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5 similar compounds to monomer 50011460

Compile data set for download or QSAR
Wt: 355.2
BDBM50011444
Wt: 489.4
BDBM50011448
Wt: 295.2
BDBM50011416
Wt: 326.3
BDBM50011426
Wt: 367.3
BDBM50011431

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50011444,50011448,50011416,50011426,50011431   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011416
PNG
(2-(4-Amino-phenyl)-4-oxo-4H-chromene-3-carboxylic ...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1ccc(N)cc1
Show InChI InChI=1S/C17H13NO4/c1-21-17(20)14-15(19)12-4-2-3-5-13(12)22-16(14)10-6-8-11(18)9-7-10/h2-9H,18H2,1H3
PDB

UniProtKB/SwissProt

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Article
PubMed
n/an/a 8.10E+5n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011426
PNG
(2-(4-Hydroxy-phenyl)-7-methoxy-4-oxo-4H-chromene-3...)
Show SMILES COC(=O)c1c(oc2cc(OC)ccc2c1=O)-c1ccc(O)cc1
Show InChI InChI=1S/C18H14O6/c1-22-12-7-8-13-14(9-12)24-17(10-3-5-11(19)6-4-10)15(16(13)20)18(21)23-2/h3-9,19H,1-2H3
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011448
PNG
(4-Oxo-2-[4-(3,4,5-trimethoxy-benzoylamino)-phenyl]...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1ccc(NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1
Show InChI InChI=1S/C27H23NO8/c1-32-20-13-16(14-21(33-2)25(20)34-3)26(30)28-17-11-9-15(10-12-17)24-22(27(31)35-4)23(29)18-7-5-6-8-19(18)36-24/h5-14H,1-4H3,(H,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011444
PNG
(7-Methoxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-c...)
Show SMILES COC(=O)c1c(oc2cc(OC)ccc2c1=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C18H13NO7/c1-24-12-7-8-13-14(9-12)26-17(15(16(13)20)18(21)25-2)10-3-5-11(6-4-10)19(22)23/h3-9H,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011431
PNG
(2-(4-Acetylamino-phenyl)-6-methoxy-4-oxo-4H-chrome...)
Show SMILES COC(=O)c1c(oc2ccc(OC)cc2c1=O)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C20H17NO6/c1-11(22)21-13-6-4-12(5-7-13)19-17(20(24)26-3)18(23)15-10-14(25-2)8-9-16(15)27-19/h4-10H,1-3H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair