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21 similar compounds to monomer 50031261

Compile data set for download or QSAR
Wt: 266.2
BDBM50023668
Wt: 268.7
BDBM50031254
Wt: 264.2
BDBM50031276
Wt: 274.3
BDBM50031280
Wt: 248.2
BDBM50031283
Wt: 284.6
BDBM50031290
Wt: 298.7
BDBM50031292
Wt: 332.3
BDBM50031255
Wt: 304.3
BDBM50031259
Wt: 290.3
BDBM50031260
Wt: 318.3
BDBM50031264
Wt: 346.4
BDBM50031267
Wt: 234.2
BDBM50031268
Wt: 360.4
BDBM50031284
Wt: 266.2
BDBM50060165
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Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50023668,50031254,50031276,50031280,50031283,50031290,50031292,50031255,50031259,50031260,50031264,50031267,50031268,50031284,50060165   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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84n/an/an/an/an/an/an/an/a



Uppsala University



Assay Description
Radioligand binding assays were performed using membranes prepared from CHO (hA1AR or hA3AR) or HEK293 (hA2AAR) cells stably expressing a single hAR ...


ACS Chem Biol 11: 2763-2772 (2016)


Article DOI: 10.1021/acschembio.6b00357
BindingDB Entry DOI: 10.7270/Q2S75F5P
More data for this
Ligand-Target Pair
Adenosine deaminase


(Homo sapiens (Human))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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100n/an/an/an/an/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Inhibition of adenosine deaminase


J Med Chem 54: 107-21 (2011)


Article DOI: 10.1021/jm101286g
BindingDB Entry DOI: 10.7270/Q2K64K1Z
More data for this
Ligand-Target Pair
Adenosine receptor


(Rattus norvegicus (rat))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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115n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]PIA from adenosine A1 receptor of rat brain membranes


J Med Chem 31: 1179-83 (1988)


Article DOI: 10.1021/jm00401a018
BindingDB Entry DOI: 10.7270/Q2QC042G
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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180n/an/an/an/an/an/an/an/a



Southern Illinois University

Curated by ChEMBL


Assay Description
Inhibitory activity against adenosine deaminase


J Med Chem 40: 3336-45 (1997)


Article DOI: 10.1021/jm970301s
BindingDB Entry DOI: 10.7270/Q2QF8S05
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031276
PNG
(2-Hydroxymethyl-5-(7-methylamino-imidazo[4,5-b]pyr...)
Show SMILES CNc1ccnc2n(cnc12)C1CC(O)C(CO)O1
Show InChI InChI=1S/C12H16N4O3/c1-13-7-2-3-14-12-11(7)15-6-16(12)10-4-8(18)9(5-17)19-10/h2-3,6,8-10,17-18H,4-5H2,1H3,(H,13,14)
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250n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50023668
PNG
(2-(7-Amino-imidazo[4,5-b]pyridin-3-yl)-5-hydroxyme...)
Show SMILES Nc1ccnc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11?/m1/s1
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380n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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583n/an/an/an/an/an/an/an/a



Uppsala University



Assay Description
Radioligand binding assays were performed using membranes prepared from CHO (hA1AR or hA3AR) or HEK293 (hA2AAR) cells stably expressing a single hAR ...


ACS Chem Biol 11: 2763-2772 (2016)


Article DOI: 10.1021/acschembio.6b00357
BindingDB Entry DOI: 10.7270/Q2S75F5P
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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645n/an/an/an/an/an/an/an/a



Uppsala University



Assay Description
Radioligand binding assays were performed using membranes prepared from CHO (hA1AR or hA3AR) or HEK293 (hA2AAR) cells stably expressing a single hAR ...


ACS Chem Biol 11: 2763-2772 (2016)


Article DOI: 10.1021/acschembio.6b00357
BindingDB Entry DOI: 10.7270/Q2S75F5P
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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660n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition of calf intestinal adenosine deaminase


J Med Chem 34: 1187-92 (1991)


Article DOI: 10.1021/jm00107a044
BindingDB Entry DOI: 10.7270/Q20V8DDM
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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660n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against calf intestine adenosine deaminase enzyme


J Med Chem 27: 274-8 (1984)


Article DOI: 10.1021/jm00369a008
BindingDB Entry DOI: 10.7270/Q2CR5TW3
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031283
PNG
(CHEMBL130928 | [5-(7-Methylamino-imidazo[4,5-b]pyr...)
Show SMILES CNc1ccnc2n(cnc12)C1CCC(CO)O1
Show InChI InChI=1S/C12H16N4O2/c1-13-9-4-5-14-12-11(9)15-7-16(12)10-3-2-8(6-17)18-10/h4-5,7-8,10,17H,2-3,6H2,1H3,(H,13,14)
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2.20E+3n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031268
PNG
(CHEMBL336531 | [5-(7-Amino-imidazo[4,5-b]pyridin-3...)
Show SMILES Nc1ccnc2n(cnc12)C1CCC(CO)O1
Show InChI InChI=1S/C11H14N4O2/c12-8-3-4-13-11-10(8)14-6-15(11)9-2-1-7(5-16)17-9/h3-4,6-7,9,16H,1-2,5H2,(H2,12,13)
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2.50E+3n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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2.90E+3n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]NECA from A2-receptor of rat striatal membranes


J Med Chem 31: 1179-83 (1988)


Article DOI: 10.1021/jm00401a018
BindingDB Entry DOI: 10.7270/Q2QC042G
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031292
PNG
(5-(5-Chloro-7-methylamino-imidazo[4,5-b]pyridin-3-...)
Show SMILES CNc1cc(Cl)nc2n(cnc12)C1CC(O)C(CO)O1
Show InChI InChI=1S/C12H15ClN4O3/c1-14-6-2-9(13)16-12-11(6)15-5-17(12)10-3-7(19)8(4-18)20-10/h2,5,7-8,10,18-19H,3-4H2,1H3,(H,14,16)
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4.20E+3n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031260
PNG
(5-(7-Cyclopropylamino-imidazo[4,5-b]pyridin-3-yl)-...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CC3)ccnc12
Show InChI InChI=1S/C14H18N4O3/c19-6-11-10(20)5-12(21-11)18-7-16-13-9(17-8-1-2-8)3-4-15-14(13)18/h3-4,7-8,10-12,19-20H,1-2,5-6H2,(H,15,17)
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5.90E+3n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031264
PNG
(5-(7-Cyclopentylamino-imidazo[4,5-b]pyridin-3-yl)-...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCCC3)ccnc12
Show InChI InChI=1S/C16H22N4O3/c21-8-13-12(22)7-14(23-13)20-9-18-15-11(5-6-17-16(15)20)19-10-3-1-2-4-10/h5-6,9-10,12-14,21-22H,1-4,7-8H2,(H,17,19)
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2.20E+4n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031290
PNG
(5-(7-Amino-5-chloro-imidazo[4,5-b]pyridin-3-yl)-2-...)
Show SMILES Nc1cc(Cl)nc2n(cnc12)C1CC(O)C(CO)O1
Show InChI InChI=1S/C11H13ClN4O3/c12-8-1-5(13)10-11(15-8)16(4-14-10)9-2-6(18)7(3-17)19-9/h1,4,6-7,9,17-18H,2-3H2,(H2,13,15)
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2.30E+4n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031259
PNG
(5-(7-Cyclobutylamino-imidazo[4,5-b]pyridin-3-yl)-2...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCC3)ccnc12
Show InChI InChI=1S/C15H20N4O3/c20-7-12-11(21)6-13(22-12)19-8-17-14-10(4-5-16-15(14)19)18-9-2-1-3-9/h4-5,8-9,11-13,20-21H,1-3,6-7H2,(H,16,18)
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2.70E+4n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50031290
PNG
(5-(7-Amino-5-chloro-imidazo[4,5-b]pyridin-3-yl)-2-...)
Show SMILES Nc1cc(Cl)nc2n(cnc12)C1CC(O)C(CO)O1
Show InChI InChI=1S/C11H13ClN4O3/c12-8-1-5(13)10-11(15-8)16(4-14-10)9-2-6(18)7(3-17)19-9/h1,4,6-7,9,17-18H,2-3H2,(H2,13,15)
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2.90E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.


J Med Chem 38: 1174-88 (1995)


Article DOI: 10.1021/jm00007a014
BindingDB Entry DOI: 10.7270/Q2HQ40KN
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031267
PNG
(5-(7-Cycloheptylamino-imidazo[4,5-b]pyridin-3-yl)-...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCCCCC3)ccnc12
Show InChI InChI=1S/C18H26N4O3/c23-10-15-14(24)9-16(25-15)22-11-20-17-13(7-8-19-18(17)22)21-12-5-3-1-2-4-6-12/h7-8,11-12,14-16,23-24H,1-6,9-10H2,(H,19,21)
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4.20E+4n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine Receptors A2a (A2a)


