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9 similar compounds to monomer 50343025

Compile data set for download or QSAR
Wt: 263.3
BDBM50343014
Wt: 261.3
BDBM50343015
Wt: 277.4
BDBM50343018
Wt: 249.3
BDBM50343019
Wt: 263.3
BDBM50343020
Wt: 263.3
BDBM50343021
Wt: 261.3
BDBM50343022
Wt: 275.3
BDBM50343023
Wt: 234.3
BDBM50036705

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50343014,50343015,50343018,50343019,50343020,50343021,50343022,50343023,50036705   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343021
PNG
((R)-N2-isobutyl-4-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)C)c1
Show InChI InChI=1S/C14H25N5/c1-10(2)8-17-14-7-12(6-13(15)18-14)19-5-4-11(9-19)16-3/h6-7,10-11,16H,4-5,8-9H2,1-3H3,(H3,15,17,18)/t11-/m1/s1
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0.200n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343018
PNG
(4-(4-methylpiperazin-1-yl)-N2-neopentylpyridine-2,...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NCC(C)(C)C)c1
Show InChI InChI=1S/C15H27N5/c1-15(2,3)11-17-14-10-12(9-13(16)18-14)20-7-5-19(4)6-8-20/h9-10H,5-8,11H2,1-4H3,(H3,16,17,18)
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0.300n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343023
PNG
((R)-N2-cyclopentyl-4-(3-(methylamino)pyrrolidin-1-...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC2CCCC2)c1
Show InChI InChI=1S/C15H25N5/c1-17-12-6-7-20(10-12)13-8-14(16)19-15(9-13)18-11-4-2-3-5-11/h8-9,11-12,17H,2-7,10H2,1H3,(H3,16,18,19)/t12-/m1/s1
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0.900n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343014
PNG
(CHEMBL1770964 | N2-isobutyl-4-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1cc(cc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C14H25N5/c1-11(2)10-16-14-9-12(8-13(15)17-14)19-6-4-18(3)5-7-19/h8-9,11H,4-7,10H2,1-3H3,(H3,15,16,17)
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2n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343019
PNG
((R)-N2-isopropyl-4-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)c1
Show InChI InChI=1S/C13H23N5/c1-9(2)16-13-7-11(6-12(14)17-13)18-5-4-10(8-18)15-3/h6-7,9-10,15H,4-5,8H2,1-3H3,(H3,14,16,17)/t10-/m1/s1
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3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343019
PNG
((R)-N2-isopropyl-4-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)c1
Show InChI InChI=1S/C13H23N5/c1-9(2)16-13-7-11(6-12(14)17-13)18-5-4-10(8-18)15-3/h6-7,9-10,15H,4-5,8H2,1-3H3,(H3,14,16,17)/t10-/m1/s1
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3.10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 24: 5489-92 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.013
BindingDB Entry DOI: 10.7270/Q25M67B1
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50036705
PNG
(CHEMBL3354816)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC(C)C)c1
Show InChI InChI=1S/C13H22N4/c1-10(2)16-13-8-12(4-6-15-13)17-7-5-11(9-17)14-3/h4,6,8,10-11,14H,5,7,9H2,1-3H3,(H,15,16)/t11-/m1/s1
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19n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 24: 5489-92 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.013
BindingDB Entry DOI: 10.7270/Q25M67B1
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50036705
PNG
(CHEMBL3354816)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC(C)C)c1
Show InChI InChI=1S/C13H22N4/c1-10(2)16-13-8-12(4-6-15-13)17-7-5-11(9-17)14-3/h4,6,8,10-11,14H,5,7,9H2,1-3H3,(H,15,16)/t11-/m1/s1
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19n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343020
PNG
((R)-N2-isopropyl-N2-methyl-4-(3-(methylamino)pyrro...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(c1)N(C)C(C)C
Show InChI InChI=1S/C14H25N5/c1-10(2)18(4)14-8-12(7-13(15)17-14)19-6-5-11(9-19)16-3/h7-8,10-11,16H,5-6,9H2,1-4H3,(H2,15,17)/t11-/m1/s1
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29n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343022
PNG
((R)-4-(3-(methylamino)pyrrolidin-1-yl)-6-(pyrrolid...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(c1)N1CCCC1
Show InChI InChI=1S/C14H23N5/c1-16-11-4-7-19(10-11)12-8-13(15)17-14(9-12)18-5-2-3-6-18/h8-9,11,16H,2-7,10H2,1H3,(H2,15,17)/t11-/m1/s1
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77n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343015
PNG
(4-(4-methylpiperazin-1-yl)-6-(pyrrolidin-1-yl)pyri...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(c1)N1CCCC1
Show InChI InChI=1S/C14H23N5/c1-17-6-8-18(9-7-17)12-10-13(15)16-14(11-12)19-4-2-3-5-19/h10-11H,2-9H2,1H3,(H2,15,16)
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100n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343023
PNG
((R)-N2-cyclopentyl-4-(3-(methylamino)pyrrolidin-1-...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC2CCCC2)c1
Show InChI InChI=1S/C15H25N5/c1-17-12-6-7-20(10-12)13-8-14(16)19-15(9-13)18-11-4-2-3-5-11/h8-9,11-12,17H,2-7,10H2,1H3,(H3,16,18,19)/t12-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343019
PNG
((R)-N2-isopropyl-4-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)c1
Show InChI InChI=1S/C13H23N5/c1-9(2)16-13-7-11(6-12(14)17-13)18-5-4-10(8-18)15-3/h6-7,9-10,15H,4-5,8H2,1-3H3,(H3,14,16,17)/t10-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343021
PNG
((R)-N2-isobutyl-4-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)C)c1
Show InChI InChI=1S/C14H25N5/c1-10(2)8-17-14-7-12(6-13(15)18-14)19-5-4-11(9-19)16-3/h6-7,10-11,16H,4-5,8-9H2,1-3H3,(H3,15,17,18)/t11-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343022
PNG
((R)-4-(3-(methylamino)pyrrolidin-1-yl)-6-(pyrrolid...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(c1)N1CCCC1
Show InChI InChI=1S/C14H23N5/c1-16-11-4-7-19(10-11)12-8-13(15)17-14(9-12)18-5-2-3-6-18/h8-9,11,16H,2-7,10H2,1H3,(H2,15,17)/t11-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343014
PNG
(CHEMBL1770964 | N2-isobutyl-4-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1cc(cc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C14H25N5/c1-11(2)10-16-14-9-12(8-13(15)17-14)19-6-4-18(3)5-7-19/h8-9,11H,4-7,10H2,1-3H3,(H3,15,16,17)
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n/an/an/an/a 50n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50036705
PNG
(CHEMBL3354816)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC(C)C)c1
Show InChI InChI=1S/C13H22N4/c1-10(2)16-13-8-12(4-6-15-13)17-7-5-11(9-17)14-3/h4,6,8,10-11,14H,5,7,9H2,1-3H3,(H,15,16)/t11-/m1/s1
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n/an/an/an/a 3.16E+3n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343015
PNG
(4-(4-methylpiperazin-1-yl)-6-(pyrrolidin-1-yl)pyri...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(c1)N1CCCC1
Show InChI InChI=1S/C14H23N5/c1-17-6-8-18(9-7-17)12-10-13(15)16-14(11-12)19-4-2-3-5-19/h10-11H,2-9H2,1H3,(H2,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair