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17 similar compounds to monomer 50038906

Compile data set for download or QSAR
Wt: 437.8
BDBM50038900
Wt: 444.2
BDBM50038901
Wt: 444.2
BDBM50038902
Wt: 409.8
BDBM50038904
Wt: 451.8
BDBM50038905
Wt: 409.8
BDBM50038908
Wt: 423.8
BDBM50038910
Wt: 423.8
BDBM50038912
Wt: 444.2
BDBM50038913
Wt: 455.8
BDBM50038915
Wt: 437.8
BDBM50038918
Wt: 437.8
BDBM50038919
Wt: 458.2
BDBM50038920
Wt: 423.8
BDBM50038921
Wt: 437.8
BDBM50038923
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50038900,50038901,50038902,50038904,50038905,50038908,50038910,50038912,50038913,50038915,50038918,50038919,50038920,50038921,50038923   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038900
PNG
(1-(7-Chloro-6-methyl-4-o-tolyl-quinolin-3-yl)-3-(2...)
Show SMILES Cc1ccccc1-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2cc(Cl)c(C)cc12
Show InChI InChI=1S/C24H18ClF2N3O/c1-13-5-3-4-6-16(13)23-17-9-14(2)18(25)11-21(17)28-12-22(23)30-24(31)29-20-8-7-15(26)10-19(20)27/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 9.30n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038920
PNG
(1-[6-Chloro-4-(2-chloro-phenyl)-8-methyl-quinolin-...)
Show SMILES Cc1cc(Cl)cc2c(c(NC(=O)Nc3ccc(F)cc3F)cnc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H15Cl2F2N3O/c1-12-8-13(24)9-16-21(15-4-2-3-5-17(15)25)20(11-28-22(12)16)30-23(31)29-19-7-6-14(26)10-18(19)27/h2-11H,1H3,(H2,29,30,31)
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n/an/a 12n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038902
PNG
(1-[6-Chloro-4-(4-chloro-phenyl)-quinolin-3-yl]-3-(...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C22H13Cl2F2N3O/c23-13-3-1-12(2-4-13)21-16-9-14(24)5-7-18(16)27-11-20(21)29-22(30)28-19-8-6-15(25)10-17(19)26/h1-11H,(H2,28,29,30)
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n/an/a 534n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038904
PNG
(1-(6-Chloro-4-phenyl-quinolin-3-yl)-3-(2,4-difluor...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccccc2)c(F)c1
Show InChI InChI=1S/C22H14ClF2N3O/c23-14-6-8-18-16(10-14)21(13-4-2-1-3-5-13)20(12-26-18)28-22(29)27-19-9-7-15(24)11-17(19)25/h1-12H,(H2,27,28,29)
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n/an/a 215n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038905
PNG
(1-[4-(2-Chloro-phenyl)-6-isopropyl-quinolin-3-yl]-...)
Show SMILES CC(C)c1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C25H20ClF2N3O/c1-14(2)15-7-9-21-18(11-15)24(17-5-3-4-6-19(17)26)23(13-29-21)31-25(32)30-22-10-8-16(27)12-20(22)28/h3-14H,1-2H3,(H2,30,31,32)
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n/an/a 14n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038908
PNG
(1-[4-(2-Chloro-phenyl)-quinolin-3-yl]-3-(2,4-diflu...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccccc3c2-c2ccccc2Cl)c(F)c1
Show InChI InChI=1S/C22H14ClF2N3O/c23-16-7-3-1-5-14(16)21-15-6-2-4-8-18(15)26-12-20(21)28-22(29)27-19-10-9-13(24)11-17(19)25/h1-12H,(H2,27,28,29)
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n/an/a 125n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038910
PNG
(1-(6-Chloro-4-p-tolyl-quinolin-3-yl)-3-(2,4-difluo...)
