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9 similar compounds to monomer 50011430

Compile data set for download or QSAR
Wt: 326.3
BDBM50011439
Wt: 296.2
BDBM50011441
Wt: 340.3
BDBM50011443
Wt: 370.3
BDBM50011447
Wt: 310.3
BDBM50011452
Wt: 282.2
BDBM50011458
Wt: 312.2
BDBM50011422
Wt: 340.3
BDBM50011425
Wt: 326.3
BDBM50011432

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50011439,50011441,50011443,50011447,50011452,50011458,50011422,50011425,50011432   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011422
PNG
(2-(4-Hydroxy-phenyl)-7-methoxy-4-oxo-4H-chromene-3...)
Show SMILES COc1ccc2c(c1)oc(-c1ccc(O)cc1)c(C(O)=O)c2=O
Show InChI InChI=1S/C17H12O6/c1-22-11-6-7-12-13(8-11)23-16(14(15(12)19)17(20)21)9-2-4-10(18)5-3-9/h2-8,18H,1H3,(H,20,21)
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PubMed
n/an/a 1.03E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011425
PNG
(2-(3,4-Dimethoxy-phenyl)-4-oxo-4H-chromene-3-carbo...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H16O6/c1-22-14-9-8-11(10-15(14)23-2)18-16(19(21)24-3)17(20)12-6-4-5-7-13(12)25-18/h4-10H,1-3H3
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011432
PNG
(2-(3,4-Dimethoxy-phenyl)-4-oxo-4H-chromene-3-carbo...)
Show SMILES COc1ccc(cc1OC)-c1oc2ccccc2c(=O)c1C(O)=O
Show InChI InChI=1S/C18H14O6/c1-22-13-8-7-10(9-14(13)23-2)17-15(18(20)21)16(19)11-5-3-4-6-12(11)24-17/h3-9H,1-2H3,(H,20,21)
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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011439
PNG
(2-(3,5-Dimethoxy-phenyl)-4-oxo-4H-chromene-3-carbo...)
Show SMILES COc1cc(OC)cc(c1)-c1oc2ccccc2c(=O)c1C(O)=O
Show InChI InChI=1S/C18H14O6/c1-22-11-7-10(8-12(9-11)23-2)17-15(18(20)21)16(19)13-5-3-4-6-14(13)24-17/h3-9H,1-2H3,(H,20,21)
PDB

UniProtKB/SwissProt

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n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011458
PNG
(2-(4-Hydroxy-phenyl)-4-oxo-4H-chromene-3-carboxyli...)
Show SMILES OC(=O)c1c(oc2ccccc2c1=O)-c1ccc(O)cc1
Show InChI InChI=1S/C16H10O5/c17-10-7-5-9(6-8-10)15-13(16(19)20)14(18)11-3-1-2-4-12(11)21-15/h1-8,17H,(H,19,20)
PDB

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n/an/a 1.60E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011443
PNG
(2-(3,5-Dimethoxy-phenyl)-4-oxo-4H-chromene-3-carbo...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C19H16O6/c1-22-12-8-11(9-13(10-12)23-2)18-16(19(21)24-3)17(20)14-6-4-5-7-15(14)25-18/h4-10H,1-3H3
PDB

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PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011452
PNG
(2-(4-Methoxy-phenyl)-4-oxo-4H-chromene-3-carboxyli...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H14O5/c1-21-12-9-7-11(8-10-12)17-15(18(20)22-2)16(19)13-5-3-4-6-14(13)23-17/h3-10H,1-2H3
PDB

UniProtKB/SwissProt

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PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011447
PNG
(4-Oxo-2-(3,4,5-trimethoxy-phenyl)-4H-chromene-3-ca...)
Show SMILES COC(=O)c1c(oc2ccccc2c1=O)-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H18O7/c1-23-14-9-11(10-15(24-2)19(14)25-3)18-16(20(22)26-4)17(21)12-7-5-6-8-13(12)27-18/h5-10H,1-4H3
PDB

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PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50011441
PNG
(2-(4-Methoxy-phenyl)-4-oxo-4H-chromene-3-carboxyli...)
Show SMILES COc1ccc(cc1)-c1oc2ccccc2c(=O)c1C(O)=O
Show InChI InChI=1S/C17H12O5/c1-21-11-8-6-10(7-9-11)16-14(17(19)20)15(18)12-4-2-3-5-13(12)22-16/h2-9H,1H3,(H,19,20)
PDB

UniProtKB/SwissProt

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Article
PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair