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4 similar compounds to monomer 25759

Compile data set for download or QSAR
Wt: 298.3
BDBM50027663
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Wt: 356.4
BDBM50267196
Wt: 356.4
BDBM50267197
Wt: 356.4
BDBM50267198

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50027663,50267196,50267197,50267198   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-2 adrenergic receptor and beta-3 adrenergic receptor


(Homo sapiens (Human))
BDBM50027663
PNG
(1-(9H-Carbazol-4-yloxy)-3-isopropylamino-propan-2-...)
Show SMILES CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12
Show InChI InChI=1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3
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MMDB

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Article
PubMed
0.114n/an/an/an/an/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]DHA from human beta2 adrenoceptor by liquid scintillation counter


Bioorg Med Chem Lett 18: 5391-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.046
BindingDB Entry DOI: 10.7270/Q2FB52RP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50267197
PNG
((2S)-1-(1H-Indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)...)
Show SMILES COc1ccccc1OCCNC[C@H](O)COc1cccc2[nH]ccc12
Show InChI InChI=1S/C20H24N2O4/c1-24-19-6-2-3-7-20(19)25-12-11-21-13-15(23)14-26-18-8-4-5-17-16(18)9-10-22-17/h2-10,15,21-23H,11-14H2,1H3/t15-/m0/s1
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2n/an/an/an/an/an/an/an/a



Rzeszów University of Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation method


Eur J Med Chem 44: 809-17 (2009)


Article DOI: 10.1016/j.ejmech.2008.05.019
BindingDB Entry DOI: 10.7270/Q29Z94QJ
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50267196
PNG
((+/-)1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)e...)
Show SMILES COc1ccccc1OCCNCC(O)COc1cccc2[nH]ccc12
Show InChI InChI=1S/C20H24N2O4/c1-24-19-6-2-3-7-20(19)25-12-11-21-13-15(23)14-26-18-8-4-5-17-16(18)9-10-22-17/h2-10,15,21-23H,11-14H2,1H3
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3n/an/an/an/an/an/an/an/a



Rzeszów University of Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation method


Eur J Med Chem 44: 809-17 (2009)


Article DOI: 10.1016/j.ejmech.2008.05.019
BindingDB Entry DOI: 10.7270/Q29Z94QJ
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50267198
PNG
((2R)-1-(1H-Indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)...)
Show SMILES COc1ccccc1OCCNC[C@@H](O)COc1cccc2[nH]ccc12
Show InChI InChI=1S/C20H24N2O4/c1-24-19-6-2-3-7-20(19)25-12-11-21-13-15(23)14-26-18-8-4-5-17-16(18)9-10-22-17/h2-10,15,21-23H,11-14H2,1H3/t15-/m1/s1
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143n/an/an/an/an/an/an/an/a



Rzeszów University of Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation method


Eur J Med Chem 44: 809-17 (2009)


Article DOI: 10.1016/j.ejmech.2008.05.019
BindingDB Entry DOI: 10.7270/Q29Z94QJ
More data for this
Ligand-Target Pair