(Rattus norvegicus (rat))
BDBM50031254
PNG
(CHEMBL275433 | [5-(7-Amino-5-chloro-imidazo[4,5-b]...)
Show SMILES Nc1cc(Cl)nc2n(cnc12)C1CCC(CO)O1
Show InChI InChI=1S/C11H13ClN4O2/c12-8-3-7(13)10-11(15-8)16(5-14-10)9-2-1-6(4-17)18-9/h3,5-6,9,17H,1-2,4H2,(H2,13,15)
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5.55E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand


J Med Chem 38: 1174-88 (1995)


Article DOI: 10.1021/jm00007a014
BindingDB Entry DOI: 10.7270/Q2HQ40KN
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031284
PNG
(5-(7-Cyclooctylamino-imidazo[4,5-b]pyridin-3-yl)-2...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCCCCCC3)ccnc12
Show InChI InChI=1S/C19H28N4O3/c24-11-16-15(25)10-17(26-16)23-12-21-18-14(8-9-20-19(18)23)22-13-6-4-2-1-3-5-7-13/h8-9,12-13,15-17,24-25H,1-7,10-11H2,(H,20,22)
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5.90E+4n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031280
PNG
(CHEMBL337739 | [5-(7-Cyclopropylamino-imidazo[4,5-...)
Show SMILES OCC1CCC(O1)n1cnc2c(NC3CC3)ccnc12
Show InChI InChI=1S/C14H18N4O2/c19-7-10-3-4-12(20-10)18-8-16-13-11(17-9-1-2-9)5-6-15-14(13)18/h5-6,8-10,12,19H,1-4,7H2,(H,15,17)
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7.80E+4n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031255
PNG
(5-(7-Cyclohexylamino-imidazo[4,5-b]pyridin-3-yl)-2...)
Show SMILES OCC1OC(CC1O)n1cnc2c(NC3CCCCC3)ccnc12
Show InChI InChI=1S/C17H24N4O3/c22-9-14-13(23)8-15(24-14)21-10-19-16-12(6-7-18-17(16)21)20-11-4-2-1-3-5-11/h6-7,10-11,13-15,22-23H,1-5,8-9H2,(H,18,20)
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8.70E+4n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine deaminase


(Bos taurus (bovine))
BDBM50031254
PNG
(CHEMBL275433 | [5-(7-Amino-5-chloro-imidazo[4,5-b]...)
Show SMILES Nc1cc(Cl)nc2n(cnc12)C1CCC(CO)O1
Show InChI InChI=1S/C11H13ClN4O2/c12-8-3-7(13)10-11(15-8)16(5-14-10)9-2-1-6(4-17)18-9/h3,5-6,9,17H,1-2,4H2,(H2,13,15)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition calf intestine adenosine deaminase


J Med Chem 38: 4019-25 (1995)


Article DOI: 10.1021/jm00020a017
BindingDB Entry DOI: 10.7270/Q2RB757R
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50031254
PNG
(CHEMBL275433 | [5-(7-Amino-5-chloro-imidazo[4,5-b]...)
Show SMILES Nc1cc(Cl)nc2n(cnc12)C1CCC(CO)O1
Show InChI InChI=1S/C11H13ClN4O2/c12-8-3-7(13)10-11(15-8)16(5-14-10)9-2-1-6(4-17)18-9/h3,5-6,9,17H,1-2,4H2,(H2,13,15)
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1.01E+5n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.


J Med Chem 38: 1174-88 (1995)


Article DOI: 10.1021/jm00007a014
BindingDB Entry DOI: 10.7270/Q2HQ40KN
More data for this
Ligand-Target Pair
Adenosine A2 receptor


(Homo sapiens (Human))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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n/an/an/an/a 1.80E+4n/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Stimulation of adenylate cyclase activity in human platelet membrane at A2 receptor


J Med Chem 31: 1179-83 (1988)


Article DOI: 10.1021/jm00401a018
BindingDB Entry DOI: 10.7270/Q2QC042G
More data for this
Ligand-Target Pair
Adenosine receptor


(Rattus norvegicus (rat))
BDBM50060165
PNG
((2R,3R,4S,5R)-2-(7-Amino-imidazo[4,5-b]pyridin-3-y...)
Show SMILES Nc1ccnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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n/an/a 6.70E+3n/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition of Adenylate cyclase activity in rat fat cell membrane at adenosine A1 receptor


J Med Chem 31: 1179-83 (1988)


Article DOI: 10.1021/jm00401a018
BindingDB Entry DOI: 10.7270/Q2QC042G
More data for this
Ligand-Target Pair