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10 similar compounds to monomer 50038219

Compile data set for download or QSAR
Wt: 204.2
BDBM50038220
Wt: 192.2
BDBM50038224
Wt: 220.3
BDBM50038227
Wt: 206.2
BDBM50038232
Purchase
Wt: 164.2
BDBM50038234
Purchase
Wt: 178.2
BDBM50038235
Wt: 202.2
BDBM50038236
Wt: 206.2
BDBM50038245
Wt: 192.2
BDBM50038252
Wt: 190.2
BDBM50038253

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50038220,50038224,50038227,50038232,50038234,50038235,50038236,50038245,50038252,50038253   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038220
PNG
(5-(2-Allyl-2H-[1,2,3]triazol-4-yl)-1-methyl-1,2,3,...)
Show SMILES CN1CCC=C(C1)c1cnn(CC=C)n1
Show InChI InChI=1S/C11H16N4/c1-3-6-15-12-8-11(13-15)10-5-4-7-14(2)9-10/h3,5,8H,1,4,6-7,9H2,2H3
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6.30n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038236
PNG
(1-Methyl-5-(2-prop-2-ynyl-2H-[1,2,3]triazol-4-yl)-...)
Show SMILES CN1CCC=C(C1)c1cnn(CC#C)n1
Show InChI InChI=1S/C11H14N4/c1-3-6-15-12-8-11(13-15)10-5-4-7-14(2)9-10/h1,5,8H,4,6-7,9H2,2H3
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7.70n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038227
PNG
(5-(2-Butyl-2H-[1,2,3]triazol-4-yl)-1-methyl-1,2,3,...)
Show SMILES CCCCn1ncc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C12H20N4/c1-3-4-8-16-13-9-12(14-16)11-6-5-7-15(2)10-11/h6,9H,3-5,7-8,10H2,1-2H3
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13n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038232
PNG
(1-Methyl-5-(2-propyl-2H-[1,2,3]triazol-4-yl)-1,2,3...)
Show SMILES CCCn1ncc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C11H18N4/c1-3-6-15-12-8-11(13-15)10-5-4-7-14(2)9-10/h5,8H,3-4,6-7,9H2,1-2H3
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15n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038224
PNG
(5-(2-Ethyl-2H-[1,2,3]triazol-4-yl)-1-methyl-1,2,3,...)
Show SMILES CCn1ncc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C10H16N4/c1-3-14-11-7-10(12-14)9-5-4-6-13(2)8-9/h5,7H,3-4,6,8H2,1-2H3
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24n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038253
PNG
(1-Methyl-5-(2-vinyl-2H-[1,2,3]triazol-4-yl)-1,2,3,...)
Show SMILES CN1CCC=C(C1)c1cnn(C=C)n1
Show InChI InChI=1S/C10H14N4/c1-3-14-11-7-10(12-14)9-5-4-6-13(2)8-9/h3,5,7H,1,4,6,8H2,2H3
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40n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038252
PNG
(5-(2-Propyl-2H-[1,2,3]triazol-4-yl)-1,2,3,6-tetrah...)
Show SMILES CCCn1ncc(n1)C1=CCCNC1
Show InChI InChI=1S/C10H16N4/c1-2-6-14-12-8-10(13-14)9-4-3-5-11-7-9/h4,8,11H,2-3,5-7H2,1H3
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77n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038245
PNG
(5-(2-Butyl-2H-[1,2,3]triazol-4-yl)-1,2,3,6-tetrahy...)
Show SMILES CCCCn1ncc(n1)C1=CCCNC1
Show InChI InChI=1S/C11H18N4/c1-2-3-7-15-13-9-11(14-15)10-5-4-6-12-8-10/h5,9,12H,2-4,6-8H2,1H3
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100n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038235
PNG
(5-(2-Ethyl-2H-[1,2,3]triazol-4-yl)-1,2,3,6-tetrahy...)
Show SMILES CCn1ncc(n1)C1=CCCNC1
Show InChI InChI=1S/C9H14N4/c1-2-13-11-7-9(12-13)8-4-3-5-10-6-8/h4,7,10H,2-3,5-6H2,1H3
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120n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038234
PNG
(5-(2-Methyl-2H-[1,2,3]triazol-4-yl)-1,2,3,6-tetrah...)
Show SMILES Cn1ncc(n1)C1=CCCNC1
Show InChI InChI=1S/C8H12N4/c1-12-10-6-8(11-12)7-3-2-4-9-5-7/h3,6,9H,2,4-5H2,1H3
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500n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50038235
PNG
(5-(2-Ethyl-2H-[1,2,3]triazol-4-yl)-1,2,3,6-tetrahy...)
Show SMILES CCn1ncc(n1)C1=CCCNC1
Show InChI InChI=1S/C9H14N4/c1-2-13-11-7-9(12-13)8-4-3-5-10-6-8/h4,7,10H,2-3,5-6H2,1H3
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n/an/an/an/a 270n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
M2 agonist activity estimated by depression of isolated guinea pig left atrium


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50038224
PNG
(5-(2-Ethyl-2H-[1,2,3]triazol-4-yl)-1-methyl-1,2,3,...)
Show SMILES CCn1ncc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C10H16N4/c1-3-14-11-7-10(12-14)9-5-4-6-13(2)8-9/h5,7H,3-4,6,8H2,1-2H3
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n/an/an/an/a>5.10E+4n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
M2 agonist activity estimated by depression of isolated guinea pig left atrium


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038224
PNG
(5-(2-Ethyl-2H-[1,2,3]triazol-4-yl)-1-methyl-1,2,3,...)
Show SMILES CCn1ncc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C10H16N4/c1-3-14-11-7-10(12-14)9-5-4-6-13(2)8-9/h5,7H,3-4,6,8H2,1-2H3
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n/an/an/an/a>1.20E+3n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
M1 agonist activity estimated by rat superior cervical ganglion depolarization


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair