BindingDB logo
myBDB logout

13 similar compounds to monomer 50029295

Compile data set for download or QSAR
Wt: 407.5
BDBM50029298
Wt: 381.5
BDBM50029302
Wt: 393.5
BDBM50029304
Wt: 395.5
BDBM50029305
Wt: 354.4
BDBM50029308
Wt: 443.5
BDBM50029310
Wt: 324.4
BDBM50029312
Wt: 395.5
BDBM50029322
Wt: 433.5
BDBM50029325
Wt: 409.5
BDBM50064570
Wt: 353.4
BDBM50064544
Purchase
Wt: 296.4
BDBM50439449
Purchase
Wt: 346.4
BDBM50439453
Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50029298,50029302,50029304,50029305,50029308,50029310,50029312,50029322,50029325,50064570,50064544,50439449,50439453   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064570
PNG
(CHEMBL64227 | N,N-Diethyl-3-[4-(2-isopropoxy-pheny...)
Show SMILES CCN(CC)C(=O)c1cccc(CN2CCN(CC2)c2ccccc2OC(C)C)c1
Show InChI InChI=1S/C25H35N3O2/c1-5-27(6-2)25(29)22-11-9-10-21(18-22)19-26-14-16-28(17-15-26)23-12-7-8-13-24(23)30-20(3)4/h7-13,18,20H,5-6,14-17,19H2,1-4H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.10n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029310
PNG
(N-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CNC(=O)c3ccccc3)c2)CC1
Show InChI InChI=1S/C28H33N3O2/c1-22(2)33-27-14-7-6-13-26(27)31-17-15-30(16-18-31)21-24-10-8-9-23(19-24)20-29-28(32)25-11-4-3-5-12-25/h3-14,19,22H,15-18,20-21H2,1-2H3,(H,29,32)
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.70n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029312
PNG
(1-(2-Isopropoxy-phenyl)-4-(3-methyl-benzyl)-pipera...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(C)c2)CC1
Show InChI InChI=1S/C21H28N2O/c1-17(2)24-21-10-5-4-9-20(21)23-13-11-22(12-14-23)16-19-8-6-7-18(3)15-19/h4-10,15,17H,11-14,16H2,1-3H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.20n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064570
PNG
(CHEMBL64227 | N,N-Diethyl-3-[4-(2-isopropoxy-pheny...)
Show SMILES CCN(CC)C(=O)c1cccc(CN2CCN(CC2)c2ccccc2OC(C)C)c1
Show InChI InChI=1S/C25H35N3O2/c1-5-27(6-2)25(29)22-11-9-10-21(18-22)19-26-14-16-28(17-15-26)23-12-7-8-13-24(23)30-20(3)4/h7-13,18,20H,5-6,14-17,19H2,1-4H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
14n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029305
PNG
(N-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN(C)C(C)=O)c2)CC1
Show InChI InChI=1S/C24H33N3O2/c1-19(2)29-24-11-6-5-10-23(24)27-14-12-26(13-15-27)18-22-9-7-8-21(16-22)17-25(4)20(3)28/h5-11,16,19H,12-15,17-18H2,1-4H3
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
17n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064544
PNG
(3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-b...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(N)=O)CC1
Show InChI InChI=1S/C21H27N3O2/c1-16(2)26-20-9-4-3-8-19(20)24-12-10-23(11-13-24)15-17-6-5-7-18(14-17)21(22)25/h3-9,14,16H,10-13,15H2,1-2H3,(H2,22,25)
KEGG

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
18n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029298
PNG
(1-(2-Isopropoxy-phenyl)-4-(3-piperidin-1-ylmethyl-...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3CCCCC3)c2)CC1
Show InChI InChI=1S/C26H37N3O/c1-22(2)30-26-12-5-4-11-25(26)29-17-15-28(16-18-29)21-24-10-8-9-23(19-24)20-27-13-6-3-7-14-27/h4-5,8-12,19,22H,3,6-7,13-18,20-21H2,1-2H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029310
PNG
(N-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CNC(=O)c3ccccc3)c2)CC1
Show InChI InChI=1S/C28H33N3O2/c1-22(2)33-27-14-7-6-13-26(27)31-17-15-30(16-18-31)21-24-10-8-9-23(19-24)20-29-28(32)25-11-4-3-5-12-25/h3-14,19,22H,15-18,20-21H2,1-2H3,(H,29,32)
Reactome pathway
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029302
PNG
(N-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CNC(C)=O)c2)CC1
Show InChI InChI=1S/C23H31N3O2/c1-18(2)28-23-10-5-4-9-22(23)26-13-11-25(12-14-26)17-21-8-6-7-20(15-21)16-24-19(3)27/h4-10,15,18H,11-14,16-17H2,1-3H3,(H,24,27)
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029305
PNG
(N-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN(C)C(C)=O)c2)CC1
Show InChI InChI=1S/C24H33N3O2/c1-19(2)29-24-11-6-5-10-23(24)27-14-12-26(13-15-27)18-22-9-7-8-21(16-22)17-25(4)20(3)28/h5-11,16,19H,12-15,17-18H2,1-4H3
Reactome pathway
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
22n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the dopamine receptor D2 using [3H]spiperinone.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029304
PNG
(1-(2-Isopropoxy-phenyl)-4-(4-pyrrolidin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCC3)cc2)CC1
Show InChI InChI=1S/C25H35N3O/c1-21(2)29-25-8-4-3-7-24(25)28-17-15-27(16-18-28)20-23-11-9-22(10-12-23)19-26-13-5-6-14-26/h3-4,7-12,21H,5-6,13-20H2,1-2H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029308
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(C)O)CC1
Show InChI InChI=1/C22H30N2O2/c1-17(2)26-22-10-5-4-9-21(22)24-13-11-23(12-14-24)16-19-7-6-8-20(15-19)18(3)25/h4-10,15,17-18,25H,11-14,16H2,1-3H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
25n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029302
PNG
(N-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CNC(C)=O)c2)CC1
Show InChI InChI=1S/C23H31N3O2/c1-18(2)28-23-10-5-4-9-22(23)26-13-11-25(12-14-26)17-21-8-6-7-20(15-21)16-24-19(3)27/h4-10,15,18H,11-14,16-17H2,1-3H3,(H,24,27)
Reactome pathway
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
28n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the dopamine receptor D2 using [3H]spiperinone.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029304
PNG
(1-(2-Isopropoxy-phenyl)-4-(4-pyrrolidin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCC3)cc2)CC1
Show InChI InChI=1S/C25H35N3O/c1-21(2)29-25-8-4-3-7-24(25)28-17-15-27(16-18-28)20-23-11-9-22(10-12-23)19-26-13-5-6-14-26/h3-4,7-12,21H,5-6,13-20H2,1-2H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
29n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029325
PNG
((4-Fluoro-phenyl)-{3-[4-(2-isopropoxy-phenyl)-pipe...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CNc3ccc(F)cc3)c2)CC1
Show InChI InChI=1S/C27H32FN3O/c1-21(2)32-27-9-4-3-8-26(27)31-16-14-30(15-17-31)20-23-7-5-6-22(18-23)19-29-25-12-10-24(28)11-13-25/h3-13,18,21,29H,14-17,19-20H2,1-2H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
29n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029322
PNG
(Butyl-{4-[4-(2-isopropoxy-phenyl)-piperazin-1-ylme...)
Show SMILES CCCCNCc1ccc(CN2CCN(CC2)c2ccccc2OC(C)C)cc1
Show InChI InChI=1S/C25H37N3O/c1-4-5-14-26-19-22-10-12-23(13-11-22)20-27-15-17-28(18-16-27)24-8-6-7-9-25(24)29-21(2)3/h6-13,21,26H,4-5,14-20H2,1-3H3
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
31n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029322
PNG
(Butyl-{4-[4-(2-isopropoxy-phenyl)-piperazin-1-ylme...)
Show SMILES CCCCNCc1ccc(CN2CCN(CC2)c2ccccc2OC(C)C)cc1
Show InChI InChI=1S/C25H37N3O/c1-4-5-14-26-19-22-10-12-23(13-11-22)20-27-15-17-28(18-16-27)24-8-6-7-9-25(24)29-21(2)3/h6-13,21,26H,4-5,14-20H2,1-3H3
Reactome pathway
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
32n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the dopamine receptor D2 using [3H]spiperinone.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029298
PNG
(1-(2-Isopropoxy-phenyl)-4-(3-piperidin-1-ylmethyl-...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3CCCCC3)c2)CC1
Show InChI InChI=1S/C26H37N3O/c1-22(2)30-26-12-5-4-11-25(26)29-17-15-28(16-18-29)21-24-10-8-9-23(19-24)20-27-13-6-3-7-14-27/h4-5,8-12,19,22H,3,6-7,13-18,20-21H2,1-2H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
41n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029308
PNG
(1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(C)O)CC1
Show InChI InChI=1/C22H30N2O2/c1-17(2)26-22-10-5-4-9-21(22)24-13-11-23(12-14-24)16-19-7-6-8-20(15-19)18(3)25/h4-10,15,17-18,25H,11-14,16H2,1-3H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
56n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the dopamine receptor D2 using [3H]spiperinone.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029325
PNG
((4-Fluoro-phenyl)-{3-[4-(2-isopropoxy-phenyl)-pipe...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CNc3ccc(F)cc3)c2)CC1
Show InChI InChI=1S/C27H32FN3O/c1-21(2)32-27-9-4-3-8-26(27)31-16-14-30(15-17-31)20-23-7-5-6-22(18-23)19-29-25-12-10-24(28)11-13-25/h3-13,18,21,29H,14-17,19-20H2,1-2H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
117n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064544
PNG
(3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-b...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(N)=O)CC1
Show InChI InChI=1S/C21H27N3O2/c1-16(2)26-20-9-4-3-8-19(20)24-12-10-23(11-13-24)15-17-6-5-7-18(14-17)21(22)25/h3-9,14,16H,10-13,15H2,1-2H3,(H2,22,25)
Reactome pathway
KEGG

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
146n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 from rat striatum


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50439449
PNG
(CHEMBL2420892)
Show SMILES CCOc1ccccc1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H24N2O/c1-2-22-19-11-7-6-10-18(19)21-14-12-20(13-15-21)16-17-8-4-3-5-9-17/h3-11H,2,12-16H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
217n/an/an/an/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor


Bioorg Med Chem Lett 23: 5077-81 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.033
BindingDB Entry DOI: 10.7270/Q2RN399W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50439453
PNG
(CHEMBL2420781)
Show SMILES CCOc1ccccc1N1CCN(Cc2cccc3ccccc23)CC1
Show InChI InChI=1S/C23H26N2O/c1-2-26-23-13-6-5-12-22(23)25-16-14-24(15-17-25)18-20-10-7-9-19-8-3-4-11-21(19)20/h3-13H,2,14-18H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
264n/an/an/an/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor


Bioorg Med Chem Lett 23: 5077-81 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.033
BindingDB Entry DOI: 10.7270/Q2RN399W
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029312
PNG
(1-(2-Isopropoxy-phenyl)-4-(3-methyl-benzyl)-pipera...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(C)c2)CC1
Show InChI InChI=1S/C21H28N2O/c1-17(2)24-21-10-5-4-9-20(21)23-13-11-22(12-14-23)16-19-8-6-7-18(3)15-19/h4-10,15,17H,11-14,16H2,1-3H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
302n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the dopamine receptor D2 using [3H]spiperinone.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair