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17 similar compounds to monomer 50038210

Compile data set for download or QSAR
Wt: 207.2
BDBM50038214
Wt: 221.3
BDBM50038215
Wt: 207.2
BDBM50038216
Wt: 191.2
BDBM50038218
Wt: 235.3
BDBM50038221
Wt: 207.2
BDBM50038223
Wt: 203.2
BDBM50038225
Wt: 179.2
BDBM50038226
Wt: 235.3
BDBM50038231
Wt: 263.3
BDBM50038237
Wt: 165.1
BDBM50038238
Purchase
Wt: 277.4
BDBM50038239
Wt: 249.3
BDBM50038241
Wt: 205.2
BDBM50038242
Wt: 179.2
BDBM50038244
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50038214,50038215,50038216,50038218,50038221,50038223,50038225,50038226,50038231,50038237,50038238,50038239,50038241,50038242,50038244   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038242
PNG
(5-(2-Allyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetr...)
Show SMILES CN1CCC=C(C1)c1nnn(CC=C)n1
Show InChI InChI=1S/C10H15N5/c1-3-6-15-12-10(11-13-15)9-5-4-7-14(2)8-9/h3,5H,1,4,6-8H2,2H3
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21n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038221
PNG
(1-Methyl-5-(2-pentyl-2H-tetrazol-5-yl)-1,2,3,6-tet...)
Show SMILES CCCCCn1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C12H21N5/c1-3-4-5-9-17-14-12(13-15-17)11-7-6-8-16(2)10-11/h7H,3-6,8-10H2,1-2H3
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26n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038239
PNG
(1-Methyl-5-(2-octyl-2H-tetrazol-5-yl)-1,2,3,6-tetr...)
Show SMILES CCCCCCCCn1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C15H27N5/c1-3-4-5-6-7-8-12-20-17-15(16-18-20)14-10-9-11-19(2)13-14/h10H,3-9,11-13H2,1-2H3
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27n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038241
PNG
(5-(2-Hexyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetr...)
Show SMILES CCCCCCn1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C13H23N5/c1-3-4-5-6-10-18-15-13(14-16-18)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3
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32n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038237
PNG
(5-(2-Heptyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tet...)
Show SMILES CCCCCCCn1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C14H25N5/c1-3-4-5-6-7-11-19-16-14(15-17-19)13-9-8-10-18(2)12-13/h9H,3-8,10-12H2,1-2H3
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37n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038215
PNG
(5-(2-Butyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetr...)
Show SMILES CCCCn1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C11H19N5/c1-3-4-8-16-13-11(12-14-16)10-6-5-7-15(2)9-10/h6H,3-5,7-9H2,1-2H3
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37n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038225
PNG
(1-Methyl-5-(2-prop-2-ynyl-2H-tetrazol-5-yl)-1,2,3,...)
Show SMILES CN1CCC=C(C1)c1nnn(CC#C)n1
Show InChI InChI=1S/C10H13N5/c1-3-6-15-12-10(11-13-15)9-5-4-7-14(2)8-9/h1,5H,4,6-8H2,2H3
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44n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038216
PNG
(1-Methyl-5-(2-propyl-2H-tetrazol-5-yl)-1,2,3,6-tet...)
Show SMILES CCCn1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C10H17N5/c1-3-6-15-12-10(11-13-15)9-5-4-7-14(2)8-9/h5H,3-4,6-8H2,1-2H3
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57n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038223
PNG
(5-(2-Isopropyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-...)
Show SMILES CC(C)n1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C10H17N5/c1-8(2)15-12-10(11-13-15)9-5-4-6-14(3)7-9/h5,8H,4,6-7H2,1-3H3
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84n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038218
PNG
(1-Methyl-5-(2-vinyl-2H-tetrazol-5-yl)-1,2,3,6-tetr...)
Show SMILES CN1CCC=C(C1)c1nnn(C=C)n1
Show InChI InChI=1S/C9H13N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h3,5H,1,4,6-7H2,2H3
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120n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038214
PNG
(1-Ethyl-5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetra...)
Show SMILES CCN1CCC=C(C1)c1nnn(CC)n1
Show InChI InChI=1S/C10H17N5/c1-3-14-7-5-6-9(8-14)10-11-13-15(4-2)12-10/h6H,3-5,7-8H2,1-2H3
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140n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038244
PNG
(1-Methyl-5-(2-methyl-2H-tetrazol-5-yl)-1,2,3,6-tet...)
Show SMILES CN1CCC=C(C1)c1nnn(C)n1
Show InChI InChI=1S/C8H13N5/c1-12-5-3-4-7(6-12)8-9-11-13(2)10-8/h4H,3,5-6H2,1-2H3
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250n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038226
PNG
(5-(2-Ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-py...)
Show SMILES CCn1nnc(n1)C1=CCCNC1
Show InChI InChI=1S/C8H13N5/c1-2-13-11-8(10-12-13)7-4-3-5-9-6-7/h4,9H,2-3,5-6H2,1H3
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960n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038238
PNG
(5-(2-Methyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-p...)
Show SMILES Cn1nnc(n1)C1=CCCNC1
Show InChI InChI=1S/C7H11N5/c1-12-10-7(9-11-12)6-3-2-4-8-5-6/h3,8H,2,4-5H2,1H3
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1.35E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038231
PNG
(1-Butyl-5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetra...)
Show SMILES CCCCN1CCC=C(C1)c1nnn(CC)n1
Show InChI InChI=1S/C12H21N5/c1-3-5-8-16-9-6-7-11(10-16)12-13-15-17(4-2)14-12/h7H,3-6,8-10H2,1-2H3
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1.40E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50038226
PNG
(5-(2-Ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-py...)
Show SMILES CCn1nnc(n1)C1=CCCNC1
Show InChI InChI=1S/C8H13N5/c1-2-13-11-8(10-12-13)7-4-3-5-9-6-7/h4,9H,2-3,5-6H2,1H3
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n/an/an/an/a 1.90E+3n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
M2 agonist activity estimated by depression of isolated guinea pig left atrium


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50038226
PNG
(5-(2-Ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-py...)
Show SMILES CCn1nnc(n1)C1=CCCNC1
Show InChI InChI=1S/C8H13N5/c1-2-13-11-8(10-12-13)7-4-3-5-9-6-7/h4,9H,2-3,5-6H2,1H3
MMDB

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n/an/an/an/a 6.40E+3n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro ability of the compound to contract isolated guinea pig ileum was used to estimate M3 agonist effect


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair