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10 similar compounds to monomer 50035398

Wt: 242.3
BDBM50450162
Wt: 180.2
BDBM50450163
Wt: 180.2
BDBM50450167
Wt: 180.2
BDBM50450168
Wt: 196.2
BDBM50450169
Wt: 242.3
BDBM50450170
Wt: 222.3
BDBM50450161
Wt: 222.3
BDBM50450166
Wt: 166.2
BDBM50035406
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Wt: 166.2
BDBM50171341
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50450162,50450163,50450167,50450168,50450169,50450170,50450161,50450166,50035406,50171341   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50171341
PNG
(3-Methyl-5-(1-methyl-pyrrolidin-2-yl)-isoxazole | ...)
Show SMILES CN1CCCC1c1cc(C)no1
Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3
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Article
PubMed
4.69n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 312: 619-26 (2005)

More data for this
Ligand-Target Pair
n-AChR


(RAT)
BDBM50035406
PNG
(3-Methyl-5-((R)-1-methyl-pyrrolidin-2-yl)-isoxazol...)
Show SMILES CN1CCC[C@@H]1c1cc(C)no1
Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m1/s1
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PubMed
44n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50450163
PNG
(CHEMBL76773)
Show SMILES C[C@@H]1CC[C@H](N1C)c1cc(C)no1
Show InChI InChI=1S/C10H16N2O/c1-7-6-10(13-11-7)9-5-4-8(2)12(9)3/h6,8-9H,4-5H2,1-3H3/t8-,9+/m1/s1
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Article
71n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 by displacement of [3H](-)-cytisine from whole rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5


(RAT)
BDBM50171341
PNG
(3-Methyl-5-(1-methyl-pyrrolidin-2-yl)-isoxazole | ...)
Show SMILES CN1CCCC1c1cc(C)no1
Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3
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PubMed
803n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 312: 619-26 (2005)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50450161
PNG
(CHEMBL77175)
Show SMILES CCCC[C@@H]1CC[C@H](N1C)c1cc(C)no1
Show InChI InChI=1S/C13H22N2O/c1-4-5-6-11-7-8-12(15(11)3)13-9-10(2)14-16-13/h9,11-12H,4-8H2,1-3H3/t11-,12+/m1/s1
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Article
1.02E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 by displacement of [3H](-)-cytisine from whole rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50171341
PNG
(3-Methyl-5-(1-methyl-pyrrolidin-2-yl)-isoxazole | ...)
Show SMILES CN1CCCC1c1cc(C)no1
Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3
PDB

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PubMed
1.97E+3n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 312: 619-26 (2005)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50450166
PNG
(CHEMBL80497)
Show SMILES CCCC[C@H]1CC[C@H](N1C)c1cc(C)no1
Show InChI InChI=1S/C13H22N2O/c1-4-5-6-11-7-8-12(15(11)3)13-9-10(2)14-16-13/h9,11-12H,4-8H2,1-3H3/t11-,12-/m0/s1
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Article
3.67E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 by displacement of [3H](-)-cytisine from whole rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50450168
PNG
(CHEMBL80526)
Show SMILES C[C@H]1CC[C@H](N1C)c1cc(C)no1
Show InChI InChI=1S/C10H16N2O/c1-7-6-10(13-11-7)9-5-4-8(2)12(9)3/h6,8-9H,4-5H2,1-3H3/t8-,9-/m0/s1
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Article
5.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 by displacement of [3H](-)-cytisine from whole rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50450162
PNG
(CHEMBL76999)
Show SMILES CN1[C@@H](CC[C@H]1c1ccccc1)c1cc(C)no1
Show InChI InChI=1S/C15H18N2O/c1-11-10-15(18-16-11)14-9-8-13(17(14)2)12-6-4-3-5-7-12/h3-7,10,13-14H,8-9H2,1-2H3/t13-,14-/m0/s1
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Article
8.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 by displacement of [3H](-)-cytisine from whole rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
n-AChR


(RAT)
BDBM50035406
PNG
(3-Methyl-5-((R)-1-methyl-pyrrolidin-2-yl)-isoxazol...)
Show SMILES CN1CCC[C@@H]1c1cc(C)no1
Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m1/s1
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
n-AChR


(RAT)
BDBM50035406
PNG
(3-Methyl-5-((R)-1-methyl-pyrrolidin-2-yl)-isoxazol...)
Show SMILES CN1CCC[C@@H]1c1cc(C)no1
Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m1/s1
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50450167
PNG
(CHEMBL75870)
Show SMILES C[C@H]1CCN(C)[C@@H]1c1cc(C)no1
Show InChI InChI=1S/C10H16N2O/c1-7-4-5-12(3)10(7)9-6-8(2)11-13-9/h6-7,10H,4-5H2,1-3H3/t7-,10-/m0/s1
PDB
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Article
>1.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 by displacement of [3H](-)-cytisine from whole rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50450169
PNG
(CHEMBL308341)
Show SMILES CN1CC[C@H](CO)[C@H]1c1cc(C)no1
Show InChI InChI=1S/C10H16N2O2/c1-7-5-9(14-11-7)10-8(6-13)3-4-12(10)2/h5,8,10,13H,3-4,6H2,1-2H3/t8-,10+/m1/s1
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Article
>1.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 by displacement of [3H](-)-cytisine from whole rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50450170
PNG
(CHEMBL308268)
Show SMILES CN1[C@@H](CC[C@@H]1c1ccccc1)c1cc(C)no1
Show InChI InChI=1S/C15H18N2O/c1-11-10-15(18-16-11)14-9-8-13(17(14)2)12-6-4-3-5-7-12/h3-7,10,13-14H,8-9H2,1-2H3/t13-,14+/m1/s1
PDB
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Article
>1.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 by displacement of [3H](-)-cytisine from whole rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair