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16 similar compounds to monomer 50041691

Compile data set for download or QSAR
Wt: 457.4
BDBM50041692
Wt: 485.5
BDBM50041693
Wt: 459.5
BDBM50041695
Wt: 431.4
BDBM50041697
Wt: 429.4
BDBM50041698
Wt: 471.5
BDBM50041704
Wt: 428.5
BDBM50041705
Wt: 423.8
BDBM50041706
Wt: 414.3
BDBM50041707
Wt: 376.4
BDBM50041708
Wt: 457.3
BDBM50041812
Wt: 430.3
BDBM50041813
Wt: 445.4
BDBM50041694
Wt: 443.4
BDBM50041699
Wt: 457.4
BDBM50041703
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50041692,50041693,50041695,50041697,50041698,50041704,50041705,50041706,50041707,50041708,50041812,50041813,50041694,50041699,50041703   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041692
PNG
(CHEMBL3358919)
Show SMILES OC(=O)C[C@@H]1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(c3)C(F)(F)F)cc21
Show InChI InChI=1/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)/t17-/s2
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n/an/an/an/a 0.0900n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041703
PNG
(CHEMBL3358912)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(c3)C(F)(F)F)cc21
Show InChI InChI=1/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)
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n/an/an/an/a 0.0730n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041694
PNG
(CHEMBL3358917)
Show SMILES CC(C)Cc1ccc(COc2ccc3[nH]c4C(CC(O)=O)CCc4c3c2)cc1C(F)(F)F
Show InChI InChI=1/C25H26F3NO3/c1-14(2)9-16-4-3-15(10-21(16)25(26,27)28)13-32-18-6-8-22-20(12-18)19-7-5-17(11-23(30)31)24(19)29-22/h3-4,6,8,10,12,14,17,29H,5,7,9,11,13H2,1-2H3,(H,30,31)
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n/an/an/an/a 0.440n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041695
PNG
(CHEMBL3358916)
Show SMILES CC(C)(C)Cc1ccc(COc2ccc3[nH]c4C(CC(O)=O)CCc4c3c2)cc1C(F)(F)F
Show InChI InChI=1/C26H28F3NO3/c1-25(2,3)13-17-5-4-15(10-21(17)26(27,28)29)14-33-18-7-9-22-20(12-18)19-8-6-16(11-23(31)32)24(19)30-22/h4-5,7,9-10,12,16,30H,6,8,11,13-14H2,1-3H3,(H,31,32)
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n/an/an/an/a 56n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041697
PNG
(CHEMBL3358915)
Show SMILES CCCc1ccc(COc2ccc3[nH]c4C(CC(O)=O)CCc4c3c2)cc1C(F)(F)F
Show InChI InChI=1/C24H24F3NO3/c1-2-3-15-5-4-14(10-20(15)24(25,26)27)13-31-17-7-9-21-19(12-17)18-8-6-16(11-22(29)30)23(18)28-21/h4-5,7,9-10,12,16,28H,2-3,6,8,11,13H2,1H3,(H,29,30)
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n/an/an/an/a 0.490n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041698
PNG
(CHEMBL3358914)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C4CC4)c(c3)C(F)(F)F)cc21
Show InChI InChI=1/C24H22F3NO3/c25-24(26,27)20-9-13(1-6-17(20)14-2-3-14)12-31-16-5-8-21-19(11-16)18-7-4-15(10-22(29)30)23(18)28-21/h1,5-6,8-9,11,14-15,28H,2-4,7,10,12H2,(H,29,30)
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n/an/an/an/a 3.70n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041699
PNG
(CHEMBL3358913)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C4CCC4)c(c3)C(F)(F)F)cc21
Show InChI InChI=1/C25H24F3NO3/c26-25(27,28)21-10-14(4-7-18(21)15-2-1-3-15)13-32-17-6-9-22-20(12-17)19-8-5-16(11-23(30)31)24(19)29-22/h4,6-7,9-10,12,15-16,29H,1-3,5,8,11,13H2,(H,30,31)
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n/an/an/an/a 0.450n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041704
PNG
(CHEMBL3358911)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCCC4)c(c3)C(F)(F)F)cc21
Show InChI InChI=1/C27H28F3NO3/c28-27(29,30)23-12-16(6-9-20(23)17-4-2-1-3-5-17)15-34-19-8-11-24-22(14-19)21-10-7-18(13-25(32)33)26(21)31-24/h6,8-9,11-12,14,17-18,31H,1-5,7,10,13,15H2,(H,32,33)
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n/an/an/an/a 0.0770n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041705
PNG
(CHEMBL3358910)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCCC4)c(c3)C#N)cc21
Show InChI InChI=1/C27H28N2O3/c28-15-20-12-17(6-9-22(20)18-4-2-1-3-5-18)16-32-21-8-11-25-24(14-21)23-10-7-19(13-26(30)31)27(23)29-25/h6,8-9,11-12,14,18-19,29H,1-5,7,10,13,16H2,(H,30,31)
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n/an/an/an/a 0.0870n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041706
PNG
(CHEMBL3358909)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(Cl)c(c3)C(F)(F)F)cc21
Show InChI InChI=1/C21H17ClF3NO3/c22-17-5-1-11(7-16(17)21(23,24)25)10-29-13-3-6-18-15(9-13)14-4-2-12(8-19(27)28)20(14)26-18/h1,3,5-7,9,12,26H,2,4,8,10H2,(H,27,28)
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n/an/an/an/a 159n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041707
PNG
(CHEMBL3358908)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C#N)c(c3)C(F)(F)F)cc21
Show InChI InChI=1/C22H17F3N2O3/c23-22(24,25)18-7-12(1-2-14(18)10-26)11-30-15-4-6-19-17(9-15)16-5-3-13(8-20(28)29)21(16)27-19/h1-2,4,6-7,9,13,27H,3,5,8,11H2,(H,28,29)
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n/an/an/an/a 141n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041708
PNG
(CHEMBL3358907)
Show SMILES COc1ccc(COc2ccc3[nH]c4C(CC(O)=O)CCc4c3c2)cc1C#N
Show InChI InChI=1/C22H20N2O4/c1-27-20-7-2-13(8-15(20)11-23)12-28-16-4-6-19-18(10-16)17-5-3-14(9-21(25)26)22(17)24-19/h2,4,6-8,10,14,24H,3,5,9,12H2,1H3,(H,25,26)
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n/an/an/an/a 120n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041812
PNG
(CHEMBL3358905)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3cc(cc(c3)C(F)(F)F)C(F)(F)F)cc21
Show InChI InChI=1/C22H17F6NO3/c23-21(24,25)13-5-11(6-14(8-13)22(26,27)28)10-32-15-2-4-18-17(9-15)16-3-1-12(7-19(30)31)20(16)29-18/h2,4-6,8-9,12,29H,1,3,7,10H2,(H,30,31)
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n/an/an/an/a 26n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041813
PNG
(CHEMBL3358904)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3cc(OC(F)(F)F)cc(c3)C#N)cc21
Show InChI InChI=1/C22H17F3N2O4/c23-22(24,25)31-16-6-12(10-26)5-13(7-16)11-30-15-2-4-19-18(9-15)17-3-1-14(8-20(28)29)21(17)27-19/h2,4-7,9,14,27H,1,3,8,11H2,(H,28,29)
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n/an/an/an/a 16n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50041693
PNG
(CHEMBL3358918)
Show SMILES OC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(CC4CCCCC4)c(c3)C(F)(F)F)cc21
Show InChI InChI=1/C28H30F3NO3/c29-28(30,31)24-13-18(6-7-19(24)12-17-4-2-1-3-5-17)16-35-21-9-11-25-23(15-21)22-10-8-20(14-26(33)34)27(22)32-25/h6-7,9,11,13,15,17,20,32H,1-5,8,10,12,14,16H2,(H,33,34)
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n/an/an/an/a 4.60n/an/an/an/a



Arena Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay


ACS Med Chem Lett 5: 1313-7 (2014)


Article DOI: 10.1021/ml500389m
BindingDB Entry DOI: 10.7270/Q29W0H4C
More data for this
Ligand-Target Pair