BindingDB logo
myBDB logout

5 similar compounds to monomer 50024522

Compile data set for download or QSAR
Wt: 331.1
BDBM50014815
Wt: 314.7
BDBM50024525
Wt: 298.2
BDBM50024488
Wt: 280.2
BDBM50024494
Wt: 296.7
BDBM50024506

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50014815,50024525,50024488,50024494,50024506   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024488
PNG
(Bis-(4-fluoro-phenyl)-pyrimidin-5-yl-methanol | CH...)
Show SMILES OC(c1ccc(F)cc1)(c1ccc(F)cc1)c1cncnc1
Show InChI InChI=1S/C17H12F2N2O/c18-15-5-1-12(2-6-15)17(22,14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,22H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 530n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


J Med Chem 30: 1359-65 (1987)


Article DOI: 10.1021/jm00391a016
BindingDB Entry DOI: 10.7270/Q2NP251P
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024494
PNG
((4-Fluoro-phenyl)-phenyl-pyrimidin-5-yl-methanol |...)
Show SMILES OC(c1ccccc1)(c1ccc(F)cc1)c1cncnc1
Show InChI InChI=1S/C17H13FN2O/c18-16-8-6-14(7-9-16)17(21,13-4-2-1-3-5-13)15-10-19-12-20-11-15/h1-12,21H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>2.20E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


J Med Chem 30: 1359-65 (1987)


Article DOI: 10.1021/jm00391a016
BindingDB Entry DOI: 10.7270/Q2NP251P
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014815
PNG
(Bis-(4-chloro-phenyl)-pyrimidin-5-yl-methanol | CH...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12Cl2N2O/c18-15-5-1-12(2-6-15)17(22,14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,22H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 71n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)


Article DOI: 10.1021/jm00163a065
BindingDB Entry DOI: 10.7270/Q2WM1F0N
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014815
PNG
(Bis-(4-chloro-phenyl)-pyrimidin-5-yl-methanol | CH...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12Cl2N2O/c18-15-5-1-12(2-6-15)17(22,14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,22H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 71n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


J Med Chem 30: 1359-65 (1987)


Article DOI: 10.1021/jm00391a016
BindingDB Entry DOI: 10.7270/Q2NP251P
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024525
PNG
((4-Chloro-phenyl)-(3-fluoro-phenyl)-pyrimidin-5-yl...)
Show SMILES OC(c1ccc(Cl)cc1)(c1cccc(F)c1)c1cncnc1
Show InChI InChI=1S/C17H12ClFN2O/c18-15-6-4-12(5-7-15)17(22,14-9-20-11-21-10-14)13-2-1-3-16(19)8-13/h1-11,22H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.65E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


J Med Chem 30: 1359-65 (1987)


Article DOI: 10.1021/jm00391a016
BindingDB Entry DOI: 10.7270/Q2NP251P
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024506
PNG
((4-Chloro-phenyl)-phenyl-pyrimidin-5-yl-methanol |...)
Show SMILES OC(c1ccccc1)(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H13ClN2O/c18-16-8-6-14(7-9-16)17(21,13-4-2-1-3-5-13)15-10-19-12-20-11-15/h1-12,21H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>2.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


J Med Chem 30: 1359-65 (1987)


Article DOI: 10.1021/jm00391a016
BindingDB Entry DOI: 10.7270/Q2NP251P
More data for this
Ligand-Target Pair