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12 similar compounds to monomer 50024791

Compile data set for download or QSAR
Wt: 292.2
BDBM50148063
Wt: 276.2
BDBM50148066
Wt: 292.2
BDBM50148067
Wt: 322.3
BDBM50148068
Wt: 276.2
BDBM50148069
Wt: 276.2
BDBM50191393
Wt: 294.2
BDBM50191416
Wt: 341.1
BDBM50191440
Wt: 296.7
BDBM50191445
Wt: 388.1
BDBM50191449
Wt: 262.2
BDBM50023867
Wt: 342.3
BDBM50023871

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50148063,50148066,50148067,50148068,50148069,50191393,50191416,50191440,50191445,50191449,50023867,50023871   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50023871
PNG
(CHEMBL1207227)
Show SMILES Oc1[nH]c2ccc(cc2c1C1=Nc2ccccc2C1=O)S(O)(=O)=O
Show InChI InChI=1S/C16H10N2O5S/c19-15-9-3-1-2-4-11(9)17-14(15)13-10-7-8(24(21,22)23)5-6-12(10)18-16(13)20/h1-7,18,20H,(H,21,22,23)
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n/an/a 40n/an/an/an/an/an/a



Georgetown University

Curated by ChEMBL


Assay Description
Inhibition of CDK1


AAPS J 8: 204-21 (2006)


Article DOI: 10.1208/aapsj080125
BindingDB Entry DOI: 10.7270/Q2TX3GBS
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50191440
PNG
((2'Z)-7-bromoindirubin | CHEMBL214173)
Show SMILES Oc1[nH]c2c(Br)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9BrN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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n/an/a>1.00E+5n/an/an/an/an/an/a



C.N.R.S.

Curated by ChEMBL


Assay Description
Inhibition of mammalian CDK5/p25


J Med Chem 49: 4638-49 (2006)


Article DOI: 10.1021/jm060314i
BindingDB Entry DOI: 10.7270/Q21G0N3Z
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50023871
PNG
(CHEMBL1207227)
Show SMILES Oc1[nH]c2ccc(cc2c1C1=Nc2ccccc2C1=O)S(O)(=O)=O
Show InChI InChI=1S/C16H10N2O5S/c19-15-9-3-1-2-4-11(9)17-14(15)13-10-7-8(24(21,22)23)5-6-12(10)18-16(13)20/h1-7,18,20H,(H,21,22,23)
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Georgetown University

Curated by ChEMBL


Assay Description
Inhibition of CDK4


AAPS J 8: 204-21 (2006)


Article DOI: 10.1208/aapsj080125
BindingDB Entry DOI: 10.7270/Q2TX3GBS
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50191449
PNG
((2'Z)-7-iodoindirubin | CHEMBL379160)
Show SMILES Oc1[nH]c2c(I)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9IN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aurora A kinase


J Med Chem 50: 4027-37 (2007)


Article DOI: 10.1021/jm070077z
BindingDB Entry DOI: 10.7270/Q2PC323X
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50191440
PNG
((2'Z)-7-bromoindirubin | CHEMBL214173)
Show SMILES Oc1[nH]c2c(Br)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9BrN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aurora B kinase


J Med Chem 50: 4027-37 (2007)


Article DOI: 10.1021/jm070077z
BindingDB Entry DOI: 10.7270/Q2PC323X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C


(Homo sapiens (Human))
BDBM50191440
PNG
((2'Z)-7-bromoindirubin | CHEMBL214173)
Show SMILES Oc1[nH]c2c(Br)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9BrN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aurora C kinase


J Med Chem 50: 4027-37 (2007)


Article DOI: 10.1021/jm070077z
BindingDB Entry DOI: 10.7270/Q2PC323X
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50191445
PNG
((2'Z)-7-chloroindirubin | CHEMBL378191)
Show SMILES Oc1[nH]c2c(Cl)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9ClN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aurora B kinase


J Med Chem 50: 4027-37 (2007)


Article DOI: 10.1021/jm070077z
BindingDB Entry DOI: 10.7270/Q2PC323X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C


(Homo sapiens (Human))
BDBM50191445
PNG
((2'Z)-7-chloroindirubin | CHEMBL378191)
Show SMILES Oc1[nH]c2c(Cl)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9ClN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aurora C kinase


J Med Chem 50: 4027-37 (2007)


Article DOI: 10.1021/jm070077z
BindingDB Entry DOI: 10.7270/Q2PC323X
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50191445
PNG
((2'Z)-7-chloroindirubin | CHEMBL378191)
Show SMILES Oc1[nH]c2c(Cl)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9ClN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aurora A kinase


J Med Chem 50: 4027-37 (2007)


Article DOI: 10.1021/jm070077z
BindingDB Entry DOI: 10.7270/Q2PC323X
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50191440
PNG
((2'Z)-7-bromoindirubin | CHEMBL214173)
Show SMILES Oc1[nH]c2c(Br)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9BrN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aurora A kinase


J Med Chem 50: 4027-37 (2007)


Article DOI: 10.1021/jm070077z
BindingDB Entry DOI: 10.7270/Q2PC323X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C


(Homo sapiens (Human))
BDBM50191449
PNG
((2'Z)-7-iodoindirubin | CHEMBL379160)
Show SMILES Oc1[nH]c2c(I)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9IN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aurora C kinase


J Med Chem 50: 4027-37 (2007)


Article DOI: 10.1021/jm070077z
BindingDB Entry DOI: 10.7270/Q2PC323X
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50191449
PNG
((2'Z)-7-iodoindirubin | CHEMBL379160)
Show SMILES Oc1[nH]c2c(I)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9IN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aurora B kinase


J Med Chem 50: 4027-37 (2007)


Article DOI: 10.1021/jm070077z
BindingDB Entry DOI: 10.7270/Q2PC323X
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50023867
PNG
(INDIRUBIN | Indirubin)
Show SMILES Oc1[nH]c2ccccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,18,20H
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n/an/a 1.00E+4n/an/an/an/an/an/a



Guru Nanak Dev University

Curated by ChEMBL


Assay Description
Inhibition of CDK1


Eur J Med Chem 45: 4968-82 (2010)


Article DOI: 10.1016/j.ejmech.2010.08.004
BindingDB Entry DOI: 10.7270/Q2348KQD
More data for this
Ligand-Target Pair
Beta-chymotrypsin


(Homo sapiens (Human))
BDBM50023867
PNG
(INDIRUBIN | Indirubin)
Show SMILES Oc1[nH]c2ccccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,18,20H
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n/an/a 1.00E+5n/an/an/an/an/an/a



Northwestern University

Curated by ChEMBL


Assay Description
Inhibitory activity against Chymotrypsinogen from Thermus flavus


J Med Chem 46: 1478-83 (2003)


Article DOI: 10.1021/jm020427b
BindingDB Entry DOI: 10.7270/Q2R78FZT
More data for this
Ligand-Target Pair
Malate dehydrogenase


(Thermus thermophilus)
BDBM50023867
PNG
(INDIRUBIN | Indirubin)
Show SMILES Oc1[nH]c2ccccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,18,20H
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n/an/a 3.00E+4n/an/an/an/an/an/a



Northwestern University

Curated by ChEMBL


Assay Description
Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavus


J Med Chem 46: 1478-83 (2003)


Article DOI: 10.1021/jm020427b
BindingDB Entry DOI: 10.7270/Q2R78FZT
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50023867
PNG
(INDIRUBIN | Indirubin)
Show SMILES Oc1[nH]c2ccccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,18,20H
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n/an/a 2.20E+3n/an/an/an/an/an/a



Northwestern University

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 2 (CDK2)


J Med Chem 46: 1478-83 (2003)


Article DOI: 10.1021/jm020427b
BindingDB Entry DOI: 10.7270/Q2R78FZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50023867
PNG
(INDIRUBIN | Indirubin)
Show SMILES Oc1[nH]c2ccccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,18,20H
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n/an/a 1.80E+4n/an/an/an/an/an/a



Northwestern University

Curated by ChEMBL


Assay Description
Inhibition of Src tyrosine kinase


J Med Chem 46: 1478-83 (2003)


Article DOI: 10.1021/jm020427b
BindingDB Entry DOI: 10.7270/Q2R78FZT
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens (Human))
BDBM50148068
PNG
(5,5'-Dimethoxy-1H,1'H-[2,3']biindolylidene-3,2'-di...)
Show SMILES COc1ccc2N=C(C(=O)c2c1)c1c(O)[nH]c2ccc(OC)cc12
Show InChI InChI=1S/C18H14N2O4/c1-23-9-3-5-13-11(7-9)15(18(22)20-13)16-17(21)12-8-10(24-2)4-6-14(12)19-16/h3-8,20,22H,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 1-cyclin B of M-phase Marthasterias glacialis oocytes


J Med Chem 47: 3236-41 (2004)


Article DOI: 10.1021/jm030561b
BindingDB Entry DOI: 10.7270/Q21J9BHQ
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens (Human))
BDBM50148063
PNG
(5-Methoxy-1H,1'H-[2,3']biindolylidene-3,2'-dione |...)
Show SMILES COc1ccc2N=C(C(=O)c2c1)c1c(O)[nH]c2ccccc12
Show InChI InChI=1S/C17H12N2O3/c1-22-9-6-7-13-11(8-9)16(20)15(18-13)14-10-4-2-3-5-12(10)19-17(14)21/h2-8,19,21H,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 1-cyclin B of M-phase Marthasterias glacialis oocytes


J Med Chem 47: 3236-41 (2004)


Article DOI: 10.1021/jm030561b
BindingDB Entry DOI: 10.7270/Q21J9BHQ
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens (Human))
BDBM50148067
PNG
(5'-Methoxy-1H,1'H-[2,3']biindolylidene-3,2'-dione ...)
Show SMILES COc1ccc2[nH]c(O)c(C3=Nc4ccccc4C3=O)c2c1
Show InChI InChI=1S/C17H12N2O3/c1-22-9-6-7-13-11(8-9)14(17(21)19-13)15-16(20)10-4-2-3-5-12(10)18-15/h2-8,19,21H,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 1-cyclin B of M-phase Marthasterias glacialis oocytes


J Med Chem 47: 3236-41 (2004)


Article DOI: 10.1021/jm030561b
BindingDB Entry DOI: 10.7270/Q21J9BHQ
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50148063
PNG
(5-Methoxy-1H,1'H-[2,3']biindolylidene-3,2'-dione |...)
Show SMILES COc1ccc2N=C(C(=O)c2c1)c1c(O)[nH]c2ccccc12
Show InChI InChI=1S/C17H12N2O3/c1-22-9-6-7-13-11(8-9)16(20)15(18-13)14-10-4-2-3-5-12(10)19-17(14)21/h2-8,19,21H,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 5-p35nck5a


J Med Chem 47: 3236-41 (2004)


Article DOI: 10.1021/jm030561b
BindingDB Entry DOI: 10.7270/Q21J9BHQ
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50148066
PNG
(5-Methyl-1H,1'H-[2,3']biindolylidene-3,2'-dione | ...)
Show SMILES Cc1ccc2N=C(C(=O)c2c1)c1c(O)[nH]c2ccccc12
Show InChI InChI=1S/C17H12N2O2/c1-9-6-7-13-11(8-9)16(20)15(18-13)14-10-4-2-3-5-12(10)19-17(14)21/h2-8,19,21H,1H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 5-p35nck5a


J Med Chem 47: 3236-41 (2004)


Article DOI: 10.1021/jm030561b
BindingDB Entry DOI: 10.7270/Q21J9BHQ
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50148067
PNG
(5'-Methoxy-1H,1'H-[2,3']biindolylidene-3,2'-dione ...)
Show SMILES COc1ccc2[nH]c(O)c(C3=Nc4ccccc4C3=O)c2c1
Show InChI InChI=1S/C17H12N2O3/c1-22-9-6-7-13-11(8-9)14(17(21)19-13)15-16(20)10-4-2-3-5-12(10)18-15/h2-8,19,21H,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 5-p35nck5a


J Med Chem 47: 3236-41 (2004)


Article DOI: 10.1021/jm030561b
BindingDB Entry DOI: 10.7270/Q21J9BHQ
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50148069
PNG
((Z)-5'-Methyl-1H,1'H-[2,3']biindolylidene-3,2'-dio...)
Show SMILES Cc1ccc2[nH]c(O)c(C3=Nc4ccccc4C3=O)c2c1
Show InChI InChI=1S/C17H12N2O2/c1-9-6-7-13-11(8-9)14(17(21)19-13)15-16(20)10-4-2-3-5-12(10)18-15/h2-8,19,21H,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 5-p35nck5a


J Med Chem 47: 3236-41 (2004)


Article DOI: 10.1021/jm030561b
BindingDB Entry DOI: 10.7270/Q21J9BHQ
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50148068
PNG
(5,5'-Dimethoxy-1H,1'H-[2,3']biindolylidene-3,2'-di...)
Show SMILES COc1ccc2N=C(C(=O)c2c1)c1c(O)[nH]c2ccc(OC)cc12
Show InChI InChI=1S/C18H14N2O4/c1-23-9-3-5-13-11(7-9)15(18(22)20-13)16-17(21)12-8-10(24-2)4-6-14(12)19-16/h3-8,20,22H,1-2H3
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n/an/a 800n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 5-p35nck5a


J Med Chem 47: 3236-41 (2004)


Article DOI: 10.1021/jm030561b
BindingDB Entry DOI: 10.7270/Q21J9BHQ
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50191393
PNG
((Z)-1'-Methyl-1H,1'H-[2,3']biindolylidene-3,2'-dio...)
Show SMILES Cn1c(O)c(C2=Nc3ccccc3C2=O)c2ccccc12
Show InChI InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)14(17(19)21)15-16(20)10-6-2-4-8-12(10)18-15/h2-9,21H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



C.N.R.S.

Curated by ChEMBL


Assay Description
Inhibition of mammalian CDK5/p25


J Med Chem 49: 4638-49 (2006)


Article DOI: 10.1021/jm060314i
BindingDB Entry DOI: 10.7270/Q21G0N3Z
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50191445
PNG
((2'Z)-7-chloroindirubin | CHEMBL378191)
Show SMILES Oc1[nH]c2c(Cl)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9ClN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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n/an/a>1.00E+5n/an/an/an/an/an/a



C.N.R.S.

Curated by ChEMBL


Assay Description
Inhibition of mammalian CDK5/p25


J Med Chem 49: 4638-49 (2006)


Article DOI: 10.1021/jm060314i
BindingDB Entry DOI: 10.7270/Q21G0N3Z
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50191449
PNG
((2'Z)-7-iodoindirubin | CHEMBL379160)
Show SMILES Oc1[nH]c2c(I)cccc2c1C1=Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9IN2O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)14-15(20)8-4-1-2-7-11(8)18-14/h1-7,19,21H
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n/an/a>1.00E+5n/an/an/an/an/an/a



C.N.R.S.

Curated by ChEMBL


Assay Description
Inhibition of mammalian CDK5/p25


J Med Chem 49: 4638-49 (2006)


Article DOI: 10.1021/jm060314i
BindingDB Entry DOI: 10.7270/Q21G0N3Z
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50191416
PNG
((2'Z)-7-fluoro-1-methylindirubin | CHEMBL378787)
Show SMILES Cn1c(O)c(C2=Nc3ccccc3C2=O)c2cccc(F)c12
Show InChI InChI=1S/C17H11FN2O2/c1-20-15-10(6-4-7-11(15)18)13(17(20)22)14-16(21)9-5-2-3-8-12(9)19-14/h2-8,22H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



C.N.R.S.

Curated by ChEMBL


Assay Description
Inhibition of mammalian CDK5/p25


J Med Chem 49: 4638-49 (2006)


Article DOI: 10.1021/jm060314i
BindingDB Entry DOI: 10.7270/Q21G0N3Z
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50023871
PNG
(CHEMBL1207227)
Show SMILES Oc1[nH]c2ccc(cc2c1C1=Nc2ccccc2C1=O)S(O)(=O)=O
Show InChI InChI=1S/C16H10N2O5S/c19-15-9-3-1-2-4-11(9)17-14(15)13-10-7-8(24(21,22)23)5-6-12(10)18-16(13)20/h1-7,18,20H,(H,21,22,23)
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n/an/a 22n/an/an/an/an/an/a



Georgetown University

Curated by ChEMBL


Assay Description
Inhibition of CDK2


AAPS J 8: 204-21 (2006)


Article DOI: 10.1208/aapsj080125
BindingDB Entry DOI: 10.7270/Q2TX3GBS
More data for this
Ligand-Target Pair