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74 similar compounds to monomer 81797

Compile data set for download or QSAR
Wt: 245.3
BDBM50455994
Wt: 245.3
BDBM50455995
Wt: 203.2
BDBM50452344
Wt: 261.4
BDBM50011252
Wt: 261.4
BDBM50011261
Wt: 281.3
BDBM50016734
Wt: 219.3
BDBM50016736
Wt: 295.4
BDBM50016738
Wt: 203.2
BDBM50018647
Wt: 189.2
BDBM50020500
Wt: 189.2
BDBM50024837
Wt: 247.3
BDBM50026774
Wt: 247.3
BDBM50026779
Wt: 243.3
BDBM50453387
Wt: 261.4
BDBM50030411
Displayed 1 to 15 (of 73 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50455994,50455995,50452344,50011252,50011261,50016734,50016736,50016738,50018647,50020500,50024837,50026774,50026779,50453387,50030411   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011261
PNG
((+)7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2[C@@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m1/s1
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2.10n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50016736
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-pro...)
Show SMILES CCCNC1CCc2cccc(OC)c2C1
Show InChI InChI=1S/C14H21NO/c1-3-9-15-12-8-7-11-5-4-6-14(16-2)13(11)10-12/h4-6,12,15H,3,7-10H2,1-2H3
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2.30n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampal membranes


J Med Chem 60: 2605-2628 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50016736
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-pro...)
Show SMILES CCCNC1CCc2cccc(OC)c2C1
Show InChI InChI=1S/C14H21NO/c1-3-9-15-12-8-7-11-5-4-6-14(16-2)13(11)10-12/h4-6,12,15H,3,7-10H2,1-2H3
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2.30n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes


J Med Chem 32: 253-6 (1989)


Article DOI: 10.1021/jm00121a045
BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50016738
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(3-...)
Show SMILES COc1cccc2CCC(Cc12)NCCCc1ccccc1
Show InChI InChI=1S/C20H25NO/c1-22-20-11-5-10-17-12-13-18(15-19(17)20)21-14-6-9-16-7-3-2-4-8-16/h2-5,7-8,10-11,18,21H,6,9,12-15H2,1H3
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2.5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampal membranes


J Med Chem 60: 2605-2628 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50016738
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(3-...)
Show SMILES COc1cccc2CCC(Cc12)NCCCc1ccccc1
Show InChI InChI=1S/C20H25NO/c1-22-20-11-5-10-17-12-13-18(15-19(17)20)21-14-6-9-16-7-3-2-4-8-16/h2-5,7-8,10-11,18,21H,6,9,12-15H2,1H3
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2.5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes


J Med Chem 32: 253-6 (1989)


Article DOI: 10.1021/jm00121a045
BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011252
PNG
(7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m0/s1
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2.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011261
PNG
((+)7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2[C@@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m1/s1
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2.90n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 1A receptor in rat brain tissue using [3H]-8-OH-DPAT as radioligand


J Med Chem 38: 150-60 (1995)


Article DOI: 10.1021/jm00001a020
BindingDB Entry DOI: 10.7270/Q2W09505
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50011261
PNG
((+)7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2[C@@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m1/s1
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30n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human Dopamine receptor D2A was determined in mouse fibroblast LtK cells using [3H]-raclopride


J Med Chem 38: 150-60 (1995)


Article DOI: 10.1021/jm00001a020
BindingDB Entry DOI: 10.7270/Q2W09505
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50016734
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-phe...)
Show SMILES COc1cccc2CCC(Cc12)NCCc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-21-19-9-5-8-16-10-11-17(14-18(16)19)20-13-12-15-6-3-2-4-7-15/h2-9,17,20H,10-14H2,1H3
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44n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes


J Med Chem 32: 253-6 (1989)


Article DOI: 10.1021/jm00121a045
BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50455994
PNG
(CHEMBL2051769)
Show SMILES CCCN1CC[C@@H]2[C@@H]1CCc1c(OC)cccc21
Show InChI InChI=1S/C16H23NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h4-6,13,15H,3,7-11H2,1-2H3/t13-,15-/m0/s1
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63n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for antagonistic activity against D2 receptor from rat striatum, used [3H]raclopride as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50455994
PNG
(CHEMBL2051769)
Show SMILES CCCN1CC[C@@H]2[C@@H]1CCc1c(OC)cccc21
Show InChI InChI=1S/C16H23NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h4-6,13,15H,3,7-11H2,1-2H3/t13-,15-/m0/s1
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66n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030411
PNG
((7R,8S)-7-(Isopropyl-propyl-amino)-8-methyl-5,6,7,...)
Show SMILES CCCN(C(C)C)[C@@H]1CCc2cccc(O)c2[C@@H]1C
Show InChI InChI=1S/C17H27NO/c1-5-11-18(12(2)3)15-10-9-14-7-6-8-16(19)17(14)13(15)4/h6-8,12-13,15,19H,5,9-11H2,1-4H3/t13-,15-/m1/s1
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81n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 1A receptor in rat brain tissue using [3H]-8-OH-DPAT as radioligand


J Med Chem 38: 150-60 (1995)


Article DOI: 10.1021/jm00001a020
BindingDB Entry DOI: 10.7270/Q2W09505
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50453387
PNG
(CHEMBL566970)
Show SMILES COc1cccc2[C@H]3CCN(CC=C)[C@H]3CCc12
Show InChI InChI=1S/C16H21NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h3-6,13,15H,1,7-11H2,2H3/t13-,15+/m1/s1
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>217n/an/an/an/an/an/an/an/a



University of G£teborg

Curated by ChEMBL


Assay Description
Tested for affinity against cloned mammalian dopamine autoreceptor (DA) D2 receptors expressed in CHO-K1 cells using [3H]spiperone as raidoligand


J Med Chem 37: 2735-53 (1994)


Article DOI: 10.1021/jm00043a013
BindingDB Entry DOI: 10.7270/Q2J96719
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50453387
PNG
(CHEMBL566970)
Show SMILES COc1cccc2[C@H]3CCN(CC=C)[C@H]3CCc12
Show InChI InChI=1S/C16H21NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h3-6,13,15H,1,7-11H2,2H3/t13-,15+/m1/s1
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>333n/an/an/an/an/an/an/an/a



University of G£teborg

Curated by ChEMBL


Assay Description
Tested for affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT in homogenized rat brain tissue


J Med Chem 37: 2735-53 (1994)


Article DOI: 10.1021/jm00043a013
BindingDB Entry DOI: 10.7270/Q2J96719
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50453387
PNG
(CHEMBL566970)
Show SMILES COc1cccc2[C@H]3CCN(CC=C)[C@H]3CCc12
Show InChI InChI=1S/C16H21NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h3-6,13,15H,1,7-11H2,2H3/t13-,15+/m1/s1
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>333n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50453387
PNG
(CHEMBL566970)
Show SMILES COc1cccc2[C@H]3CCN(CC=C)[C@H]3CCc12
Show InChI InChI=1S/C16H21NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h3-6,13,15H,1,7-11H2,2H3/t13-,15+/m1/s1
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>339n/an/an/an/an/an/an/an/a



University of G£teborg

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian dopamine D2 autoreceptor, expressed in CHO-K1 cells, using [3H]U-86170 as radioligand


J Med Chem 37: 2735-53 (1994)


Article DOI: 10.1021/jm00043a013
BindingDB Entry DOI: 10.7270/Q2J96719
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50453387
PNG
(CHEMBL566970)
Show SMILES COc1cccc2[C@H]3CCN(CC=C)[C@H]3CCc12
Show InChI InChI=1S/C16H21NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h3-6,13,15H,1,7-11H2,2H3/t13-,15+/m1/s1
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>339n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for agonistic activity against D2 receptor from cloned CHO cells, used [3H]U-86170 as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50030411
PNG
((7R,8S)-7-(Isopropyl-propyl-amino)-8-methyl-5,6,7,...)
Show SMILES CCCN(C(C)C)[C@@H]1CCc2cccc(O)c2[C@@H]1C
Show InChI InChI=1S/C17H27NO/c1-5-11-18(12(2)3)15-10-9-14-7-6-8-16(19)17(14)13(15)4/h6-8,12-13,15,19H,5,9-11H2,1-4H3/t13-,15-/m1/s1
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614n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human Dopamine receptor D2A was determined in mouse fibroblast LtK cells using [3H]-raclopride


J Med Chem 38: 150-60 (1995)


Article DOI: 10.1021/jm00001a020
BindingDB Entry DOI: 10.7270/Q2W09505
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50455995
PNG
(CHEMBL2051973)
Show SMILES CCCN1CC[C@H]2[C@@H]1CCc1c(OC)cccc21
Show InChI InChI=1S/C16H23NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h4-6,13,15H,3,7-11H2,1-2H3/t13-,15+/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for antagonistic activity against D2 receptor from rat striatum, used [3H]raclopride as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50453387
PNG
(CHEMBL566970)
Show SMILES COc1cccc2[C@H]3CCN(CC=C)[C@H]3CCc12
Show InChI InChI=1S/C16H21NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h3-6,13,15H,1,7-11H2,2H3/t13-,15+/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for antagonistic activity against D2 receptor from rat striatum, used [3H]raclopride as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50455995
PNG
(CHEMBL2051973)
Show SMILES CCCN1CC[C@H]2[C@@H]1CCc1c(OC)cccc21
Show InChI InChI=1S/C16H23NO/c1-3-10-17-11-9-13-12-5-4-6-16(18-2)14(12)7-8-15(13)17/h4-6,13,15H,3,7-11H2,1-2H3/t13-,15+/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011252
PNG
(7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m0/s1
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1.04E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011252
PNG
(7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m0/s1
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2.92E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 1A receptor in rat brain tissue using [3H]-8-OH-DPAT as radioligand


J Med Chem 38: 150-60 (1995)


Article DOI: 10.1021/jm00001a020
BindingDB Entry DOI: 10.7270/Q2W09505
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011252
PNG
(7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m0/s1
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2.92E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Phenylethanolamine N-methyltransferase


(Bos taurus (bovine))
BDBM50024837
PNG
(5-Methoxy-1,2,3,4-tetrahydro-1,4-methano-naphthale...)
Show SMILES COc1cccc2C3CC(C[C@H]3N)c12
Show InChI InChI=1S/C12H15NO/c1-14-11-4-2-3-8-9-5-7(12(8)11)6-10(9)13/h2-4,7,9-10H,5-6,13H2,1H3/t7?,9?,10-/m1/s1
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>2.00E+6n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
In vitro inhibition of bovine phenylethylamine N-methyl-transferase (PNMT) using radiochemical assay.


J Med Chem 30: 2208-16 (1988)


Article DOI: 10.1021/jm00395a006
BindingDB Entry DOI: 10.7270/Q2CC119N
More data for this
Ligand-Target Pair
Phenylethanolamine N-methyltransferase


(Bos taurus (bovine))
BDBM50020500
PNG
(5-Methoxy-1,2,3,4-tetrahydro-1,4-methano-naphthale...)
Show SMILES COc1cccc2C3CC(CC3N)c12
Show InChI InChI=1S/C12H15NO/c1-14-11-4-2-3-8-9-5-7(12(8)11)6-10(9)13/h2-4,7,9-10H,5-6,13H2,1H3
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>2.00E+6n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against bovine phenylethanolamine N-methyl-transferase


J Med Chem 32: 478-86 (1989)


Article DOI: 10.1021/jm00122a032
BindingDB Entry DOI: 10.7270/Q2P55P32
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50452344
PNG
(CHEMBL2114055)
Show SMILES Oc1cccc2[C@H]3CCCN[C@@H]3CCc12
Show InChI InChI=1S/C13H17NO/c15-13-5-1-3-9-10-4-2-8-14-12(10)7-6-11(9)13/h1,3,5,10,12,14-15H,2,4,6-8H2/t10-,12-/m1/s1
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n/an/a 2.37E+3n/an/an/an/an/an/a



University of G£teborg

Curated by ChEMBL


Assay Description
In vitro for binding affinity against sigma receptor using [3H](+)-3-PPP as radioligand


J Med Chem 30: 2169-74 (1988)


Article DOI: 10.1021/jm00395a002
BindingDB Entry DOI: 10.7270/Q2MW2HQJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452344
PNG
(CHEMBL2114055)
Show SMILES Oc1cccc2[C@H]3CCCN[C@@H]3CCc12
Show InChI InChI=1S/C13H17NO/c15-13-5-1-3-9-10-4-2-8-14-12(10)7-6-11(9)13/h1,3,5,10,12,14-15H,2,4,6-8H2/t10-,12-/m1/s1
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n/an/a 1.55E+3n/an/an/an/an/an/a



University of G£teborg

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand


J Med Chem 30: 2169-74 (1988)


Article DOI: 10.1021/jm00395a002
BindingDB Entry DOI: 10.7270/Q2MW2HQJ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50018647
PNG
((R,R)-1,2,3,4,4a,5,6,10b-Octahydro-benzo[f]quinoli...)
Show SMILES Oc1cccc2C3CCCNC3CCc12
Show InChI InChI=1S/C13H17NO/c15-13-5-1-3-9-10-4-2-8-14-12(10)7-6-11(9)13/h1,3,5,10,12,14-15H,2,4,6-8H2
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n/an/a 1.49E+4n/an/an/an/an/an/a



University of G£teborg

Curated by ChEMBL


Assay Description
In vitro for binding affinity against sigma receptor using [3H](+)-3-PPP as radioligand


J Med Chem 30: 2169-74 (1988)


Article DOI: 10.1021/jm00395a002
BindingDB Entry DOI: 10.7270/Q2MW2HQJ
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50026779
PNG
(7,10-Dimethoxy-1,2,3,4,4a,5,6,10b-octahydro-benzo[...)
Show SMILES COc1ccc(OC)c2C3CCCN[C@H]3CCc12
Show InChI InChI=1S/C15H21NO2/c1-17-13-7-8-14(18-2)15-10-4-3-9-16-12(10)6-5-11(13)15/h7-8,10,12,16H,3-6,9H2,1-2H3/t10?,12-/m0/s1
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n/an/an/an/a 200n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor agonist activity in rabbit ear artery


J Med Chem 24: 1432-7 (1982)


Article DOI: 10.1021/jm00144a012
BindingDB Entry DOI: 10.7270/Q2XW4KB0
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50026774
PNG
(7,10-Dimethoxy-1,2,3,4,4a,5,6,10b-octahydro-benzo[...)
Show SMILES COc1ccc(OC)c2C3CCCN[C@@H]3CCc12
Show InChI InChI=1S/C15H21NO2/c1-17-13-7-8-14(18-2)15-10-4-3-9-16-12(10)6-5-11(13)15/h7-8,10,12,16H,3-6,9H2,1-2H3/t10?,12-/m1/s1
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n/an/an/an/a 170n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor agonist activity in rabbit ear artery


J Med Chem 24: 1432-7 (1982)


Article DOI: 10.1021/jm00144a012
BindingDB Entry DOI: 10.7270/Q2XW4KB0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50018647
PNG
((R,R)-1,2,3,4,4a,5,6,10b-Octahydro-benzo[f]quinoli...)
Show SMILES Oc1cccc2C3CCCNC3CCc12
Show InChI InChI=1S/C13H17NO/c15-13-5-1-3-9-10-4-2-8-14-12(10)7-6-11(9)13/h1,3,5,10,12,14-15H,2,4,6-8H2
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n/an/a 7.50E+3n/an/an/an/an/an/a



University of G£teborg

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand


J Med Chem 30: 2169-74 (1988)


Article DOI: 10.1021/jm00395a002
BindingDB Entry DOI: 10.7270/Q2MW2HQJ
More data for this
Ligand-Target Pair