Show SMILES Cc1ccc(cc1)-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2ccc(Cl)cc12
Show InChI InChI=1S/C23H16ClF2N3O/c1-13-2-4-14(5-3-13)22-17-10-15(24)6-8-19(17)27-12-21(22)29-23(30)28-20-9-7-16(25)11-18(20)26/h2-12H,1H3,(H2,28,29,30)
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n/an/a 160n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038913
PNG
(1-[6-Chloro-4-(3-chloro-phenyl)-quinolin-3-yl]-3-(...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2cccc(Cl)c2)c(F)c1
Show InChI InChI=1S/C22H13Cl2F2N3O/c23-13-3-1-2-12(8-13)21-16-9-14(24)4-6-18(16)27-11-20(21)29-22(30)28-19-7-5-15(25)10-17(19)26/h1-11H,(H2,28,29,30)
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n/an/a 90.6n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038915
PNG
(1-[4-(2-Chloro-phenyl)-6,8-dimethyl-quinolin-3-yl]...)
Show SMILES Cc1cc(C)c2ncc(NC(=O)Nc3c(F)cc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C24H17ClF3N3O/c1-12-7-13(2)22-16(8-12)21(15-5-3-4-6-17(15)25)20(11-29-22)30-24(32)31-23-18(27)9-14(26)10-19(23)28/h3-11H,1-2H3,(H2,30,31,32)
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n/an/a 15n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038912
PNG
(1-[4-(2-Chloro-phenyl)-6-methyl-quinolin-3-yl]-3-(...)
Show SMILES Cc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C23H16ClF2N3O/c1-13-6-8-19-16(10-13)22(15-4-2-3-5-17(15)24)21(12-27-19)29-23(30)28-20-9-7-14(25)11-18(20)26/h2-12H,1H3,(H2,28,29,30)
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n/an/a 16.8n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038918
PNG
(1-[4-(2-Chloro-phenyl)-6,8-dimethyl-quinolin-3-yl]...)
Show SMILES Cc1cc(C)c2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C24H18ClF2N3O/c1-13-9-14(2)23-17(10-13)22(16-5-3-4-6-18(16)25)21(12-28-23)30-24(31)29-20-8-7-15(26)11-19(20)27/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 9.20n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038921
PNG
(3-(6-Chloro-4-phenyl-quinolin-3-yl)-1-(2,4-difluor...)
Show SMILES CN(C(=O)Nc1cnc2ccc(Cl)cc2c1-c1ccccc1)c1ccc(F)cc1F
Show InChI InChI=1S/C23H16ClF2N3O/c1-29(21-10-8-16(25)12-18(21)26)23(30)28-20-13-27-19-9-7-15(24)11-17(19)22(20)14-5-3-2-4-6-14/h2-13H,1H3,(H,28,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038919
PNG
(1-[4-(2-Chloro-phenyl)-6-ethyl-quinolin-3-yl]-3-(2...)
Show SMILES CCc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C24H18ClF2N3O/c1-2-14-7-9-20-17(11-14)23(16-5-3-4-6-18(16)25)22(13-28-20)30-24(31)29-21-10-8-15(26)12-19(21)27/h3-13H,2H2,1H3,(H2,29,30,31)
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n/an/a 14n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038923
PNG
(1-[4-(2-Chloro-phenyl)-6,7-dimethyl-quinolin-3-yl]...)
Show SMILES Cc1cc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2cc1C
Show InChI InChI=1S/C24H18ClF2N3O/c1-13-9-17-21(10-14(13)2)28-12-22(23(17)16-5-3-4-6-18(16)25)30-24(31)29-20-8-7-15(26)11-19(20)27/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 5.80n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038901
PNG
(1-[6-Chloro-4-(2-chloro-phenyl)-quinolin-3-yl]-3-(...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccccc2Cl)c(F)c1
Show InChI InChI=1S/C22H13Cl2F2N3O/c23-12-5-7-18-15(9-12)21(14-3-1-2-4-16(14)24)20(11-27-18)29-22(30)28-19-8-6-13(25)10-17(19)26/h1-11H,(H2,28,29,30)
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n/an/a 21.2n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair