BindingDB logo
myBDB logout

31 similar compounds to monomer 50088398

Compile data set for download or QSAR
Wt: 469.5
BDBM50029316
Wt: 585.6
BDBM50088394
Wt: 585.6
BDBM50088395
Wt: 587.6
BDBM50088396
Wt: 544.6
BDBM50088397
Wt: 574.6
BDBM50088399
Wt: 602.6
BDBM50088400
Wt: 572.6
BDBM50088401
Wt: 577.0
BDBM50088402
Wt: 556.6
BDBM50088403
Wt: 558.6
BDBM50088404
Wt: 540.6
BDBM50088405
Wt: 532.5
BDBM50088406
Wt: 560.6
BDBM50088407
Wt: 572.6
BDBM50088408
Displayed 1 to 15 (of 31 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 50029316,50088394,50088395,50088396,50088397,50088399,50088400,50088401,50088402,50088403,50088404,50088405,50088406,50088407,50088408   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088405
PNG
(1,3-Dioxo-2-p-tolyl-2,3-dihydro-1H-isoindole-5-car...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(C)cc2)CC1
Show InChI InChI=1S/C32H36N4O4/c1-22(2)40-29-8-5-4-7-28(29)35-19-17-34(18-20-35)16-6-15-33-30(37)24-11-14-26-27(21-24)32(39)36(31(26)38)25-12-9-23(3)10-13-25/h4-5,7-14,21-22H,6,15-20H2,1-3H3,(H,33,37)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.160n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.330n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088397
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1
Show InChI InChI=1S/C31H33FN4O4/c1-21(2)40-28-10-4-3-9-27(28)35-17-15-34(16-18-35)14-6-13-33-29(37)22-11-12-25-26(19-22)31(39)36(30(25)38)24-8-5-7-23(32)20-24/h3-5,7-12,19-21H,6,13-18H2,1-2H3,(H,33,37)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.410n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088401
PNG
(2-(4-Methoxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoi...)
Show SMILES COc1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)NCC(O)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C32H36N4O6/c1-21(2)42-29-7-5-4-6-28(29)35-16-14-34(15-17-35)20-24(37)19-33-30(38)22-8-13-26-27(18-22)32(40)36(31(26)39)23-9-11-25(41-3)12-10-23/h4-13,18,21,24,37H,14-17,19-20H2,1-3H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.770n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088395
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.800n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088404
PNG
(2-(4-Hydroxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoi...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C31H34N4O6/c1-20(2)41-28-6-4-3-5-27(28)34-15-13-33(14-16-34)19-24(37)18-32-29(38)21-7-12-25-26(17-21)31(40)35(30(25)39)22-8-10-23(36)11-9-22/h3-12,17,20,24,36-37H,13-16,18-19H2,1-2H3,(H,32,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.880n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088403
PNG
(1,3-Dioxo-2-m-tolyl-2,3-dihydro-1H-isoindole-5-car...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(C)c2)CC1
Show InChI InChI=1S/C32H36N4O5/c1-21(2)41-29-10-5-4-9-28(29)35-15-13-34(14-16-35)20-25(37)19-33-30(38)23-11-12-26-27(18-23)32(40)36(31(26)39)24-8-6-7-22(3)17-24/h4-12,17-18,21,25,37H,13-16,19-20H2,1-3H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.900n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088402
PNG
(2-(4-Chloro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C31H33ClN4O5/c1-20(2)41-28-6-4-3-5-27(28)35-15-13-34(14-16-35)19-24(37)18-33-29(38)21-7-12-25-26(17-21)31(40)36(30(25)39)23-10-8-22(32)9-11-23/h3-12,17,20,24,37H,13-16,18-19H2,1-2H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.950n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088400
PNG
(2-(3,4-Dimethoxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-...)
Show SMILES COc1ccc(cc1OC)N1C(=O)c2ccc(cc2C1=O)C(=O)NCC(O)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C33H38N4O7/c1-21(2)44-28-8-6-5-7-27(28)36-15-13-35(14-16-36)20-24(38)19-34-31(39)22-9-11-25-26(17-22)33(41)37(32(25)40)23-10-12-29(42-3)30(18-23)43-4/h5-12,17-18,21,24,38H,13-16,19-20H2,1-4H3,(H,34,39)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.980n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088408
PNG
(2-(2-Methoxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoi...)
Show SMILES COc1ccccc1N1C(=O)c2ccc(cc2C1=O)C(=O)NCC(O)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C32H36N4O6/c1-21(2)42-29-11-7-4-8-26(29)35-16-14-34(15-17-35)20-23(37)19-33-30(38)22-12-13-24-25(18-22)32(40)36(31(24)39)27-9-5-6-10-28(27)41-3/h4-13,18,21,23,37H,14-17,19-20H2,1-3H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.47n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088407
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1
Show InChI InChI=1S/C31H33FN4O5/c1-20(2)41-28-9-4-3-8-27(28)35-14-12-34(13-15-35)19-24(37)18-33-29(38)21-10-11-25-26(16-21)31(40)36(30(25)39)23-7-5-6-22(32)17-23/h3-11,16-17,20,24,37H,12-15,18-19H2,1-2H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.5n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088396
PNG
(2-(4-Nitro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoind...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)[N+]([O-])=O)CC1
Show InChI InChI=1S/C31H33N5O7/c1-20(2)43-28-6-4-3-5-27(28)34-15-13-33(14-16-34)19-24(37)18-32-29(38)21-7-12-25-26(17-21)31(40)35(30(25)39)22-8-10-23(11-9-22)36(41)42/h3-12,17,20,24,37H,13-16,18-19H2,1-2H3,(H,32,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.80n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029316
PNG
(2-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3C(=O)c4ccccc4C3=O)c2)CC1
Show InChI InChI=1S/C29H31N3O3/c1-21(2)35-27-13-6-5-12-26(27)31-16-14-30(15-17-31)19-22-8-7-9-23(18-22)20-32-28(33)24-10-3-4-11-25(24)29(32)34/h3-13,18,21H,14-17,19-20H2,1-2H3
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.60n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088399
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES COC(CNC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1cccc(F)c1)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C32H35FN4O5/c1-21(2)42-29-10-5-4-9-28(29)36-15-13-35(14-16-36)20-25(41-3)19-34-30(38)22-11-12-26-27(17-22)32(40)37(31(26)39)24-8-6-7-23(33)18-24/h4-12,17-18,21,25H,13-16,19-20H2,1-3H3,(H,34,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
6.90n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]-LSD as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
15n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards recombinant human 5-hydroxytryptamine 1A receptor was determined using [3H]-8-OH-DPAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088397
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1
Show InChI InChI=1S/C31H33FN4O4/c1-21(2)40-28-10-4-3-9-27(28)35-17-15-34(16-18-35)14-6-13-33-29(37)22-11-12-25-26(19-22)31(39)36(30(25)38)24-8-5-7-23(32)20-24/h3-5,7-12,19-21H,6,13-18H2,1-2H3,(H,33,37)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
22n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50088406
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES COc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1
Show InChI InChI=1S/C29H29FN4O5/c1-39-26-8-3-2-7-25(26)33-13-11-32(12-14-33)18-22(35)17-31-27(36)19-9-10-23-24(15-19)29(38)34(28(23)37)21-6-4-5-20(30)16-21/h2-10,15-16,22,35H,11-14,17-18H2,1H3,(H,31,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
22n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards recombinant human Dopamine receptor D2L was determined using [3H]-spiperone as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
25n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards recombinant human Dopamine receptor D2S was determined using [3H]-spiperone as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088404
PNG
(2-(4-Hydroxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoi...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C31H34N4O6/c1-20(2)41-28-6-4-3-5-27(28)34-15-13-33(14-16-34)19-24(37)18-32-29(38)21-7-12-25-26(17-21)31(40)35(30(25)39)22-8-10-23(36)11-9-22/h3-12,17,20,24,36-37H,13-16,18-19H2,1-2H3,(H,32,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
28n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088405
PNG
(1,3-Dioxo-2-p-tolyl-2,3-dihydro-1H-isoindole-5-car...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(C)cc2)CC1
Show InChI InChI=1S/C32H36N4O4/c1-22(2)40-29-8-5-4-7-28(29)35-19-17-34(18-20-35)16-6-15-33-30(37)24-11-14-26-27(21-24)32(39)36(31(26)38)25-12-9-23(3)10-13-25/h4-5,7-14,21-22H,6,15-20H2,1-3H3,(H,33,37)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
37n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
38n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards histamine H1 receptor was determined in guinea pig brain using [3H]-pyrilamine as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088396
PNG
(2-(4-Nitro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoind...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)[N+]([O-])=O)CC1
Show InChI InChI=1S/C31H33N5O7/c1-20(2)43-28-6-4-3-5-27(28)34-15-13-33(14-16-34)19-24(37)18-32-29(38)21-7-12-25-26(17-21)31(40)35(30(25)39)22-8-10-23(11-9-22)36(41)42/h3-12,17,20,24,37H,13-16,18-19H2,1-2H3,(H,32,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
38n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088395
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
40n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088401
PNG
(2-(4-Methoxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoi...)
Show SMILES COc1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)NCC(O)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C32H36N4O6/c1-21(2)42-29-7-5-4-6-28(29)35-16-14-34(15-17-35)20-24(37)19-33-30(38)22-8-13-26-27(18-22)32(40)36(31(26)39)23-9-11-25(41-3)12-10-23/h4-13,18,21,24,37H,14-17,19-20H2,1-3H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
51n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
52n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088402
PNG
(2-(4-Chloro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C31H33ClN4O5/c1-20(2)41-28-6-4-3-5-27(28)35-15-13-34(14-16-35)19-24(37)18-33-29(38)21-7-12-25-26(17-21)31(40)36(30(25)39)23-10-8-22(32)9-11-23/h3-12,17,20,24,37H,13-16,18-19H2,1-2H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
55n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088400
PNG
(2-(3,4-Dimethoxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-...)
Show SMILES COc1ccc(cc1OC)N1C(=O)c2ccc(cc2C1=O)C(=O)NCC(O)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C33H38N4O7/c1-21(2)44-28-8-6-5-7-27(28)36-15-13-35(14-16-36)20-24(38)19-34-31(39)22-9-11-25-26(17-22)33(41)37(32(25)40)23-10-12-29(42-3)30(18-23)43-4/h5-12,17-18,21,24,38H,13-16,19-20H2,1-4H3,(H,34,39)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
56n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029316
PNG
(2-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(CN3C(=O)c4ccccc4C3=O)c2)CC1
Show InChI InChI=1S/C29H31N3O3/c1-21(2)35-27-13-6-5-12-26(27)31-16-14-30(15-17-31)19-22-8-7-9-23(18-22)20-32-28(33)24-10-3-4-11-25(24)29(32)34/h3-13,18,21H,14-17,19-20H2,1-2H3
Reactome pathway
KEGG

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
57n/an/an/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Affinity against the dopamine receptor D2 using [3H]spiperinone.


J Med Chem 38: 4211-22 (1995)


Article DOI: 10.1021/jm00021a010
BindingDB Entry DOI: 10.7270/Q2C53MH2
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
62n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards recombinant human Dopamine receptor D3 was determined using [3H]-spiperone as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088408
PNG
(2-(2-Methoxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoi...)
Show SMILES COc1ccccc1N1C(=O)c2ccc(cc2C1=O)C(=O)NCC(O)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C32H36N4O6/c1-21(2)42-29-11-7-4-8-26(29)35-16-14-34(15-17-35)20-23(37)19-33-30(38)22-12-13-24-25(18-22)32(40)36(31(24)39)27-9-5-6-10-28(27)41-3/h4-13,18,21,23,37H,14-17,19-20H2,1-3H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
72n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088403
PNG
(1,3-Dioxo-2-m-tolyl-2,3-dihydro-1H-isoindole-5-car...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(C)c2)CC1
Show InChI InChI=1S/C32H36N4O5/c1-21(2)41-29-10-5-4-9-28(29)35-15-13-34(14-16-35)20-25(37)19-33-30(38)23-11-12-26-27(18-23)32(40)36(31(26)39)24-8-6-7-22(3)17-24/h4-12,17-18,21,25,37H,13-16,19-20H2,1-3H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
73n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088407
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1
Show InChI InChI=1S/C31H33FN4O5/c1-20(2)41-28-9-4-3-8-27(28)35-14-12-34(13-15-35)19-24(37)18-33-29(38)21-10-11-25-26(16-21)31(40)36(30(25)39)23-7-5-6-22(32)17-23/h3-11,16-17,20,24,37H,12-15,18-19H2,1-2H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
75n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(NEONATAL RAT)
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
169n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat alpha-2B adrenergic receptor was determined using [3H]-yohimbine as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088399
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES COC(CNC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1cccc(F)c1)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C32H35FN4O5/c1-21(2)42-29-10-5-4-9-28(29)36-15-13-35(14-16-36)20-25(41-3)19-34-30(38)22-11-12-26-27(17-22)32(40)37(31(26)39)24-8-6-7-23(33)18-24/h4-12,17-18,21,25H,13-16,19-20H2,1-3H3,(H,34,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
407n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088397
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1
Show InChI InChI=1S/C31H33FN4O4/c1-21(2)40-28-10-4-3-9-27(28)35-17-15-34(16-18-35)14-6-13-33-29(37)22-11-12-25-26(19-22)31(39)36(30(25)38)24-8-5-7-23(32)20-24/h3-5,7-12,19-21H,6,13-18H2,1-2H3,(H,33,37)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
482n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50088406
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES COc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1
Show InChI InChI=1S/C29H29FN4O5/c1-39-26-8-3-2-7-25(26)33-13-11-32(12-14-33)18-22(35)17-31-27(36)19-9-10-23-24(15-19)29(38)34(28(23)37)21-6-4-5-20(30)16-21/h2-10,15-16,22,35H,11-14,17-18H2,1H3,(H,31,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
540n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088402
PNG
(2-(4-Chloro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C31H33ClN4O5/c1-20(2)41-28-6-4-3-5-27(28)35-15-13-34(14-16-35)19-24(37)18-33-29(38)21-7-12-25-26(17-21)31(40)36(30(25)39)23-10-8-22(32)9-11-23/h3-12,17,20,24,37H,13-16,18-19H2,1-2H3,(H,33,38)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
606n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088408
PNG
(2-(2-Methoxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoi...)
