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30 similar compounds to monomer 50019624

Compile data set for download or QSAR
Wt: 378.5
BDBM50019592
Wt: 304.3
BDBM50019594
Wt: 298.3
BDBM50019596
Wt: 330.4
BDBM50019597
Wt: 302.4
BDBM50019599
Wt: 344.4
BDBM50019601
Wt: 358.5
BDBM50019602
Wt: 350.4
BDBM50019604
Wt: 358.5
BDBM50019605
Wt: 274.3
BDBM50019629
Wt: 316.4
BDBM50019630
Wt: 316.4
BDBM50019631
Wt: 274.3
BDBM50019634
Wt: 302.4
BDBM50019635
Wt: 286.3
BDBM50019636
Displayed 1 to 15 (of 30 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50019592,50019594,50019596,50019597,50019599,50019601,50019602,50019604,50019605,50019629,50019630,50019631,50019634,50019635,50019636   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019592
PNG
(1-(2-Ethoxy-ethyl)-2-(4-phenethyl-piperazin-1-yl)-...)
Show SMILES CCOCCn1c(nc2ccccc12)N1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C23H30N4O/c1-2-28-19-18-27-22-11-7-6-10-21(22)24-23(27)26-16-14-25(15-17-26)13-12-20-8-4-3-5-9-20/h3-11H,2,12-19H2,1H3
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n/an/a 31n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019636
PNG
(2-(4-Methyl-piperazin-1-yl)-1-(2-vinyloxy-ethyl)-1...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2n1CCOC=C
Show InChI InChI=1S/C16H22N4O/c1-3-21-13-12-20-15-7-5-4-6-14(15)17-16(20)19-10-8-18(2)9-11-19/h3-7H,1,8-13H2,2H3
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019596
PNG
(2-(4-Methyl-piperazin-1-yl)-1-(2-prop-2-ynyloxy-et...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2n1CCOCC#C
Show InChI InChI=1S/C17H22N4O/c1-3-13-22-14-12-21-16-7-5-4-6-15(16)18-17(21)20-10-8-19(2)9-11-20/h1,4-7H,8-14H2,2H3
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019597
PNG
(2-(4-Butyl-piperazin-1-yl)-1-(2-ethoxy-ethyl)-1H-b...)
Show SMILES CCCCN1CCN(CC1)c1nc2ccccc2n1CCOCC
Show InChI InChI=1S/C19H30N4O/c1-3-5-10-21-11-13-22(14-12-21)19-20-17-8-6-7-9-18(17)23(19)15-16-24-4-2/h6-9H,3-5,10-16H2,1-2H3
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019599
PNG
(2-(4-Methyl-piperazin-1-yl)-1-(2-propoxy-ethyl)-1H...)
Show SMILES CCCOCCn1c(nc2ccccc12)N1CCN(C)CC1
Show InChI InChI=1S/C17H26N4O/c1-3-13-22-14-12-21-16-7-5-4-6-15(16)18-17(21)20-10-8-19(2)9-11-20/h4-7H,3,8-14H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019601
PNG
(1-(2-Ethoxy-ethyl)-2-(4-pentyl-piperazin-1-yl)-1H-...)
Show SMILES CCCCCN1CCN(CC1)c1nc2ccccc2n1CCOCC
Show InChI InChI=1S/C20H32N4O/c1-3-5-8-11-22-12-14-23(15-13-22)20-21-18-9-6-7-10-19(18)24(20)16-17-25-4-2/h6-7,9-10H,3-5,8,11-17H2,1-2H3
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n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019602
PNG
(1-(2-Ethoxy-ethyl)-2-(4-hexyl-piperazin-1-yl)-1H-b...)
Show SMILES CCCCCCN1CCN(CC1)c1nc2ccccc2n1CCOCC
Show InChI InChI=1S/C21H34N4O/c1-3-5-6-9-12-23-13-15-24(16-14-23)21-22-19-10-7-8-11-20(19)25(21)17-18-26-4-2/h7-8,10-11H,3-6,9,12-18H2,1-2H3
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n/an/a 8.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019604
PNG
(1-(2-Ethoxy-ethyl)-2-(4-phenyl-piperazin-1-yl)-1H-...)
Show SMILES CCOCCn1c(nc2ccccc12)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H26N4O/c1-2-26-17-16-25-20-11-7-6-10-19(20)22-21(25)24-14-12-23(13-15-24)18-8-4-3-5-9-18/h3-11H,2,12-17H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019605
PNG
(1-(2-Ethoxy-ethyl)-2-(4-pentyl-[1,4]diazepan-1-yl)...)
Show SMILES CCCCCN1CCCN(CC1)c1nc2ccccc2n1CCOCC
Show InChI InChI=1S/C21H34N4O/c1-3-5-8-12-23-13-9-14-24(16-15-23)21-22-19-10-6-7-11-20(19)25(21)17-18-26-4-2/h6-7,10-11H,3-5,8-9,12-18H2,1-2H3
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n/an/a 7.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019630
PNG
(1-(2-Ethoxy-ethyl)-2-(4-ethyl-[1,4]diazepan-1-yl)-...)
Show SMILES CCOCCn1c(nc2ccccc12)N1CCCN(CC)CC1
Show InChI InChI=1S/C18H28N4O/c1-3-20-10-7-11-21(13-12-20)18-19-16-8-5-6-9-17(16)22(18)14-15-23-4-2/h5-6,8-9H,3-4,7,10-15H2,1-2H3
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n/an/a 16n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019629
PNG
(1-(2-Ethoxy-ethyl)-2-piperazin-1-yl-1H-benzoimidaz...)
Show SMILES CCOCCn1c(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C15H22N4O/c1-2-20-12-11-19-14-6-4-3-5-13(14)17-15(19)18-9-7-16-8-10-18/h3-6,16H,2,7-12H2,1H3
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n/an/a 11n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019634
PNG
(1-(2-Methoxy-ethyl)-2-(4-methyl-piperazin-1-yl)-1H...)
Show SMILES COCCn1c(nc2ccccc12)N1CCN(C)CC1
Show InChI InChI=1S/C15H22N4O/c1-17-7-9-18(10-8-17)15-16-13-5-3-4-6-14(13)19(15)11-12-20-2/h3-6H,7-12H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019631
PNG
(1-(2-Ethoxy-ethyl)-2-(4-propyl-piperazin-1-yl)-1H-...)
Show SMILES CCCN1CCN(CC1)c1nc2ccccc2n1CCOCC
Show InChI InChI=1S/C18H28N4O/c1-3-9-20-10-12-21(13-11-20)18-19-16-7-5-6-8-17(16)22(18)14-15-23-4-2/h5-8H,3-4,9-15H2,1-2H3
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n/an/a 16n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019635
PNG
(1-(2-Ethoxy-ethyl)-2-(4-ethyl-piperazin-1-yl)-1H-b...)
Show SMILES CCOCCn1c(nc2ccccc12)N1CCN(CC)CC1
Show InChI InChI=1S/C17H26N4O/c1-3-19-9-11-20(12-10-19)17-18-15-7-5-6-8-16(15)21(17)13-14-22-4-2/h5-8H,3-4,9-14H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019594
PNG
(2-{2-[2-(4-Methyl-piperazin-1-yl)-benzoimidazol-1-...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2n1CCOCCO
Show InChI InChI=1S/C16H24N4O2/c1-18-6-8-19(9-7-18)16-17-14-4-2-3-5-15(14)20(16)10-12-22-13-11-21/h2-5,21H,6-13H2,1H3
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n/an/a 42n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair