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3 similar compounds to monomer 50036012

Compile data set for download or QSAR
Wt: 532.6
BDBM50036015
Wt: 620.6
BDBM50035993
Wt: 648.7
BDBM50036011

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50036015,50035993,50036011   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50035993
PNG
(4-{2-[3-(4-carboxybenzoyl)-1-methyl-1H-2-indolyldi...)
Show SMILES Cn1c(SSc2c(C(=O)c3ccc(cc3)C(O)=O)c3ccccc3n2C)c(C(=O)c2ccc(cc2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C34H24N2O6S2/c1-35-25-9-5-3-7-23(25)27(29(37)19-11-15-21(16-12-19)33(39)40)31(35)43-44-32-28(24-8-4-6-10-26(24)36(32)2)30(38)20-13-17-22(18-14-20)34(41)42/h3-18H,1-2H3,(H,39,40)(H,41,42)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibitory concentration of the against pp60v-src tyrosine kinase obtained from v-src baculovirus-infected insect cells


J Med Chem 38: 58-67 (1995)


Article DOI: 10.1021/jm00001a011
BindingDB Entry DOI: 10.7270/Q26Q1W8F
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50035993
PNG
(4-{2-[3-(4-carboxybenzoyl)-1-methyl-1H-2-indolyldi...)
Show SMILES Cn1c(SSc2c(C(=O)c3ccc(cc3)C(O)=O)c3ccccc3n2C)c(C(=O)c2ccc(cc2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C34H24N2O6S2/c1-35-25-9-5-3-7-23(25)27(29(37)19-11-15-21(16-12-19)33(39)40)31(35)43-44-32-28(24-8-4-6-10-26(24)36(32)2)30(38)20-13-17-22(18-14-20)34(41)42/h3-18H,1-2H3,(H,39,40)(H,41,42)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.50E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibitory concentration compound against EFGR tyrosine kinase obtained from plasma membrane vesicles from cultured A431 cells


J Med Chem 38: 58-67 (1995)


Article DOI: 10.1021/jm00001a011
BindingDB Entry DOI: 10.7270/Q26Q1W8F
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50036015
PNG
(CHEMBL349322 | [2-(3-Benzoyl-1-methyl-1H-indol-2-y...)
Show SMILES Cn1c(SSc2c(C(=O)c3ccccc3)c3ccccc3n2C)c(C(=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C32H24N2O2S2/c1-33-25-19-11-9-17-23(25)27(29(35)21-13-5-3-6-14-21)31(33)37-38-32-28(30(36)22-15-7-4-8-16-22)24-18-10-12-20-26(24)34(32)2/h3-20H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibitory concentration compound against EFGR tyrosine kinase obtained from plasma membrane vesicles from cultured A431 cells


J Med Chem 38: 58-67 (1995)


Article DOI: 10.1021/jm00001a011
BindingDB Entry DOI: 10.7270/Q26Q1W8F
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50036015
PNG
(CHEMBL349322 | [2-(3-Benzoyl-1-methyl-1H-indol-2-y...)
Show SMILES Cn1c(SSc2c(C(=O)c3ccccc3)c3ccccc3n2C)c(C(=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C32H24N2O2S2/c1-33-25-19-11-9-17-23(25)27(29(35)21-13-5-3-6-14-21)31(33)37-38-32-28(30(36)22-15-7-4-8-16-22)24-18-10-12-20-26(24)34(32)2/h3-20H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibitory concentration of the against pp60v-src tyrosine kinase obtained from v-src baculovirus-infected insect cells


J Med Chem 38: 58-67 (1995)


Article DOI: 10.1021/jm00001a011
BindingDB Entry DOI: 10.7270/Q26Q1W8F
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50036011
PNG
(CHEMBL346553 | methyl 4-{1-methyl-2-[1-methyl-3-(4...)
Show SMILES COC(=O)c1ccc(cc1)C(=O)c1c(SSc2c(C(=O)c3ccc(cc3)C(=O)OC)c3ccccc3n2C)n(C)c2ccccc12
Show InChI InChI=1S/C36H28N2O6S2/c1-37-27-11-7-5-9-25(27)29(31(39)21-13-17-23(18-14-21)35(41)43-3)33(37)45-46-34-30(26-10-6-8-12-28(26)38(34)2)32(40)22-15-19-24(20-16-22)36(42)44-4/h5-20H,1-4H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.10E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibitory concentration of the against pp60v-src tyrosine kinase obtained from v-src baculovirus-infected insect cells


J Med Chem 38: 58-67 (1995)


Article DOI: 10.1021/jm00001a011
BindingDB Entry DOI: 10.7270/Q26Q1W8F
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50036011
PNG
(CHEMBL346553 | methyl 4-{1-methyl-2-[1-methyl-3-(4...)
Show SMILES COC(=O)c1ccc(cc1)C(=O)c1c(SSc2c(C(=O)c3ccc(cc3)C(=O)OC)c3ccccc3n2C)n(C)c2ccccc12
Show InChI InChI=1S/C36H28N2O6S2/c1-37-27-11-7-5-9-25(27)29(31(39)21-13-17-23(18-14-21)35(41)43-3)33(37)45-46-34-30(26-10-6-8-12-28(26)38(34)2)32(40)22-15-19-24(20-16-22)36(42)44-4/h5-20H,1-4H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibitory concentration compound against EFGR tyrosine kinase obtained from plasma membrane vesicles from cultured A431 cells


J Med Chem 38: 58-67 (1995)


Article DOI: 10.1021/jm00001a011
BindingDB Entry DOI: 10.7270/Q26Q1W8F
More data for this
Ligand-Target Pair