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28 similar compounds to monomer 50031290

Compile data set for download or QSAR
Wt: 266.2
BDBM50023668
Wt: 268.7
BDBM50031254
Wt: 250.2
BDBM50031261
Wt: 282.7
BDBM50031265
Wt: 264.2
BDBM50031276
Wt: 298.7
BDBM50031292
Wt: 338.7
BDBM50031253
Wt: 352.8
BDBM50031258
Wt: 324.7
BDBM50031262
Wt: 336.8
BDBM50031263
Wt: 366.8
BDBM50031273
Wt: 308.7
BDBM50031275
Wt: 380.8
BDBM50031285
Wt: 322.7
BDBM50031286
Wt: 394.8
BDBM50031289
Displayed 1 to 15 (of 28 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50023668,50031254,50031261,50031265,50031276,50031292,50031253,50031258,50031262,50031263,50031273,50031275,50031285,50031286,50031289   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031261
PNG
(5-(7-Amino-imidazo[4,5-b]pyridin-3-yl)-2-hydroxyme...)
Show SMILES Nc1ccnc2n(cnc12)C1CC(O)C(CO)O1
Show InChI InChI=1S/C11H14N4O3/c12-6-1-2-13-11-10(6)14-5-15(11)9-3-7(17)8(4-16)18-9/h1-2,5,7-9,16-17H,3-4H2,(H2,12,13)
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190n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031276
PNG
(2-Hydroxymethyl-5-(7-methylamino-imidazo[4,5-b]pyr...)
Show SMILES CNc1ccnc2n(cnc12)C1CC(O)C(CO)O1
Show InChI InChI=1S/C12H16N4O3/c1-13-7-2-3-14-12-11(7)15-6-16(12)10-4-8(18)9(5-17)19-10/h2-3,6,8-10,17-18H,4-5H2,1H3,(H,13,14)
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250n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50023668
PNG
(2-(7-Amino-imidazo[4,5-b]pyridin-3-yl)-5-hydroxyme...)
Show SMILES Nc1ccnc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11?/m1/s1
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380n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031292
PNG
(5-(5-Chloro-7-methylamino-imidazo[4,5-b]pyridin-3-...)
Show SMILES CNc1cc(Cl)nc2n(cnc12)C1CC(O)C(CO)O1
Show InChI InChI=1S/C12H15ClN4O3/c1-14-6-2-9(13)16-12-11(6)15-5-17(12)10-3-7(19)8(4-18)20-10/h2,5,7-8,10,18-19H,3-4H2,1H3,(H,14,16)
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4.20E+3n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031265
PNG
(CHEMBL130172 | [5-(5-Chloro-7-methylamino-imidazo[...)
Show SMILES CNc1cc(Cl)nc2n(cnc12)C1CCC(CO)O1
Show InChI InChI=1S/C12H15ClN4O2/c1-14-8-4-9(13)16-12-11(8)15-6-17(12)10-3-2-7(5-18)19-10/h4,6-7,10,18H,2-3,5H2,1H3,(H,14,16)
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1.10E+4n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine Receptors A2a (A2a)


(Rattus norvegicus (rat))
BDBM50031254
PNG
(CHEMBL275433 | [5-(7-Amino-5-chloro-imidazo[4,5-b]...)
Show SMILES Nc1cc(Cl)nc2n(cnc12)C1CCC(CO)O1
Show InChI InChI=1S/C11H13ClN4O2/c12-8-3-7(13)10-11(15-8)16(5-14-10)9-2-1-6(4-17)18-9/h3,5-6,9,17H,1-2,4H2,(H2,13,15)
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5.55E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand


J Med Chem 38: 1174-88 (1995)


Article DOI: 10.1021/jm00007a014
BindingDB Entry DOI: 10.7270/Q2HQ40KN
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031262
PNG
(5-(5-Chloro-7-cyclopropylamino-imidazo[4,5-b]pyrid...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CC3)cc(Cl)nc12
Show InChI InChI=1S/C14H17ClN4O3/c15-11-3-8(17-7-1-2-7)13-14(18-11)19(6-16-13)12-4-9(21)10(5-20)22-12/h3,6-7,9-10,12,20-21H,1-2,4-5H2,(H,17,18)
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7.50E+4n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031285
PNG
(5-(5-Chloro-7-cycloheptylamino-imidazo[4,5-b]pyrid...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCCCCC3)cc(Cl)nc12
Show InChI InChI=1S/C18H25ClN4O3/c19-15-7-12(21-11-5-3-1-2-4-6-11)17-18(22-15)23(10-20-17)16-8-13(25)14(9-24)26-16/h7,10-11,13-14,16,24-25H,1-6,8-9H2,(H,21,22)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031286
PNG
(CHEMBL130652 | [5-(5-Chloro-7-cyclobutylamino-imid...)
Show SMILES OCC1CCC(O1)n1cnc2c(NC3CCC3)cc(Cl)nc12
Show InChI InChI=1S/C15H19ClN4O2/c16-12-6-11(18-9-2-1-3-9)14-15(19-12)20(8-17-14)13-5-4-10(7-21)22-13/h6,8-10,13,21H,1-5,7H2,(H,18,19)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031275
PNG
(CHEMBL437219 | [5-(5-Chloro-7-cyclopropylamino-imi...)
Show SMILES OCC1CCC(O1)n1cnc2c(NC3CC3)cc(Cl)nc12
Show InChI InChI=1S/C14H17ClN4O2/c15-11-5-10(17-8-1-2-8)13-14(18-11)19(7-16-13)12-4-3-9(6-20)21-12/h5,7-9,12,20H,1-4,6H2,(H,17,18)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031273
PNG
(5-(5-Chloro-7-cyclohexylamino-imidazo[4,5-b]pyridi...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCCCC3)cc(Cl)nc12
Show InChI InChI=1S/C17H23ClN4O3/c18-14-6-11(20-10-4-2-1-3-5-10)16-17(21-14)22(9-19-16)15-7-12(24)13(8-23)25-15/h6,9-10,12-13,15,23-24H,1-5,7-8H2,(H,20,21)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031263
PNG
(CHEMBL129891 | [5-(5-Chloro-7-cyclopentylamino-imi...)
Show SMILES OCC1CCC(O1)n1cnc2c(NC3CCCC3)cc(Cl)nc12
Show InChI InChI=1S/C16H21ClN4O2/c17-13-7-12(19-10-3-1-2-4-10)15-16(20-13)21(9-18-15)14-6-5-11(8-22)23-14/h7,9-11,14,22H,1-6,8H2,(H,19,20)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031258
PNG
(5-(5-Chloro-7-cyclopentylamino-imidazo[4,5-b]pyrid...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCCC3)cc(Cl)nc12
Show InChI InChI=1S/C16H21ClN4O3/c17-13-5-10(19-9-3-1-2-4-9)15-16(20-13)21(8-18-15)14-6-11(23)12(7-22)24-14/h5,8-9,11-12,14,22-23H,1-4,6-7H2,(H,19,20)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031254
PNG
(CHEMBL275433 | [5-(7-Amino-5-chloro-imidazo[4,5-b]...)
Show SMILES Nc1cc(Cl)nc2n(cnc12)C1CCC(CO)O1
Show InChI InChI=1S/C11H13ClN4O2/c12-8-3-7(13)10-11(15-8)16(5-14-10)9-2-1-6(4-17)18-9/h3,5-6,9,17H,1-2,4H2,(H2,13,15)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031253
PNG
(5-(5-Chloro-7-cyclobutylamino-imidazo[4,5-b]pyridi...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCC3)cc(Cl)nc12
Show InChI InChI=1S/C15H19ClN4O3/c16-12-4-9(18-8-2-1-3-8)14-15(19-12)20(7-17-14)13-5-10(22)11(6-21)23-13/h4,7-8,10-11,13,21-22H,1-3,5-6H2,(H,18,19)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031289
PNG
(5-(5-Chloro-7-cyclooctylamino-imidazo[4,5-b]pyridi...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCCCCCC3)cc(Cl)nc12
Show InChI InChI=1S/C19H27ClN4O3/c20-16-8-13(22-12-6-4-2-1-3-5-7-12)18-19(23-16)24(11-21-18)17-9-14(26)15(10-25)27-17/h8,11-12,14-15,17,25-26H,1-7,9-10H2,(H,22,23)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50031254
PNG
(CHEMBL275433 | [5-(7-Amino-5-chloro-imidazo[4,5-b]...)
Show SMILES Nc1cc(Cl)nc2n(cnc12)C1CCC(CO)O1
Show InChI InChI=1S/C11H13ClN4O2/c12-8-3-7(13)10-11(15-8)16(5-14-10)9-2-1-6(4-17)18-9/h3,5-6,9,17H,1-2,4H2,(H2,13,15)
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1.01E+5n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.


J Med Chem 38: 1174-88 (1995)


Article DOI: 10.1021/jm00007a014
BindingDB Entry DOI: 10.7270/Q2HQ40KN
More data for this
Ligand-Target Pair