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34 similar compounds to monomer 50299749

Wt: 397.5
BDBM50312531
Wt: 397.5
BDBM50312527
Purchase
Wt: 397.5
BDBM50312529
Wt: 375.5
BDBM50335381
Wt: 361.5
BDBM50335382
Wt: 347.4
BDBM50335383
Wt: 333.4
BDBM50335384
Wt: 319.4
BDBM50335385
Wt: 305.4
BDBM50335386
Wt: 375.5
BDBM50335387
Wt: 361.5
BDBM50335388
Wt: 347.4
BDBM50335389
Wt: 333.4
BDBM50335390
Wt: 319.4
BDBM50335391
Wt: 305.4
BDBM50335392
Displayed 1 to 15 (of 34 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 109 hits for monomerid = 50312531,50312527,50312529,50335381,50335382,50335383,50335384,50335385,50335386,50335387,50335388,50335389,50335390,50335391,50335392   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-glucosidase


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GBA2 by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50312531
PNG
(CHEMBL1088292 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20-,21+,22?/m0/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Beta-glucosidase


(Homo sapiens)
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a<1n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GBA2 by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of sucrase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Homo sapiens)
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide


J Med Chem 57: 9096-104 (2014)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry


J Med Chem 57: 9096-104 (2014)

More data for this
Ligand-Target Pair
Beta-glucosidase


(Homo sapiens)
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GBA2 (unknown origin)


J Med Chem 57: 9096-104 (2014)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide


J Med Chem 57: 9096-104 (2014)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry


J Med Chem 57: 9096-104 (2014)

More data for this
Ligand-Target Pair
Beta-glucosidase


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GBA2 (unknown origin)


J Med Chem 57: 9096-104 (2014)

More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal sucrase (unknown origin)


J Med Chem 57: 9096-104 (2014)

More data for this
Ligand-Target Pair
Lactase-phlorizin hydrolase


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a 2.00E+5n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal lactase (unknown origin)


J Med Chem 57: 9096-104 (2014)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of intestinal maltase (unknown origin)


J Med Chem 57: 9096-104 (2014)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GCS by cell-based assay


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Homo sapiens)
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GCS by cell-based assay


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Homo sapiens)
BDBM50312531
PNG
(CHEMBL1088292 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20-,21+,22?/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GCS by cell-based assay


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Lactase-phlorizin hydrolase


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of lactase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Lactase-phlorizin hydrolase


(Homo sapiens)
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 3.75E+5n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of lactase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Lactase-phlorizin hydrolase


(Homo sapiens)
BDBM50312531
PNG
(CHEMBL1088292 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20-,21+,22?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of lactase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Beta-glucosidase


(Homo sapiens)
BDBM50312531
PNG
(CHEMBL1088292 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20-,21+,22?/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GBA2 by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of lysosomal alpha-glucosidase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of lysosomal alpha-glucosidase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50312531
PNG
(CHEMBL1088292 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20-,21+,22?/m0/s1
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n/an/a 5.00E+5n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of lysosomal alpha-glucosidase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Glycogen debranching enzyme


(Homo sapiens)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of glycogen glycogen de-branching enzyme by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Glycogen debranching enzyme


(Homo sapiens)
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of glycogen glycogen de-branching enzyme by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Glycogen debranching enzyme


(Homo sapiens)
BDBM50312531
PNG
(CHEMBL1088292 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20-,21+,22?/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of glycogen glycogen de-branching enzyme by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of maltase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50312529
PNG
(CHEMBL1088158 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of maltase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50312531
PNG
(CHEMBL1088292 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20-,21+,22?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of maltase by HPLC


J Med Chem 53: 689-98 (2010)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50335389
PNG
(CHEMBL1651631 | N-Heptoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C18H37NO5/c1-2-3-4-5-8-11-24-12-9-6-7-10-19-13-16(21)18(23)17(22)15(19)14-20/h15-18,20-23H,2-14H2,1H3/t15-,16+,17-,18-/m1/s1
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n/an/a 1.75E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50335390
PNG
(CHEMBL1651630 | N-Hexoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C17H35NO5/c1-2-3-4-7-10-23-11-8-5-6-9-18-12-15(20)17(22)16(21)14(18)13-19/h14-17,19-22H,2-13H2,1H3/t14-,15+,16-,17-/m1/s1
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n/an/a 2.05E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50335391
PNG
(CHEMBL1651629 | N-Pentoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C16H33NO5/c1-2-3-6-9-22-10-7-4-5-8-17-11-14(19)16(21)15(20)13(17)12-18/h13-16,18-21H,2-12H2,1H3/t13-,14+,15-,16-/m1/s1
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n/an/a 7.05E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50335392
PNG
(CHEMBL1651628 | N-Butoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO5/c1-2-3-8-21-9-6-4-5-7-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335382
PNG
(CHEMBL1651638 | N-Octoxypentyl-L-ido-1-deoxynojiri...)
Show SMILES CCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO
Show InChI InChI=1S/C19H39NO5/c1-2-3-4-5-6-9-12-25-13-10-7-8-11-20-14-17(22)19(24)18(23)16(20)15-21/h16-19,21-24H,2-15H2,1H3/t16-,17-,18+,19+/m0/s1
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n/an/a 50n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335383
PNG
(CHEMBL1651637 | N-Heptoxypentyl-L-ido-1-deoxynojir...)
Show SMILES CCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO
Show InChI InChI=1S/C18H37NO5/c1-2-3-4-5-8-11-24-12-9-6-7-10-19-13-16(21)18(23)17(22)15(19)14-20/h15-18,20-23H,2-14H2,1H3/t15-,16-,17+,18+/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335384
PNG
(CHEMBL1651636 | N-Hexoxypentyl-L-ido-1-deoxynojiri...)
Show SMILES CCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO
Show InChI InChI=1S/C17H35NO5/c1-2-3-4-7-10-23-11-8-5-6-9-18-12-15(20)17(22)16(21)14(18)13-19/h14-17,19-22H,2-13H2,1H3/t14-,15-,16+,17+/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335385
PNG
(CHEMBL1651635 | N-Pentoxypentyl-L-ido-1-deoxynojir...)
Show SMILES CCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO
Show InChI InChI=1S/C16H33NO5/c1-2-3-6-9-22-10-7-4-5-8-17-11-14(19)16(21)15(20)13(17)12-18/h13-16,18-21H,2-12H2,1H3/t13-,14-,15+,16+/m0/s1
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n/an/a 150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335386
PNG
(CHEMBL1651634 | N-Butoxypentyl-L-ido-1-deoxynojiri...)
Show SMILES CCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO
Show InChI InChI=1S/C15H31NO5/c1-2-3-8-21-9-6-4-5-7-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13-,14+,15+/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335387
PNG
(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C20H41NO5/c1-2-3-4-5-6-7-10-13-26-14-11-8-9-12-21-15-18(23)20(25)19(24)17(21)16-22/h17-20,22-25H,2-16H2,1H3/t17-,18+,19-,20-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335388
PNG
(CHEMBL1651632 | N-Octoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C19H39NO5/c1-2-3-4-5-6-9-12-25-13-10-7-8-11-20-14-17(22)19(24)18(23)16(20)15-21/h16-19,21-24H,2-15H2,1H3/t16-,17+,18-,19-/m1/s1
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335389
PNG
(CHEMBL1651631 | N-Heptoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C18H37NO5/c1-2-3-4-5-8-11-24-12-9-6-7-10-19-13-16(21)18(23)17(22)15(19)14-20/h15-18,20-23H,2-14H2,1H3/t15-,16+,17-,18-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335390
PNG
(CHEMBL1651630 | N-Hexoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C17H35NO5/c1-2-3-4-7-10-23-11-8-5-6-9-18-12-15(20)17(22)16(21)14(18)13-19/h14-17,19-22H,2-13H2,1H3/t14-,15+,16-,17-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335391
PNG
(CHEMBL1651629 | N-Pentoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C16H33NO5/c1-2-3-6-9-22-10-7-4-5-8-17-11-14(19)16(21)15(20)13(17)12-18/h13-16,18-21H,2-12H2,1H3/t13-,14+,15-,16-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Ceramide glucosyltransferase


(Mus musculus)
BDBM50335392
PNG
(CHEMBL1651628 | N-Butoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO5/c1-2-3-8-21-9-6-4-5-7-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50335386
PNG
(CHEMBL1651634 | N-Butoxypentyl-L-ido-1-deoxynojiri...)
Show SMILES CCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO
Show InChI InChI=1S/C15H31NO5/c1-2-3-8-21-9-6-4-5-7-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13-,14+,15+/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50335387
PNG
(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C20H41NO5/c1-2-3-4-5-6-7-10-13-26-14-11-8-9-12-21-15-18(23)20(25)19(24)17(21)16-22/h17-20,22-25H,2-16H2,1H3/t17-,18+,19-,20-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50335388
PNG
(CHEMBL1651632 | N-Octoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C19H39NO5/c1-2-3-4-5-6-9-12-25-13-10-7-8-11-20-14-17(22)19(24)18(23)16(20)15-21/h16-19,21-24H,2-15H2,1H3/t16-,17+,18-,19-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM50312527
PNG
(CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pent...)
Show SMILES OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


ACS Med Chem Lett 2: 119-123 (2011)

More data for this
Ligand-Target Pair
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