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7 similar compounds to monomer 50008535

Compile data set for download or QSAR
Wt: 206.2
BDBM50008540
Wt: 206.2
BDBM50008549
Purchase
Wt: 206.2
BDBM50008551
Purchase
Wt: 176.2
BDBM50008552
Purchase
Wt: 206.2
BDBM50008559
Purchase
Wt: 206.2
BDBM50008565
Purchase
Wt: 386.3
BDBM50310599

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50008540,50008549,50008551,50008552,50008559,50008565,50310599   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholinesterases; ACHE & BCHE


(Homo sapiens (Human))
BDBM50008540
PNG
(6,7-Dimethoxy-2-methyl-indan-1-one | CHEMBL350916)
Show SMILES COc1ccc2CC(C)C(=O)c2c1OC
Show InChI InChI=1S/C12H14O3/c1-7-6-8-4-5-9(14-2)12(15-3)10(8)11(7)13/h4-5,7H,6H2,1-3H3
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PubMed
n/an/a 87n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
IC50 against acetylcholinesterase; value ranges from 1-4900 nM.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Cholinesterases; ACHE & BCHE


(Homo sapiens (Human))
BDBM50008551
PNG
(4,7-Dimethoxy-2-methyl-indan-1-one | CHEMBL423419)
Show SMILES COc1ccc(OC)c2C(=O)C(C)Cc12
Show InChI InChI=1S/C12H14O3/c1-7-6-8-9(14-2)4-5-10(15-3)11(8)12(7)13/h4-5,7H,6H2,1-3H3
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Article
PubMed
n/an/a 36n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
IC50 against acetylcholinesterase; value ranges from 1-4900 nM.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Cholinesterases; ACHE & BCHE


(Homo sapiens (Human))
BDBM50008565
PNG
(5,6-Dimethoxy-2-methyl-indan-1-one | CHEMBL154848)
Show SMILES COc1cc2CC(C)C(=O)c2cc1OC
Show InChI InChI=1S/C12H14O3/c1-7-4-8-5-10(14-2)11(15-3)6-9(8)12(7)13/h5-7H,4H2,1-3H3
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Article
PubMed
n/an/a 5.20n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Cholinesterases; ACHE & BCHE


(Homo sapiens (Human))
BDBM50008552
PNG
(4-Methoxy-2-methyl-indan-1-one | CHEMBL422338)
Show SMILES COc1cccc2C(=O)C(C)Cc12
Show InChI InChI=1S/C11H12O2/c1-7-6-9-8(11(7)12)4-3-5-10(9)13-2/h3-5,7H,6H2,1-2H3
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Article
PubMed
n/an/a 380n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50008540
PNG
(6,7-Dimethoxy-2-methyl-indan-1-one | CHEMBL350916)
Show SMILES COc1ccc2CC(C)C(=O)c2c1OC
Show InChI InChI=1S/C12H14O3/c1-7-6-8-4-5-9(14-2)12(15-3)10(8)11(7)13/h4-5,7H,6H2,1-3H3
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Article
PubMed
n/an/a 380n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
IC50 against acetylcholinesterase; value ranges from 1.3-380 nM.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Cholinesterases; ACHE & BCHE


(Homo sapiens (Human))
BDBM50008559
PNG
(4,5-Dimethoxy-2-methyl-indan-1-one | CHEMBL155371)
Show SMILES COc1ccc2C(=O)C(C)Cc2c1OC
Show InChI InChI=1S/C12H14O3/c1-7-6-9-8(11(7)13)4-5-10(14-2)12(9)15-3/h4-5,7H,6H2,1-3H3
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Article
PubMed
n/an/a 20n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50310599
PNG
(5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5...)
Show SMILES COc1cc2CC(C(=O)c3cc(OC)c(OC)c(OC)c3)C(=O)c2cc1OC
Show InChI InChI=1S/C21H22O7/c1-24-15-7-11-6-14(20(23)13(11)10-16(15)25-2)19(22)12-8-17(26-3)21(28-5)18(9-12)27-4/h7-10,14H,6H2,1-5H3
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Article
PubMed
n/an/a 2.70n/an/an/an/an/an/a



Alwar Pharmacy College

Curated by ChEMBL


Assay Description
Inhibition of Electrophorus electricus AChE by Ellman's method


Bioorg Med Chem Lett 19: 5075-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.042
BindingDB Entry DOI: 10.7270/Q2Z0389S
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50008551
PNG
(4,7-Dimethoxy-2-methyl-indan-1-one | CHEMBL423419)
Show SMILES COc1ccc(OC)c2C(=O)C(C)Cc12
Show InChI InChI=1S/C12H14O3/c1-7-6-8-9(14-2)4-5-10(15-3)11(8)12(7)13/h4-5,7H,6H2,1-3H3
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Article
PubMed
n/an/a 380n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
IC50 against acetylcholinesterase; value ranges from 1.3-380 nM.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50008559
PNG
(4,5-Dimethoxy-2-methyl-indan-1-one | CHEMBL155371)
Show SMILES COc1ccc2C(=O)C(C)Cc2c1OC
Show InChI InChI=1S/C12H14O3/c1-7-6-9-8(11(7)13)4-5-10(14-2)12(9)15-3/h4-5,7H,6H2,1-3H3
PDB
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Article
PubMed
n/an/a 380n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
IC50 against acetylcholinesterase; value ranges from 1.3-380 nM.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Cholinesterases; ACHE & BCHE


(Homo sapiens (Human))
BDBM50008549
PNG
(5,7-Dimethoxy-2-methyl-indan-1-one | CHEMBL152826)
Show SMILES COc1cc2CC(C)C(=O)c2c(OC)c1
Show InChI InChI=1S/C12H14O3/c1-7-4-8-5-9(14-2)6-10(15-3)11(8)12(7)13/h5-7H,4H2,1-3H3
PDB
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Article
PubMed
n/an/a 25n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50008565
PNG
(5,6-Dimethoxy-2-methyl-indan-1-one | CHEMBL154848)
Show SMILES COc1cc2CC(C)C(=O)c2cc1OC
Show InChI InChI=1S/C12H14O3/c1-7-4-8-5-10(14-2)11(15-3)6-9(8)12(7)13/h5-7H,4H2,1-3H3
PDB
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Article
PubMed
n/an/a 380n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
IC50 against acetylcholinesterase; value ranges from 1.3-380 nM.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50008552
PNG
(4-Methoxy-2-methyl-indan-1-one | CHEMBL422338)
Show SMILES COc1cccc2C(=O)C(C)Cc12
Show InChI InChI=1S/C11H12O2/c1-7-6-9-8(11(7)12)4-3-5-10(9)13-2/h3-5,7H,6H2,1-2H3
PDB
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Article
PubMed
n/an/a 12n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50008549
PNG
(5,7-Dimethoxy-2-methyl-indan-1-one | CHEMBL152826)
Show SMILES COc1cc2CC(C)C(=O)c2c(OC)c1
Show InChI InChI=1S/C12H14O3/c1-7-4-8-5-9(14-2)6-10(15-3)11(8)12(7)13/h5-7H,4H2,1-3H3
PDB
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Article
PubMed
n/an/a 380n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
IC50 against acetylcholinesterase; value ranges from 1.3-380 nM.


J Med Chem 35: 584-9 (1992)


Article DOI: 10.1021/jm00081a022
BindingDB Entry DOI: 10.7270/Q20G3J3J
More data for this
Ligand-Target Pair