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2 similar compounds to monomer 50388182

Compile data set for download or QSAR
Wt: 406.4
BDBM50328425
Wt: 505.5
BDBM50015488

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328425,50015488   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (Human))
BDBM50328425
PNG
(CHEMBL1257445 | N-(4-(6-(pyridin-3-yl)imidazo[1,2-...)
Show SMILES O=C(Nc1ccc(Nc2nc(cn3ccnc23)-c2cccnc2)cc1)c1ccccc1
Show InChI InChI=1S/C24H18N6O/c31-24(17-5-2-1-3-6-17)28-20-10-8-19(9-11-20)27-22-23-26-13-14-30(23)16-21(29-22)18-7-4-12-25-15-18/h1-16H,(H,27,29)(H,28,31)
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 3.75E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human aurora A


Bioorg Med Chem Lett 20: 5988-93 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.091
BindingDB Entry DOI: 10.7270/Q2H995D7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015488
PNG
(CHEMBL3264994)
Show SMILES CC(C)(C)c1ccc(Nc2nc(cn3ccnc23)-c2cccc(NC(=O)c3ccc(cc3)C(O)=O)c2)cc1
Show InChI InChI=1S/C30H27N5O3/c1-30(2,3)22-11-13-23(14-12-22)32-26-27-31-15-16-35(27)18-25(34-26)21-5-4-6-24(17-21)33-28(36)19-7-9-20(10-8-19)29(37)38/h4-18H,1-3H3,(H,32,34)(H,33,36)(H,37,38)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 65n/an/an/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair