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12 similar compounds to monomer 50024981

Compile data set for download or QSAR
Wt: 183.2
BDBM50024979
Wt: 193.2
BDBM50024980
Wt: 231.2
BDBM50024983
Wt: 181.2
BDBM50024985
Wt: 197.2
BDBM50024987
Wt: 155.1
BDBM50024988
Purchase
Wt: 260.1
BDBM50024989
Wt: 183.2
BDBM50024990
Wt: 183.2
BDBM50024992
Wt: 169.2
BDBM50024993
Purchase
Wt: 197.2
BDBM50024994
Wt: 179.1
BDBM50024995

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50024979,50024980,50024983,50024985,50024987,50024988,50024989,50024990,50024992,50024993,50024994,50024995   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024983
PNG
(3-Benzyloxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyr...)
Show SMILES C(Oc1noc2CC[NH2+]Cc12)c1ccccc1
Show InChI InChI=1S/C13H14N2O2/c1-2-4-10(5-3-1)9-16-13-11-8-14-7-6-12(11)17-15-13/h1-5,14H,6-9H2/p+1
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n/an/an/an/a>5.00E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024988
PNG
(3-Methoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyrid...)
Show SMILES COc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C7H10N2O2/c1-10-7-5-4-8-3-2-6(5)11-9-7/h8H,2-4H2,1H3/p+1
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n/an/a 4.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of radioactive N-propylbenzilycholine mustard ([3H]-PrBCM) to rat brain membranes


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024987
PNG
(3-Butoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridi...)
Show SMILES CCCCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C10H16N2O2/c1-2-3-6-13-10-8-7-11-5-4-9(8)14-12-10/h11H,2-7H2,1H3/p+1
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n/an/an/an/a>5.00E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024985
PNG
(3-Allyloxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyri...)
Show SMILES C=CCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H12N2O2/c1-2-5-12-9-7-6-10-4-3-8(7)13-11-9/h2,10H,1,3-6H2/p+1
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n/an/an/an/a 1.30E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024988
PNG
(3-Methoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyrid...)
Show SMILES COc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C7H10N2O2/c1-10-7-5-4-8-3-2-6(5)11-9-7/h8H,2-4H2,1H3/p+1
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n/an/an/an/a 1.80E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024990
PNG
(3-Propoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyrid...)
Show SMILES CCCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H14N2O2/c1-2-5-12-9-7-6-10-4-3-8(7)13-11-9/h10H,2-6H2,1H3/p+1
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n/an/an/an/a>5.00E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024989
PNG
(3-(2-Bromo-allyloxy)-4,5,6,7-tetrahydro-isoxazolo[...)
Show SMILES BrC(=C)COc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H11BrN2O2/c1-6(10)5-13-9-7-4-11-3-2-8(7)14-12-9/h11H,1-5H2/p+1
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n/an/an/an/a>5.00E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024993
PNG
(3-Ethoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridi...)
Show SMILES CCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C8H12N2O2/c1-2-11-8-6-5-9-4-3-7(6)12-10-8/h9H,2-5H2,1H3/p+1
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n/an/an/an/a 3.40E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024979
PNG
(3-Ethoxy-5-methyl-4,5,6,7-tetrahydro-isoxazolo[4,5...)
Show SMILES CCOc1noc2CC[NH+](C)Cc12
Show InChI InChI=1S/C9H14N2O2/c1-3-12-9-7-6-11(2)5-4-8(7)13-10-9/h3-6H2,1-2H3/p+1
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n/an/an/an/a 1.60E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024995
PNG
(3-Prop-2-ynyloxy-4,5,6,7-tetrahydro-isoxazolo[4,5-...)
Show SMILES C#CCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H10N2O2/c1-2-5-12-9-7-6-10-4-3-8(7)13-11-9/h1,10H,3-6H2/p+1
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n/an/an/an/a 1.20E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024994
PNG
(3-Isobutoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyr...)
Show SMILES CC(C)COc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C10H16N2O2/c1-7(2)6-13-10-8-5-11-4-3-9(8)14-12-10/h7,11H,3-6H2,1-2H3/p+1
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n/an/an/an/a>5.00E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024992
PNG
(3-Isopropoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]py...)
Show SMILES CC(C)Oc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H14N2O2/c1-6(2)12-9-7-5-10-4-3-8(7)13-11-9/h6,10H,3-5H2,1-2H3/p+1
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n/an/an/an/a>5.00E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024983
PNG
(3-Benzyloxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyr...)
Show SMILES C(Oc1noc2CC[NH2+]Cc12)c1ccccc1
Show InChI InChI=1S/C13H14N2O2/c1-2-4-10(5-3-1)9-16-13-11-8-14-7-6-12(11)17-15-13/h1-5,14H,6-9H2/p+1
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n/an/a 3.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024992
PNG
(3-Isopropoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]py...)
Show SMILES CC(C)Oc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H14N2O2/c1-6(2)12-9-7-5-10-4-3-8(7)13-11-9/h6,10H,3-5H2,1-2H3/p+1
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n/an/a 3.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024990
PNG
(3-Propoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyrid...)
Show SMILES CCCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H14N2O2/c1-2-5-12-9-7-6-10-4-3-8(7)13-11-9/h10H,2-6H2,1H3/p+1
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024985
PNG
(3-Allyloxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyri...)
Show SMILES C=CCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H12N2O2/c1-2-5-12-9-7-6-10-4-3-8(7)13-11-9/h2,10H,1,3-6H2/p+1
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n/an/a 9.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024979
PNG
(3-Ethoxy-5-methyl-4,5,6,7-tetrahydro-isoxazolo[4,5...)
Show SMILES CCOc1noc2CC[NH+](C)Cc12
Show InChI InChI=1S/C9H14N2O2/c1-3-12-9-7-6-11(2)5-4-8(7)13-10-9/h3-6H2,1-2H3/p+1
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n/an/a 2.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50024987
PNG
(3-Butoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridi...)
Show SMILES CCCCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C10H16N2O2/c1-2-3-6-13-10-8-7-11-5-4-9(8)14-12-10/h11H,2-7H2,1H3/p+1
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50024994
PNG
(3-Isobutoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyr...)
Show SMILES CC(C)COc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C10H16N2O2/c1-7(2)6-13-10-8-5-11-4-3-9(8)14-12-10/h7,11H,3-6H2,1-2H3/p+1
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n/an/a 4.90E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024995
PNG
(3-Prop-2-ynyloxy-4,5,6,7-tetrahydro-isoxazolo[4,5-...)
Show SMILES C#CCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H10N2O2/c1-2-5-12-9-7-6-10-4-3-8(7)13-11-9/h1,10H,3-6H2/p+1
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n/an/a 5.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024989
PNG
(3-(2-Bromo-allyloxy)-4,5,6,7-tetrahydro-isoxazolo[...)
Show SMILES BrC(=C)COc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H11BrN2O2/c1-6(10)5-13-9-7-4-11-3-2-8(7)14-12-9/h11H,1-5H2/p+1
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n/an/a 1.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024993
PNG
(3-Ethoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridi...)
Show SMILES CCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C8H12N2O2/c1-2-11-8-6-5-9-4-3-7(6)12-10-8/h9H,2-5H2,1H3/p+1
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n/an/a 6.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of solubilized, purified rat liver HMG-CoA reductase.


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024987
PNG
(3-Butoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridi...)
Show SMILES CCCCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C10H16N2O2/c1-2-3-6-13-10-8-7-11-5-4-9(8)14-12-10/h11H,2-7H2,1H3/p+1
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n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of radioactive N-propylbenzilycholine mustard ([3H]-PrBCM) to rat brain membranes


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024994
PNG
(3-Isobutoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyr...)
Show SMILES CC(C)COc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C10H16N2O2/c1-7(2)6-13-10-8-5-11-4-3-9(8)14-12-10/h7,11H,3-6H2,1-2H3/p+1
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of radioactive N-propylbenzilycholine mustard ([3H]-PrBCM) to rat brain membranes


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50024989
PNG
(3-(2-Bromo-allyloxy)-4,5,6,7-tetrahydro-isoxazolo[...)
Show SMILES BrC(=C)COc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H11BrN2O2/c1-6(10)5-13-9-7-4-11-3-2-8(7)14-12-9/h11H,1-5H2/p+1
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n/an/a 2.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against peripheral Muscarinic acetylcholine receptor in guinea pig ileum as inhibition of acetylcholine induced muscle...


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50024992
PNG
(3-Isopropoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]py...)
Show SMILES CC(C)Oc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H14N2O2/c1-6(2)12-9-7-5-10-4-3-8(7)13-11-9/h6,10H,3-5H2,1-2H3/p+1
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n/an/a 1.10E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against peripheral Muscarinic acetylcholine receptor in guinea pig ileum as inhibition of acetylcholine induced muscle...


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50024990
PNG
(3-Propoxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyrid...)
Show SMILES CCCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C9H14N2O2/c1-2-5-12-9-7-6-10-4-3-8(7)13-11-9/h10H,2-6H2,1H3/p+1
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n/an/a 3.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against peripheral Muscarinic acetylcholine receptor in guinea pig ileum as inhibition of acetylcholine induced muscle...


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50024983
PNG
(3-Benzyloxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyr...)
Show SMILES C(Oc1noc2CC[NH2+]Cc12)c1ccccc1
Show InChI InChI=1S/C13H14N2O2/c1-2-4-10(5-3-1)9-16-13-11-8-14-7-6-12(11)17-15-13/h1-5,14H,6-9H2/p+1
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n/an/a 4.80E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against peripheral Muscarinic acetylcholine receptor in guinea pig ileum as inhibition of acetylcholine induced muscle...


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50024980
PNG
(3-But-2-ynyloxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c...)
Show SMILES CC#CCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C10H12N2O2/c1-2-3-6-13-10-8-7-11-5-4-9(8)14-12-10/h11H,4-7H2,1H3/p+1
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n/an/a 5.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of radioactive N-propylbenzilycholine mustard ([3H]-PrBCM) to rat brain membranes


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50024980
PNG
(3-But-2-ynyloxy-4,5,6,7-tetrahydro-isoxazolo[4,5-c...)
Show SMILES CC#CCOc1noc2CC[NH2+]Cc12
Show InChI InChI=1S/C10H12N2O2/c1-2-3-6-13-10-8-7-11-5-4-9(8)14-12-10/h11H,4-7H2,1H3/p+1
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n/an/an/an/a 4.50E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine


J Med Chem 29: 1004-9 (1986)


Article DOI: 10.1021/jm00156a018
BindingDB Entry DOI: 10.7270/Q2XP73XW
More data for this
Ligand-Target Pair