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16 similar compounds to monomer 16312

Compile data set for download or QSAR
Wt: 268.2
BDBM50022490
Wt: 248.2
BDBM50022395
Wt: 286.2
BDBM50022396
Wt: 310.3
BDBM50022447
Wt: 298.2
BDBM50022499
Wt: 294.3
BDBM50022401
Wt: 246.2
BDBM50022453
Wt: 261.2
BDBM50022405
Wt: 236.1
BDBM50022464
Purchase
Wt: 250.2
BDBM50022419
Wt: 274.3
BDBM50022421
Wt: 297.1
BDBM50022473
Wt: 218.2
BDBM50022425
Purchase
Wt: 252.6
BDBM50022480
Wt: 232.2
BDBM50022486
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50022490,50022395,50022396,50022447,50022499,50022401,50022453,50022405,50022464,50022419,50022421,50022473,50022425,50022480,50022486   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022421
PNG
(6-(tert-butyl)spiro[3,4-dihydro-2H-chromene-4,4'-(...)
Show SMILES CC(C)(C)c1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C15H18N2O3/c1-14(2,3)9-4-5-11-10(8-9)15(6-7-20-11)12(18)16-13(19)17-15/h4-5,8H,6-7H2,1-3H3,(H2,16,17,18,19)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022499
PNG
(7-methoxyspiro[3,4-dihydro-2H-benzo[h]chromene-4,4...)
Show SMILES COc1cccc2c3OCCC4(NC(=O)NC4=O)c3ccc12
Show InChI InChI=1S/C16H14N2O4/c1-21-12-4-2-3-10-9(12)5-6-11-13(10)22-8-7-16(11)14(19)17-15(20)18-16/h2-6H,7-8H2,1H3,(H2,17,18,19,20)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022464
PNG
(6-fluoro-(4'R)-spiro[3,4-dihydro-2H-chromene-4,4'-...)
Show SMILES Fc1ccc2OCC[C@@]3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022395
PNG
(6-methoxyspiro[3,4-dihydro-2H-chromene-4,4'-(tetra...)
Show SMILES COc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C12H12N2O4/c1-17-7-2-3-9-8(6-7)12(4-5-18-9)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022486
PNG
(6-methylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Show SMILES Cc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C12H12N2O3/c1-7-2-3-9-8(6-7)12(4-5-17-9)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022401
PNG
(8-phenylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Show SMILES O=C1NC(=O)C2(CCOc3c(cccc23)-c2ccccc2)N1
Show InChI InChI=1S/C17H14N2O3/c20-15-17(19-16(21)18-15)9-10-22-14-12(7-4-8-13(14)17)11-5-2-1-3-6-11/h1-8H,9-10H2,(H2,18,19,20,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022473
PNG
(6-bromospiro[3,4-dihydro-2H-chromene-4,4'-(tetrahy...)
Show SMILES Brc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C11H9BrN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022396
PNG
(7-trifluoromethylspiro[3,4-dihydro-2H-chromene-4,4...)
Show SMILES FC(F)(F)c1ccc2c(OCCC22NC(=O)NC2=O)c1
Show InChI InChI=1S/C12H9F3N2O3/c13-12(14,15)6-1-2-7-8(5-6)20-4-3-11(7)9(18)16-10(19)17-11/h1-2,5H,3-4H2,(H2,16,17,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50022419
PNG
(6-fluoro-1'-methyl-(4'S)-spiro[3,4-dihydro-2H-chro...)
Show SMILES CN1C(=O)N[C@]2(CCOc3ccc(F)cc23)C1=O
Show InChI InChI=1S/C12H11FN2O3/c1-15-10(16)12(14-11(15)17)4-5-18-9-3-2-7(13)6-8(9)12/h2-3,6H,4-5H2,1H3,(H,14,17)/t12-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified human placenta aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022425
PNG
(2,3-dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolid...)
Show SMILES O=C1NC(=O)C2(CCOc3ccccc23)N1
Show InChI InChI=1S/C11H10N2O3/c14-9-11(13-10(15)12-9)5-6-16-8-4-2-1-3-7(8)11/h1-4H,5-6H2,(H2,12,13,14,15)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022447
PNG
(6-phenoxyspiro[3,4-dihydro-2H-chromene-4,4'-(tetra...)
Show SMILES O=C1NC(=O)C2(CCOc3ccc(Oc4ccccc4)cc23)N1
Show InChI InChI=1S/C17H14N2O4/c20-15-17(19-16(21)18-15)8-9-22-14-7-6-12(10-13(14)17)23-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H2,18,19,20,21)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022453
PNG
(6,8-dimethylspiro[3,4-dihydro-2H-chromene-4,4'-(te...)
Show SMILES Cc1cc(C)c2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C13H14N2O3/c1-7-5-8(2)10-9(6-7)13(3-4-18-10)11(16)14-12(17)15-13/h5-6H,3-4H2,1-2H3,(H2,14,15,16,17)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022480
PNG
(CHEMBL78963 | c6-chlorospiro[3,4-dihydro-2H-chrome...)
Show SMILES Clc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C11H9ClN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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n/an/a 100n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022490
PNG
(CHEMBL81353 | cspiro[2,3-dihydro-1H-benzo[f]chrome...)
Show SMILES O=C1NC(=O)C2(CCOc3ccc4ccccc4c23)N1
Show InChI InChI=1S/C15H12N2O3/c18-13-15(17-14(19)16-13)7-8-20-11-6-5-9-3-1-2-4-10(9)12(11)15/h1-6H,7-8H2,(H2,16,17,18,19)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022405
PNG
(2',5'-dioxospiro[3,4-dihydro-2H-chromene-4,4'-(tet...)
Show SMILES NC(=O)c1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C12H11N3O4/c13-9(16)6-1-2-8-7(5-6)12(3-4-19-8)10(17)14-11(18)15-12/h1-2,5H,3-4H2,(H2,13,16)(H2,14,15,17,18)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair