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14 similar compounds to monomer 50075353

Compile data set for download or QSAR
Wt: 392.4
BDBM50029774
Purchase
Wt: 396.4
BDBM50075342
Wt: 420.5
BDBM50075343
Wt: 446.4
BDBM50075344
Wt: 378.4
BDBM50075345
Wt: 408.4
BDBM50075346
Wt: 406.5
BDBM50075347
Wt: 394.4
BDBM50075348
Wt: 406.5
BDBM50075349
Wt: 394.4
BDBM50075350
Wt: 392.4
BDBM50075351
Wt: 412.9
BDBM50075352
Wt: 392.4
BDBM50075354
Wt: 434.5
BDBM50075355

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 50029774,50075342,50075343,50075344,50075345,50075346,50075347,50075348,50075349,50075350,50075351,50075352,50075354,50075355   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinoid receptor


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/a 20n/an/an/an/an/an/a



Allergan Inc

Curated by ChEMBL


Assay Description
Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor beta


Bioorg Med Chem Lett 11: 765-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00058-0
BindingDB Entry DOI: 10.7270/Q2348JN3
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 7n/an/an/an/an/a



Allergan Inc

Curated by ChEMBL


Assay Description
Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor gamma


Bioorg Med Chem Lett 11: 765-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00058-0
BindingDB Entry DOI: 10.7270/Q2348JN3
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 3n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Binding constant for baculovirus-expressed Retinoic acid receptor RAR gamma


J Med Chem 38: 4764-7 (1996)


Article DOI: 10.1021/jm00024a003
BindingDB Entry DOI: 10.7270/Q22N5194
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 2n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Binding constant for baculovirus-expressed Retinoic acid receptor RAR beta


J Med Chem 38: 4764-7 (1996)


Article DOI: 10.1021/jm00024a003
BindingDB Entry DOI: 10.7270/Q22N5194
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075342
PNG
(4-[8-(4-Fluoro-phenyl)-5,5-dimethyl-5,6-dihydro-na...)
Show SMILES CC1(C)CC=C(c2ccc(F)cc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H21FO2/c1-27(2)16-15-23(20-10-12-22(28)13-11-20)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(29)30/h5-15,17H,16H2,1-2H3,(H,29,30)
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n/an/an/a 85n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075344
PNG
(4-[5,5-Dimethyl-8-(4-trifluoromethyl-phenyl)-5,6-d...)
Show SMILES CC1(C)CC=C(c2ccc(cc2)C(F)(F)F)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H21F3O2/c1-27(2)16-15-23(20-10-12-22(13-11-20)28(29,30)31)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(32)33/h5-15,17H,16H2,1-2H3,(H,32,33)
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n/an/an/a 29n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075345
PNG
(4-(5,5-Dimethyl-8-phenyl-5,6-dihydro-naphthalen-2-...)
Show SMILES CC1(C)CC=C(c2ccccc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O2/c1-27(2)17-16-23(21-6-4-3-5-7-21)24-18-20(12-15-25(24)27)9-8-19-10-13-22(14-11-19)26(28)29/h3-7,10-16,18H,17H2,1-2H3,(H,28,29)
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n/an/an/a 147n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075343
PNG
(4-[8-(4-Isopropyl-phenyl)-5,5-dimethyl-5,6-dihydro...)
Show SMILES CC(C)c1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C30H28O2/c1-20(2)23-12-14-24(15-13-23)26-17-18-30(3,4)28-16-9-22(19-27(26)28)6-5-21-7-10-25(11-8-21)29(31)32/h7-17,19-20H,18H2,1-4H3,(H,31,32)
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n/an/an/a 11n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075347
PNG
(4-[8-(3,5-Dimethyl-phenyl)-5,5-dimethyl-5,6-dihydr...)
Show SMILES Cc1cc(C)cc(c1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26O2/c1-19-15-20(2)17-24(16-19)25-13-14-29(3,4)27-12-9-22(18-26(25)27)6-5-21-7-10-23(11-8-21)28(30)31/h7-13,15-18H,14H2,1-4H3,(H,30,31)
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n/an/an/a 274n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075348
PNG
(4-[8-(3-Hydroxy-phenyl)-5,5-dimethyl-5,6-dihydro-n...)
Show SMILES CC1(C)CC=C(c2cccc(O)c2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O3/c1-27(2)15-14-23(21-4-3-5-22(28)17-21)24-16-19(10-13-25(24)27)7-6-18-8-11-20(12-9-18)26(29)30/h3-5,8-14,16-17,28H,15H2,1-2H3,(H,29,30)
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n/an/an/a 919n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075346
PNG
(4-[8-(4-Methoxy-phenyl)-5,5-dimethyl-5,6-dihydro-n...)
Show SMILES COc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O3/c1-28(2)17-16-24(21-11-13-23(31-3)14-12-21)25-18-20(8-15-26(25)28)5-4-19-6-9-22(10-7-19)27(29)30/h6-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 36n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075343
PNG
(4-[8-(4-Isopropyl-phenyl)-5,5-dimethyl-5,6-dihydro...)
Show SMILES CC(C)c1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C30H28O2/c1-20(2)23-12-14-24(15-13-23)26-17-18-30(3,4)28-16-9-22(19-27(26)28)6-5-21-7-10-25(11-8-21)29(31)32/h7-17,19-20H,18H2,1-4H3,(H,31,32)
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n/an/an/a 171n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075345
PNG
(4-(5,5-Dimethyl-8-phenyl-5,6-dihydro-naphthalen-2-...)
Show SMILES CC1(C)CC=C(c2ccccc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O2/c1-27(2)17-16-23(21-6-4-3-5-7-21)24-18-20(12-15-25(24)27)9-8-19-10-13-22(14-11-19)26(28)29/h3-7,10-16,18H,17H2,1-2H3,(H,28,29)
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n/an/an/a 42n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075349
PNG
(4-[8-(4-Ethyl-phenyl)-5,5-dimethyl-5,6-dihydro-nap...)
Show SMILES CCc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26O2/c1-4-20-7-12-23(13-8-20)25-17-18-29(2,3)27-16-11-22(19-26(25)27)6-5-21-9-14-24(15-10-21)28(30)31/h7-17,19H,4,18H2,1-3H3,(H,30,31)
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n/an/an/a 10n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075350
PNG
(4-[8-(4-Hydroxy-phenyl)-5,5-dimethyl-5,6-dihydro-n...)
Show SMILES CC1(C)CC=C(c2ccc(O)cc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O3/c1-27(2)16-15-23(20-10-12-22(28)13-11-20)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(29)30/h5-15,17,28H,16H2,1-2H3,(H,29,30)
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n/an/an/a 72n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075350
PNG
(4-[8-(4-Hydroxy-phenyl)-5,5-dimethyl-5,6-dihydro-n...)
Show SMILES CC1(C)CC=C(c2ccc(O)cc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O3/c1-27(2)16-15-23(20-10-12-22(28)13-11-20)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(29)30/h5-15,17,28H,16H2,1-2H3,(H,29,30)
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n/an/an/a 98n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075349
PNG
(4-[8-(4-Ethyl-phenyl)-5,5-dimethyl-5,6-dihydro-nap...)
Show SMILES CCc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26O2/c1-4-20-7-12-23(13-8-20)25-17-18-29(2,3)27-16-11-22(19-26(25)27)6-5-21-9-14-24(15-10-21)28(30)31/h7-17,19H,4,18H2,1-3H3,(H,30,31)
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n/an/an/a 40n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075345
PNG
(4-(5,5-Dimethyl-8-phenyl-5,6-dihydro-naphthalen-2-...)
Show SMILES CC1(C)CC=C(c2ccccc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O2/c1-27(2)17-16-23(21-6-4-3-5-7-21)24-18-20(12-15-25(24)27)9-8-19-10-13-22(14-11-19)26(28)29/h3-7,10-16,18H,17H2,1-2H3,(H,28,29)
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n/an/an/a 33n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075351
PNG
(4-(5,5-Dimethyl-8-o-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccccc1C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-6-4-5-7-23(19)24-16-17-28(2,3)26-15-12-21(18-25(24)26)9-8-20-10-13-22(14-11-20)27(29)30/h4-7,10-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 35n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075349
PNG
(4-[8-(4-Ethyl-phenyl)-5,5-dimethyl-5,6-dihydro-nap...)
Show SMILES CCc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26O2/c1-4-20-7-12-23(13-8-20)25-17-18-29(2,3)27-16-11-22(19-26(25)27)6-5-21-9-14-24(15-10-21)28(30)31/h7-17,19H,4,18H2,1-3H3,(H,30,31)
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n/an/an/a 19n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075352
PNG
(4-[8-(4-Chloro-phenyl)-5,5-dimethyl-5,6-dihydro-na...)
Show SMILES CC1(C)CC=C(c2ccc(Cl)cc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H21ClO2/c1-27(2)16-15-23(20-10-12-22(28)13-11-20)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(29)30/h5-15,17H,16H2,1-2H3,(H,29,30)
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n/an/an/a 27n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075348
PNG
(4-[8-(3-Hydroxy-phenyl)-5,5-dimethyl-5,6-dihydro-n...)
Show SMILES CC1(C)CC=C(c2cccc(O)c2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O3/c1-27(2)15-14-23(21-4-3-5-22(28)17-21)24-16-19(10-13-25(24)27)7-6-18-8-11-20(12-9-18)26(29)30/h3-5,8-14,16-17,28H,15H2,1-2H3,(H,29,30)
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n/an/an/a 254n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075342
PNG
(4-[8-(4-Fluoro-phenyl)-5,5-dimethyl-5,6-dihydro-na...)
Show SMILES CC1(C)CC=C(c2ccc(F)cc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H21FO2/c1-27(2)16-15-23(20-10-12-22(28)13-11-20)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(29)30/h5-15,17H,16H2,1-2H3,(H,29,30)
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n/an/an/a 82n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075347
PNG
(4-[8-(3,5-Dimethyl-phenyl)-5,5-dimethyl-5,6-dihydr...)
Show SMILES Cc1cc(C)cc(c1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26O2/c1-19-15-20(2)17-24(16-19)25-13-14-29(3,4)27-12-9-22(18-26(25)27)6-5-21-7-10-23(11-8-21)28(30)31/h7-13,15-18H,14H2,1-4H3,(H,30,31)
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n/an/an/a 1.05E+3n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075344
PNG
(4-[5,5-Dimethyl-8-(4-trifluoromethyl-phenyl)-5,6-d...)
Show SMILES CC1(C)CC=C(c2ccc(cc2)C(F)(F)F)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H21F3O2/c1-27(2)16-15-23(20-10-12-22(13-11-20)28(29,30)31)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(32)33/h5-15,17H,16H2,1-2H3,(H,32,33)
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n/an/an/a 57n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075352
PNG
(4-[8-(4-Chloro-phenyl)-5,5-dimethyl-5,6-dihydro-na...)
Show SMILES CC1(C)CC=C(c2ccc(Cl)cc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H21ClO2/c1-27(2)16-15-23(20-10-12-22(28)13-11-20)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(29)30/h5-15,17H,16H2,1-2H3,(H,29,30)
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n/an/an/a 58n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075352
PNG
(4-[8-(4-Chloro-phenyl)-5,5-dimethyl-5,6-dihydro-na...)
Show SMILES CC1(C)CC=C(c2ccc(Cl)cc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H21ClO2/c1-27(2)16-15-23(20-10-12-22(28)13-11-20)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(29)30/h5-15,17H,16H2,1-2H3,(H,29,30)
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n/an/an/a 18n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075354
PNG
(4-(5,5-Dimethyl-8-m-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1cccc(c1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-5-4-6-23(17-19)24-15-16-28(2,3)26-14-11-21(18-25(24)26)8-7-20-9-12-22(13-10-20)27(29)30/h4-6,9-15,17-18H,16H2,1-3H3,(H,29,30)
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n/an/an/a 67n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075354
PNG
(4-(5,5-Dimethyl-8-m-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1cccc(c1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-5-4-6-23(17-19)24-15-16-28(2,3)26-14-11-21(18-25(24)26)8-7-20-9-12-22(13-10-20)27(29)30/h4-6,9-15,17-18H,16H2,1-3H3,(H,29,30)
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n/an/an/a 51n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075343
PNG
(4-[8-(4-Isopropyl-phenyl)-5,5-dimethyl-5,6-dihydro...)
Show SMILES CC(C)c1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C30H28O2/c1-20(2)23-12-14-24(15-13-23)26-17-18-30(3,4)28-16-9-22(19-27(26)28)6-5-21-7-10-25(11-8-21)29(31)32/h7-17,19-20H,18H2,1-4H3,(H,31,32)
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n/an/an/a 90n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075354
PNG
(4-(5,5-Dimethyl-8-m-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1cccc(c1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-5-4-6-23(17-19)24-15-16-28(2,3)26-14-11-21(18-25(24)26)8-7-20-9-12-22(13-10-20)27(29)30/h4-6,9-15,17-18H,16H2,1-3H3,(H,29,30)
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n/an/an/a 276n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 7n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075355
PNG
(4-[8-(4-tert-Butyl-phenyl)-5,5-dimethyl-5,6-dihydr...)
Show SMILES CC(C)(C)c1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C31H30O2/c1-30(2,3)25-15-13-23(14-16-25)26-18-19-31(4,5)28-17-10-22(20-27(26)28)7-6-21-8-11-24(12-9-21)29(32)33/h8-18,20H,19H2,1-5H3,(H,32,33)
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n/an/an/a 21n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075346
PNG
(4-[8-(4-Methoxy-phenyl)-5,5-dimethyl-5,6-dihydro-n...)
Show SMILES COc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O3/c1-28(2)17-16-24(21-11-13-23(31-3)14-12-21)25-18-20(8-15-26(25)28)5-4-19-6-9-22(10-7-19)27(29)30/h6-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 16n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075350
PNG
(4-[8-(4-Hydroxy-phenyl)-5,5-dimethyl-5,6-dihydro-n...)
Show SMILES CC1(C)CC=C(c2ccc(O)cc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O3/c1-27(2)16-15-23(20-10-12-22(28)13-11-20)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(29)30/h5-15,17,28H,16H2,1-2H3,(H,29,30)
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n/an/an/a 229n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 7n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075355
PNG
(4-[8-(4-tert-Butyl-phenyl)-5,5-dimethyl-5,6-dihydr...)
Show SMILES CC(C)(C)c1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C31H30O2/c1-30(2,3)25-15-13-23(14-16-25)26-18-19-31(4,5)28-17-10-22(20-27(26)28)7-6-21-8-11-24(12-9-21)29(32)33/h8-18,20H,19H2,1-5H3,(H,32,33)
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n/an/an/a 94n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075344
PNG
(4-[5,5-Dimethyl-8-(4-trifluoromethyl-phenyl)-5,6-d...)
Show SMILES CC1(C)CC=C(c2ccc(cc2)C(F)(F)F)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H21F3O2/c1-27(2)16-15-23(20-10-12-22(13-11-20)28(29,30)31)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(32)33/h5-15,17H,16H2,1-2H3,(H,32,33)
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n/an/an/a 44n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075351
PNG
(4-(5,5-Dimethyl-8-o-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccccc1C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-6-4-5-7-23(19)24-16-17-28(2,3)26-15-12-21(18-25(24)26)9-8-20-10-13-22(14-11-20)27(29)30/h4-7,10-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 103n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075351
PNG
(4-(5,5-Dimethyl-8-o-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccccc1C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-6-4-5-7-23(19)24-16-17-28(2,3)26-15-12-21(18-25(24)26)9-8-20-10-13-22(14-11-20)27(29)30/h4-7,10-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 29n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075355
PNG
(4-[8-(4-tert-Butyl-phenyl)-5,5-dimethyl-5,6-dihydr...)
Show SMILES CC(C)(C)c1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C31H30O2/c1-30(2,3)25-15-13-23(14-16-25)26-18-19-31(4,5)28-17-10-22(20-27(26)28)7-6-21-8-11-24(12-9-21)29(32)33/h8-18,20H,19H2,1-5H3,(H,32,33)
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n/an/an/a 178n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50075346
PNG
(4-[8-(4-Methoxy-phenyl)-5,5-dimethyl-5,6-dihydro-n...)
Show SMILES COc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O3/c1-28(2)17-16-24(21-11-13-23(31-3)14-12-21)25-18-20(8-15-26(25)28)5-4-19-6-9-22(10-7-19)27(29)30/h6-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 60n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075347
PNG
(4-[8-(3,5-Dimethyl-phenyl)-5,5-dimethyl-5,6-dihydr...)
Show SMILES Cc1cc(C)cc(c1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26O2/c1-19-15-20(2)17-24(16-19)25-13-14-29(3,4)27-12-9-22(18-26(25)27)6-5-21-7-10-23(11-8-21)28(30)31/h7-13,15-18H,14H2,1-4H3,(H,30,31)
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n/an/an/a 408n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 16n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075342
PNG
(4-[8-(4-Fluoro-phenyl)-5,5-dimethyl-5,6-dihydro-na...)
Show SMILES CC1(C)CC=C(c2ccc(F)cc2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H21FO2/c1-27(2)16-15-23(20-10-12-22(28)13-11-20)24-17-19(7-14-25(24)27)4-3-18-5-8-21(9-6-18)26(29)30/h5-15,17H,16H2,1-2H3,(H,29,30)
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n/an/an/a 52n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50075348
PNG
(4-[8-(3-Hydroxy-phenyl)-5,5-dimethyl-5,6-dihydro-n...)
Show SMILES CC1(C)CC=C(c2cccc(O)c2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O3/c1-27(2)15-14-23(21-4-3-5-22(28)17-21)24-16-19(10-13-25(24)27)7-6-18-8-11-20(12-9-18)26(29)30/h3-5,8-14,16-17,28H,15H2,1-2H3,(H,29,30)
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n/an/an/a 162n/an/an/an/an/a



Allergan Inc.

Curated by ChEMBL


Assay Description
Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay


Bioorg Med Chem Lett 9: 573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00047-5
BindingDB Entry DOI: 10.7270/Q2SN084D
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/a 31n/an/an/an/an/an/a



Allergan Inc

Curated by ChEMBL


Assay Description
Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor alpha


Bioorg Med Chem Lett 11: 765-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00058-0
BindingDB Entry DOI: 10.7270/Q2348JN3
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 6n/an/an/an/an/a



Allergan Inc

Curated by ChEMBL


Assay Description
Binding affinity towards retinoic acid receptor gamma was determined using [3H]-ATRA (5 nM) as radioligand


Bioorg Med Chem Lett 11: 765-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00058-0
BindingDB Entry DOI: 10.7270/Q2348JN3
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha/gamma


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/a 3n/an/an/an/an/an/a



Allergan Inc

Curated by ChEMBL


Assay Description
Binding affinity towards retinoic acid receptor alpha was determined using [3H]-ATRA (5 nM) as radioligand


Bioorg Med Chem Lett 11: 765-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00058-0
BindingDB Entry DOI: 10.7270/Q2348JN3
More data for this
Ligand-Target Pair
Retinoic acid receptor alpha/Retinoid X receptor alpha


(Homo sapiens (Human))
BDBM50029774
PNG
(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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n/an/an/a 17n/an/an/an/an/a



Allergan Inc

Curated by ChEMBL


Assay Description
Binding affinity towards retinoic acid receptor alpha was determined using [3H]-ATRA (5 nM) as radioligand


Bioorg Med Chem Lett 11: 765-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00058-0
BindingDB Entry DOI: 10.7270/Q2348JN3
More data for this
Ligand-Target Pair
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