Show SMILES COc1ccccc1N1C(=O)c2ccc(cc2C1=O)C(=O)NCC(O)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C32H36N4O6/c1-21(2)42-29-11-7-4-8-26(29)35-16-14-34(15-17-35)20-23(37)19-33-30(38)22-12-13-24-25(18-22)32(40)36(31(24)39)27-9-5-6-10-28(27)41-3/h4-13,18,21,23,37H,14-17,19-20H2,1-3H3,(H,33,38)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.64E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088396
PNG
(2-(4-Nitro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoind...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)[N+]([O-])=O)CC1
Show InChI InChI=1S/C31H33N5O7/c1-20(2)43-28-6-4-3-5-27(28)34-15-13-33(14-16-34)19-24(37)18-32-29(38)21-7-12-25-26(17-21)31(40)35(30(25)39)22-8-10-23(11-9-22)36(41)42/h3-12,17,20,24,37H,13-16,18-19H2,1-2H3,(H,32,38)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088407
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1
Show InChI InChI=1S/C31H33FN4O5/c1-20(2)41-28-9-4-3-8-27(28)35-14-12-34(13-15-35)19-24(37)18-33-29(38)21-10-11-25-26(16-21)31(40)36(30(25)39)23-7-5-6-22(32)17-23/h3-11,16-17,20,24,37H,12-15,18-19H2,1-2H3,(H,33,38)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088404
PNG
(2-(4-Hydroxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoi...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C31H34N4O6/c1-20(2)41-28-6-4-3-5-27(28)34-15-13-33(14-16-34)19-24(37)18-32-29(38)21-7-12-25-26(17-21)31(40)35(30(25)39)22-8-10-23(36)11-9-22/h3-12,17,20,24,36-37H,13-16,18-19H2,1-2H3,(H,32,38)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088395
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088394
PNG
(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Show SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1
Show InChI InChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088405
PNG
(1,3-Dioxo-2-p-tolyl-2,3-dihydro-1H-isoindole-5-car...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(C)cc2)CC1
Show InChI InChI=1S/C32H36N4O4/c1-22(2)40-29-8-5-4-7-28(29)35-19-17-34(18-20-35)16-6-15-33-30(37)24-11-14-26-27(21-24)32(39)36(31(26)38)25-12-9-23(3)10-13-25/h4-5,7-14,21-22H,6,15-20H2,1-3H3,(H,33,37)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088399
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES COC(CNC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1cccc(F)c1)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C32H35FN4O5/c1-21(2)42-29-10-5-4-9-28(29)36-15-13-35(14-16-36)20-25(41-3)19-34-30(38)22-11-12-26-27(17-22)32(40)37(31(26)39)24-8-6-7-23(33)18-24/h4-12,17-18,21,25H,13-16,19-20H2,1-3H3,(H,34,38)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088403
PNG
(1,3-Dioxo-2-m-tolyl-2,3-dihydro-1H-isoindole-5-car...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(C)c2)CC1
Show InChI InChI=1S/C32H36N4O5/c1-21(2)41-29-10-5-4-9-28(29)35-15-13-34(14-16-35)20-25(37)19-33-30(38)23-11-12-26-27(18-23)32(40)36(31(26)39)24-8-6-7-22(3)17-24/h4-12,17-18,21,25,37H,13-16,19-20H2,1-3H3,(H,33,38)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088401
PNG
(2-(4-Methoxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoi...)
Show SMILES COc1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)NCC(O)CN1CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C32H36N4O6/c1-21(2)42-29-7-5-4-6-28(29)35-16-14-34(15-17-35)20-24(37)19-33-30(38)22-8-13-26-27(18-22)32(40)36(31(26)39)23-9-11-25(41-3)12-10-23/h4-13,18,21,24,37H,14-17,19-20H2,1-3H3,(H,33,38)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50088406
PNG
(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Show SMILES COc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1
Show InChI InChI=1S/C29H29FN4O5/c1-39-26-8-3-2-7-25(26)33-13-11-32(12-14-33)18-22(35)17-31-27(36)19-9-10-23-24(15-19)29(38)34(28(23)37)21-6-4-5-20(30)16-21/h2-10,15-16,22,35H,11-14,17-18H2,1H3,(H,31,36)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand


J Med Chem 43: 2183-95 (2000)


Article DOI: 10.1021/jm9905918
BindingDB Entry DOI: 10.7270/Q2XW4J20
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 51 total )  |  Next  |  Last  >>