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6 similar compounds to monomer 50018219

Compile data set for download or QSAR
Wt: 370.3
BDBM50018218
Wt: 308.3
BDBM50285632
Wt: 334.3
BDBM50285634
Wt: 320.3
BDBM50285635
Wt: 334.3
BDBM50285636
Wt: 320.3
BDBM50285638

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50018218,50285632,50285634,50285635,50285636,50285638   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50285634
PNG
((R)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCCC[C@@H]1C(O)=O
Show InChI InChI=1S/C17H22N2O5/c20-15(18-24)11-13(10-12-6-2-1-3-7-12)16(21)19-9-5-4-8-14(19)17(22)23/h1-3,6-7,13-14,24H,4-5,8-11H2,(H,18,20)(H,22,23)/t13-,14-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit lung angiotensin-converting enzyme(ACE)


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50285636
PNG
((S)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCCC[C@H]1C(O)=O
Show InChI InChI=1S/C17H22N2O5/c20-15(18-24)11-13(10-12-6-2-1-3-7-12)16(21)19-9-5-4-8-14(19)17(22)23/h1-3,6-7,13-14,24H,4-5,8-11H2,(H,18,20)(H,22,23)/t13-,14+/m1/s1
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human Leukotriene A4 hydrolase


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50285636
PNG
((S)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCCC[C@H]1C(O)=O
Show InChI InChI=1S/C17H22N2O5/c20-15(18-24)11-13(10-12-6-2-1-3-7-12)16(21)19-9-5-4-8-14(19)17(22)23/h1-3,6-7,13-14,24H,4-5,8-11H2,(H,18,20)(H,22,23)/t13-,14+/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit lung angiotensin-converting enzyme(ACE)


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50285635
PNG
((S)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C16H20N2O5/c19-14(17-23)10-12(9-11-5-2-1-3-6-11)15(20)18-8-4-7-13(18)16(21)22/h1-3,5-6,12-13,23H,4,7-10H2,(H,17,19)(H,21,22)/t12-,13+/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit lung angiotensin-converting enzyme (ACE)


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50285632
PNG
((S)-2-[((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)...)
Show SMILES C[C@H](N(C)C(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C15H20N2O5/c1-10(15(20)21)17(2)14(19)12(9-13(18)16-22)8-11-6-4-3-5-7-11/h3-7,10,12,22H,8-9H2,1-2H3,(H,16,18)(H,20,21)/t10-,12+/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit lung angiotensin-converting enzyme(ACE)


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50285632
PNG
((S)-2-[((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)...)
Show SMILES C[C@H](N(C)C(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C15H20N2O5/c1-10(15(20)21)17(2)14(19)12(9-13(18)16-22)8-11-6-4-3-5-7-11/h3-7,10,12,22H,8-9H2,1-2H3,(H,16,18)(H,20,21)/t10-,12+/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney neutral endopeptidase (NEP)


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Oryctolagus cuniculus)
BDBM50285638
PNG
((R)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C16H20N2O5/c19-14(17-23)10-12(9-11-5-2-1-3-6-11)15(20)18-8-4-7-13(18)16(21)22/h1-3,5-6,12-13,23H,4,7-10H2,(H,17,19)(H,21,22)/t12-,13-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit lung angiotensin-converting enzyme (ACE)


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50285636
PNG
((S)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCCC[C@H]1C(O)=O
Show InChI InChI=1S/C17H22N2O5/c20-15(18-24)11-13(10-12-6-2-1-3-7-12)16(21)19-9-5-4-8-14(19)17(22)23/h1-3,6-7,13-14,24H,4-5,8-11H2,(H,18,20)(H,22,23)/t13-,14+/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney neutral endopeptidase (NEP)


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50018218
PNG
((R,S)2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino...)
Show SMILES ONC(=O)CC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H22N2O5/c23-18(22-27)13-16(11-14-7-3-1-4-8-14)19(24)21-17(20(25)26)12-15-9-5-2-6-10-15/h1-10,16-17,27H,11-13H2,(H,21,24)(H,22,23)(H,25,26)
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n/an/a 130n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)


Article DOI: 10.1021/jm00127a017
BindingDB Entry DOI: 10.7270/Q2610Z9F
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50018218
PNG
((R,S)2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino...)
Show SMILES ONC(=O)CC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H22N2O5/c23-18(22-27)13-16(11-14-7-3-1-4-8-14)19(24)21-17(20(25)26)12-15-9-5-2-6-10-15/h1-10,16-17,27H,11-13H2,(H,21,24)(H,22,23)(H,25,26)
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of neutral endopeptidase activity in rabbit kidney with 20 nM [3H]-D-Ala2-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)


Article DOI: 10.1021/jm00127a017
BindingDB Entry DOI: 10.7270/Q2610Z9F
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50018218
PNG
((R,S)2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino...)
Show SMILES ONC(=O)CC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H22N2O5/c23-18(22-27)13-16(11-14-7-3-1-4-8-14)19(24)21-17(20(25)26)12-15-9-5-2-6-10-15/h1-10,16-17,27H,11-13H2,(H,21,24)(H,22,23)(H,25,26)
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UA 498 CNRS

Curated by ChEMBL


Assay Description
Inhibition of [3H]Ala2-Leu-enkephalin binding to Neutral endopeptidase (NEP)


J Med Chem 31: 1825-31 (1988)


Article DOI: 10.1021/jm00117a025
BindingDB Entry DOI: 10.7270/Q2R49RC8
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50285634
PNG
((R)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCCC[C@@H]1C(O)=O
Show InChI InChI=1S/C17H22N2O5/c20-15(18-24)11-13(10-12-6-2-1-3-7-12)16(21)19-9-5-4-8-14(19)17(22)23/h1-3,6-7,13-14,24H,4-5,8-11H2,(H,18,20)(H,22,23)/t13-,14-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Gyeongsang National University (GNU)

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase


Eur J Med Chem 46: 1593-603 (2011)


Article DOI: 10.1016/j.ejmech.2011.02.007
BindingDB Entry DOI: 10.7270/Q2K64JDG
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50285632
PNG
((S)-2-[((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)...)
Show SMILES C[C@H](N(C)C(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C15H20N2O5/c1-10(15(20)21)17(2)14(19)12(9-13(18)16-22)8-11-6-4-3-5-7-11/h3-7,10,12,22H,8-9H2,1-2H3,(H,16,18)(H,20,21)/t10-,12+/m0/s1
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n/an/a 3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human Leukotriene A4 hydrolase


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50285634
PNG
((R)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCCC[C@@H]1C(O)=O
Show InChI InChI=1S/C17H22N2O5/c20-15(18-24)11-13(10-12-6-2-1-3-7-12)16(21)19-9-5-4-8-14(19)17(22)23/h1-3,6-7,13-14,24H,4-5,8-11H2,(H,18,20)(H,22,23)/t13-,14-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human Leukotriene A4 hydrolase


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50285635
PNG
((S)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C16H20N2O5/c19-14(17-23)10-12(9-11-5-2-1-3-6-11)15(20)18-8-4-7-13(18)16(21)22/h1-3,5-6,12-13,23H,4,7-10H2,(H,17,19)(H,21,22)/t12-,13+/m1/s1
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n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human Leukotriene A4 hydrolase


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50285638
PNG
((R)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C16H20N2O5/c19-14(17-23)10-12(9-11-5-2-1-3-6-11)15(20)18-8-4-7-13(18)16(21)22/h1-3,5-6,12-13,23H,4,7-10H2,(H,17,19)(H,21,22)/t12-,13-/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human Leukotriene A4 hydrolase


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50285635
PNG
((S)-1-((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)-...)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C16H20N2O5/c19-14(17-23)10-12(9-11-5-2-1-3-6-11)15(20)18-8-4-7-13(18)16(21)22/h1-3,5-6,12-13,23H,4,7-10H2,(H,17,19)(H,21,22)/t12-,13+/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney neutral endopeptidase (NEP)


Bioorg Med Chem Lett 5: 2517-2522 (1995)


Article DOI: 10.1016/0960-894X(95)00441-U
BindingDB Entry DOI: 10.7270/Q2959J1M
More data for this
Ligand-Target Pair