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22 similar compounds to monomer 50342985

Compile data set for download or QSAR
Wt: 248.3
BDBM50342981
Wt: 262.3
BDBM50342982
Wt: 248.3
BDBM50342983
Wt: 262.3
BDBM50342984
Wt: 288.3
BDBM50342986
Wt: 276.3
BDBM50342990
Wt: 250.3
BDBM50342992
Wt: 264.3
BDBM50342993
Wt: 264.3
BDBM50342994
Wt: 276.3
BDBM50342995
Wt: 252.3
BDBM50342997
Wt: 262.3
BDBM50343001
Wt: 250.3
BDBM50343005
Wt: 264.3
BDBM50343006
Wt: 264.3
BDBM50343007
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50342981,50342982,50342983,50342984,50342986,50342990,50342992,50342993,50342994,50342995,50342997,50343001,50343005,50343006,50343007   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342990
PNG
(CHEMBL1771001 | N4-cyclopentyl-6-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1cc(NC2CCCC2)nc(N)n1
Show InChI InChI=1S/C14H24N6/c1-19-6-8-20(9-7-19)13-10-12(17-14(15)18-13)16-11-4-2-3-5-11/h10-11H,2-9H2,1H3,(H3,15,16,17,18)
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1n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343007
PNG
((R)-N2-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)C)n1
Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-13-17-11(14)6-12(18-13)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1
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1n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342992
PNG
((R)-N4-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NC(C)C)nc(N)n1
Show InChI InChI=1S/C12H22N6/c1-8(2)15-10-6-11(17-12(13)16-10)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1
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3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342994
PNG
((R)-N4-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCC(C)C)nc(N)n1
Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-11-6-12(18-13(14)17-11)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1
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4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343005
PNG
((R)-N2-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)n1
Show InChI InChI=1S/C12H22N6/c1-8(2)15-12-16-10(13)6-11(17-12)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1
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6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 24: 5489-92 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.013
BindingDB Entry DOI: 10.7270/Q25M67B1
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342982
PNG
(4-(4-Methylpiperazin-1-yl)-6-pyrrolidin-1-ylpyrimi...)
Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-17-6-8-19(9-7-17)12-10-11(15-13(14)16-12)18-4-2-3-5-18/h10H,2-9H2,1H3,(H2,14,15,16)
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6n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343005
PNG
((R)-N2-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)n1
Show InChI InChI=1S/C12H22N6/c1-8(2)15-12-16-10(13)6-11(17-12)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1
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6n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342981
PNG
(4-(piperazin-1-yl)-6-(pyrrolidin-1-yl)pyrimidin-2-...)
Show SMILES Nc1nc(cc(n1)N1CCNCC1)N1CCCC1
Show InChI InChI=1S/C12H20N6/c13-12-15-10(17-5-1-2-6-17)9-11(16-12)18-7-3-14-4-8-18/h9,14H,1-8H2,(H2,13,15,16)
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8n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342995
PNG
((R)-N4-cyclopentyl-6-(3-(methylamino)pyrrolidin-1-...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NC2CCCC2)nc(N)n1
Show InChI InChI=1S/C14H24N6/c1-16-11-6-7-20(9-11)13-8-12(18-14(15)19-13)17-10-4-2-3-5-10/h8,10-11,16H,2-7,9H2,1H3,(H3,15,17,18,19)/t11-/m1/s1
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9n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342984
PNG
((R)-4-(3-(methylamino)pyrrolidin-1-yl)-6-(pyrrolid...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(nc(N)n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-15-10-4-7-19(9-10)12-8-11(16-13(14)17-12)18-5-2-3-6-18/h8,10,15H,2-7,9H2,1H3,(H2,14,16,17)/t10-/m1/s1
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36n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342986
PNG
(CHEMBL1770997 | rac-4-(pyrrolidin-1-yl)-6-(tetrahy...)
Show SMILES Nc1nc(cc(n1)N1CC2CCCNC2C1)N1CCCC1
Show InChI InChI=1S/C15H24N6/c16-15-18-13(20-6-1-2-7-20)8-14(19-15)21-9-11-4-3-5-17-12(11)10-21/h8,11-12,17H,1-7,9-10H2,(H2,16,18,19)
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40n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342997
PNG
((R)-2-(2-amino-6-(3-(methylamino)pyrrolidin-1-yl)p...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCCO)nc(N)n1
Show InChI InChI=1S/C11H20N6O/c1-13-8-2-4-17(7-8)10-6-9(14-3-5-18)15-11(12)16-10/h6,8,13,18H,2-5,7H2,1H3,(H3,12,14,15,16)/t8-/m1/s1
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44n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342993
PNG
((R)-N4-isopropyl-N4-methyl-6-(3-(methylamino)pyrro...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(nc(N)n1)N(C)C(C)C
Show InChI InChI=1S/C13H24N6/c1-9(2)18(4)11-7-12(17-13(14)16-11)19-6-5-10(8-19)15-3/h7,9-10,15H,5-6,8H2,1-4H3,(H2,14,16,17)/t10-/m1/s1
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51n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342983
PNG
((R)-4-(3-aminopyrrolidin-1-yl)-6-(pyrrolidin-1-yl)...)
Show SMILES N[C@@H]1CCN(C1)c1cc(nc(N)n1)N1CCCC1
Show InChI InChI=1S/C12H20N6/c13-9-3-6-18(8-9)11-7-10(15-12(14)16-11)17-4-1-2-5-17/h7,9H,1-6,8,13H2,(H2,14,15,16)/t9-/m1/s1
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64n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343001
PNG
(6-(4-methylpiperazin-1-yl)-2-(pyrrolidin-1-yl)pyri...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-17-6-8-18(9-7-17)12-10-11(14)15-13(16-12)19-4-2-3-5-19/h10H,2-9H2,1H3,(H2,14,15,16)
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132n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343006
PNG
((R)-N2-isopropyl-N2-methyl-6-(3-(methylamino)pyrro...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(n1)N(C)C(C)C
Show InChI InChI=1S/C13H24N6/c1-9(2)18(4)13-16-11(14)7-12(17-13)19-6-5-10(8-19)15-3/h7,9-10,15H,5-6,8H2,1-4H3,(H2,14,16,17)/t10-/m1/s1
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140n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342981
PNG
(4-(piperazin-1-yl)-6-(pyrrolidin-1-yl)pyrimidin-2-...)
Show SMILES Nc1nc(cc(n1)N1CCNCC1)N1CCCC1
Show InChI InChI=1S/C12H20N6/c13-12-15-10(17-5-1-2-6-17)9-11(16-12)18-7-3-14-4-8-18/h9,14H,1-8H2,(H2,13,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342982
PNG
(4-(4-Methylpiperazin-1-yl)-6-pyrrolidin-1-ylpyrimi...)
Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-17-6-8-19(9-7-17)12-10-11(15-13(14)16-12)18-4-2-3-5-18/h10H,2-9H2,1H3,(H2,14,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342984
PNG
((R)-4-(3-(methylamino)pyrrolidin-1-yl)-6-(pyrrolid...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(nc(N)n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-15-10-4-7-19(9-10)12-8-11(16-13(14)17-12)18-5-2-3-6-18/h8,10,15H,2-7,9H2,1H3,(H2,14,16,17)/t10-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342992
PNG
((R)-N4-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NC(C)C)nc(N)n1
Show InChI InChI=1S/C12H22N6/c1-8(2)15-10-6-11(17-12(13)16-10)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342994
PNG
((R)-N4-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCC(C)C)nc(N)n1
Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-11-6-12(18-13(14)17-11)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342995
PNG
((R)-N4-cyclopentyl-6-(3-(methylamino)pyrrolidin-1-...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NC2CCCC2)nc(N)n1
Show InChI InChI=1S/C14H24N6/c1-16-11-6-7-20(9-11)13-8-12(18-14(15)19-13)17-10-4-2-3-5-10/h8,10-11,16H,2-7,9H2,1H3,(H3,15,17,18,19)/t11-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343005
PNG
((R)-N2-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)n1
Show InChI InChI=1S/C12H22N6/c1-8(2)15-12-16-10(13)6-11(17-12)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343007
PNG
((R)-N2-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)C)n1
Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-13-17-11(14)6-12(18-13)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342990
PNG
(CHEMBL1771001 | N4-cyclopentyl-6-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1cc(NC2CCCC2)nc(N)n1
Show InChI InChI=1S/C14H24N6/c1-19-6-8-20(9-7-19)13-10-12(17-14(15)18-13)16-11-4-2-3-5-11/h10-11H,2-9H2,1H3,(H3,15,16,17,18)
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n/an/an/an/a 101n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair