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12 similar compounds to monomer 50011422

Compile data set for download or QSAR
Wt: 326.3
BDBM50011439
Wt: 296.2
BDBM50011441
Wt: 416.4
BDBM50011445
Wt: 345.1
BDBM50011450
Wt: 310.3
BDBM50011452
Wt: 296.2
BDBM50011455
Wt: 282.2
BDBM50011458
Wt: 386.3
BDBM50011461
Wt: 341.2
BDBM50011420
Wt: 326.3
BDBM50011426
Wt: 356.3
BDBM50011430
Wt: 326.3
BDBM50011432

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50011439,50011441,50011445,50011450,50011452,50011455,50011458,50011461,50011420,50011426,50011430,50011432   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011420
PNG
(7-Methoxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-c...)
Show SMILES COc1ccc2c(c1)oc(-c1ccc(cc1)[N+]([O-])=O)c(C(O)=O)c2=O
Show InChI InChI=1S/C17H11NO7/c1-24-11-6-7-12-13(8-11)25-16(14(15(12)19)17(20)21)9-2-4-10(5-3-9)18(22)23/h2-8H,1H3,(H,20,21)
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011426
PNG
(2-(4-Hydroxy-phenyl)-7-methoxy-4-oxo-4H-chromene-3...)
Show SMILES COC(=O)c1c(oc2cc(OC)ccc2c1=O)-c1ccc(O)cc1
Show InChI InChI=1S/C18H14O6/c1-22-12-7-8-13-14(9-12)24-17(10-3-5-11(19)6-4-10)15(16(13)20)18(21)23-2/h3-9,19H,1-2H3
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011430
PNG
(4-Oxo-2-(3,4,5-trimethoxy-phenyl)-4H-chromene-3-ca...)
Show SMILES COc1cc(cc(OC)c1OC)-c1oc2ccccc2c(=O)c1C(O)=O
Show InChI InChI=1S/C19H16O7/c1-23-13-8-10(9-14(24-2)18(13)25-3)17-15(19(21)22)16(20)11-6-4-5-7-12(11)26-17/h4-9H,1-3H3,(H,21,22)
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011432
PNG
(2-(3,4-Dimethoxy-phenyl)-4-oxo-4H-chromene-3-carbo...)
Show SMILES COc1ccc(cc1OC)-c1oc2ccccc2c(=O)c1C(O)=O
Show InChI InChI=1S/C18H14O6/c1-22-13-8-7-10(9-14(13)23-2)17-15(18(20)21)16(19)11-5-3-4-6-12(11)24-17/h3-9H,1-2H3,(H,20,21)
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011439
PNG
(2-(3,5-Dimethoxy-phenyl)-4-oxo-4H-chromene-3-carbo...)
Show SMILES COc1cc(OC)cc(c1)-c1oc2ccccc2c(=O)c1C(O)=O
Show InChI InChI=1S/C18H14O6/c1-22-11-7-10(8-12(9-11)23-2)17-15(18(20)21)16(19)13-5-3-4-6-14(13)24-17/h3-9H,1-2H3,(H,20,21)
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011455
PNG
(2-(4-Hydroxy-phenyl)-4-oxo-4H-chromene-3-carboxyli...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1ccc(O)cc1
Show InChI InChI=1S/C17H12O5/c1-21-17(20)14-15(19)12-4-2-3-5-13(12)22-16(14)10-6-8-11(18)9-7-10/h2-9,18H,1H3
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n/an/a 4.39E+5n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011445
PNG
(2-(4-Benzyloxy-phenyl)-7-methoxy-4-oxo-4H-chromene...)
Show SMILES COC(=O)c1c(oc2cc(OC)ccc2c1=O)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C25H20O6/c1-28-19-12-13-20-21(14-19)31-24(22(23(20)26)25(27)29-2)17-8-10-18(11-9-17)30-15-16-6-4-3-5-7-16/h3-14H,15H2,1-2H3
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011452
PNG
(2-(4-Methoxy-phenyl)-4-oxo-4H-chromene-3-carboxyli...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H14O5/c1-21-12-9-7-11(8-10-12)17-15(18(20)22-2)16(19)13-5-3-4-6-14(13)23-17/h3-10H,1-2H3
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011450
PNG
(2-(4-Bromo-phenyl)-4-oxo-4H-chromene-3-carboxylic ...)
Show SMILES OC(=O)c1c(oc2ccccc2c1=O)-c1ccc(Br)cc1
Show InChI InChI=1S/C16H9BrO4/c17-10-7-5-9(6-8-10)15-13(16(19)20)14(18)11-3-1-2-4-12(11)21-15/h1-8H,(H,19,20)
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011461
PNG
(2-(4-Benzyloxy-phenyl)-4-oxo-4H-chromene-3-carboxy...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C24H18O5/c1-27-24(26)21-22(25)19-9-5-6-10-20(19)29-23(21)17-11-13-18(14-12-17)28-15-16-7-3-2-4-8-16/h2-14H,15H2,1H3
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011458
PNG
(2-(4-Hydroxy-phenyl)-4-oxo-4H-chromene-3-carboxyli...)
Show SMILES OC(=O)c1c(oc2ccccc2c1=O)-c1ccc(O)cc1
Show InChI InChI=1S/C16H10O5/c17-10-7-5-9(6-8-10)15-13(16(19)20)14(18)11-3-1-2-4-12(11)21-15/h1-8,17H,(H,19,20)
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n/an/a 1.60E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011441
PNG
(2-(4-Methoxy-phenyl)-4-oxo-4H-chromene-3-carboxyli...)
Show SMILES COc1ccc(cc1)-c1oc2ccccc2c(=O)c1C(O)=O
Show InChI InChI=1S/C17H12O5/c1-21-11-8-6-10(7-9-11)16-14(17(19)20)15(18)12-4-2-3-5-13(12)22-16/h2-9H,1H3,(H,19,20)
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair