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7 similar compounds to monomer 50412352

Wt: 441.5
BDBM50043254
Wt: 441.5
BDBM50043273
Wt: 538.0
BDBM50412353
Wt: 503.5
BDBM50412354
Wt: 469.5
BDBM50412355
Wt: 455.5
BDBM50412356
Wt: 483.6
BDBM50412357

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50043254,50043273,50412353,50412354,50412355,50412356,50412357   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II AT1B


(RAT)
BDBM50043254
PNG
(4'-(6-Acetylamino-2-butyl-benzoimidazol-1-ylmethyl...)
Show SMILES CCCCc1nc2ccc(NC(C)=O)cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C27H27N3O3/c1-3-4-9-26-29-24-15-14-21(28-18(2)31)16-25(24)30(26)17-19-10-12-20(13-11-19)22-7-5-6-8-23(22)27(32)33/h5-8,10-16H,3-4,9,17H2,1-2H3,(H,28,31)(H,32,33)
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PubMed
n/an/a 180n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043273
PNG
(4'-(5-Acetylamino-2-butyl-benzoimidazol-1-ylmethyl...)
Show SMILES CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C27H27N3O3/c1-3-4-9-26-29-24-16-21(28-18(2)31)14-15-25(24)30(26)17-19-10-12-20(13-11-19)22-7-5-6-8-23(22)27(32)33/h5-8,10-16H,3-4,9,17H2,1-2H3,(H,28,31)(H,32,33)
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n/an/a 460n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
AGTR1


(RAT)
BDBM50043273
PNG
(4'-(5-Acetylamino-2-butyl-benzoimidazol-1-ylmethyl...)
Show SMILES CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C27H27N3O3/c1-3-4-9-26-29-24-16-21(28-18(2)31)14-15-25(24)30(26)17-19-10-12-20(13-11-19)22-7-5-6-8-23(22)27(32)33/h5-8,10-16H,3-4,9,17H2,1-2H3,(H,28,31)(H,32,33)
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Article
PubMed
n/an/an/a 10n/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in rat aorta


Eur J Med Chem 43: 1808-12 (2008)

More data for this
Ligand-Target Pair
AGTR1


(RAT)
BDBM50412357
PNG
(CHEMBL519564)
Show SMILES CCCCC(=O)Nc1ccc2n(Cc3ccc(cc3)-c3ccccc3C(O)=O)c(CCCC)nc2c1
Show InChI InChI=1S/C30H33N3O3/c1-3-5-11-28-32-26-19-23(31-29(34)12-6-4-2)17-18-27(26)33(28)20-21-13-15-22(16-14-21)24-9-7-8-10-25(24)30(35)36/h7-10,13-19H,3-6,11-12,20H2,1-2H3,(H,31,34)(H,35,36)
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n/an/an/a 398n/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in rat aorta


Eur J Med Chem 43: 1808-12 (2008)

More data for this
Ligand-Target Pair
AGTR1


(RAT)
BDBM50412354
PNG
(CHEMBL486847)
Show SMILES CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C32H29N3O3/c1-2-3-13-30-34-28-20-25(33-31(36)24-9-5-4-6-10-24)18-19-29(28)35(30)21-22-14-16-23(17-15-22)26-11-7-8-12-27(26)32(37)38/h4-12,14-20H,2-3,13,21H2,1H3,(H,33,36)(H,37,38)
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n/an/an/a 251n/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in rat aorta


Eur J Med Chem 43: 1808-12 (2008)

More data for this
Ligand-Target Pair
AGTR1


(RAT)
BDBM50412355
PNG
(CHEMBL471505)
Show SMILES CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C29H31N3O3/c1-3-5-11-27-31-25-18-22(30-28(33)8-4-2)16-17-26(25)32(27)19-20-12-14-21(15-13-20)23-9-6-7-10-24(23)29(34)35/h6-7,9-10,12-18H,3-5,8,11,19H2,1-2H3,(H,30,33)(H,34,35)
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n/an/an/a 79.4n/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in rat aorta


Eur J Med Chem 43: 1808-12 (2008)

More data for this
Ligand-Target Pair
AGTR1


(RAT)
BDBM50412356
PNG
(CHEMBL471334)
Show SMILES CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C28H29N3O3/c1-3-5-10-26-30-24-17-21(29-27(32)4-2)15-16-25(24)31(26)18-19-11-13-20(14-12-19)22-8-6-7-9-23(22)28(33)34/h6-9,11-17H,3-5,10,18H2,1-2H3,(H,29,32)(H,33,34)
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PubMed
n/an/an/a 19.9n/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in rat aorta


Eur J Med Chem 43: 1808-12 (2008)

More data for this
Ligand-Target Pair
AGTR1


(RAT)
BDBM50412353
PNG
(CHEMBL486848)
Show SMILES CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C32H28ClN3O3/c1-2-3-12-30-35-28-19-23(34-31(37)26-10-6-7-11-27(26)33)17-18-29(28)36(30)20-21-13-15-22(16-14-21)24-8-4-5-9-25(24)32(38)39/h4-11,13-19H,2-3,12,20H2,1H3,(H,34,37)(H,38,39)
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PubMed
n/an/an/a 316n/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in rat aorta


Eur J Med Chem 43: 1808-12 (2008)

More data for this
Ligand-Target Pair