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8 similar compounds to monomer 50011420

Compile data set for download or QSAR
Wt: 343.2
BDBM50011436
Wt: 311.2
BDBM50011440
Wt: 355.2
BDBM50011444
Wt: 325.2
BDBM50011457
Wt: 341.2
BDBM50011459
Wt: 355.2
BDBM50011419
Purchase
Wt: 312.2
BDBM50011422
Wt: 537.5
BDBM50011423

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50011436,50011440,50011444,50011457,50011459,50011419,50011422,50011423   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011419
PNG
(6-Methoxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-c...)
Show SMILES COC(=O)c1c(oc2ccc(OC)cc2c1=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C18H13NO7/c1-24-12-7-8-14-13(9-12)16(20)15(18(21)25-2)17(26-14)10-3-5-11(6-4-10)19(22)23/h3-9H,1-2H3
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PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011422
PNG
(2-(4-Hydroxy-phenyl)-7-methoxy-4-oxo-4H-chromene-3...)
Show SMILES COc1ccc2c(c1)oc(-c1ccc(O)cc1)c(C(O)=O)c2=O
Show InChI InChI=1S/C17H12O6/c1-22-11-6-7-12-13(8-11)23-16(14(15(12)19)17(20)21)9-2-4-10(18)5-3-9/h2-8,18H,1H3,(H,20,21)
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PubMed
n/an/a 1.03E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011423
PNG
(5,7-Bis-benzyloxy-2-(4-nitro-phenyl)-4-oxo-4H-chro...)
Show SMILES COC(=O)c1c(oc2cc(OCc3ccccc3)cc(OCc3ccccc3)c2c1=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C31H23NO8/c1-37-31(34)28-29(33)27-25(39-19-21-10-6-3-7-11-21)16-24(38-18-20-8-4-2-5-9-20)17-26(27)40-30(28)22-12-14-23(15-13-22)32(35)36/h2-17H,18-19H2,1H3
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011459
PNG
(6-Methoxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-c...)
Show SMILES COc1ccc2oc(-c3ccc(cc3)[N+]([O-])=O)c(C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C17H11NO7/c1-24-11-6-7-13-12(8-11)15(19)14(17(20)21)16(25-13)9-2-4-10(5-3-9)18(22)23/h2-8H,1H3,(H,20,21)
PDB

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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011440
PNG
(2-(4-Nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic ...)
Show SMILES OC(=O)c1c(oc2ccccc2c1=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C16H9NO6/c18-14-11-3-1-2-4-12(11)23-15(13(14)16(19)20)9-5-7-10(8-6-9)17(21)22/h1-8H,(H,19,20)
PDB

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PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011444
PNG
(7-Methoxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-c...)
Show SMILES COC(=O)c1c(oc2cc(OC)ccc2c1=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C18H13NO7/c1-24-12-7-8-13-14(9-12)26-17(15(16(13)20)18(21)25-2)10-3-5-11(6-4-10)19(22)23/h3-9H,1-2H3
PDB

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011457
PNG
(2-(4-Nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic ...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C17H11NO6/c1-23-17(20)14-15(19)12-4-2-3-5-13(12)24-16(14)10-6-8-11(9-7-10)18(21)22/h2-9H,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
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Article
PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011436
PNG
(5,7-Dihydroxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene...)
Show SMILES OC(=O)c1c([O-])c2c(cc(O)cc2=[OH+])oc1-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C16H9NO8/c18-9-5-10(19)12-11(6-9)25-15(13(14(12)20)16(21)22)7-1-3-8(4-2-7)17(23)24/h1-6,18,20H,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair