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28 similar compounds to monomer 50029257

Compile data set for download or QSAR
Wt: 407.5
BDBM50029298
Wt: 421.5
BDBM50029300
Wt: 435.5
BDBM50029309
Wt: 443.5
BDBM50029310
Wt: 421.5
BDBM50036812
Wt: 421.5
BDBM50036813
Wt: 435.6
BDBM50064553
Wt: 463.6
BDBM50064554
Wt: 435.6
BDBM50064560
Wt: 465.6
BDBM50064565
Wt: 435.5
BDBM50064566
Wt: 449.6
BDBM50064568
Wt: 409.5
BDBM50064570
Wt: 439.5
BDBM50064528
Wt: 407.5
BDBM50064529
Displayed 1 to 15 (of 28 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50029298,50029300,50029309,50029310,50036812,50036813,50064553,50064554,50064560,50064565,50064566,50064568,50064570,50064528,50064529   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064529
PNG
(Azepan-1-yl-{3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(Cc2cccc(c2)C(=O)N2CCCCCC2)CC1
Show InChI InChI=1S/C25H33N3O2/c1-30-24-12-5-4-11-23(24)27-17-15-26(16-18-27)20-21-9-8-10-22(19-21)25(29)28-13-6-2-3-7-14-28/h4-5,8-12,19H,2-3,6-7,13-18,20H2,1H3
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0.460n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064565
PNG
(CHEMBL59167 | N,N-Dibutyl-3-[4-(2-isopropoxy-pheny...)
Show SMILES CCCCN(CCCC)C(=O)c1cccc(CN2CCN(CC2)c2ccccc2OC(C)C)c1
Show InChI InChI=1S/C29H43N3O2/c1-5-7-16-32(17-8-6-2)29(33)26-13-11-12-25(22-26)23-30-18-20-31(21-19-30)27-14-9-10-15-28(27)34-24(3)4/h9-15,22,24H,5-8,16-21,23H2,1-4H3
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0.800n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064568
PNG
(CHEMBL292107 | N-Cyclohexyl-3-[4-(2-isopropoxy-phe...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(=O)N(C)C2CCCCC2)CC1
Show InChI InChI=1S/C28H39N3O2/c1-22(2)33-27-15-8-7-14-26(27)31-18-16-30(17-19-31)21-23-10-9-11-24(20-23)28(32)29(3)25-12-5-4-6-13-25/h7-11,14-15,20,22,25H,4-6,12-13,16-19,21H2,1-3H3
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1.20n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064570
PNG
(CHEMBL64227 | N,N-Diethyl-3-[4-(2-isopropoxy-pheny...)
Show SMILES CCN(CC)C(=O)c1cccc(CN2CCN(CC2)c2ccccc2OC(C)C)c1
Show InChI InChI=1S/C25H35N3O2/c1-5-27(6-2)25(29)22-11-9-10-21(18-22)19-26-14-16-28(17-15-26)23-12-7-8-13-24(23)30-20(3)4/h7-13,18,20H,5-6,14-17,19H2,1-4H3
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2.10n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064553
PNG
((4-{2-[4-(2-Isopropoxy-phenyl)-piperazin-1-yl]-eth...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCc2ccc(cc2)C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C27H37N3O2/c1-22(2)32-26-9-5-4-8-25(26)29-20-18-28(19-21-29)17-14-23-10-12-24(13-11-23)27(31)30-15-6-3-7-16-30/h4-5,8-13,22H,3,6-7,14-21H2,1-2H3
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2.5n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029310
PNG
(N-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CNC(=O)c3ccccc3)c2)CC1
Show InChI InChI=1S/C28H33N3O2/c1-22(2)33-27-14-7-6-13-26(27)31-17-15-30(16-18-31)21-24-10-8-9-23(19-24)20-29-28(32)25-11-4-3-5-12-25/h3-14,19,22H,15-18,20-21H2,1-2H3,(H,29,32)
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3.70n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064566
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(=O)N2CCCCC2=O)CC1
Show InChI InChI=1S/C26H33N3O3/c1-20(2)32-24-11-4-3-10-23(24)28-16-14-27(15-17-28)19-21-8-7-9-22(18-21)26(31)29-13-6-5-12-25(29)30/h3-4,7-11,18,20H,5-6,12-17,19H2,1-2H3
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3.90n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064528
PNG
(CHEMBL60675 | {3-[4-(4-Fluoro-2-isopropoxy-phenyl)...)
Show SMILES CC(C)Oc1cc(F)ccc1N1CCN(Cc2cccc(c2)C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C26H34FN3O2/c1-20(2)32-25-18-23(27)9-10-24(25)29-15-13-28(14-16-29)19-21-7-6-8-22(17-21)26(31)30-11-4-3-5-12-30/h6-10,17-18,20H,3-5,11-16,19H2,1-2H3
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4.20n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064568
PNG
(CHEMBL292107 | N-Cyclohexyl-3-[4-(2-isopropoxy-phe...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(=O)N(C)C2CCCCC2)CC1
Show InChI InChI=1S/C28H39N3O2/c1-22(2)33-27-15-8-7-14-26(27)31-18-16-30(17-19-31)21-23-10-9-11-24(20-23)28(32)29(3)25-12-5-4-6-13-25/h7-11,14-15,20,22,25H,4-6,12-13,16-19,21H2,1-3H3
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5.40n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50036812
PNG
(CHEMBL10327 | {2-[4-(2-Isopropoxy-phenyl)-piperazi...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2ccccc2C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-13-7-6-12-24(25)28-18-16-27(17-19-28)20-22-10-4-5-11-23(22)26(30)29-14-8-3-9-15-29/h4-7,10-13,21H,3,8-9,14-20H2,1-2H3
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6.80n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor of rat brain synaptosomal preparations


J Med Chem 37: 1060-2 (1994)


Article DOI: 10.1021/jm00034a003
BindingDB Entry DOI: 10.7270/Q23R0RXB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029309
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3C(=O)CCCC3=O)c2)CC1
Show InChI InChI=1S/C26H33N3O3/c1-20(2)32-24-10-4-3-9-23(24)28-15-13-27(14-16-28)18-21-7-5-8-22(17-21)19-29-25(30)11-6-12-26(29)31/h3-5,7-10,17,20H,6,11-16,18-19H2,1-2H3
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8.60n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029300
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3CCCCC3=O)c2)CC1
Show InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-11-4-3-10-24(25)28-16-14-27(15-17-28)19-22-8-7-9-23(18-22)20-29-13-6-5-12-26(29)30/h3-4,7-11,18,21H,5-6,12-17,19-20H2,1-2H3
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10n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor of rat brain synaptosomal preparations


J Med Chem 37: 1060-2 (1994)


Article DOI: 10.1021/jm00034a003
BindingDB Entry DOI: 10.7270/Q23R0RXB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029300
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3CCCCC3=O)c2)CC1
Show InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-11-4-3-10-24(25)28-16-14-27(15-17-28)19-22-8-7-9-23(18-22)20-29-13-6-5-12-26(29)30/h3-4,7-11,18,21H,5-6,12-17,19-20H2,1-2H3
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10n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064570
PNG
(CHEMBL64227 | N,N-Diethyl-3-[4-(2-isopropoxy-pheny...)
Show SMILES CCN(CC)C(=O)c1cccc(CN2CCN(CC2)c2ccccc2OC(C)C)c1
Show InChI InChI=1S/C25H35N3O2/c1-5-27(6-2)25(29)22-11-9-10-21(18-22)19-26-14-16-28(17-15-26)23-12-7-8-13-24(23)30-20(3)4/h7-13,18,20H,5-6,14-17,19H2,1-4H3
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14n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064565
PNG
(CHEMBL59167 | N,N-Dibutyl-3-[4-(2-isopropoxy-pheny...)
Show SMILES CCCCN(CCCC)C(=O)c1cccc(CN2CCN(CC2)c2ccccc2OC(C)C)c1
Show InChI InChI=1S/C29H43N3O2/c1-5-7-16-32(17-8-6-2)29(33)26-13-11-12-25(22-26)23-30-18-20-31(21-19-30)27-14-9-10-15-28(27)34-24(3)4/h9-15,22,24H,5-8,16-21,23H2,1-4H3
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16n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064554
PNG
((4-{4-[4-(2-Isopropoxy-phenyl)-piperazin-1-yl]-but...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCc2ccc(cc2)C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C29H41N3O2/c1-24(2)34-28-12-5-4-11-27(28)31-22-20-30(21-23-31)17-9-6-10-25-13-15-26(16-14-25)29(33)32-18-7-3-8-19-32/h4-5,11-16,24H,3,6-10,17-23H2,1-2H3
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16n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064554
PNG
((4-{4-[4-(2-Isopropoxy-phenyl)-piperazin-1-yl]-but...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCc2ccc(cc2)C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C29H41N3O2/c1-24(2)34-28-12-5-4-11-27(28)31-22-20-30(21-23-31)17-9-6-10-25-13-15-26(16-14-25)29(33)32-18-7-3-8-19-32/h4-5,11-16,24H,3,6-10,17-23H2,1-2H3
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16n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064528
PNG
(CHEMBL60675 | {3-[4-(4-Fluoro-2-isopropoxy-phenyl)...)
Show SMILES CC(C)Oc1cc(F)ccc1N1CCN(Cc2cccc(c2)C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C26H34FN3O2/c1-20(2)32-25-18-23(27)9-10-24(25)29-15-13-28(14-16-29)19-21-7-6-8-22(17-21)26(31)30-11-4-3-5-12-30/h6-10,17-18,20H,3-5,11-16,19H2,1-2H3
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19n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029298
PNG
(1-(2-Isopropoxy-phenyl)-4-(3-piperidin-1-ylmethyl-...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3CCCCC3)c2)CC1
Show InChI InChI=1S/C26H37N3O/c1-22(2)30-26-12-5-4-11-25(26)29-17-15-28(16-18-29)21-24-10-8-9-23(19-24)20-27-13-6-3-7-14-27/h4-5,8-12,19,22H,3,6-7,13-18,20-21H2,1-2H3
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20n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029310
PNG
(N-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CNC(=O)c3ccccc3)c2)CC1
Show InChI InChI=1S/C28H33N3O2/c1-22(2)33-27-14-7-6-13-26(27)31-17-15-30(16-18-31)21-24-10-8-9-23(19-24)20-29-28(32)25-11-4-3-5-12-25/h3-14,19,22H,15-18,20-21H2,1-2H3,(H,29,32)
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20n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064553
PNG
((4-{2-[4-(2-Isopropoxy-phenyl)-piperazin-1-yl]-eth...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCc2ccc(cc2)C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C27H37N3O2/c1-22(2)32-26-9-5-4-8-25(26)29-20-18-28(19-21-29)17-14-23-10-12-24(13-11-23)27(31)30-15-6-3-7-16-30/h4-5,8-13,22H,3,6-7,14-21H2,1-2H3
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24n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50036812
PNG
(CHEMBL10327 | {2-[4-(2-Isopropoxy-phenyl)-piperazi...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2ccccc2C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-13-7-6-12-24(25)28-18-16-27(17-19-28)20-22-10-4-5-11-23(22)26(30)29-14-8-3-9-15-29/h4-7,10-13,21H,3,8-9,14-20H2,1-2H3
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37n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine D2 receptors in rat brain synaptosomal preparations


J Med Chem 37: 1060-2 (1994)


Article DOI: 10.1021/jm00034a003
BindingDB Entry DOI: 10.7270/Q23R0RXB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064566
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(=O)N2CCCCC2=O)CC1
Show InChI InChI=1S/C26H33N3O3/c1-20(2)32-24-11-4-3-10-23(24)28-16-14-27(15-17-28)19-21-8-7-9-22(18-21)26(31)29-13-6-5-12-25(29)30/h3-4,7-11,18,20H,5-6,12-17,19H2,1-2H3
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39n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029298
PNG
(1-(2-Isopropoxy-phenyl)-4-(3-piperidin-1-ylmethyl-...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3CCCCC3)c2)CC1
Show InChI InChI=1S/C26H37N3O/c1-22(2)30-26-12-5-4-11-25(26)29-17-15-28(16-18-29)21-24-10-8-9-23(19-24)20-27-13-6-3-7-14-27/h4-5,8-12,19,22H,3,6-7,13-18,20-21H2,1-2H3
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41n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029309
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3C(=O)CCCC3=O)c2)CC1
Show InChI InChI=1S/C26H33N3O3/c1-20(2)32-24-10-4-3-9-23(24)28-15-13-27(14-16-28)18-21-7-5-8-22(17-21)19-29-25(30)11-6-12-26(29)31/h3-5,7-10,17,20H,6,11-16,18-19H2,1-2H3
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63n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the dopamine receptor D2 using [3H]spiperinone.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50036813
PNG
(CHEMBL10417 | {4-[4-(2-Isopropoxy-phenyl)-piperazi...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2ccc(cc2)C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-9-5-4-8-24(25)28-18-16-27(17-19-28)20-22-10-12-23(13-11-22)26(30)29-14-6-3-7-15-29/h4-5,8-13,21H,3,6-7,14-20H2,1-2H3
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100n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine D2 receptors in rat brain synaptosomal preparations


J Med Chem 37: 1060-2 (1994)


Article DOI: 10.1021/jm00034a003
BindingDB Entry DOI: 10.7270/Q23R0RXB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029300
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3CCCCC3=O)c2)CC1
Show InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-11-4-3-10-24(25)28-16-14-27(15-17-28)19-22-8-7-9-23(18-22)20-29-13-6-5-12-26(29)30/h3-4,7-11,18,21H,5-6,12-17,19-20H2,1-2H3
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120n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine D2 receptors in rat brain synaptosomal preparations


J Med Chem 37: 1060-2 (1994)


Article DOI: 10.1021/jm00034a003
BindingDB Entry DOI: 10.7270/Q23R0RXB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029300
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3CCCCC3=O)c2)CC1
Show InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-11-4-3-10-24(25)28-16-14-27(15-17-28)19-22-8-7-9-23(18-22)20-29-13-6-5-12-26(29)30/h3-4,7-11,18,21H,5-6,12-17,19-20H2,1-2H3
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120n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the dopamine receptor D2 using [3H]spiperinone.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064560
PNG
((3-{1-[4-(2-Isopropoxy-phenyl)-piperazin-1-yl]-eth...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC1)C(C)c1cccc(c1)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H37N3O2/c1-21(2)32-26-13-6-5-12-25(26)29-18-16-28(17-19-29)22(3)23-10-9-11-24(20-23)27(31)30-14-7-4-8-15-30/h5-6,9-13,20-22H,4,7-8,14-19H2,1-3H3
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122n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064529
PNG
(Azepan-1-yl-{3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(Cc2cccc(c2)C(=O)N2CCCCCC2)CC1
Show InChI InChI=1S/C25H33N3O2/c1-30-24-12-5-4-11-23(24)27-17-15-26(16-18-27)20-21-9-8-10-22(19-21)25(29)28-13-6-2-3-7-14-28/h4-5,8-12,19H,2-3,6-7,13-18,20H2,1H3
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201n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50036813
PNG
(CHEMBL10417 | {4-[4-(2-Isopropoxy-phenyl)-piperazi...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2ccc(cc2)C(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-9-5-4-8-24(25)28-18-16-27(17-19-28)20-22-10-12-23(13-11-22)26(30)29-14-6-3-7-15-29/h4-5,8-13,21H,3,6-7,14-20H2,1-2H3
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560n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor of rat brain synaptosomal preparations


J Med Chem 37: 1060-2 (1994)


Article DOI: 10.1021/jm00034a003
BindingDB Entry DOI: 10.7270/Q23R0RXB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064560
PNG
((3-{1-[4-(2-Isopropoxy-phenyl)-piperazin-1-yl]-eth...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC1)C(C)c1cccc(c1)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H37N3O2/c1-21(2)32-26-13-6-5-12-25(26)29-18-16-28(17-19-29)22(3)23-10-9-11-24(20-23)27(31)30-14-7-4-8-15-30/h5-6,9-13,20-22H,4,7-8,14-19H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair