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2 similar compounds to monomer 50076476

Compile data set for download or QSAR
Wt: 203.1
BDBM50038038
Wt: 215.1
BDBM50076477

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50038038,50076477   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50038038
PNG
((S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl...)
Show SMILES N[C@@H](CCn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H9N3O5/c7-3(4(10)11)1-2-9-5(12)8-6(13)14-9/h3H,1-2,7H2,(H,10,11)(H,8,12,13)/t3-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
2.30E+4n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50038038
PNG
((S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl...)
Show SMILES N[C@@H](CCn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H9N3O5/c7-3(4(10)11)1-2-9-5(12)8-6(13)14-9/h3H,1-2,7H2,(H,10,11)(H,8,12,13)/t3-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
3.60E+4n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned metabotropic glutamate receptor 5


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50038038
PNG
((S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl...)
Show SMILES N[C@@H](CCn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H9N3O5/c7-3(4(10)11)1-2-9-5(12)8-6(13)14-9/h3H,1-2,7H2,(H,10,11)(H,8,12,13)/t3-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.84E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50038038
PNG
((S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl...)
Show SMILES N[C@@H](CCn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H9N3O5/c7-3(4(10)11)1-2-9-5(12)8-6(13)14-9/h3H,1-2,7H2,(H,10,11)(H,8,12,13)/t3-/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50038038
PNG
((S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl...)
Show SMILES N[C@@H](CCn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H9N3O5/c7-3(4(10)11)1-2-9-5(12)8-6(13)14-9/h3H,1-2,7H2,(H,10,11)(H,8,12,13)/t3-/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



Universit£ Ren£ Descartes-Paris V

Curated by ChEMBL


Assay Description
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inacti...


J Med Chem 48: 2534-47 (2005)


Article DOI: 10.1021/jm049092j
BindingDB Entry DOI: 10.7270/Q23X87FM
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50076477
PNG
(1-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-cy...)
Show SMILES N[C@@]1(C[C@@H](C1)n1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H9N3O5/c8-7(4(11)12)1-3(2-7)10-5(13)9-6(14)15-10/h3H,1-2,8H2,(H,11,12)(H,9,13,14)/t3-,7+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.10E+4n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Compound was tested for the stimulation of Phosphoinositide (PI) hydrolysis in BHK cells expresssing mGluR5a receptor


J Med Chem 42: 1639-47 (1999)


Article DOI: 10.1021/jm9806897
BindingDB Entry DOI: 10.7270/Q2028QQF
More data for this
Ligand-Target Pair