074,50047020,50062600,50109385,50109387,50109391,50159011,50265407,50265436   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50265436
PNG
(1-Phenylpropyl-4-phenylpiperidine-4-carbonitrile |...)
Show SMILES N#CC1(CCN(CCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C21H24N2/c22-18-21(20-11-5-2-6-12-20)13-16-23(17-14-21)15-7-10-19-8-3-1-4-9-19/h1-6,8-9,11-12H,7,10,13-17H2
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0.380n/an/an/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma 1 opioid receptor in rat brain cerebellum


Eur J Med Chem 43: 1304-8 (2008)


Article DOI: 10.1016/j.ejmech.2007.09.026
BindingDB Entry DOI: 10.7270/Q2W37W3G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50159011
PNG
(4-Benzyl-1-(4-phenyl-butyl)-piperidine | CHEMBL178...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-8-19(9-4-1)12-7-15-22-16-13-21(14-17-22)18-20-10-5-2-6-11-20/h1-6,8-11,21H,7,12-18H2
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0.400n/an/an/an/an/an/an/an/a



NSTRI

Curated by ChEMBL


Assay Description
Displacement of [3H](+)pentazocine from sigma1 receptor in Dunkin Hartley guinea pig brain membrane after 120 mins by liquid scintillation counting a...


Eur J Med Chem 64: 488-97 (2013)


Article DOI: 10.1016/j.ejmech.2013.04.013
BindingDB Entry DOI: 10.7270/Q2WM1FTD
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50159011
PNG
(4-Benzyl-1-(4-phenyl-butyl)-piperidine | CHEMBL178...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-8-19(9-4-1)12-7-15-22-16-13-21(14-17-22)18-20-10-5-2-6-11-20/h1-6,8-11,21H,7,12-18H2
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0.490n/an/an/an/an/an/an/an/a



Universit£ di Modena and Reggio Emilia

Curated by ChEMBL


Assay Description
Inhibitory constant against sigma receptor type 2 using 3 nM [3H]ditolylguanidine


J Med Chem 48: 266-73 (2005)


Article DOI: 10.1021/jm049433t
BindingDB Entry DOI: 10.7270/Q2JH3MZW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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0.800n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranes


J Med Chem 34: 3360-5 (1992)


Article DOI: 10.1021/jm00116a003
BindingDB Entry DOI: 10.7270/Q2MC8XZR
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50007396
PNG
(4-Phenyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL11...)
Show SMILES C(CCN1CCC(CC1)c1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C22H29N/c1-4-10-20(11-5-1)12-6-3-9-17-23-18-15-22(16-19-23)21-13-7-2-8-14-21/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12,15-19H2
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0.900n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranes


J Med Chem 34: 3360-5 (1992)


Article DOI: 10.1021/jm00116a003
BindingDB Entry DOI: 10.7270/Q2MC8XZR
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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1n/an/an/an/an/an/an/an/a



New York University

Curated by ChEMBL


Assay Description
Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]-haloperidol in the presence of 25 nM unlabeled spiperone


J Med Chem 36: 3923-8 (1994)


Article DOI: 10.1021/jm00076a021
BindingDB Entry DOI: 10.7270/Q2H13122
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50159011
PNG
(4-Benzyl-1-(4-phenyl-butyl)-piperidine | CHEMBL178...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-8-19(9-4-1)12-7-15-22-16-13-21(14-17-22)18-20-10-5-2-6-11-20/h1-6,8-11,21H,7,12-18H2
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1.40n/an/an/an/an/an/an/an/a



Universit£ di Modena and Reggio Emilia

Curated by ChEMBL


Assay Description
Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocine


J Med Chem 48: 266-73 (2005)


Article DOI: 10.1021/jm049433t
BindingDB Entry DOI: 10.7270/Q2JH3MZW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50265407
PNG
(1-Propyl-4-phenylpiperidine-4-carbonitrile | CHEMB...)
Show SMILES CCCN1CCC(CC1)(C#N)c1ccccc1
Show InChI InChI=1S/C15H20N2/c1-2-10-17-11-8-15(13-16,9-12-17)14-6-4-3-5-7-14/h3-7H,2,8-12H2,1H3
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1.70n/an/an/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma 1 opioid receptor in rat brain cerebellum


Eur J Med Chem 43: 1304-8 (2008)


Article DOI: 10.1016/j.ejmech.2007.09.026
BindingDB Entry DOI: 10.7270/Q2W37W3G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50109385
PNG
(4-Methyl-1-(3-phenyl-propyl)-piperidine | CHEMBL35...)
Show SMILES CC1CCN(CCCc2ccccc2)CC1
Show InChI InChI=1S/C15H23N/c1-14-9-12-16(13-10-14)11-5-8-15-6-3-2-4-7-15/h2-4,6-7,14H,5,8-13H2,1H3
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3.40n/an/an/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocine


Bioorg Med Chem Lett 12: 497-500 (2002)


Article DOI: 10.1016/s0960-894x(01)00788-0
BindingDB Entry DOI: 10.7270/Q2CN7365
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50047020
PNG
(1-Isopropyl-4,4-diphenyl-piperidine (prodipine) | ...)
Show SMILES CC(C)N1CCC(CC1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H25N/c1-17(2)21-15-13-20(14-16-21,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17H,13-16H2,1-2H3
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4.80n/an/an/an/an/an/an/an/a



Institut f£r Toxikologie

Curated by ChEMBL


Assay Description
Inhibitory constant for cytochrome P450 2D6


J Med Chem 36: 1136-45 (1993)


Article DOI: 10.1021/jm00061a004
BindingDB Entry DOI: 10.7270/Q2GM87X6
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50109387
PNG
(3-Methyl-1-(3-phenyl-propyl)-piperidine | CHEMBL14...)
Show SMILES CC1CCCN(CCCc2ccccc2)C1
Show InChI InChI=1S/C15H23N/c1-14-7-5-11-16(13-14)12-6-10-15-8-3-2-4-9-15/h2-4,8-9,14H,5-7,10-13H2,1H3
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5.30n/an/an/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocine


Bioorg Med Chem Lett 12: 497-500 (2002)


Article DOI: 10.1016/s0960-894x(01)00788-0
BindingDB Entry DOI: 10.7270/Q2CN7365
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50109391
PNG
(1-(3-Phenyl-propyl)-piperidine | CHEMBL148108)
Show SMILES C(CN1CCCCC1)Cc1ccccc1
Show InChI InChI=1S/C14H21N/c1-3-8-14(9-4-1)10-7-13-15-11-5-2-6-12-15/h1,3-4,8-9H,2,5-7,10-13H2
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143n/an/an/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocine


Bioorg Med Chem Lett 12: 497-500 (2002)


Article DOI: 10.1016/s0960-894x(01)00788-0
BindingDB Entry DOI: 10.7270/Q2CN7365
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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440n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by PDSP Ki Database




Eur J Pharmacol 168: 387-92 (1989)


BindingDB Entry DOI: 10.7270/Q23R0RC5
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50159011
PNG
(4-Benzyl-1-(4-phenyl-butyl)-piperidine | CHEMBL178...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-8-19(9-4-1)12-7-15-22-16-13-21(14-17-22)18-20-10-5-2-6-11-20/h1-6,8-11,21H,7,12-18H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universit£ di Modena and Reggio Emilia

Curated by ChEMBL


Assay Description
Inhibitory constant against dopamine D2 receptor using 0.2 nM [3H]-spiperone


J Med Chem 48: 266-73 (2005)


Article DOI: 10.1021/jm049433t
BindingDB Entry DOI: 10.7270/Q2JH3MZW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50159011
PNG
(4-Benzyl-1-(4-phenyl-butyl)-piperidine | CHEMBL178...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-8-19(9-4-1)12-7-15-22-16-13-21(14-17-22)18-20-10-5-2-6-11-20/h1-6,8-11,21H,7,12-18H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universit£ di Modena and Reggio Emilia

Curated by ChEMBL


Assay Description
Inhibitory constant was determined against 5-hydroxytryptamine 1A receptor using 1.2 nM [3H]8-OH-DPAT


J Med Chem 48: 266-73 (2005)


Article DOI: 10.1021/jm049433t
BindingDB Entry DOI: 10.7270/Q2JH3MZW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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1.52E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain


J Med Chem 31: 1968-71 (1988)


Article DOI: 10.1021/jm00118a018
BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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1.98E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranes


J Med Chem 34: 3360-5 (1992)


Article DOI: 10.1021/jm00116a003
BindingDB Entry DOI: 10.7270/Q2MC8XZR
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50062600
PNG
(1-tert-Butyl-4,4-diphenyl-piperidine | Budipine | ...)
Show SMILES CC(C)(C)N1CCC(CC1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Mol Pharmacol 45: 125-35 (1994)


BindingDB Entry DOI: 10.7270/Q2NG4P5C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Displacement of [3H]-mesulergine from 5HT2C receptor expressed in CHO cell membranes after 90 mins by scintillation counting


Bioorg Med Chem Lett 22: 2560-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.122
BindingDB Entry DOI: 10.7270/Q2JD4XSQ
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50062600
PNG
(1-tert-Butyl-4,4-diphenyl-piperidine | Budipine | ...)
Show SMILES CC(C)(C)N1CCC(CC1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Mol Pharmacol 45: 125-35 (1994)


BindingDB Entry DOI: 10.7270/Q2NG4P5C
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor


(Homo sapiens (Human))
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells


J Med Chem 39: 4017-26 (1996)


Article DOI: 10.1021/jm9603936
BindingDB Entry DOI: 10.7270/Q23F4NQT
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Dopamine receptor D1 in rat membranes using [3H]-SCH-23,390 as radioligand


J Med Chem 34: 3360-5 (1992)


Article DOI: 10.1021/jm00116a003
BindingDB Entry DOI: 10.7270/Q2MC8XZR
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007396
PNG
(4-Phenyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL11...)
Show SMILES C(CCN1CCC(CC1)c1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C22H29N/c1-4-10-20(11-5-1)12-6-3-9-17-23-18-15-22(16-19-23)21-13-7-2-8-14-21/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12,15-19H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity determined in radioreceptor binding assay by using [3H]-SCH-23,390 radioligand against dopamine receptor D1


J Med Chem 34: 3360-5 (1992)


Article DOI: 10.1021/jm00116a003
BindingDB Entry DOI: 10.7270/Q2MC8XZR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2A) Receptor subtype.


J Med Chem 43: 984-94 (2000)


Article DOI: 10.1021/jm990428c
BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.


J Med Chem 43: 984-94 (2000)


Article DOI: 10.1021/jm990428c
BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2C) Receptor subtype.


J Med Chem 43: 984-94 (2000)


Article DOI: 10.1021/jm990428c
BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50062600
PNG
(1-tert-Butyl-4,4-diphenyl-piperidine | Budipine | ...)
Show SMILES CC(C)(C)N1CCC(CC1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3
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MMDB

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n/an/a 851n/an/an/an/an/an/a



TCG Lifesciences Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Eur J Med Chem 46: 618-30 (2011)


Article DOI: 10.1016/j.ejmech.2010.11.042
BindingDB Entry DOI: 10.7270/Q2WQ052W
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007396
PNG
(4-Phenyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL11...)
Show SMILES C(CCN1CCC(CC1)c1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C22H29N/c1-4-10-20(11-5-1)12-6-3-9-17-23-18-15-22(16-19-23)21-13-7-2-8-14-21/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12,15-19H2
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n/an/a 210n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards dopamine receptor D2 by using [3H]-domperidone as radioligand


J Med Chem 34: 3360-5 (1992)


Article DOI: 10.1021/jm00116a003
BindingDB Entry DOI: 10.7270/Q2MC8XZR
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50007396
PNG
(4-Phenyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL11...)
Show SMILES C(CCN1CCC(CC1)c1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C22H29N/c1-4-10-20(11-5-1)12-6-3-9-17-23-18-15-22(16-19-23)21-13-7-2-8-14-21/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12,15-19H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards PCP receptor in rat brain membrane [3H]-MK-801 as radioligand


J Med Chem 34: 3360-5 (1992)


Article DOI: 10.1021/jm00116a003
BindingDB Entry DOI: 10.7270/Q2MC8XZR
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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n/an/a 165n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 by using [3H]-domperidone as radioligand


J Med Chem 34: 3360-5 (1992)


Article DOI: 10.1021/jm00116a003
BindingDB Entry DOI: 10.7270/Q2MC8XZR
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50007400
PNG
(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
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n/an/a 335n/an/an/an/an/an/a



New York University

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in bovine striatal homogenate using 200 pM [3H]- spiperone and 250 nM unlabeled ketanserin


J Med Chem 36: 3923-8 (1994)


Article DOI: 10.1021/jm00076a021
BindingDB Entry DOI: 10.7270/Q2H13122
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Homo sapiens (Human))
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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n/an/a 9.00E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles


J Med Chem 32: 1217-30 (1989)


Article DOI: 10.1021/jm00126a013
BindingDB Entry DOI: 10.7270/Q2TQ60JR
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Homo sapiens (Human))
BDBM50018143
PNG
(2-(4-Phenyl-piperidin-1-yl)-ethanol | CHEMBL20399)
Show SMILES OCCN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C13H19NO/c15-11-10-14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-5,13,15H,6-11H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles


J Med Chem 32: 1217-30 (1989)


Article DOI: 10.1021/jm00126a013
BindingDB Entry DOI: 10.7270/Q2TQ60JR
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Homo sapiens (Human))
BDBM50018074
PNG
(1-(2-Hydroxy-butyl)-1-methyl-4-phenyl-piperidinium...)
Show SMILES CCC(O)C[N+]1(C)CCC(CC1)c1ccccc1
Show InChI InChI=1S/C16H26NO/c1-3-16(18)13-17(2)11-9-15(10-12-17)14-7-5-4-6-8-14/h4-8,15-16,18H,3,9-13H2,1-2H3/q+1
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles


J Med Chem 32: 1217-30 (1989)


Article DOI: 10.1021/jm00126a013
BindingDB Entry DOI: 10.7270/Q2TQ60JR
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Homo sapiens (Human))
BDBM50018145
PNG
(1-Cyclohexyl-4-phenyl-piperidine | CHEMBL283141)
Show SMILES C1CCC(CC1)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-3-7-15(8-4-1)16-11-13-18(14-12-16)17-9-5-2-6-10-17/h1,3-4,7-8,16-17H,2,5-6,9-14H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles


J Med Chem 32: 1217-30 (1989)


Article DOI: 10.1021/jm00126a013
BindingDB Entry DOI: 10.7270/Q2TQ60JR
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Homo sapiens (Human))
BDBM50018106
PNG
(1-(4-Phenyl-piperidin-1-yl)-butan-2-ol | CHEMBL283...)
Show SMILES CCC(O)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C15H23NO/c1-2-15(17)12-16-10-8-14(9-11-16)13-6-4-3-5-7-13/h3-7,14-15,17H,2,8-12H2,1H3
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n/an/a 300n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles


J Med Chem 32: 1217-30 (1989)


Article DOI: 10.1021/jm00126a013
BindingDB Entry DOI: 10.7270/Q2TQ60JR
More data for this
Ligand-Target Pair