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6 similar compounds to monomer 50014758

Compile data set for download or QSAR
Wt: 295.7
BDBM50014813
Wt: 330.2
BDBM50014757
Wt: 309.7
BDBM50014789
Wt: 344.2
BDBM50014795
Wt: 330.2
BDBM50014805
Wt: 330.2
BDBM50014806

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50014813,50014757,50014789,50014795,50014805,50014806   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014757
PNG
((4-Chloro-phenyl)-(2-chloro-phenyl)-pyridin-3-yl-m...)
Show SMILES OC(c1ccc(Cl)cc1)(c1cccnc1)c1ccccc1Cl
Show InChI InChI=1S/C18H13Cl2NO/c19-15-9-7-13(8-10-15)18(22,14-4-3-11-21-12-14)16-5-1-2-6-17(16)20/h1-12,22H
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n/an/an/an/a>2.00E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)


Article DOI: 10.1021/jm00163a065
BindingDB Entry DOI: 10.7270/Q2WM1F0N
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014789
PNG
((4-Chloro-phenyl)-pyridin-3-yl-p-tolyl-methanol : ...)
Show SMILES Cc1ccc(cc1)C(O)(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C19H16ClNO/c1-14-4-6-15(7-5-14)19(22,17-3-2-12-21-13-17)16-8-10-18(20)11-9-16/h2-13,22H,1H3
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n/an/an/an/a 230n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)


Article DOI: 10.1021/jm00163a065
BindingDB Entry DOI: 10.7270/Q2WM1F0N
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014813
PNG
((4-Chloro-phenyl)-phenyl-pyridin-3-yl-methanol | C...)
Show SMILES OC(c1ccccc1)(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C18H14ClNO/c19-17-10-8-15(9-11-17)18(21,14-5-2-1-3-6-14)16-7-4-12-20-13-16/h1-13,21H
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n/an/an/an/a>2.00E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)


Article DOI: 10.1021/jm00163a065
BindingDB Entry DOI: 10.7270/Q2WM1F0N
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014805
PNG
(Bis-(3-chloro-phenyl)-pyridin-3-yl-methanol | CHEM...)
Show SMILES OC(c1cccnc1)(c1cccc(Cl)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C18H13Cl2NO/c19-16-7-1-4-13(10-16)18(22,15-6-3-9-21-12-15)14-5-2-8-17(20)11-14/h1-12,22H
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n/an/an/an/a 4.50E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)


Article DOI: 10.1021/jm00163a065
BindingDB Entry DOI: 10.7270/Q2WM1F0N
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014806
PNG
((2,4-Dichloro-phenyl)-phenyl-pyridin-3-yl-methanol...)
Show SMILES OC(c1ccccc1)(c1cccnc1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13Cl2NO/c19-15-8-9-16(17(20)11-15)18(22,13-5-2-1-3-6-13)14-7-4-10-21-12-14/h1-12,22H
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PubMed
n/an/an/an/a>2.00E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)


Article DOI: 10.1021/jm00163a065
BindingDB Entry DOI: 10.7270/Q2WM1F0N
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014795
PNG
(3-[Bis-(4-chloro-phenyl)-methoxy-methyl]-pyridine ...)
Show SMILES COC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C19H15Cl2NO/c1-23-19(16-3-2-12-22-13-16,14-4-8-17(20)9-5-14)15-6-10-18(21)11-7-15/h2-13H,1H3
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Article
PubMed
n/an/an/an/a 1.60E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)


Article DOI: 10.1021/jm00163a065
BindingDB Entry DOI: 10.7270/Q2WM1F0N
More data for this
Ligand-Target Pair