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16 similar compounds to monomer 50005347

Wt: 399.4
BDBM50043253
Wt: 399.4
BDBM50043258
Wt: 398.4
BDBM50043261
Wt: 399.4
BDBM50043262
Wt: 398.4
BDBM50043267
Wt: 399.4
BDBM50043272
Wt: 441.5
BDBM50043273
Wt: 398.4
BDBM50043274
Wt: 398.4
BDBM50043278
Wt: 370.4
BDBM50324039
Wt: 449.3
BDBM50324040
Wt: 449.3
BDBM50324041
Wt: 528.2
BDBM50324042
Wt: 474.5
BDBM50324043
Wt: 476.5
BDBM50324045
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50043253,50043258,50043261,50043262,50043267,50043272,50043273,50043274,50043278,50324039,50324040,50324041,50324042,50324043,50324045   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II AT1B


(RAT)
BDBM50043253
PNG
(4'-(7-Amino-2-butyl-benzoimidazol-1-ylmethyl)-biph...)
Show SMILES CCCCc1nc2cccc(N)c2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C25H25N3O2/c1-2-3-11-23-27-22-10-6-9-21(26)24(22)28(23)16-17-12-14-18(15-13-17)19-7-4-5-8-20(19)25(29)30/h4-10,12-15H,2-3,11,16,26H2,1H3,(H,29,30)
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n/an/a 1.06E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
AGTR1


(RAT)
BDBM50043258
PNG
(4'-(5-Amino-2-butyl-benzoimidazol-1-ylmethyl)-biph...)
Show SMILES CCCCc1nc2cc(N)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C25H25N3O2/c1-2-3-8-24-27-22-15-19(26)13-14-23(22)28(24)16-17-9-11-18(12-10-17)20-6-4-5-7-21(20)25(29)30/h4-7,9-15H,2-3,8,16,26H2,1H3,(H,29,30)
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n/an/an/a 15.8n/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in rat aorta


Eur J Med Chem 43: 1808-12 (2008)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043262
PNG
(4'-(4-Amino-2-butyl-benzoimidazol-1-ylmethyl)-biph...)
Show SMILES CCCCc1nc2c(N)cccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C25H25N3O2/c1-2-3-11-23-27-24-21(26)9-6-10-22(24)28(23)16-17-12-14-18(15-13-17)19-7-4-5-8-20(19)25(29)30/h4-10,12-15H,2-3,11,16,26H2,1H3,(H,29,30)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043261
PNG
(4'-(2-Butyl-6-methyl-benzoimidazol-1-ylmethyl)-bip...)
Show SMILES CCCCc1nc2ccc(C)cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C26H26N2O2/c1-3-4-9-25-27-23-15-10-18(2)16-24(23)28(25)17-19-11-13-20(14-12-19)21-7-5-6-8-22(21)26(29)30/h5-8,10-16H,3-4,9,17H2,1-2H3,(H,29,30)
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n/an/a 850n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043267
PNG
(4'-(2-Butyl-5-methyl-benzoimidazol-1-ylmethyl)-bip...)
Show SMILES CCCCc1nc2cc(C)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C26H26N2O2/c1-3-4-9-25-27-23-16-18(2)10-15-24(23)28(25)17-19-11-13-20(14-12-19)21-7-5-6-8-22(21)26(29)30/h5-8,10-16H,3-4,9,17H2,1-2H3,(H,29,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043273
PNG
(4'-(5-Acetylamino-2-butyl-benzoimidazol-1-ylmethyl...)
Show SMILES CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C27H27N3O3/c1-3-4-9-26-29-24-16-21(28-18(2)31)14-15-25(24)30(26)17-19-10-12-20(13-11-19)22-7-5-6-8-23(22)27(32)33/h5-8,10-16H,3-4,9,17H2,1-2H3,(H,28,31)(H,32,33)
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n/an/a 460n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043272
PNG
(4'-(6-Amino-2-butyl-benzoimidazol-1-ylmethyl)-biph...)
Show SMILES CCCCc1nc2ccc(N)cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C25H25N3O2/c1-2-3-8-24-27-22-14-13-19(26)15-23(22)28(24)16-17-9-11-18(12-10-17)20-6-4-5-7-21(20)25(29)30/h4-7,9-15H,2-3,8,16,26H2,1H3,(H,29,30)
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n/an/a 540n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043274
PNG
(4'-(2-Butyl-7-methyl-benzoimidazol-1-ylmethyl)-bip...)
Show SMILES CCCCc1nc2cccc(C)c2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C26H26N2O2/c1-3-4-12-24-27-23-11-7-8-18(2)25(23)28(24)17-19-13-15-20(16-14-19)21-9-5-6-10-22(21)26(29)30/h5-11,13-16H,3-4,12,17H2,1-2H3,(H,29,30)
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n/an/a 480n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043278
PNG
(4'-(2-Butyl-4-methyl-benzoimidazol-1-ylmethyl)-bip...)
Show SMILES CCCCc1nc2c(C)cccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C26H26N2O2/c1-3-4-12-24-27-25-18(2)8-7-11-23(25)28(24)17-19-13-15-20(16-14-19)21-9-5-6-10-22(21)26(29)30/h5-11,13-16H,3-4,12,17H2,1-2H3,(H,29,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50324039
PNG
(4'-[(2-Propyl-1H-benzo[d]imidazol-1-yl)methyl]biph...)
Show SMILES CCCc1nc2ccccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H22N2O2/c1-2-7-23-25-21-10-5-6-11-22(21)26(23)16-17-12-14-18(15-13-17)19-8-3-4-9-20(19)24(27)28/h3-6,8-15H,2,7,16H2,1H3,(H,27,28)
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n/an/an/an/a 1.90E+3n/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Activation of Gal4-tagged human PPARgamma expressed in CHO cells by luciferase reporter gene assay


Bioorg Med Chem 18: 5885-95 (2010)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50324040
PNG
(4'-[(5-Bromo-2-propyl-1H-benzo[d]imidazol-1-yl)met...)
Show SMILES CCCc1nc2cc(Br)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H21BrN2O2/c1-2-5-23-26-21-14-18(25)12-13-22(21)27(23)15-16-8-10-17(11-9-16)19-6-3-4-7-20(19)24(28)29/h3-4,6-14H,2,5,15H2,1H3,(H,28,29)
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n/an/an/an/a 400n/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Activation of Gal4-tagged human PPARgamma expressed in CHO cells by luciferase reporter gene assay


Bioorg Med Chem 18: 5885-95 (2010)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50324041
PNG
(4'-[(6-Bromo-2-propyl-1H-benzo[d]imidazol-1-yl)met...)
Show SMILES CCCc1nc2ccc(Br)cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H21BrN2O2/c1-2-5-23-26-21-13-12-18(25)14-22(21)27(23)15-16-8-10-17(11-9-16)19-6-3-4-7-20(19)24(28)29/h3-4,6-14H,2,5,15H2,1H3,(H,28,29)
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n/an/an/an/a 470n/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Activation of Gal4-tagged human PPARgamma expressed in CHO cells by luciferase reporter gene assay


Bioorg Med Chem 18: 5885-95 (2010)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50324042
PNG
(4'-[(5,6-Dibromo-2-propyl-1H-benzo[d]imidazol-1-yl...)
Show SMILES CCCc1nc2cc(Br)c(Br)cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H20Br2N2O2/c1-2-5-23-27-21-12-19(25)20(26)13-22(21)28(23)14-15-8-10-16(11-9-15)17-6-3-4-7-18(17)24(29)30/h3-4,6-13H,2,5,14H2,1H3,(H,29,30)
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n/an/an/an/a 400n/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Activation of Gal4-tagged human PPARgamma expressed in CHO cells by luciferase reporter gene assay


Bioorg Med Chem 18: 5885-95 (2010)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50324043
PNG
(4'-[(5-(Phenylcarbonyl)-2-propyl-1H-benzo[d]imidaz...)
Show SMILES CCCc1nc2cc(ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(=O)c1ccccc1
Show InChI InChI=1S/C31H26N2O3/c1-2-8-29-32-27-19-24(30(34)23-9-4-3-5-10-23)17-18-28(27)33(29)20-21-13-15-22(16-14-21)25-11-6-7-12-26(25)31(35)36/h3-7,9-19H,2,8,20H2,1H3,(H,35,36)
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n/an/an/an/a 580n/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Activation of Gal4-tagged human PPARgamma expressed in CHO cells by luciferase reporter gene assay


Bioorg Med Chem 18: 5885-95 (2010)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50324045
PNG
(4'-[(5-(Hydroxy(phenyl)methyl)-2-propyl-1H-benzo[d...)
Show SMILES CCCc1nc2cc(ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(O)c1ccccc1
Show InChI InChI=1S/C31H28N2O3/c1-2-8-29-32-27-19-24(30(34)23-9-4-3-5-10-23)17-18-28(27)33(29)20-21-13-15-22(16-14-21)25-11-6-7-12-26(25)31(35)36/h3-7,9-19,30,34H,2,8,20H2,1H3,(H,35,36)
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n/an/an/an/a 2.90E+3n/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Activation of Gal4-tagged human PPARgamma expressed in CHO cells by luciferase reporter gene assay


Bioorg Med Chem 18: 5885-95 (2010)

More data for this
Ligand-Target Pair
PPAR alpha/gamma


(Homo sapiens (human))
BDBM50324039
PNG
(4'-[(2-Propyl-1H-benzo[d]imidazol-1-yl)methyl]biph...)
Show SMILES CCCc1nc2ccccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H22N2O2/c1-2-7-23-25-21-10-5-6-11-22(21)26(23)16-17-12-14-18(15-13-17)19-8-3-4-9-20(19)24(27)28/h3-6,8-15H,2,7,16H2,1H3,(H,27,28)
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n/an/an/an/a 4.17E+3n/an/an/an/a



Universit£t Innsbruck

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
AGTR1


(RAT)
BDBM50043273
PNG
(4'-(5-Acetylamino-2-butyl-benzoimidazol-1-ylmethyl...)
Show SMILES CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C27H27N3O3/c1-3-4-9-26-29-24-16-21(28-18(2)31)14-15-25(24)30(26)17-19-10-12-20(13-11-19)22-7-5-6-8-23(22)27(32)33/h5-8,10-16H,3-4,9,17H2,1-2H3,(H,28,31)(H,32,33)
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n/an/an/a 10n/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in rat aorta


Eur J Med Chem 43: 1808-12 (2008)

More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043258
PNG
(4'-(5-Amino-2-butyl-benzoimidazol-1-ylmethyl)-biph...)
Show SMILES CCCCc1nc2cc(N)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C25H25N3O2/c1-2-3-8-24-27-22-15-19(26)13-14-23(22)28(24)16-17-9-11-18(12-10-17)20-6-4-5-7-21(20)25(29)30/h4-7,9-15H,2-3,8,16,26H2,1H3,(H,29,30)
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n/an/a 820n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair